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UniProtKB - P12114 (SQT1_CAEEL)
Protein
Cuticle collagen sqt-1
Gene
sqt-1
Organism
Caenorhabditis elegans
Status
Functioni
Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. This is a collagen critical for organismal morphogenesis. Mutations in sqt-1 can lengthen, shorten, or helically twist the entire animal.
GO - Molecular functioni
- structural constituent of collagen and cuticulin-based cuticle Source: WormBase
GO - Biological processi
- collagen and cuticulin-based cuticle development Source: WormBase
- cuticle development involved in collagen and cuticulin-based cuticle molting cycle Source: WormBase
Names & Taxonomyi
Protein namesi | Recommended name: Cuticle collagen sqt-1Alternative name(s): Protein roller-5 Protein squat-1 |
Gene namesi | Name:sqt-1 Synonyms:rol-5 ORF Names:B0491.2 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | B0491.2 ; CE02104 ; WBGene00005016 ; sqt-1 |
Subcellular locationi
Other locations
- collagen trimer Source: UniProtKB-KW
Keywords - Cellular componenti
CuticlePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127596 | 1 – 324 | Cuticle collagen sqt-1Add BLAST | 324 |
Keywords - PTMi
Disulfide bondProteomic databases
EPDi | P12114 |
PaxDbi | P12114 |
PeptideAtlasi | P12114 |
Expressioni
Gene expression databases
Bgeei | WBGene00005016, Expressed in multi-cellular organism and 3 other tissues |
Interactioni
Subunit structurei
Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
Protein-protein interaction databases
BioGRIDi | 40038, 2 interactors |
IntActi | P12114, 1 interactor |
STRINGi | 6239.B0491.2.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 68 – 108 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 127 – 153 | Triple-helical regionAdd BLAST | 27 | |
Regioni | 129 – 324 | DisorderedSequence analysisAdd BLAST | 196 | |
Regioni | 171 – 231 | Triple-helical regionAdd BLAST | 61 | |
Regioni | 237 – 299 | Triple-helical regionAdd BLAST | 63 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 83 – 101 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 224 – 240 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the cuticular collagen family.Curated
Keywords - Domaini
Collagen, RepeatPhylogenomic databases
eggNOGi | KOG3544, Eukaryota |
HOGENOMi | CLU_001074_4_4_1 |
InParanoidi | P12114 |
OMAi | EHPIGRP |
OrthoDBi | 1351852at2759 |
PhylomeDBi | P12114 |
Family and domain databases
InterProi | View protein in InterPro IPR002486, Col_cuticle_N IPR008160, Collagen |
Pfami | View protein in Pfam PF01484, Col_cuticle_N, 1 hit PF01391, Collagen, 1 hit |
SMARTi | View protein in SMART SM01088, Col_cuticle_N, 1 hit |
i Sequence
Sequence statusi: Complete.
P12114-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVKLACYVT ASVTVATLMV CFMTMSTIYS EVDGFREKLD TEMNVFRQST
60 70 80 90 100
NGLWKDIVVI GRSSKRVRRQ YEETNATPTP HADGSPSAPP GQPPAVPPVF
110 120 130 140 150
NQPKTPNGAN GNGPTCNCNA DNKCPAGPSG PKGVPGVPGL DGVPGLDGVP
160 170 180 190 200
GVGADDIAPQ RESVGCFTCP QGPVGPPGAL GRPGPRGLPG PRGQNGNPGR
210 220 230 240 250
DGQPGHPGEQ GSSGQIGKIG EPGPPGEKGR DAEHPIGRPG PKGPRGDQGP
260 270 280 290 300
TGPAGQNGLH GPPGEPGTVG PEGPSGKQGR QGPDGTQGET GPDGRPGKDA
310 320
EYCQCPDKSP PSEAVNANRG YRNI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 158 | A → V in AAA65468 (PubMed:3180220).Curated | 1 | |
Sequence conflicti | 238 | R → G in AAA65468 (PubMed:3180220).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03146 Genomic DNA Translation: AAA65468.1 Z49907 Genomic DNA Translation: CAA90084.1 |
PIRi | A31920 T18763 |
RefSeqi | NP_496421.1, NM_064020.5 |
Genome annotation databases
EnsemblMetazoai | B0491.2.1; B0491.2.1; WBGene00005016 B0491.2.2; B0491.2.2; WBGene00005016 B0491.2.3; B0491.2.3; WBGene00005016 |
UCSCi | B0491.2.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03146 Genomic DNA Translation: AAA65468.1 Z49907 Genomic DNA Translation: CAA90084.1 |
PIRi | A31920 T18763 |
RefSeqi | NP_496421.1, NM_064020.5 |
3D structure databases
AlphaFoldDBi | P12114 |
SMRi | P12114 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 40038, 2 interactors |
IntActi | P12114, 1 interactor |
STRINGi | 6239.B0491.2.1 |
Proteomic databases
EPDi | P12114 |
PaxDbi | P12114 |
PeptideAtlasi | P12114 |
Genome annotation databases
EnsemblMetazoai | B0491.2.1; B0491.2.1; WBGene00005016 B0491.2.2; B0491.2.2; WBGene00005016 B0491.2.3; B0491.2.3; WBGene00005016 |
UCSCi | B0491.2.1, c. elegans |
Organism-specific databases
WormBasei | B0491.2 ; CE02104 ; WBGene00005016 ; sqt-1 |
Phylogenomic databases
eggNOGi | KOG3544, Eukaryota |
HOGENOMi | CLU_001074_4_4_1 |
InParanoidi | P12114 |
OMAi | EHPIGRP |
OrthoDBi | 1351852at2759 |
PhylomeDBi | P12114 |
Miscellaneous databases
PROi | PR:P12114 |
Gene expression databases
Bgeei | WBGene00005016, Expressed in multi-cellular organism and 3 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR002486, Col_cuticle_N IPR008160, Collagen |
Pfami | View protein in Pfam PF01484, Col_cuticle_N, 1 hit PF01391, Collagen, 1 hit |
SMARTi | View protein in SMART SM01088, Col_cuticle_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SQT1_CAEEL | |
Accessioni | P12114Primary (citable) accession number: P12114 Secondary accession number(s): Q17509 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | July 22, 2008 | |
Last modified: | May 25, 2022 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families