Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P12235 (ADT1_HUMAN)

Protein

ADP/ATP translocase 1

Gene

SLC25A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80ADPBy similarity1
Binding sitei92ADPBy similarity1
Binding sitei235ADPBy similarity1

GO - Molecular functioni

  • adenine transmembrane transporter activity Source: ProtInc
  • ATP:ADP antiporter activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processHost-virus interaction, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
R-HSA-422356 Regulation of insulin secretion

Protein family/group databases

TCDBi2.A.29.1.2 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 1
Alternative name(s):
ADP,ATP carrier protein 1
ADP,ATP carrier protein, heart/skeletal muscle isoform T1
Adenine nucleotide translocator 1
Short name:
ANT 1
Solute carrier family 25 member 4
Gene namesi
Name:SLC25A4
Synonyms:ANT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000151729.10
HGNCiHGNC:10990 SLC25A4
MIMi103220 gene
neXtProtiNX_P12235

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 37Helical; Name=1By similarityAdd BLAST30
Transmembranei75 – 99Helical; Name=2By similarityAdd BLAST25
Transmembranei110 – 130Helical; Name=3By similarityAdd BLAST21
Transmembranei179 – 199Helical; Name=4By similarityAdd BLAST21
Transmembranei211 – 231Helical; Name=5By similarityAdd BLAST21
Transmembranei274 – 291Helical; Name=6By similarityAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Involvement in diseasei

Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 2 (PEOA2)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.
See also OMIM:609283
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03881490A → D in PEOA2; decreased function in ADP transport. 2 Publications1
Natural variantiVAR_02245998L → P in PEOA2; decreased function in ADP transport. 3 PublicationsCorresponds to variant dbSNP:rs104893876EnsemblClinVar.1
Natural variantiVAR_022460104D → G in PEOA2; decreased function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs28999114EnsemblClinVar.1
Natural variantiVAR_012111114A → P in PEOA2; decreased function in ADP transport. 3 PublicationsCorresponds to variant dbSNP:rs104893873EnsemblClinVar.1
Natural variantiVAR_012112289V → M in PEOA2. 2 PublicationsCorresponds to variant dbSNP:rs104893874EnsemblClinVar.1
Mitochondrial DNA depletion syndrome 12B, cardiomyopathic type (MTDPS12B)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive mitochondrial disorder characterized by childhood onset of slowly progressive hypertrophic cardiomyopathy and generalized skeletal myopathy resulting in exercise intolerance and, in some patients, muscle weakness and atrophy. Skeletal muscle biopsy shows ragged red fibers, mtDNA depletion, and accumulation of abnormal mitochondria.
See also OMIM:615418
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038815123A → D in MTDPS12B; loss of function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs121912683EnsemblClinVar.1
Natural variantiVAR_078073236R → P in MTDPS12B; loss of function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs770816416EnsemblClinVar.1
Mitochondrial DNA depletion syndrome 12A, cardiomyopathic type (MTDPS12A)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant mitochondrial disorder characterized by severe hypotonia due to mitochondrial dysfunction apparent at birth. Affected infants have respiratory insufficiency requiring mechanical ventilation and have poor or no motor development. Many die in infancy, and those that survive have profound hypotonia with significant muscle weakness and inability to walk independently. Some patients develop hypertrophic cardiomyopathy. Muscle samples show mtDNA depletion and severe combined mitochondrial respiratory chain deficiencies.
See also OMIM:617184
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07807180R → H in MTDPS12A; decreased function in ADP transport. 1 PublicationCorresponds to variant dbSNP:rs886041081EnsemblClinVar.1
Natural variantiVAR_078072235R → G in MTDPS12A; severely decreased function in ADP transport. 1 PublicationCorresponds to variant dbSNP:rs886041082EnsemblClinVar.1

Keywords - Diseasei

Cardiomyopathy, Disease mutation, Primary mitochondrial disease, Progressive external ophthalmoplegia

Organism-specific databases

DisGeNETi291
MalaCardsiSLC25A4
MIMi609283 phenotype
615418 phenotype
617184 phenotype
OpenTargetsiENSG00000151729
Orphaneti254892 Autosomal dominant progressive external ophthalmoplegia
1369 Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome
PharmGKBiPA35866

Chemistry databases

DrugBankiDB01736 [3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium
DB00171 Adenosine triphosphate
DB02426 Carboxyatractyloside
DB03429 Cardiolipin
DB00720 Clodronate
DB04178 Di-Stearoyl-3-Sn-Phosphatidylcholine

Polymorphism and mutation databases

BioMutaiSLC25A4
DMDMi113455

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000905742 – 298ADP/ATP translocase 1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1
Modified residuei7PhosphoserineBy similarity1
Modified residuei147N6-succinyllysineBy similarity1
Modified residuei160S-nitrosocysteineBy similarity1
Modified residuei245N6-succinyllysineBy similarity1
Modified residuei272N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

EPDiP12235
MaxQBiP12235
PaxDbiP12235
PeptideAtlasiP12235
PRIDEiP12235
ProteomicsDBi52836
TopDownProteomicsiP12235

PTM databases

iPTMnetiP12235
PhosphoSitePlusiP12235
SwissPalmiP12235

Expressioni

Gene expression databases

BgeeiENSG00000151729 Expressed in 234 organ(s), highest expression level in left ventricle myocardium
CleanExiHS_SLC25A4
ExpressionAtlasiP12235 baseline and differential
GenevisibleiP12235 HS

Organism-specific databases

HPAiHPA046835
HPA071684

Interactioni

Subunit structurei

Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP (By similarity). Homodimer.By similarity
(Microbial infection) Interacts with HIV-1 Vpr.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi106788, 66 interactors
DIPiDIP-33116N
IntActiP12235, 30 interactors
MINTiP12235
STRINGi9606.ENSP00000281456

Structurei

3D structure databases

ProteinModelPortaliP12235
SMRiP12235
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 240Important for transport activity1 Publication6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 240Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00390000011543
HOGENOMiHOG000165727
HOVERGENiHBG108348
InParanoidiP12235
KOiK05863
OMAiQVMFGKV
OrthoDBiEOG091G0ULB
PhylomeDBiP12235
TreeFamiTF300743

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P12235-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDHAWSFLK DFLAGGVAAA VSKTAVAPIE RVKLLLQVQH ASKQISAEKQ 
        60         70         80         90        100
YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQLFL 
       110        120        130        140        150
GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGAA 
       160        170        180        190        200
QREFHGLGDC IIKIFKSDGL RGLYQGFNVS VQGIIIYRAA YFGVYDTAKG 
       210        220        230        240        250
MLPDPKNVHI FVSWMIAQSV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM 
       260        270        280        290 
YTGTVDCWRK IAKDEGAKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYV
Length:298
Mass (Da):33,064
Last modified:January 23, 2007 - v4
Checksum:i59F0DFAEC4E7CFBB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYG0V9GYG0_HUMAN
ADP/ATP translocase 1
SLC25A4
208Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16G → A in AAA61223 (PubMed:2823266).Curated1
Sequence conflicti147 – 149KGA → RR in AAA61223 (PubMed:2823266).Curated3
Sequence conflicti227V → L in AAA61223 (PubMed:2823266).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07807180R → H in MTDPS12A; decreased function in ADP transport. 1 PublicationCorresponds to variant dbSNP:rs886041081EnsemblClinVar.1
Natural variantiVAR_03881490A → D in PEOA2; decreased function in ADP transport. 2 Publications1
Natural variantiVAR_02245998L → P in PEOA2; decreased function in ADP transport. 3 PublicationsCorresponds to variant dbSNP:rs104893876EnsemblClinVar.1
Natural variantiVAR_022460104D → G in PEOA2; decreased function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs28999114EnsemblClinVar.1
Natural variantiVAR_012111114A → P in PEOA2; decreased function in ADP transport. 3 PublicationsCorresponds to variant dbSNP:rs104893873EnsemblClinVar.1
Natural variantiVAR_038815123A → D in MTDPS12B; loss of function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs121912683EnsemblClinVar.1
Natural variantiVAR_078072235R → G in MTDPS12A; severely decreased function in ADP transport. 1 PublicationCorresponds to variant dbSNP:rs886041082EnsemblClinVar.1
Natural variantiVAR_078073236R → P in MTDPS12B; loss of function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs770816416EnsemblClinVar.1
Natural variantiVAR_012112289V → M in PEOA2. 2 PublicationsCorresponds to variant dbSNP:rs104893874EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02966 mRNA Translation: AAA61223.1
J04982 Genomic DNA Translation: AAA51736.1
HQ206346 Genomic DNA Translation: ADP92294.1
HQ206347 Genomic DNA Translation: ADP92295.1
HQ206348 Genomic DNA Translation: ADP92296.1
HQ206349 Genomic DNA Translation: ADP92297.1
HQ206350 Genomic DNA Translation: ADP92298.1
HQ206351 Genomic DNA Translation: ADP92299.1
HQ206352 Genomic DNA Translation: ADP92300.1
HQ206353 Genomic DNA Translation: ADP92301.1
HQ206354 Genomic DNA Translation: ADP92302.1
HQ206355 Genomic DNA Translation: ADP92303.1
HQ206356 Genomic DNA Translation: ADP92304.1
HQ206357 Genomic DNA Translation: ADP92305.1
HQ206358 Genomic DNA Translation: ADP92306.1
HQ206359 Genomic DNA Translation: ADP92307.1
HQ206360 Genomic DNA Translation: ADP92308.1
HQ206361 Genomic DNA Translation: ADP92309.1
HQ206362 Genomic DNA Translation: ADP92310.1
HQ206363 Genomic DNA Translation: ADP92311.1
HQ206364 Genomic DNA Translation: ADP92312.1
HQ206365 Genomic DNA Translation: ADP92313.1
HQ206366 Genomic DNA Translation: ADP92314.1
HQ206367 Genomic DNA Translation: ADP92315.1
HQ206368 Genomic DNA Translation: ADP92316.1
HQ206369 Genomic DNA Translation: ADP92317.1
HQ206370 Genomic DNA Translation: ADP92318.1
HQ206371 Genomic DNA Translation: ADP92319.1
HQ206372 Genomic DNA Translation: ADP92320.1
HQ206373 Genomic DNA Translation: ADP92321.1
HQ206374 Genomic DNA Translation: ADP92322.1
HQ206375 Genomic DNA Translation: ADP92323.1
HQ206376 Genomic DNA Translation: ADP92324.1
HQ206377 Genomic DNA Translation: ADP92325.1
HQ206378 Genomic DNA Translation: ADP92326.1
HQ206379 Genomic DNA Translation: ADP92327.1
HQ206380 Genomic DNA Translation: ADP92328.1
HQ206381 Genomic DNA Translation: ADP92329.1
HQ206382 Genomic DNA Translation: ADP92330.1
HQ206383 Genomic DNA Translation: ADP92331.1
HQ206384 Genomic DNA Translation: ADP92332.1
HQ206385 Genomic DNA Translation: ADP92333.1
CH471056 Genomic DNA Translation: EAX04655.1
CH471056 Genomic DNA Translation: EAX04656.1
BC008664 mRNA Translation: AAH08664.1
BC061589 mRNA Translation: AAH61589.1
BC063643 mRNA Translation: AAH63643.1
J03593 mRNA Translation: AAA36751.1
CCDSiCCDS34114.1
PIRiA44778
RefSeqiNP_001142.2, NM_001151.3
UniGeneiHs.246506

Genome annotation databases

EnsembliENST00000281456; ENSP00000281456; ENSG00000151729
GeneIDi291
KEGGihsa:291
UCSCiuc003ixd.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02966 mRNA Translation: AAA61223.1
J04982 Genomic DNA Translation: AAA51736.1
HQ206346 Genomic DNA Translation: ADP92294.1
HQ206347 Genomic DNA Translation: ADP92295.1
HQ206348 Genomic DNA Translation: ADP92296.1
HQ206349 Genomic DNA Translation: ADP92297.1
HQ206350 Genomic DNA Translation: ADP92298.1
HQ206351 Genomic DNA Translation: ADP92299.1
HQ206352 Genomic DNA Translation: ADP92300.1
HQ206353 Genomic DNA Translation: ADP92301.1
HQ206354 Genomic DNA Translation: ADP92302.1
HQ206355 Genomic DNA Translation: ADP92303.1
HQ206356 Genomic DNA Translation: ADP92304.1
HQ206357 Genomic DNA Translation: ADP92305.1
HQ206358 Genomic DNA Translation: ADP92306.1
HQ206359 Genomic DNA Translation: ADP92307.1
HQ206360 Genomic DNA Translation: ADP92308.1
HQ206361 Genomic DNA Translation: ADP92309.1
HQ206362 Genomic DNA Translation: ADP92310.1
HQ206363 Genomic DNA Translation: ADP92311.1
HQ206364 Genomic DNA Translation: ADP92312.1
HQ206365 Genomic DNA Translation: ADP92313.1
HQ206366 Genomic DNA Translation: ADP92314.1
HQ206367 Genomic DNA Translation: ADP92315.1
HQ206368 Genomic DNA Translation: ADP92316.1
HQ206369 Genomic DNA Translation: ADP92317.1
HQ206370 Genomic DNA Translation: ADP92318.1
HQ206371 Genomic DNA Translation: ADP92319.1
HQ206372 Genomic DNA Translation: ADP92320.1
HQ206373 Genomic DNA Translation: ADP92321.1
HQ206374 Genomic DNA Translation: ADP92322.1
HQ206375 Genomic DNA Translation: ADP92323.1
HQ206376 Genomic DNA Translation: ADP92324.1
HQ206377 Genomic DNA Translation: ADP92325.1
HQ206378 Genomic DNA Translation: ADP92326.1
HQ206379 Genomic DNA Translation: ADP92327.1
HQ206380 Genomic DNA Translation: ADP92328.1
HQ206381 Genomic DNA Translation: ADP92329.1
HQ206382 Genomic DNA Translation: ADP92330.1
HQ206383 Genomic DNA Translation: ADP92331.1
HQ206384 Genomic DNA Translation: ADP92332.1
HQ206385 Genomic DNA Translation: ADP92333.1
CH471056 Genomic DNA Translation: EAX04655.1
CH471056 Genomic DNA Translation: EAX04656.1
BC008664 mRNA Translation: AAH08664.1
BC061589 mRNA Translation: AAH61589.1
BC063643 mRNA Translation: AAH63643.1
J03593 mRNA Translation: AAA36751.1
CCDSiCCDS34114.1
PIRiA44778
RefSeqiNP_001142.2, NM_001151.3
UniGeneiHs.246506

3D structure databases

ProteinModelPortaliP12235
SMRiP12235
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106788, 66 interactors
DIPiDIP-33116N
IntActiP12235, 30 interactors
MINTiP12235
STRINGi9606.ENSP00000281456

Chemistry databases

DrugBankiDB01736 [3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium
DB00171 Adenosine triphosphate
DB02426 Carboxyatractyloside
DB03429 Cardiolipin
DB00720 Clodronate
DB04178 Di-Stearoyl-3-Sn-Phosphatidylcholine

Protein family/group databases

TCDBi2.A.29.1.2 the mitochondrial carrier (mc) family

PTM databases

iPTMnetiP12235
PhosphoSitePlusiP12235
SwissPalmiP12235

Polymorphism and mutation databases

BioMutaiSLC25A4
DMDMi113455

Proteomic databases

EPDiP12235
MaxQBiP12235
PaxDbiP12235
PeptideAtlasiP12235
PRIDEiP12235
ProteomicsDBi52836
TopDownProteomicsiP12235

Protocols and materials databases

DNASUi291
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281456; ENSP00000281456; ENSG00000151729
GeneIDi291
KEGGihsa:291
UCSCiuc003ixd.4 human

Organism-specific databases

CTDi291
DisGeNETi291
EuPathDBiHostDB:ENSG00000151729.10
GeneCardsiSLC25A4
HGNCiHGNC:10990 SLC25A4
HPAiHPA046835
HPA071684
MalaCardsiSLC25A4
MIMi103220 gene
609283 phenotype
615418 phenotype
617184 phenotype
neXtProtiNX_P12235
OpenTargetsiENSG00000151729
Orphaneti254892 Autosomal dominant progressive external ophthalmoplegia
1369 Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome
PharmGKBiPA35866
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00390000011543
HOGENOMiHOG000165727
HOVERGENiHBG108348
InParanoidiP12235
KOiK05863
OMAiQVMFGKV
OrthoDBiEOG091G0ULB
PhylomeDBiP12235
TreeFamiTF300743

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
R-HSA-422356 Regulation of insulin secretion

Miscellaneous databases

ChiTaRSiSLC25A4 human
GeneWikiiSLC25A4
GenomeRNAii291
PROiPR:P12235
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151729 Expressed in 234 organ(s), highest expression level in left ventricle myocardium
CleanExiHS_SLC25A4
ExpressionAtlasiP12235 baseline and differential
GenevisibleiP12235 HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiADT1_HUMAN
AccessioniPrimary (citable) accession number: P12235
Secondary accession number(s): D3DP59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 215 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again