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Protein

ADP/ATP translocase 1

Gene

SLC25A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei80ADPBy similarity1
Binding sitei92ADPBy similarity1
Binding sitei235ADPBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • adenine transmembrane transporter activity Source: ProtInc
  • ATP:ADP antiporter activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1268020 Mitochondrial protein import
R-HSA-180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
R-HSA-422356 Regulation of insulin secretion

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.29.1.2 the mitochondrial carrier (mc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ADP/ATP translocase 1
Alternative name(s):
ADP,ATP carrier protein 1
ADP,ATP carrier protein, heart/skeletal muscle isoform T1
Adenine nucleotide translocator 1
Short name:
ANT 1
Solute carrier family 25 member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC25A4
Synonyms:ANT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000151729.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10990 SLC25A4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
103220 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P12235

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 37Helical; Name=1By similarityAdd BLAST30
Transmembranei75 – 99Helical; Name=2By similarityAdd BLAST25
Transmembranei110 – 130Helical; Name=3By similarityAdd BLAST21
Transmembranei179 – 199Helical; Name=4By similarityAdd BLAST21
Transmembranei211 – 231Helical; Name=5By similarityAdd BLAST21
Transmembranei274 – 291Helical; Name=6By similarityAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 2 (PEOA2)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.
See also OMIM:609283
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03881490A → D in PEOA2; decreased function in ADP transport. 2 Publications1
Natural variantiVAR_02245998L → P in PEOA2; decreased function in ADP transport. 3 PublicationsCorresponds to variant dbSNP:rs104893876EnsemblClinVar.1
Natural variantiVAR_022460104D → G in PEOA2; decreased function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs28999114EnsemblClinVar.1
Natural variantiVAR_012111114A → P in PEOA2; decreased function in ADP transport. 3 PublicationsCorresponds to variant dbSNP:rs104893873EnsemblClinVar.1
Natural variantiVAR_012112289V → M in PEOA2. 2 PublicationsCorresponds to variant dbSNP:rs104893874EnsemblClinVar.1
Mitochondrial DNA depletion syndrome 12B, cardiomyopathic type (MTDPS12B)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive mitochondrial disorder characterized by childhood onset of slowly progressive hypertrophic cardiomyopathy and generalized skeletal myopathy resulting in exercise intolerance and, in some patients, muscle weakness and atrophy. Skeletal muscle biopsy shows ragged red fibers, mtDNA depletion, and accumulation of abnormal mitochondria.
See also OMIM:615418
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038815123A → D in MTDPS12B; loss of function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs121912683EnsemblClinVar.1
Natural variantiVAR_078073236R → P in MTDPS12B; loss of function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs770816416EnsemblClinVar.1
Mitochondrial DNA depletion syndrome 12A, cardiomyopathic type (MTDPS12A)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant mitochondrial disorder characterized by severe hypotonia due to mitochondrial dysfunction apparent at birth. Affected infants have respiratory insufficiency requiring mechanical ventilation and have poor or no motor development. Many die in infancy, and those that survive have profound hypotonia with significant muscle weakness and inability to walk independently. Some patients develop hypertrophic cardiomyopathy. Muscle samples show mtDNA depletion and severe combined mitochondrial respiratory chain deficiencies.
See also OMIM:617184
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07807180R → H in MTDPS12A; decreased function in ADP transport. 1 PublicationCorresponds to variant dbSNP:rs886041081EnsemblClinVar.1
Natural variantiVAR_078072235R → G in MTDPS12A; severely decreased function in ADP transport. 1 PublicationCorresponds to variant dbSNP:rs886041082EnsemblClinVar.1

Keywords - Diseasei

Cardiomyopathy, Disease mutation, Primary mitochondrial disease, Progressive external ophthalmoplegia

Organism-specific databases

DisGeNET

More...
DisGeNETi
291

MalaCards human disease database

More...
MalaCardsi
SLC25A4
MIMi609283 phenotype
615418 phenotype
617184 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000151729

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
254892 Autosomal dominant progressive external ophthalmoplegia
1369 Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35866

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01736 [3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium
DB00171 Adenosine triphosphate
DB02426 Carboxyatractyloside
DB03429 Cardiolipin
DB00720 Clodronate
DB04178 Di-Stearoyl-3-Sn-Phosphatidylcholine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC25A4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
113455

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000905742 – 298ADP/ATP translocase 1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycine1 Publication1
Modified residuei7PhosphoserineBy similarity1
Modified residuei147N6-succinyllysineBy similarity1
Modified residuei160S-nitrosocysteineBy similarity1
Modified residuei245N6-succinyllysineBy similarity1
Modified residuei272N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P12235

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P12235

MaxQB - The MaxQuant DataBase

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MaxQBi
P12235

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P12235

PeptideAtlas

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PeptideAtlasi
P12235

PRoteomics IDEntifications database

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PRIDEi
P12235

ProteomicsDB human proteome resource

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ProteomicsDBi
52836

Consortium for Top Down Proteomics

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TopDownProteomicsi
P12235

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P12235

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P12235

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P12235

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151729 Expressed in 234 organ(s), highest expression level in left ventricle myocardium

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC25A4

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P12235 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P12235 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046835
HPA071684

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP (By similarity). Homodimer.By similarity
(Microbial infection) Interacts with HIV-1 Vpr.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106788, 66 interactors

Database of interacting proteins

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DIPi
DIP-33116N

Protein interaction database and analysis system

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IntActi
P12235, 30 interactors

Molecular INTeraction database

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MINTi
P12235

STRING: functional protein association networks

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STRINGi
9606.ENSP00000281456

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P12235

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P12235

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni235 – 240Important for transport activity1 Publication6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi235 – 240Nucleotide carrier signature motifBy similarity6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0749 Eukaryota
ENOG410XNW0 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154622

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000165727

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108348

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P12235

KEGG Orthology (KO)

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KOi
K05863

Identification of Orthologs from Complete Genome Data

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OMAi
QVMFGKV

Database of Orthologous Groups

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OrthoDBi
101221at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P12235

TreeFam database of animal gene trees

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TreeFami
TF300743

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR24089 PTHR24089, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00153 Mito_carr, 3 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00927 ADPTRNSLCASE
PR00926 MITOCARRIER

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103506 SSF103506, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50920 SOLCAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P12235-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDHAWSFLK DFLAGGVAAA VSKTAVAPIE RVKLLLQVQH ASKQISAEKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQLFL
110 120 130 140 150
GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGAA
160 170 180 190 200
QREFHGLGDC IIKIFKSDGL RGLYQGFNVS VQGIIIYRAA YFGVYDTAKG
210 220 230 240 250
MLPDPKNVHI FVSWMIAQSV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YTGTVDCWRK IAKDEGAKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYV
Length:298
Mass (Da):33,064
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59F0DFAEC4E7CFBB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYG0V9GYG0_HUMAN
ADP/ATP translocase 1
SLC25A4
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16G → A in AAA61223 (PubMed:2823266).Curated1
Sequence conflicti147 – 149KGA → RR in AAA61223 (PubMed:2823266).Curated3
Sequence conflicti227V → L in AAA61223 (PubMed:2823266).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07807180R → H in MTDPS12A; decreased function in ADP transport. 1 PublicationCorresponds to variant dbSNP:rs886041081EnsemblClinVar.1
Natural variantiVAR_03881490A → D in PEOA2; decreased function in ADP transport. 2 Publications1
Natural variantiVAR_02245998L → P in PEOA2; decreased function in ADP transport. 3 PublicationsCorresponds to variant dbSNP:rs104893876EnsemblClinVar.1
Natural variantiVAR_022460104D → G in PEOA2; decreased function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs28999114EnsemblClinVar.1
Natural variantiVAR_012111114A → P in PEOA2; decreased function in ADP transport. 3 PublicationsCorresponds to variant dbSNP:rs104893873EnsemblClinVar.1
Natural variantiVAR_038815123A → D in MTDPS12B; loss of function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs121912683EnsemblClinVar.1
Natural variantiVAR_078072235R → G in MTDPS12A; severely decreased function in ADP transport. 1 PublicationCorresponds to variant dbSNP:rs886041082EnsemblClinVar.1
Natural variantiVAR_078073236R → P in MTDPS12B; loss of function in ADP transport. 2 PublicationsCorresponds to variant dbSNP:rs770816416EnsemblClinVar.1
Natural variantiVAR_012112289V → M in PEOA2. 2 PublicationsCorresponds to variant dbSNP:rs104893874EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J02966 mRNA Translation: AAA61223.1
J04982 Genomic DNA Translation: AAA51736.1
HQ206346 Genomic DNA Translation: ADP92294.1
HQ206347 Genomic DNA Translation: ADP92295.1
HQ206348 Genomic DNA Translation: ADP92296.1
HQ206349 Genomic DNA Translation: ADP92297.1
HQ206350 Genomic DNA Translation: ADP92298.1
HQ206351 Genomic DNA Translation: ADP92299.1
HQ206352 Genomic DNA Translation: ADP92300.1
HQ206353 Genomic DNA Translation: ADP92301.1
HQ206354 Genomic DNA Translation: ADP92302.1
HQ206355 Genomic DNA Translation: ADP92303.1
HQ206356 Genomic DNA Translation: ADP92304.1
HQ206357 Genomic DNA Translation: ADP92305.1
HQ206358 Genomic DNA Translation: ADP92306.1
HQ206359 Genomic DNA Translation: ADP92307.1
HQ206360 Genomic DNA Translation: ADP92308.1
HQ206361 Genomic DNA Translation: ADP92309.1
HQ206362 Genomic DNA Translation: ADP92310.1
HQ206363 Genomic DNA Translation: ADP92311.1
HQ206364 Genomic DNA Translation: ADP92312.1
HQ206365 Genomic DNA Translation: ADP92313.1
HQ206366 Genomic DNA Translation: ADP92314.1
HQ206367 Genomic DNA Translation: ADP92315.1
HQ206368 Genomic DNA Translation: ADP92316.1
HQ206369 Genomic DNA Translation: ADP92317.1
HQ206370 Genomic DNA Translation: ADP92318.1
HQ206371 Genomic DNA Translation: ADP92319.1
HQ206372 Genomic DNA Translation: ADP92320.1
HQ206373 Genomic DNA Translation: ADP92321.1
HQ206374 Genomic DNA Translation: ADP92322.1
HQ206375 Genomic DNA Translation: ADP92323.1
HQ206376 Genomic DNA Translation: ADP92324.1
HQ206377 Genomic DNA Translation: ADP92325.1
HQ206378 Genomic DNA Translation: ADP92326.1
HQ206379 Genomic DNA Translation: ADP92327.1
HQ206380 Genomic DNA Translation: ADP92328.1
HQ206381 Genomic DNA Translation: ADP92329.1
HQ206382 Genomic DNA Translation: ADP92330.1
HQ206383 Genomic DNA Translation: ADP92331.1
HQ206384 Genomic DNA Translation: ADP92332.1
HQ206385 Genomic DNA Translation: ADP92333.1
CH471056 Genomic DNA Translation: EAX04655.1
CH471056 Genomic DNA Translation: EAX04656.1
BC008664 mRNA Translation: AAH08664.1
BC061589 mRNA Translation: AAH61589.1
BC063643 mRNA Translation: AAH63643.1
J03593 mRNA Translation: AAA36751.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34114.1

Protein sequence database of the Protein Information Resource

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PIRi
A44778

NCBI Reference Sequences

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RefSeqi
NP_001142.2, NM_001151.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.246506

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000281456; ENSP00000281456; ENSG00000151729

Database of genes from NCBI RefSeq genomes

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GeneIDi
291

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:291

UCSC genome browser

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UCSCi
uc003ixd.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02966 mRNA Translation: AAA61223.1
J04982 Genomic DNA Translation: AAA51736.1
HQ206346 Genomic DNA Translation: ADP92294.1
HQ206347 Genomic DNA Translation: ADP92295.1
HQ206348 Genomic DNA Translation: ADP92296.1
HQ206349 Genomic DNA Translation: ADP92297.1
HQ206350 Genomic DNA Translation: ADP92298.1
HQ206351 Genomic DNA Translation: ADP92299.1
HQ206352 Genomic DNA Translation: ADP92300.1
HQ206353 Genomic DNA Translation: ADP92301.1
HQ206354 Genomic DNA Translation: ADP92302.1
HQ206355 Genomic DNA Translation: ADP92303.1
HQ206356 Genomic DNA Translation: ADP92304.1
HQ206357 Genomic DNA Translation: ADP92305.1
HQ206358 Genomic DNA Translation: ADP92306.1
HQ206359 Genomic DNA Translation: ADP92307.1
HQ206360 Genomic DNA Translation: ADP92308.1
HQ206361 Genomic DNA Translation: ADP92309.1
HQ206362 Genomic DNA Translation: ADP92310.1
HQ206363 Genomic DNA Translation: ADP92311.1
HQ206364 Genomic DNA Translation: ADP92312.1
HQ206365 Genomic DNA Translation: ADP92313.1
HQ206366 Genomic DNA Translation: ADP92314.1
HQ206367 Genomic DNA Translation: ADP92315.1
HQ206368 Genomic DNA Translation: ADP92316.1
HQ206369 Genomic DNA Translation: ADP92317.1
HQ206370 Genomic DNA Translation: ADP92318.1
HQ206371 Genomic DNA Translation: ADP92319.1
HQ206372 Genomic DNA Translation: ADP92320.1
HQ206373 Genomic DNA Translation: ADP92321.1
HQ206374 Genomic DNA Translation: ADP92322.1
HQ206375 Genomic DNA Translation: ADP92323.1
HQ206376 Genomic DNA Translation: ADP92324.1
HQ206377 Genomic DNA Translation: ADP92325.1
HQ206378 Genomic DNA Translation: ADP92326.1
HQ206379 Genomic DNA Translation: ADP92327.1
HQ206380 Genomic DNA Translation: ADP92328.1
HQ206381 Genomic DNA Translation: ADP92329.1
HQ206382 Genomic DNA Translation: ADP92330.1
HQ206383 Genomic DNA Translation: ADP92331.1
HQ206384 Genomic DNA Translation: ADP92332.1
HQ206385 Genomic DNA Translation: ADP92333.1
CH471056 Genomic DNA Translation: EAX04655.1
CH471056 Genomic DNA Translation: EAX04656.1
BC008664 mRNA Translation: AAH08664.1
BC061589 mRNA Translation: AAH61589.1
BC063643 mRNA Translation: AAH63643.1
J03593 mRNA Translation: AAA36751.1
CCDSiCCDS34114.1
PIRiA44778
RefSeqiNP_001142.2, NM_001151.3
UniGeneiHs.246506

3D structure databases

ProteinModelPortaliP12235
SMRiP12235
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106788, 66 interactors
DIPiDIP-33116N
IntActiP12235, 30 interactors
MINTiP12235
STRINGi9606.ENSP00000281456

Chemistry databases

DrugBankiDB01736 [3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium
DB00171 Adenosine triphosphate
DB02426 Carboxyatractyloside
DB03429 Cardiolipin
DB00720 Clodronate
DB04178 Di-Stearoyl-3-Sn-Phosphatidylcholine

Protein family/group databases

TCDBi2.A.29.1.2 the mitochondrial carrier (mc) family

PTM databases

iPTMnetiP12235
PhosphoSitePlusiP12235
SwissPalmiP12235

Polymorphism and mutation databases

BioMutaiSLC25A4
DMDMi113455

Proteomic databases

EPDiP12235
jPOSTiP12235
MaxQBiP12235
PaxDbiP12235
PeptideAtlasiP12235
PRIDEiP12235
ProteomicsDBi52836
TopDownProteomicsiP12235

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
291
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281456; ENSP00000281456; ENSG00000151729
GeneIDi291
KEGGihsa:291
UCSCiuc003ixd.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
291
DisGeNETi291
EuPathDBiHostDB:ENSG00000151729.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC25A4
HGNCiHGNC:10990 SLC25A4
HPAiHPA046835
HPA071684
MalaCardsiSLC25A4
MIMi103220 gene
609283 phenotype
615418 phenotype
617184 phenotype
neXtProtiNX_P12235
OpenTargetsiENSG00000151729
Orphaneti254892 Autosomal dominant progressive external ophthalmoplegia
1369 Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome
PharmGKBiPA35866

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00940000154622
HOGENOMiHOG000165727
HOVERGENiHBG108348
InParanoidiP12235
KOiK05863
OMAiQVMFGKV
OrthoDBi101221at2759
PhylomeDBiP12235
TreeFamiTF300743

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
R-HSA-422356 Regulation of insulin secretion

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC25A4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC25A4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
291

Protein Ontology

More...
PROi
PR:P12235

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151729 Expressed in 234 organ(s), highest expression level in left ventricle myocardium
CleanExiHS_SLC25A4
ExpressionAtlasiP12235 baseline and differential
GenevisibleiP12235 HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12235
Secondary accession number(s): D3DP59
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 217 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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