UniProtKB - P12235 (ADT1_HUMAN)
Protein
ADP/ATP translocase 1
Gene
SLC25A4
Organism
Homo sapiens (Human)
Status
Functioni
Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 80 | ADPBy similarity | 1 | |
Binding sitei | 92 | ADPBy similarity | 1 | |
Binding sitei | 235 | ADPBy similarity | 1 |
GO - Molecular functioni
- adenine transmembrane transporter activity Source: ProtInc
- ATP:ADP antiporter activity Source: InterPro
GO - Biological processi
- ADP transport Source: UniProtKB
- apoptotic mitochondrial changes Source: Ensembl
- generation of precursor metabolites and energy Source: ProtInc
- mitochondrial ADP transmembrane transport Source: InterPro
- mitochondrial ATP transmembrane transport Source: InterPro
- mitochondrial genome maintenance Source: ProtInc
- negative regulation of necroptotic process Source: BHF-UCL
- regulation of insulin secretion Source: Reactome
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction, Transport |
Enzyme and pathway databases
PathwayCommonsi | P12235 |
Reactomei | R-HSA-1268020, Mitochondrial protein import R-HSA-180897, Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
SIGNORi | P12235 |
Protein family/group databases
TCDBi | 2.A.29.1.2, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: ADP/ATP translocase 1Alternative name(s): ADP,ATP carrier protein 1 ADP,ATP carrier protein, heart/skeletal muscle isoform T1 Adenine nucleotide translocator 1 Short name: ANT 1 Solute carrier family 25 member 4 |
Gene namesi | Name:SLC25A4 Synonyms:ANT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10990, SLC25A4 |
MIMi | 103220, gene |
neXtProti | NX_P12235 |
VEuPathDBi | HostDB:ENSG00000151729.10 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- Membrane 1 Publication
Note: The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). May localize to non-mitochondrial membranes (PubMed:27641616).By similarity1 Publication
Mitochondrion
- integral component of mitochondrial membrane Source: UniProtKB
- mitochondrial inner membrane Source: Reactome
- mitochondrion Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
Other locations
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 8 – 37 | Helical; Name=1By similarityAdd BLAST | 30 | |
Transmembranei | 75 – 99 | Helical; Name=2By similarityAdd BLAST | 25 | |
Transmembranei | 110 – 130 | Helical; Name=3By similarityAdd BLAST | 21 | |
Transmembranei | 179 – 199 | Helical; Name=4By similarityAdd BLAST | 21 | |
Transmembranei | 211 – 231 | Helical; Name=5By similarityAdd BLAST | 21 | |
Transmembranei | 274 – 291 | Helical; Name=6By similarityAdd BLAST | 18 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Involvement in diseasei
Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 2 (PEOA2)7 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038814 | 90 | A → D in PEOA2; decreased function in ADP transport. 2 Publications | 1 | |
Natural variantiVAR_022459 | 98 | L → P in PEOA2; decreased function in ADP transport. 3 PublicationsCorresponds to variant dbSNP:rs104893876EnsemblClinVar. | 1 | |
Natural variantiVAR_022460 | 104 | D → G in PEOA2; decreased function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs28999114EnsemblClinVar. | 1 | |
Natural variantiVAR_012111 | 114 | A → P in PEOA2; decreased function in ADP transport. 3 PublicationsCorresponds to variant dbSNP:rs104893873EnsemblClinVar. | 1 | |
Natural variantiVAR_012112 | 289 | V → M in PEOA2. 2 PublicationsCorresponds to variant dbSNP:rs104893874EnsemblClinVar. | 1 |
Mitochondrial DNA depletion syndrome 12B, cardiomyopathic type (MTDPS12B)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive mitochondrial disorder characterized by childhood onset of slowly progressive hypertrophic cardiomyopathy and generalized skeletal myopathy resulting in exercise intolerance and, in some patients, muscle weakness and atrophy. Skeletal muscle biopsy shows ragged red fibers, mtDNA depletion, and accumulation of abnormal mitochondria.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038815 | 123 | A → D in MTDPS12B; loss of function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs121912683EnsemblClinVar. | 1 | |
Natural variantiVAR_078073 | 236 | R → P in MTDPS12B; loss of function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs770816416EnsemblClinVar. | 1 |
Mitochondrial DNA depletion syndrome 12A, cardiomyopathic type (MTDPS12A)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant mitochondrial disorder characterized by severe hypotonia due to mitochondrial dysfunction apparent at birth. Affected infants have respiratory insufficiency requiring mechanical ventilation and have poor or no motor development. Many die in infancy, and those that survive have profound hypotonia with significant muscle weakness and inability to walk independently. Some patients develop hypertrophic cardiomyopathy. Muscle samples show mtDNA depletion and severe combined mitochondrial respiratory chain deficiencies.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_078071 | 80 | R → H in MTDPS12A; decreased function in ADP transport. 1 PublicationCorresponds to variant dbSNP:rs886041081EnsemblClinVar. | 1 | |
Natural variantiVAR_078072 | 235 | R → G in MTDPS12A; severely decreased function in ADP transport. 1 PublicationCorresponds to variant dbSNP:rs886041082EnsemblClinVar. | 1 |
Keywords - Diseasei
Cardiomyopathy, Disease variant, Primary mitochondrial disease, Progressive external ophthalmoplegiaOrganism-specific databases
DisGeNETi | 291 |
MalaCardsi | SLC25A4 |
MIMi | 609283, phenotype 615418, phenotype 617184, phenotype |
OpenTargetsi | ENSG00000151729 |
Orphaneti | 254892, Autosomal dominant progressive external ophthalmoplegia 1369, Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome |
PharmGKBi | PA35866 |
Miscellaneous databases
Pharosi | P12235, Tbio |
Chemistry databases
DrugBanki | DB01736, [3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium DB00171, ATP DB02426, Carboxyatractyloside DB00720, Clodronic acid DB04178, Di-Stearoyl-3-Sn-Phosphatidylcholine DB01077, Etidronic acid DB03429, Tetrastearoyl cardiolipin |
DrugCentrali | P12235 |
Genetic variation databases
BioMutai | SLC25A4 |
DMDMi | 113455 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000090574 | 2 – 298 | ADP/ATP translocase 1Add BLAST | 297 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylglycine1 Publication | 1 | |
Modified residuei | 7 | PhosphoserineBy similarity | 1 | |
Modified residuei | 52 | N6,N6,N6-trimethyllysineBy similarity | 1 | |
Modified residuei | 147 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 160 | S-nitrosocysteineBy similarity | 1 | |
Modified residuei | 245 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 272 | N6-succinyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Methylation, Phosphoprotein, S-nitrosylationProteomic databases
EPDi | P12235 |
jPOSTi | P12235 |
MassIVEi | P12235 |
MaxQBi | P12235 |
PaxDbi | P12235 |
PeptideAtlasi | P12235 |
PRIDEi | P12235 |
ProteomicsDBi | 52836 |
TopDownProteomicsi | P12235 |
PTM databases
iPTMneti | P12235 |
MetOSitei | P12235 |
PhosphoSitePlusi | P12235 |
SwissPalmi | P12235 |
Expressioni
Tissue specificityi
Expressed in erythrocytes (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000151729, Expressed in left ventricle myocardium and 247 other tissues |
ExpressionAtlasi | P12235, baseline and differential |
Genevisiblei | P12235, HS |
Organism-specific databases
HPAi | ENSG00000151729, Group enriched (heart muscle, skeletal muscle, tongue) |
Interactioni
Subunit structurei
Homodimer (By similarity).
Found in a complex with ARL2, ARL2BP and SLC25A4 (By similarity).
Interacts with ARL2BP (By similarity).
By similarity(Microbial infection) Interacts with HIV-1 Vpr.
1 PublicationBinary interactionsi
Hide detailsP12235
With | #Exp. | IntAct |
---|---|---|
LRRK2 [Q5S007] | 2 | EBI-359074,EBI-5323863 |
NR4A1 - isoform 1 [P22736-1] | 2 | EBI-359074,EBI-16085263 |
Protein-protein interaction databases
BioGRIDi | 106788, 116 interactors |
DIPi | DIP-33116N |
IntActi | P12235, 44 interactors |
MINTi | P12235 |
STRINGi | 9606.ENSP00000281456 |
Miscellaneous databases
RNActi | P12235, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 6 – 98 | Solcar 1Add BLAST | 93 | |
Repeati | 111 – 201 | Solcar 2Add BLAST | 91 | |
Repeati | 212 – 297 | Solcar 3Add BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 235 – 240 | Important for transport activity1 Publication | 6 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 235 – 240 | Nucleotide carrier signature motifBy similarity | 6 |
Domaini
The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0749, Eukaryota |
GeneTreei | ENSGT00940000154622 |
InParanoidi | P12235 |
OMAi | LGWIVTT |
OrthoDBi | 870903at2759 |
PhylomeDBi | P12235 |
TreeFami | TF300743 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002113, ADT_euk_type IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
PANTHERi | PTHR45635, PTHR45635, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00927, ADPTRNSLCASE PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P12235-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDHAWSFLK DFLAGGVAAA VSKTAVAPIE RVKLLLQVQH ASKQISAEKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQLFL
110 120 130 140 150
GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGAA
160 170 180 190 200
QREFHGLGDC IIKIFKSDGL RGLYQGFNVS VQGIIIYRAA YFGVYDTAKG
210 220 230 240 250
MLPDPKNVHI FVSWMIAQSV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YTGTVDCWRK IAKDEGAKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketV9GYG0 | V9GYG0_HUMAN | ADP/ATP translocase 1 | SLC25A4 | 208 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 16 | G → A in AAA61223 (PubMed:2823266).Curated | 1 | |
Sequence conflicti | 147 – 149 | KGA → RR in AAA61223 (PubMed:2823266).Curated | 3 | |
Sequence conflicti | 227 | V → L in AAA61223 (PubMed:2823266).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_078071 | 80 | R → H in MTDPS12A; decreased function in ADP transport. 1 PublicationCorresponds to variant dbSNP:rs886041081EnsemblClinVar. | 1 | |
Natural variantiVAR_038814 | 90 | A → D in PEOA2; decreased function in ADP transport. 2 Publications | 1 | |
Natural variantiVAR_022459 | 98 | L → P in PEOA2; decreased function in ADP transport. 3 PublicationsCorresponds to variant dbSNP:rs104893876EnsemblClinVar. | 1 | |
Natural variantiVAR_022460 | 104 | D → G in PEOA2; decreased function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs28999114EnsemblClinVar. | 1 | |
Natural variantiVAR_012111 | 114 | A → P in PEOA2; decreased function in ADP transport. 3 PublicationsCorresponds to variant dbSNP:rs104893873EnsemblClinVar. | 1 | |
Natural variantiVAR_038815 | 123 | A → D in MTDPS12B; loss of function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs121912683EnsemblClinVar. | 1 | |
Natural variantiVAR_078072 | 235 | R → G in MTDPS12A; severely decreased function in ADP transport. 1 PublicationCorresponds to variant dbSNP:rs886041082EnsemblClinVar. | 1 | |
Natural variantiVAR_078073 | 236 | R → P in MTDPS12B; loss of function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs770816416EnsemblClinVar. | 1 | |
Natural variantiVAR_012112 | 289 | V → M in PEOA2. 2 PublicationsCorresponds to variant dbSNP:rs104893874EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02966 mRNA Translation: AAA61223.1 J04982 Genomic DNA Translation: AAA51736.1 HQ206346 Genomic DNA Translation: ADP92294.1 HQ206347 Genomic DNA Translation: ADP92295.1 HQ206348 Genomic DNA Translation: ADP92296.1 HQ206349 Genomic DNA Translation: ADP92297.1 HQ206350 Genomic DNA Translation: ADP92298.1 HQ206351 Genomic DNA Translation: ADP92299.1 HQ206352 Genomic DNA Translation: ADP92300.1 HQ206353 Genomic DNA Translation: ADP92301.1 HQ206354 Genomic DNA Translation: ADP92302.1 HQ206355 Genomic DNA Translation: ADP92303.1 HQ206356 Genomic DNA Translation: ADP92304.1 HQ206357 Genomic DNA Translation: ADP92305.1 HQ206358 Genomic DNA Translation: ADP92306.1 HQ206359 Genomic DNA Translation: ADP92307.1 HQ206360 Genomic DNA Translation: ADP92308.1 HQ206361 Genomic DNA Translation: ADP92309.1 HQ206362 Genomic DNA Translation: ADP92310.1 HQ206363 Genomic DNA Translation: ADP92311.1 HQ206364 Genomic DNA Translation: ADP92312.1 HQ206365 Genomic DNA Translation: ADP92313.1 HQ206366 Genomic DNA Translation: ADP92314.1 HQ206367 Genomic DNA Translation: ADP92315.1 HQ206368 Genomic DNA Translation: ADP92316.1 HQ206369 Genomic DNA Translation: ADP92317.1 HQ206370 Genomic DNA Translation: ADP92318.1 HQ206371 Genomic DNA Translation: ADP92319.1 HQ206372 Genomic DNA Translation: ADP92320.1 HQ206373 Genomic DNA Translation: ADP92321.1 HQ206374 Genomic DNA Translation: ADP92322.1 HQ206375 Genomic DNA Translation: ADP92323.1 HQ206376 Genomic DNA Translation: ADP92324.1 HQ206377 Genomic DNA Translation: ADP92325.1 HQ206378 Genomic DNA Translation: ADP92326.1 HQ206379 Genomic DNA Translation: ADP92327.1 HQ206380 Genomic DNA Translation: ADP92328.1 HQ206381 Genomic DNA Translation: ADP92329.1 HQ206382 Genomic DNA Translation: ADP92330.1 HQ206383 Genomic DNA Translation: ADP92331.1 HQ206384 Genomic DNA Translation: ADP92332.1 HQ206385 Genomic DNA Translation: ADP92333.1 CH471056 Genomic DNA Translation: EAX04655.1 CH471056 Genomic DNA Translation: EAX04656.1 BC008664 mRNA Translation: AAH08664.1 BC061589 mRNA Translation: AAH61589.1 BC063643 mRNA Translation: AAH63643.1 J03593 mRNA Translation: AAA36751.1 |
CCDSi | CCDS34114.1 |
PIRi | A44778 |
RefSeqi | NP_001142.2, NM_001151.3 |
Genome annotation databases
Ensembli | ENST00000281456; ENSP00000281456; ENSG00000151729 |
GeneIDi | 291 |
KEGGi | hsa:291 |
UCSCi | uc003ixd.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02966 mRNA Translation: AAA61223.1 J04982 Genomic DNA Translation: AAA51736.1 HQ206346 Genomic DNA Translation: ADP92294.1 HQ206347 Genomic DNA Translation: ADP92295.1 HQ206348 Genomic DNA Translation: ADP92296.1 HQ206349 Genomic DNA Translation: ADP92297.1 HQ206350 Genomic DNA Translation: ADP92298.1 HQ206351 Genomic DNA Translation: ADP92299.1 HQ206352 Genomic DNA Translation: ADP92300.1 HQ206353 Genomic DNA Translation: ADP92301.1 HQ206354 Genomic DNA Translation: ADP92302.1 HQ206355 Genomic DNA Translation: ADP92303.1 HQ206356 Genomic DNA Translation: ADP92304.1 HQ206357 Genomic DNA Translation: ADP92305.1 HQ206358 Genomic DNA Translation: ADP92306.1 HQ206359 Genomic DNA Translation: ADP92307.1 HQ206360 Genomic DNA Translation: ADP92308.1 HQ206361 Genomic DNA Translation: ADP92309.1 HQ206362 Genomic DNA Translation: ADP92310.1 HQ206363 Genomic DNA Translation: ADP92311.1 HQ206364 Genomic DNA Translation: ADP92312.1 HQ206365 Genomic DNA Translation: ADP92313.1 HQ206366 Genomic DNA Translation: ADP92314.1 HQ206367 Genomic DNA Translation: ADP92315.1 HQ206368 Genomic DNA Translation: ADP92316.1 HQ206369 Genomic DNA Translation: ADP92317.1 HQ206370 Genomic DNA Translation: ADP92318.1 HQ206371 Genomic DNA Translation: ADP92319.1 HQ206372 Genomic DNA Translation: ADP92320.1 HQ206373 Genomic DNA Translation: ADP92321.1 HQ206374 Genomic DNA Translation: ADP92322.1 HQ206375 Genomic DNA Translation: ADP92323.1 HQ206376 Genomic DNA Translation: ADP92324.1 HQ206377 Genomic DNA Translation: ADP92325.1 HQ206378 Genomic DNA Translation: ADP92326.1 HQ206379 Genomic DNA Translation: ADP92327.1 HQ206380 Genomic DNA Translation: ADP92328.1 HQ206381 Genomic DNA Translation: ADP92329.1 HQ206382 Genomic DNA Translation: ADP92330.1 HQ206383 Genomic DNA Translation: ADP92331.1 HQ206384 Genomic DNA Translation: ADP92332.1 HQ206385 Genomic DNA Translation: ADP92333.1 CH471056 Genomic DNA Translation: EAX04655.1 CH471056 Genomic DNA Translation: EAX04656.1 BC008664 mRNA Translation: AAH08664.1 BC061589 mRNA Translation: AAH61589.1 BC063643 mRNA Translation: AAH63643.1 J03593 mRNA Translation: AAA36751.1 |
CCDSi | CCDS34114.1 |
PIRi | A44778 |
RefSeqi | NP_001142.2, NM_001151.3 |
3D structure databases
SMRi | P12235 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106788, 116 interactors |
DIPi | DIP-33116N |
IntActi | P12235, 44 interactors |
MINTi | P12235 |
STRINGi | 9606.ENSP00000281456 |
Chemistry databases
DrugBanki | DB01736, [3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium DB00171, ATP DB02426, Carboxyatractyloside DB00720, Clodronic acid DB04178, Di-Stearoyl-3-Sn-Phosphatidylcholine DB01077, Etidronic acid DB03429, Tetrastearoyl cardiolipin |
DrugCentrali | P12235 |
Protein family/group databases
TCDBi | 2.A.29.1.2, the mitochondrial carrier (mc) family |
PTM databases
iPTMneti | P12235 |
MetOSitei | P12235 |
PhosphoSitePlusi | P12235 |
SwissPalmi | P12235 |
Genetic variation databases
BioMutai | SLC25A4 |
DMDMi | 113455 |
Proteomic databases
EPDi | P12235 |
jPOSTi | P12235 |
MassIVEi | P12235 |
MaxQBi | P12235 |
PaxDbi | P12235 |
PeptideAtlasi | P12235 |
PRIDEi | P12235 |
ProteomicsDBi | 52836 |
TopDownProteomicsi | P12235 |
Protocols and materials databases
Antibodypediai | 28911, 152 antibodies |
DNASUi | 291 |
Genome annotation databases
Ensembli | ENST00000281456; ENSP00000281456; ENSG00000151729 |
GeneIDi | 291 |
KEGGi | hsa:291 |
UCSCi | uc003ixd.4, human |
Organism-specific databases
CTDi | 291 |
DisGeNETi | 291 |
GeneCardsi | SLC25A4 |
HGNCi | HGNC:10990, SLC25A4 |
HPAi | ENSG00000151729, Group enriched (heart muscle, skeletal muscle, tongue) |
MalaCardsi | SLC25A4 |
MIMi | 103220, gene 609283, phenotype 615418, phenotype 617184, phenotype |
neXtProti | NX_P12235 |
OpenTargetsi | ENSG00000151729 |
Orphaneti | 254892, Autosomal dominant progressive external ophthalmoplegia 1369, Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome |
PharmGKBi | PA35866 |
VEuPathDBi | HostDB:ENSG00000151729.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0749, Eukaryota |
GeneTreei | ENSGT00940000154622 |
InParanoidi | P12235 |
OMAi | LGWIVTT |
OrthoDBi | 870903at2759 |
PhylomeDBi | P12235 |
TreeFami | TF300743 |
Enzyme and pathway databases
PathwayCommonsi | P12235 |
Reactomei | R-HSA-1268020, Mitochondrial protein import R-HSA-180897, Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
SIGNORi | P12235 |
Miscellaneous databases
BioGRID-ORCSi | 291, 6 hits in 874 CRISPR screens |
ChiTaRSi | SLC25A4, human |
GeneWikii | SLC25A4 |
GenomeRNAii | 291 |
Pharosi | P12235, Tbio |
PROi | PR:P12235 |
RNActi | P12235, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151729, Expressed in left ventricle myocardium and 247 other tissues |
ExpressionAtlasi | P12235, baseline and differential |
Genevisiblei | P12235, HS |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002113, ADT_euk_type IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
PANTHERi | PTHR45635, PTHR45635, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00927, ADPTRNSLCASE PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADT1_HUMAN | |
Accessioni | P12235Primary (citable) accession number: P12235 Secondary accession number(s): D3DP59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 230 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families