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UniProtKB - P12234 (MPCP_BOVIN)
Protein
Phosphate carrier protein, mitochondrial
Gene
SLC25A3
Organism
Bos taurus (Bovine)
Status
Functioni
Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H+. May play a role regulation of the mitochondrial permeability transition pore (mPTP).
GO - Molecular functioni
- inorganic phosphate transmembrane transporter activity Source: GO_Central
- protein-containing complex binding Source: Ensembl
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- mitochondrial phosphate ion transmembrane transport Source: InterPro
- phosphate ion transmembrane transport Source: GO_Central
Keywordsi
Biological process | Symport, Transport |
Protein family/group databases
TCDBi | 2.A.29.4.1, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphate carrier protein, mitochondrialAlternative name(s): Phosphate transport protein Short name: PTP Solute carrier family 25 member 3 |
Gene namesi | Name:SLC25A3 Synonyms:PHC |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000012890 |
VGNCi | VGNC:49965, SLC25A3 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Mitochondrion
- integral component of mitochondrial inner membrane Source: GO_Central
- mitochondrial inner membrane Source: AgBase
- mitochondrion Source: AgBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 50 – 63 | Mitochondrial intermembraneSequence analysisAdd BLAST | 14 | |
Transmembranei | 64 – 86 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 87 – 121 | Mitochondrial matrixSequence analysisAdd BLAST | 35 | |
Transmembranei | 122 – 141 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 142 – 161 | Mitochondrial intermembraneSequence analysisAdd BLAST | 20 | |
Transmembranei | 162 – 183 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 184 – 218 | Mitochondrial matrixSequence analysisAdd BLAST | 35 | |
Transmembranei | 219 – 238 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 239 – 261 | Mitochondrial intermembraneSequence analysisAdd BLAST | 23 | |
Transmembranei | 262 – 284 | Helical; Name=5Sequence analysisAdd BLAST | 23 | |
Topological domaini | 285 – 314 | Mitochondrial matrixSequence analysisAdd BLAST | 30 | |
Transmembranei | 315 – 333 | Helical; Name=6Sequence analysisAdd BLAST | 19 | |
Topological domaini | 334 – 362 | Mitochondrial intermembraneSequence analysisAdd BLAST | 29 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 49 | Mitochondrion1 PublicationAdd BLAST | 49 | |
ChainiPRO_0000019255 | 50 – 362 | Phosphate carrier protein, mitochondrialAdd BLAST | 313 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 99 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 112 | N6-methyllysineBy similarity | 1 | |
Modified residuei | 196 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 209 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
PaxDbi | P12234 |
PeptideAtlasi | P12234 |
PRIDEi | P12234 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000012890, Expressed in heart and 95 other tissues |
Interactioni
Subunit structurei
Interacts with PPIF; the interaction is impaired by CsA.
By similarityProtein-protein interaction databases
BioGRIDi | 159730, 1 interactor |
STRINGi | 9913.ENSBTAP00000017131 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 63 – 147 | Solcar 1Add BLAST | 85 | |
Repeati | 160 – 244 | Solcar 2Add BLAST | 85 | |
Repeati | 261 – 339 | Solcar 3Add BLAST | 79 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0767, Eukaryota |
GeneTreei | ENSGT00390000008708 |
HOGENOMi | CLU_039456_3_1_1 |
InParanoidi | P12234 |
OMAi | KFFFFEY |
OrthoDBi | 963446at2759 |
TreeFami | TF314119 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf IPR044677, Pic2/Mir1-like |
PANTHERi | PTHR45671, PTHR45671, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform A (identifier: P12234-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYSSVVHLAR ANPFNAPHLQ LVHDGLAGPR SDPAGPPGPP RRSRNLAAAA
60 70 80 90 100
VEEQYSCDYG SGRFFILCGL GGIISCGTTH TALVPLDLVK CRMQVDPQKY
110 120 130 140 150
KSIFNGFSVT LKEDGFRGLA KGWAPTFIGY SLQGLCKFGF YEVFKVLYSN
160 170 180 190 200
MLGEENAYLW RTSLYLAASA SAEFFADIAL APMEAAKVRI QTQPGYANTL
210 220 230 240 250
RDAAPKMYKE EGLKAFYKGV APLWMRQIPY TMMKFACFER TVEALYKFVV
260 270 280 290 300
PKPRSECSKP EQLVVTFVAG YIAGVFCAIV SHPADSVVSV LNKEKGSSAS
310 320 330 340 350
EVLKRLGFRG VWKGLFARII MIGTLTALQW FIYDSVKVYF RLPRPPPPEM
360
PESLKKKLGY TQ
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003268 | 54 – 83 | QYSCD…THTAL → YSCEYGSAKFYALCGFGGVL SCGLTHTAV in isoform B. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77338 Genomic DNA No translation available. X05340 mRNA Translation: CAA28951.1 BC149996 mRNA Translation: AAI49997.1 |
PIRi | C53737 D53737 |
RefSeqi | NP_777082.1, NM_174657.2 [P12234-1] XP_005206570.1, XM_005206513.3 [P12234-2] |
Genome annotation databases
Ensembli | ENSBTAT00000017131; ENSBTAP00000017131; ENSBTAG00000012890 [P12234-1] ENSBTAT00000053663; ENSBTAP00000048807; ENSBTAG00000012890 [P12234-2] |
GeneIDi | 282477 |
KEGGi | bta:282477 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77338 Genomic DNA No translation available. X05340 mRNA Translation: CAA28951.1 BC149996 mRNA Translation: AAI49997.1 |
PIRi | C53737 D53737 |
RefSeqi | NP_777082.1, NM_174657.2 [P12234-1] XP_005206570.1, XM_005206513.3 [P12234-2] |
3D structure databases
AlphaFoldDBi | P12234 |
SMRi | P12234 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 159730, 1 interactor |
STRINGi | 9913.ENSBTAP00000017131 |
Protein family/group databases
TCDBi | 2.A.29.4.1, the mitochondrial carrier (mc) family |
Proteomic databases
PaxDbi | P12234 |
PeptideAtlasi | P12234 |
PRIDEi | P12234 |
Genome annotation databases
Ensembli | ENSBTAT00000017131; ENSBTAP00000017131; ENSBTAG00000012890 [P12234-1] ENSBTAT00000053663; ENSBTAP00000048807; ENSBTAG00000012890 [P12234-2] |
GeneIDi | 282477 |
KEGGi | bta:282477 |
Organism-specific databases
CTDi | 5250 |
VEuPathDBi | HostDB:ENSBTAG00000012890 |
VGNCi | VGNC:49965, SLC25A3 |
Phylogenomic databases
eggNOGi | KOG0767, Eukaryota |
GeneTreei | ENSGT00390000008708 |
HOGENOMi | CLU_039456_3_1_1 |
InParanoidi | P12234 |
OMAi | KFFFFEY |
OrthoDBi | 963446at2759 |
TreeFami | TF314119 |
Gene expression databases
Bgeei | ENSBTAG00000012890, Expressed in heart and 95 other tissues |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf IPR044677, Pic2/Mir1-like |
PANTHERi | PTHR45671, PTHR45671, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MPCP_BOVIN | |
Accessioni | P12234Primary (citable) accession number: P12234 Secondary accession number(s): A6QQU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | May 25, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families