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Entry version 204 (17 Jun 2020)
Sequence version 2 (01 Dec 2000)
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Protein

Integrin alpha-PS2

Gene

if

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Involved in the function and/or development of the olfactory system.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion, Olfaction, Sensory transduction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-114608 Platelet degranulation
R-DME-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-DME-1566977 Fibronectin matrix formation
R-DME-202733 Cell surface interactions at the vascular wall
R-DME-2129379 Molecules associated with elastic fibres
R-DME-216083 Integrin cell surface interactions
R-DME-3000170 Syndecan interactions
R-DME-3000178 ECM proteoglycans
R-DME-354192 Integrin signaling
R-DME-5674135 MAP2K and MAPK activation
R-DME-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin alpha-PS2
Alternative name(s):
Position-specific antigen subunit alpha-2
Protein inflated
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:if
ORF Names:CG9623
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0001250 if

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 1341ExtracellularSequence analysisAdd BLAST1310
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1342 – 1366HelicalSequence analysisAdd BLAST25
Topological domaini1367 – 1396CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001632332 – 1396Integrin alpha-PS2Add BLAST1365
ChainiPRO_000001632432 – ?1243Integrin alpha-PS2 heavy chainAdd BLAST1212
ChainiPRO_0000016325?1244 – 1396Integrin alpha-PS2 light chainAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi584N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi598N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi741N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi783N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi833N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi959N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1005N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1299N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1307N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The heavy-light chain cleavage site is either in 1230-1231, or 1233-1234, or 1243-1244.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P12080

PRoteomics IDEntifications database

More...
PRIDEi
P12080

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In ovaries, highly expressed in follicle cells. At syncytial blastoderm stage, expressed in the embryonic mesodermal precursors but not in the ectoderm. At embryonic stages 7 and 10, expression is restricted to the mesoderm. At stage 12, expressed in the gonadal sheath and the interstitial cells of the gonad. In stage 16 embryos, expressed in the somatic and visceral muscles where localizes to sites of attachment between adjacent muscles. In third larval instar wing imaginal disk, expressed in the ventral compartment and in a subset of adepithelial and peripodial cells (at protein level).4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout embryonic and larval development with peaks of expression during mid-embryogenesis and at third larval instar (at protein level). The relative ratio of isoform 1/PS2C and isoform 2/PS2M8 varies widely during development.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0001250 Expressed in Malpighian tubule and 27 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P12080 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P12080 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-PS2 associates with beta-PS.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
58994, 29 interactors

Database of interacting proteins

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DIPi
DIP-23111N

Protein interaction database and analysis system

More...
IntActi
P12080, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0074131

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P12080

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati36 – 106FG-GAP 1PROSITE-ProRule annotationAdd BLAST71
Repeati117 – 174FG-GAP 2PROSITE-ProRule annotationAdd BLAST58
Repeati186 – 239FG-GAP 3PROSITE-ProRule annotationAdd BLAST54
Repeati266 – 317FG-GAP 4PROSITE-ProRule annotationAdd BLAST52
Repeati318 – 383FG-GAP 5PROSITE-ProRule annotationAdd BLAST66
Repeati386 – 445FG-GAP 6PROSITE-ProRule annotationAdd BLAST60
Repeati452 – 514FG-GAP 7PROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi932 – 938Ser-rich7
Compositional biasi1015 – 1023Ser-rich9
Compositional biasi1049 – 1054Ser-rich6
Compositional biasi1217 – 1226Ser-rich10

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3637 Eukaryota
ENOG410XPVZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169118

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004111_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P12080

Identification of Orthologs from Complete Genome Data

More...
OMAi
NNEDAFE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P12080

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839 FG-GAP, 2 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01185 INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00191 Int_alpha, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF69179 SSF69179, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform PS2C (identifier: P12080-1) [UniParc]FASTAAdd to basket
Also known as: D, F

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGDSIHRRR MALHCPITSL ILLLIAMSAH GYNIDLPSYV RFRQSSNSMF
60 70 80 90 100
GFSIAMHKGR SGFYGNQNNV SLIVGAPKFD TSRYQQGVTE AGGVFKCSLN
110 120 130 140 150
DDDCKLVPFD SKGNNRNVDK EVVDRKSYQW LGATVATGRD SDLVVACAPR
160 170 180 190 200
YVFHTMTPSR AFRIDPVGTC FTSHNFEEFY EVSPCRTNNW GYHRQGSCQA
210 220 230 240 250
GFSAAINGNG SRLFIGAPGS WYWQGQTYSI PPDAKFPFKP PLYQPFGTGG
260 270 280 290 300
MASSHDVTRP ENQVFSTSES ASVNDDSYLG YSMVTGDFDG DRSEDVAIGM
310 320 330 340 350
PRGGNLVGRI VVNRWNMANI FNITGRQIGE YFGYSLATSD VDGDGLDDLL
360 370 380 390 400
IGAPMYTDPD NVEGKYDVGR VYILLQGGPT EEKRWTTEHI RDGYHSKGRF
410 420 430 440 450
GLALTTLGDV NGDGYGDFAV GAPYDGPEGR GVVYIFHGSP MGPLAKPSQI
460 470 480 490 500
IKSEQLVEGA PYPRTFGFAL SGGLDMDGNT YPDLAVGAYS SDQVFIFKSR
510 520 530 540 550
PVAAVNAETS FASNSKLISL DDRSCQLVRD HKKVPCMLLT TCWSYTGRYL
560 570 580 590 600
PEQLDFDVSW LLDAKKLLNP RMFFLRDEGK NIRNQTIRLN YGQKYCLNET
610 620 630 640 650
VYLLDKVQDK LTPLEVEARY NLRSSRPLDP MVRHRRSILE PVIDQNREIV
660 670 680 690 700
LRDAINIQKN CGPDNICEPD LKLKVSTVDK YLFGSPEPLV IEVFISNTNE
710 720 730 740 750
DAFEAAFYMV TPPDLQFRKL QQLGEKKDTP ITCSPPTPEN NHTLKCDIGN
760 770 780 790 800
PLESGKIAHF KISLVPEEKY GSSSSYDFYW EANSTNLEKP GSEYDNKIRQ
810 820 830 840 850
SVGIWVDTDL DIKGTSLPDY QLYKADDYKE LENATKEDDI GPQVVHIYEI
860 870 880 890 900
RNNRPSIIEE AEVFIHLPYE TIVGDPLMYL LNQPETGGKI QCDDVAFNEY
910 920 930 940 950
NLLLDEKLVK KSYLQAQGAI WNSAQVSGQS SSSSSSGGAS VHIEKARGEG
960 970 980 990 1000
FVRGVLVSNS TDAGDKLSPK QVEQRRQEDT LEALGDASFV HRDRASQAVQ
1010 1020 1030 1040 1050
EPQVNQTSFT TYSTSSSSSG SGAPSAQLRG HSTQGHIQMA GPVQHTSSSS
1060 1070 1080 1090 1100
SSNYRSWPAQ QQQQHQQLLL AGSGGSGLGS PVTFNDKSQF GGRNNNFHTG
1110 1120 1130 1140 1150
TLDLGTLNRG NVDNELYRSQ GQYQNPSQSL GQSQGQFQAN ANQGHYQGQN
1160 1170 1180 1190 1200
QAQFQARNPG FQGQTSYQGQ TQYSGQPGGY QTHHVTYSSG SKPYYGRENE
1210 1220 1230 1240 1250
DFYDEDNLQQ ATPGHWSSSS SSSSSSGTRR LRRSNDKDGA TEKPLQIDLN
1260 1270 1280 1290 1300
SPCQSARCKS IRCVVTNLGT EDGDAAFVAI RARMVAKTME KLASNVPLNV
1310 1320 1330 1340 1350
STLAVANVTL LPFIGAPKDA IVKTHEIFYK AEPEPLQVPD VVPLWVVVLA
1360 1370 1380 1390
ACAGALIFLL LVWLLYKCGF FNRNRPTDHS QERQPLRNGY HGDEHL
Length:1,396
Mass (Da):154,322
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2384B07DDBA28372
GO
Isoform PS2M8 (identifier: P12080-2) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     225-249: Missing.

Show »
Length:1,371
Mass (Da):151,586
Checksum:iCC0A5E79515FEF92
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM50700 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAM50700 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29A → G in AAC12788 (PubMed:2961459).Curated1
Sequence conflicti968 – 976SPKQVEQRR → RSQASGATA in AAC12788 (PubMed:2961459).Curated9
Sequence conflicti1063 – 1064Missing (PubMed:2961459).Curated2
Sequence conflicti1235N → D in AAC12788 (PubMed:2961459).Curated1
Sequence conflicti1242E → K in AAC12788 (PubMed:2961459).Curated1
Sequence conflicti1245L → Q in AAC12788 (PubMed:2961459).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002739225 – 249Missing in isoform PS2M8. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M19059 mRNA Translation: AAC12788.1
AE014298 Genomic DNA Translation: AAF48661.1
AE014298 Genomic DNA Translation: AAN09423.2
AE014298 Genomic DNA Translation: ACZ95312.1
AE014298 Genomic DNA Translation: ACZ95313.1
AY118840 mRNA Translation: AAM50700.1 Sequence problems.

Protein sequence database of the Protein Information Resource

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PIRi
A29637

NCBI Reference Sequences

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RefSeqi
NP_001162777.1, NM_001169306.2 [P12080-1]
NP_001162778.1, NM_001169307.1 [P12080-1]
NP_523378.2, NM_078654.2 [P12080-1]
NP_728021.2, NM_167544.2 [P12080-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0074357; FBpp0074131; FBgn0001250 [P12080-1]
FBtr0301352; FBpp0290566; FBgn0001250 [P12080-2]
FBtr0301353; FBpp0290567; FBgn0001250 [P12080-1]
FBtr0301354; FBpp0290568; FBgn0001250 [P12080-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
32661

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG9623

UCSC genome browser

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UCSCi
CG9623-RA d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19059 mRNA Translation: AAC12788.1
AE014298 Genomic DNA Translation: AAF48661.1
AE014298 Genomic DNA Translation: AAN09423.2
AE014298 Genomic DNA Translation: ACZ95312.1
AE014298 Genomic DNA Translation: ACZ95313.1
AY118840 mRNA Translation: AAM50700.1 Sequence problems.
PIRiA29637
RefSeqiNP_001162777.1, NM_001169306.2 [P12080-1]
NP_001162778.1, NM_001169307.1 [P12080-1]
NP_523378.2, NM_078654.2 [P12080-1]
NP_728021.2, NM_167544.2 [P12080-2]

3D structure databases

SMRiP12080
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi58994, 29 interactors
DIPiDIP-23111N
IntActiP12080, 2 interactors
STRINGi7227.FBpp0074131

Proteomic databases

PaxDbiP12080
PRIDEiP12080

Genome annotation databases

EnsemblMetazoaiFBtr0074357; FBpp0074131; FBgn0001250 [P12080-1]
FBtr0301352; FBpp0290566; FBgn0001250 [P12080-2]
FBtr0301353; FBpp0290567; FBgn0001250 [P12080-1]
FBtr0301354; FBpp0290568; FBgn0001250 [P12080-1]
GeneIDi32661
KEGGidme:Dmel_CG9623
UCSCiCG9623-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
32661
FlyBaseiFBgn0001250 if

Phylogenomic databases

eggNOGiKOG3637 Eukaryota
ENOG410XPVZ LUCA
GeneTreeiENSGT00940000169118
HOGENOMiCLU_004111_4_0_1
InParanoidiP12080
OMAiNNEDAFE
PhylomeDBiP12080

Enzyme and pathway databases

ReactomeiR-DME-114608 Platelet degranulation
R-DME-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-DME-1566977 Fibronectin matrix formation
R-DME-202733 Cell surface interactions at the vascular wall
R-DME-2129379 Molecules associated with elastic fibres
R-DME-216083 Integrin cell surface interactions
R-DME-3000170 Syndecan interactions
R-DME-3000178 ECM proteoglycans
R-DME-354192 Integrin signaling
R-DME-5674135 MAP2K and MAPK activation
R-DME-6798695 Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
32661 0 hits in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
if fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32661

Protein Ontology

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PROi
PR:P12080

Gene expression databases

BgeeiFBgn0001250 Expressed in Malpighian tubule and 27 other tissues
ExpressionAtlasiP12080 differential
GenevisibleiP12080 DM

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITA2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12080
Secondary accession number(s): E1JJN2
, Q8IR07, Q8MSG3, Q9VXB6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: December 1, 2000
Last modified: June 17, 2020
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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