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Protein

Fatty acid-binding protein, intestinal

Gene

FABP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83Fatty acidBy similarity1
Binding sitei107Fatty acidBy similarity1

GO - Molecular functioni

  • fatty acid binding Source: ProtInc
  • long-chain fatty acid binding Source: GO_Central

GO - Biological processi

  • intestinal lipid absorption Source: GO_Central
  • triglyceride catabolic process Source: Reactome

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-163560 Triglyceride catabolism

Chemistry databases

SwissLipidsiSLP:000001520

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, intestinal
Alternative name(s):
Fatty acid-binding protein 2
Intestinal-type fatty acid-binding protein
Short name:
I-FABP
Gene namesi
Name:FABP2
Synonyms:FABPI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000145384.3
HGNCiHGNC:3556 FABP2
MIMi134640 gene
neXtProtiNX_P12104

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi39L → G: Reduced stability. 1 Publication1
Mutagenesisi64E → G: Localized reduction in stability. 1 Publication1
Mutagenesisi65L → A: Reduced stability. 1 Publication1
Mutagenesisi65L → G: Reduced stability. 1 Publication1
Mutagenesisi67V → G: Localized reduction in stability. 1 Publication1
Mutagenesisi90L → G: Reduced stability. 1 Publication1
Mutagenesisi123V → G: Reduced stability. 1 Publication1

Organism-specific databases

DisGeNETi2169
PharmGKBiPA27957

Chemistry databases

ChEMBLiCHEMBL4879
DrugBankiDB04557 Arachidonic Acid
DB00783 Estradiol
DB01050 Ibuprofen
DB08231 MYRISTIC ACID
DB03796 Palmitic Acid
DB01138 Sulfinpyrazone

Polymorphism and mutation databases

BioMutaiFABP2
DMDMi119805

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000673282 – 132Fatty acid-binding protein, intestinalAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP12104
PeptideAtlasiP12104
PRIDEiP12104
ProteomicsDBi52825

PTM databases

iPTMnetiP12104
PhosphoSitePlusiP12104

Expressioni

Tissue specificityi

Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.1 Publication

Inductioni

By EGF.1 Publication

Gene expression databases

BgeeiENSG00000145384
CleanExiHS_FABP2
GenevisibleiP12104 HS

Organism-specific databases

HPAiCAB047325
CAB047326
HPA034607

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi108467, 3 interactors
IntActiP12104, 3 interactors
STRINGi9606.ENSP00000274024

Chemistry databases

BindingDBiP12104

Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 14Combined sources10
Helixi15 – 22Combined sources8
Helixi26 – 32Combined sources7
Turni33 – 35Combined sources3
Beta strandi38 – 44Combined sources7
Beta strandi47 – 53Combined sources7
Beta strandi58 – 64Combined sources7
Beta strandi69 – 72Combined sources4
Beta strandi74 – 76Combined sources3
Beta strandi78 – 86Combined sources9
Beta strandi89 – 96Combined sources8
Turni97 – 99Combined sources3
Beta strandi102 – 110Combined sources9
Beta strandi113 – 120Combined sources8
Beta strandi123 – 131Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KZWNMR-A2-132[»]
1KZXNMR-A2-132[»]
2MJINMR-A2-132[»]
2MO5NMR-A2-132[»]
3AKMX-ray1.90A/B/C/D2-132[»]
3IFBNMR-A2-132[»]
ProteinModelPortaliP12104
SMRiP12104
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12104

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP12104
KOiK08751
OrthoDBiEOG091G0QSV
PhylomeDBiP12104
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR031272 FABP2
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF89 PTHR11955:SF89, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFDSTWKVD RSENYDKFME KMGVNIVKRK LAAHDNLKLT ITQEGNKFTV
60 70 80 90 100
KESSAFRNIE VVFELGVTFN YNLADGTELR GTWSLEGNKL IGKFKRTDNG
110 120 130
NELNTVREII GDELVQTYVY EGVEAKRIFK KD
Length:132
Mass (Da):15,207
Last modified:January 23, 2007 - v2
Checksum:i68330E3D81792CAF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00237955A → T Found in 29% of the population; associated with increased plasma insulin concentration, increased fat oxidation and insulin resistance; 2-fold greater affinity for long-chain fatty acids. 4 PublicationsCorresponds to variant dbSNP:rs1799883Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18079 Genomic DNA Translation: AAA52417.1
AC092656 Genomic DNA No translation available.
BC069466 mRNA Translation: AAH69466.1
BC069617 mRNA Translation: AAH69617.1
BC069625 mRNA Translation: AAH69625.1
BC069637 mRNA Translation: AAH69637.1
BC111791 mRNA Translation: AAI11792.1
CCDSiCCDS3712.1
PIRiA29781 FZHUI
RefSeqiNP_000125.2, NM_000134.3
UniGeneiHs.282265

Genome annotation databases

EnsembliENST00000274024; ENSP00000274024; ENSG00000145384
GeneIDi2169
KEGGihsa:2169
UCSCiuc003icw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFABPI_HUMAN
AccessioniPrimary (citable) accession number: P12104
Secondary accession number(s): Q2NKJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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