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Entry version 216 (10 Feb 2021)
Sequence version 2 (01 May 1992)
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Protein

Histidine--tRNA ligase, cytoplasmic

Gene

HARS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 5.4 sec(-1) for aminoacylation of tRNA(His) (PubMed:29235198). kcat is 4.1 sec(-1) for histidine. (PubMed:29235198). kcat is 5.8 sec(-1) for ATP (PubMed:29235198).1 Publication
  1. KM=8.0 µM for histidine1 Publication
  2. KM=0.872 µM for tRNA(His)1 Publication
  3. KM=44.2 µM for ATP1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei157L-histidineCombined sources1 Publication1
    Binding sitei173L-histidineCombined sources1 Publication1
    Binding sitei177L-histidineCombined sources1 Publication1
    Binding sitei326L-histidineCombined sources1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminoacyl-tRNA synthetase, Ligase
    Biological processProtein biosynthesis
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    6.1.1.21, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    P12081

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-379716, Cytosolic tRNA aminoacylation

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Histidine--tRNA ligase, cytoplasmic (EC:6.1.1.211 Publication)
    Alternative name(s):
    Histidyl-tRNA synthetase
    Short name:
    HisRS
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:HARS1Imported
    Synonyms:HARS, HRS
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:4816, HARS1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    142810, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P12081

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    HostDB:ENSG00000170445.12

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Usher syndrome 3B (USH3B)1 Publication
    The disease is caused by variants affecting the gene represented in this entry.
    Disease descriptionA syndrome characterized by progressive vision and hearing loss during early childhood. Some patients have the so-called 'Charles Bonnet syndrome,' involving decreased visual acuity and vivid visual hallucinations. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH3 is characterized by postlingual, progressive hearing loss, variable vestibular dysfunction, and onset of retinitis pigmentosa symptoms, including nyctalopia, constriction of the visual fields, and loss of central visual acuity, usually by the second decade of life.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067918454Y → S in USH3B. 1 PublicationCorresponds to variant dbSNP:rs387906639EnsemblClinVar.1
    Charcot-Marie-Tooth disease 2W (CMT2W)3 Publications
    The disease is caused by variants affecting the gene represented in this entry.
    Disease descriptionAn autosomal dominant, axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2W patients manifest a peripheral neuropathy mainly affecting the lower limbs and resulting in gait difficulties and distal sensory impairment. Most patients also have upper limb involvement.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_075064132T → I in CMT2W; loss-of-function variant. 1 PublicationCorresponds to variant dbSNP:rs143473232EnsemblClinVar.1
    Natural variantiVAR_075065134P → H in CMT2W; loss-of-function variant. 1 PublicationCorresponds to variant dbSNP:rs863225122EnsemblClinVar.1
    Natural variantiVAR_069022137R → Q in CMT2W; has a neurotoxic effect in an animal model; results in loss of function. 1 PublicationCorresponds to variant dbSNP:rs191391414EnsemblClinVar.1
    Natural variantiVAR_083003155V → G in CMT2W; unknown pathological significance; fails to complement deletion of the yeast ortholog; decreases histidine-tRNA ligase activity; increases in the KM for ATP binding; does not disrupt dimerization. 1 PublicationCorresponds to variant dbSNP:rs1239341211EnsemblClinVar.1
    Natural variantiVAR_075066175D → E in CMT2W; hypomorphic variant. 1 PublicationCorresponds to variant dbSNP:rs863225123EnsemblClinVar.1
    Natural variantiVAR_069024238V → A in CMT2W; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs536175170Ensembl.1
    Natural variantiVAR_083004330Y → C in CMT2W; fails to complement deletion of the yeast ortholog; decreases histidine-tRNA ligase activity; increases in the KM for ATP binding; does not disrupt dimerization. 1 PublicationCorresponds to variant dbSNP:rs1554106881EnsemblClinVar.1
    Natural variantiVAR_083005356S → N in CMT2W; unknown pathological significance; fails to complement deletion of the yeast ortholog; decreases histidine-tRNA ligase activity; increases in the KM for ATP binding; does not disrupt dimerization. 1 PublicationCorresponds to variant dbSNP:rs144322728EnsemblClinVar.1
    Natural variantiVAR_075067364D → Y in CMT2W; loss-of-function variant. 1 PublicationCorresponds to variant dbSNP:rs863225124EnsemblClinVar.1
    Natural variantiVAR_069026505P → S in CMT2W; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs747156884Ensembl.1

    Keywords - Diseasei

    Charcot-Marie-Tooth disease, Deafness, Disease variant, Neurodegeneration, Neuropathy, Retinitis pigmentosa, Usher syndrome

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    3035

    GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

    More...
    GeneReviewsi
    HARS

    MalaCards human disease database

    More...
    MalaCardsi
    HARS1
    MIMi614504, phenotype
    616625, phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000170445

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    488333, Autosomal dominant Charcot-Marie-Tooth disease type 2W
    231183, Usher syndrome type 3

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA29191

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P12081, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4002

    Drug and drug target database

    More...
    DrugBanki
    DB00117, Histidine

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    HARS

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    135123

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001363322 – 509Histidine--tRNA ligase, cytoplasmicAdd BLAST508

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
    Modified residuei66PhosphoserineBy similarity1
    Modified residuei356PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P12081

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P12081

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P12081

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P12081

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P12081

    PeptideAtlas

    More...
    PeptideAtlasi
    P12081

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P12081

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    12704 [P12081-1]
    14349
    52824 [P12081-1]
    5502

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P12081

    MetOSite database of methionine sulfoxide sites

    More...
    MetOSitei
    P12081

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P12081

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P12081

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Brain, heart, liver and kidney.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000170445, Expressed in adenohypophysis and 233 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P12081, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P12081, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000170445, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    3 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    P12081
    With#Exp.IntAct
    itself2EBI-1057566,EBI-1057566

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    109285, 57 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-37596N

    Protein interaction database and analysis system

    More...
    IntActi
    P12081, 11 interactors

    Molecular INTeraction database

    More...
    MINTi
    P12081

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000425634

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P12081

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P12081, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1509
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P12081

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P12081

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 59WHEP-TRSAdd BLAST57

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni130 – 132L-histidine bindingCombined sources1 Publication3
    Regioni330 – 331L-histidine bindingCombined sources1 Publication2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1936, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000005922

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P12081

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    CDFDFIG

    Database of Orthologous Groups

    More...
    OrthoDBi
    1065556at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P12081

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300652

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00773, HisRS-like_core, 1 hit
    cd00859, HisRS_anticodon, 1 hit

    Database of protein disorder

    More...
    DisProti
    DP01668

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.800, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00127, His_tRNA_synth, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR006195, aa-tRNA-synth_II
    IPR004154, Anticodon-bd
    IPR036621, Anticodon-bd_dom_sf
    IPR015807, His-tRNA-ligase
    IPR041715, HisRS-like_core
    IPR004516, HisRS/HisZ
    IPR033656, HisRS_anticodon
    IPR009068, S15_NS1_RNA-bd
    IPR000738, WHEP-TRS_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03129, HGTP_anticodon, 1 hit
    PF13393, tRNA-synt_His, 1 hit
    PF00458, WHEP-TRS, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF001549, His-tRNA_synth, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00991, WHEP-TRS, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47060, SSF47060, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00442, hisS, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50862, AA_TRNA_LIGASE_II, 1 hit
    PS00762, WHEP_TRS_1, 1 hit
    PS51185, WHEP_TRS_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P12081-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAERAALEEL VKLQGERVRG LKQQKASAEL IEEEVAKLLK LKAQLGPDES
    60 70 80 90 100
    KQKFVLKTPK GTRDYSPRQM AVREKVFDVI IRCFKRHGAE VIDTPVFELK
    110 120 130 140 150
    ETLMGKYGED SKLIYDLKDQ GGELLSLRYD LTVPFARYLA MNKLTNIKRY
    160 170 180 190 200
    HIAKVYRRDN PAMTRGRYRE FYQCDFDIAG NFDPMIPDAE CLKIMCEILS
    210 220 230 240 250
    SLQIGDFLVK VNDRRILDGM FAICGVSDSK FRTICSSVDK LDKVSWEEVK
    260 270 280 290 300
    NEMVGEKGLA PEVADRIGDY VQQHGGVSLV EQLLQDPKLS QNKQALEGLG
    310 320 330 340 350
    DLKLLFEYLT LFGIDDKISF DLSLARGLDY YTGVIYEAVL LQTPAQAGEE
    360 370 380 390 400
    PLGVGSVAAG GRYDGLVGMF DPKGRKVPCV GLSIGVERIF SIVEQRLEAL
    410 420 430 440 450
    EEKIRTTETQ VLVASAQKKL LEERLKLVSE LWDAGIKAEL LYKKNPKLLN
    460 470 480 490 500
    QLQYCEEAGI PLVAIIGEQE LKDGVIKLRS VTSREEVDVR REDLVEEIKR

    RTGQPLCIC
    Length:509
    Mass (Da):57,411
    Last modified:May 1, 1992 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65D8BB71CE79B1FF
    GO
    Isoform 2 (identifier: P12081-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         60-99: Missing.

    Show »
    Length:469
    Mass (Da):52,720
    Checksum:iB02783AB9FED1E1D
    GO
    Isoform 3 (identifier: P12081-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         60-99: Missing.
         155-174: Missing.

    Show »
    Length:449
    Mass (Da):50,156
    Checksum:i9B97F9CC4FE63BB9
    GO
    Isoform 4 (identifier: P12081-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         155-174: Missing.

    Show »
    Length:489
    Mass (Da):54,847
    Checksum:iE0C0825FF411F391
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    B4DDD8B4DDD8_HUMAN
    Histidine--tRNA ligase, cytoplasmic
    HARS1
    435Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B4E1C5B4E1C5_HUMAN
    Histidine--tRNA ligase, cytoplasmic
    HARS1
    395Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E7ETE2E7ETE2_HUMAN
    Histidine--tRNA ligase, cytoplasmic
    HARS1
    512Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A6Q8PF47A0A6Q8PF47_HUMAN
    Histidine--tRNA ligase, cytoplasmic
    HARS1
    511Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A6Q8PHA5A0A6Q8PHA5_HUMAN
    Histidine--tRNA ligase, cytoplasmic
    HARS1
    473Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A6Q8PHE3A0A6Q8PHE3_HUMAN
    Histidine--tRNA ligase, cytoplasmic
    HARS1
    399Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A6Q8PF07A0A6Q8PF07_HUMAN
    Histidine--tRNA ligase
    HARS1
    440Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A6Q8PFF2A0A6Q8PFF2_HUMAN
    Histidine--tRNA ligase, cytoplasmic
    HARS1
    470Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RF05D6RF05_HUMAN
    Histidine--tRNA ligase, cytoplasmic
    HARS1
    60Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2R8YCI2A0A2R8YCI2_HUMAN
    Histidine--tRNA ligase, cytoplasmic
    HARS1
    84Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    There are more potential isoformsShow all

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence CAA28956 differs from that shown. Reason: Frameshift.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6A → P in CAA28956 (PubMed:3554142).Curated1
    Sequence conflicti126S → P in BAG58213 (PubMed:14702039).Curated1
    Sequence conflicti165R → G in CAA28956 (PubMed:3554142).Curated1
    Sequence conflicti181N → Q in CAA28956 (PubMed:3554142).Curated1
    Sequence conflicti186I → N in CAA28956 (PubMed:3554142).Curated1
    Sequence conflicti191C → S in CAA28956 (PubMed:3554142).Curated1
    Sequence conflicti206D → N in CAA28956 (PubMed:3554142).Curated1
    Sequence conflicti223I → V in CAA28956 (PubMed:3554142).Curated1
    Sequence conflicti227S → P in CAA28956 (PubMed:3554142).Curated1
    Sequence conflicti284L → V in CAA28956 (PubMed:3554142).Curated1
    Sequence conflicti347A → E in CAA28956 (PubMed:3554142).Curated1
    Sequence conflicti373 – 374KG → QR in CAA28956 (PubMed:3554142).Curated2
    Sequence conflicti375R → L in BAG58213 (PubMed:14702039).Curated1
    Sequence conflicti493D → E in CAA28956 (PubMed:3554142).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_0690215A → E1 PublicationCorresponds to variant dbSNP:rs78741041EnsemblClinVar.1
    Natural variantiVAR_075064132T → I in CMT2W; loss-of-function variant. 1 PublicationCorresponds to variant dbSNP:rs143473232EnsemblClinVar.1
    Natural variantiVAR_075065134P → H in CMT2W; loss-of-function variant. 1 PublicationCorresponds to variant dbSNP:rs863225122EnsemblClinVar.1
    Natural variantiVAR_069022137R → Q in CMT2W; has a neurotoxic effect in an animal model; results in loss of function. 1 PublicationCorresponds to variant dbSNP:rs191391414EnsemblClinVar.1
    Natural variantiVAR_083003155V → G in CMT2W; unknown pathological significance; fails to complement deletion of the yeast ortholog; decreases histidine-tRNA ligase activity; increases in the KM for ATP binding; does not disrupt dimerization. 1 PublicationCorresponds to variant dbSNP:rs1239341211EnsemblClinVar.1
    Natural variantiVAR_075066175D → E in CMT2W; hypomorphic variant. 1 PublicationCorresponds to variant dbSNP:rs863225123EnsemblClinVar.1
    Natural variantiVAR_069023205G → D1 PublicationCorresponds to variant dbSNP:rs147288996EnsemblClinVar.1
    Natural variantiVAR_069024238V → A in CMT2W; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs536175170Ensembl.1
    Natural variantiVAR_083004330Y → C in CMT2W; fails to complement deletion of the yeast ortholog; decreases histidine-tRNA ligase activity; increases in the KM for ATP binding; does not disrupt dimerization. 1 PublicationCorresponds to variant dbSNP:rs1554106881EnsemblClinVar.1
    Natural variantiVAR_083005356S → N in CMT2W; unknown pathological significance; fails to complement deletion of the yeast ortholog; decreases histidine-tRNA ligase activity; increases in the KM for ATP binding; does not disrupt dimerization. 1 PublicationCorresponds to variant dbSNP:rs144322728EnsemblClinVar.1
    Natural variantiVAR_075067364D → Y in CMT2W; loss-of-function variant. 1 PublicationCorresponds to variant dbSNP:rs863225124EnsemblClinVar.1
    Natural variantiVAR_069025376K → R1 PublicationCorresponds to variant dbSNP:rs139447495EnsemblClinVar.1
    Natural variantiVAR_061908399A → V. Corresponds to variant dbSNP:rs34732372EnsemblClinVar.1
    Natural variantiVAR_067918454Y → S in USH3B. 1 PublicationCorresponds to variant dbSNP:rs387906639EnsemblClinVar.1
    Natural variantiVAR_069026505P → S in CMT2W; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs747156884Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04511860 – 99Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST40
    Alternative sequenceiVSP_046662155 – 174Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST20

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    Z11518 mRNA Translation: CAA77607.1
    X05345 mRNA Translation: CAA28956.1 Frameshift.
    AK295219 mRNA Translation: BAG58213.1
    AK302295 mRNA Translation: BAG63635.1
    AK225776 mRNA No translation available.
    AC116353 Genomic DNA No translation available.
    BC011807 mRNA Translation: AAH11807.1
    BC080514 mRNA Translation: AAH80514.1
    M96646 Genomic DNA Translation: AAA58668.1
    U18936 Genomic DNA Translation: AAA73973.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS4237.1 [P12081-1]
    CCDS58976.1 [P12081-2]
    CCDS58977.1 [P12081-3]
    CCDS58978.1 [P12081-4]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    I37559, SYHUHT

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001244969.1, NM_001258040.2 [P12081-2]
    NP_001244970.1, NM_001258041.2 [P12081-4]
    NP_001244971.1, NM_001258042.2 [P12081-3]
    NP_002100.2, NM_002109.5 [P12081-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000307633; ENSP00000304668; ENSG00000170445 [P12081-3]
    ENST00000438307; ENSP00000411511; ENSG00000170445 [P12081-2]
    ENST00000457527; ENSP00000387893; ENSG00000170445 [P12081-4]
    ENST00000504156; ENSP00000425634; ENSG00000170445 [P12081-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    3035

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:3035

    UCSC genome browser

    More...
    UCSCi
    uc003lgv.6, human [P12081-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    Z11518 mRNA Translation: CAA77607.1
    X05345 mRNA Translation: CAA28956.1 Frameshift.
    AK295219 mRNA Translation: BAG58213.1
    AK302295 mRNA Translation: BAG63635.1
    AK225776 mRNA No translation available.
    AC116353 Genomic DNA No translation available.
    BC011807 mRNA Translation: AAH11807.1
    BC080514 mRNA Translation: AAH80514.1
    M96646 Genomic DNA Translation: AAA58668.1
    U18936 Genomic DNA Translation: AAA73973.1
    CCDSiCCDS4237.1 [P12081-1]
    CCDS58976.1 [P12081-2]
    CCDS58977.1 [P12081-3]
    CCDS58978.1 [P12081-4]
    PIRiI37559, SYHUHT
    RefSeqiNP_001244969.1, NM_001258040.2 [P12081-2]
    NP_001244970.1, NM_001258041.2 [P12081-4]
    NP_001244971.1, NM_001258042.2 [P12081-3]
    NP_002100.2, NM_002109.5 [P12081-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1X59NMR-A1-60[»]
    2LW7NMR-A2-60[»]
    A399-509[»]
    4G84X-ray2.40A/B54-506[»]
    4G85X-ray3.11A/B1-506[»]
    4PHCX-ray2.84A/B/C/D1-509[»]
    4X5OX-ray2.80A/B1-509[»]
    5W6MX-ray3.70A/B54-503[»]
    6O76X-ray2.79A/B1-509[»]
    SMRiP12081
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi109285, 57 interactors
    DIPiDIP-37596N
    IntActiP12081, 11 interactors
    MINTiP12081
    STRINGi9606.ENSP00000425634

    Chemistry databases

    BindingDBiP12081
    ChEMBLiCHEMBL4002
    DrugBankiDB00117, Histidine

    PTM databases

    iPTMnetiP12081
    MetOSiteiP12081
    PhosphoSitePlusiP12081
    SwissPalmiP12081

    Genetic variation databases

    BioMutaiHARS
    DMDMi135123

    Proteomic databases

    EPDiP12081
    jPOSTiP12081
    MassIVEiP12081
    MaxQBiP12081
    PaxDbiP12081
    PeptideAtlasiP12081
    PRIDEiP12081
    ProteomicsDBi12704 [P12081-1]
    14349
    52824 [P12081-1]
    5502

    Protocols and materials databases

    ABCD curated depository of sequenced antibodies

    More...
    ABCDi
    P12081, 2 sequenced antibodies

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    15372, 281 antibodies

    Genome annotation databases

    EnsembliENST00000307633; ENSP00000304668; ENSG00000170445 [P12081-3]
    ENST00000438307; ENSP00000411511; ENSG00000170445 [P12081-2]
    ENST00000457527; ENSP00000387893; ENSG00000170445 [P12081-4]
    ENST00000504156; ENSP00000425634; ENSG00000170445 [P12081-1]
    GeneIDi3035
    KEGGihsa:3035
    UCSCiuc003lgv.6, human [P12081-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    3035
    DisGeNETi3035

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    HARS1
    GeneReviewsiHARS
    HGNCiHGNC:4816, HARS1
    HPAiENSG00000170445, Low tissue specificity
    MalaCardsiHARS1
    MIMi142810, gene
    614504, phenotype
    616625, phenotype
    neXtProtiNX_P12081
    OpenTargetsiENSG00000170445
    Orphaneti488333, Autosomal dominant Charcot-Marie-Tooth disease type 2W
    231183, Usher syndrome type 3
    PharmGKBiPA29191
    VEuPathDBiHostDB:ENSG00000170445.12

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1936, Eukaryota
    GeneTreeiENSGT00390000005922
    InParanoidiP12081
    OMAiCDFDFIG
    OrthoDBi1065556at2759
    PhylomeDBiP12081
    TreeFamiTF300652

    Enzyme and pathway databases

    BRENDAi6.1.1.21, 2681
    PathwayCommonsiP12081
    ReactomeiR-HSA-379716, Cytosolic tRNA aminoacylation

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    3035, 697 hits in 877 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    HARS, human
    EvolutionaryTraceiP12081

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    HARS

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    3035
    PharosiP12081, Tchem

    Protein Ontology

    More...
    PROi
    PR:P12081
    RNActiP12081, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000170445, Expressed in adenohypophysis and 233 other tissues
    ExpressionAtlasiP12081, baseline and differential
    GenevisibleiP12081, HS

    Family and domain databases

    CDDicd00773, HisRS-like_core, 1 hit
    cd00859, HisRS_anticodon, 1 hit
    DisProtiDP01668
    Gene3Di3.40.50.800, 1 hit
    HAMAPiMF_00127, His_tRNA_synth, 1 hit
    InterProiView protein in InterPro
    IPR006195, aa-tRNA-synth_II
    IPR004154, Anticodon-bd
    IPR036621, Anticodon-bd_dom_sf
    IPR015807, His-tRNA-ligase
    IPR041715, HisRS-like_core
    IPR004516, HisRS/HisZ
    IPR033656, HisRS_anticodon
    IPR009068, S15_NS1_RNA-bd
    IPR000738, WHEP-TRS_dom
    PfamiView protein in Pfam
    PF03129, HGTP_anticodon, 1 hit
    PF13393, tRNA-synt_His, 1 hit
    PF00458, WHEP-TRS, 1 hit
    PIRSFiPIRSF001549, His-tRNA_synth, 1 hit
    SMARTiView protein in SMART
    SM00991, WHEP-TRS, 1 hit
    SUPFAMiSSF47060, SSF47060, 1 hit
    TIGRFAMsiTIGR00442, hisS, 1 hit
    PROSITEiView protein in PROSITE
    PS50862, AA_TRNA_LIGASE_II, 1 hit
    PS00762, WHEP_TRS_1, 1 hit
    PS51185, WHEP_TRS_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHARS1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12081
    Secondary accession number(s): B4DHQ1
    , B4DY73, D6REN6, J3KNE5
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: May 1, 1992
    Last modified: February 10, 2021
    This is version 216 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Human entries with genetic variants
      List of human entries with genetic variants
    4. Human variants curated from literature reports
      Index of human variants curated from literature reports
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families
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