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UniProtKB - P12074 (CX6A1_HUMAN)

Entry version 197 (25 May 2022)
Sequence version 4 (15 Jul 1999)
Previous versions | rss
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Protein

Cytochrome c oxidase subunit 6A1, mitochondrial

Gene

COX6A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P12074

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-611105, Respiratory electron transport
R-HSA-9707564, Cytoprotection by HMOX1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P12074

SIGNOR Signaling Network Open Resource

More...SIGNORi		P12074

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00705

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-liver
Cytochrome c oxidase subunit VIA-liver
Short name:
COX VIa-L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COX6A1
Synonyms:COX6AL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2277, COX6A1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602072, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P12074

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000111775

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 34Mitochondrial matrix1 Publication10
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 59HelicalBy similarityAdd BLAST25
Topological domaini60 – 109Mitochondrial intermembrane1 PublicationAdd BLAST50

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Charcot-Marie-Tooth disease, recessive, intermediate type, D (CMTRID)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Recessive intermediate forms of Charcot-Marie-Tooth disease are characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.
Related information in OMIM

Keywords - Diseasei

Charcot-Marie-Tooth disease, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...DisGeNETi		1337

MalaCards human disease database

More...MalaCardsi		COX6A1
MIMi616039, phenotype

Open Targets

More...OpenTargetsi		ENSG00000111775

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		435998, Autosomal recessive intermediate Charcot-Marie-Tooth disease type D

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26794

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P12074, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		COX6A1

Domain mapping of disease mutations (DMDM)

More...DMDMi		6166030

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 24Mitochondrion1 PublicationAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000611925 – 109Cytochrome c oxidase subunit 6A1, mitochondrialAdd BLAST85

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P12074

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P12074

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P12074

MaxQB - The MaxQuant DataBase

More...MaxQBi		P12074

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P12074

PeptideAtlas

More...PeptideAtlasi		P12074

PRoteomics IDEntifications database

More...PRIDEi		P12074

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52823

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P12074

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P12074

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P12074

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P12074

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111775, Expressed in prefrontal cortex and 118 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P12074, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P12074, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111775, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C, COX7A2 (or COX7A1), COX7B, COX7C, COX8A and NDUFA4, which are encoded in the nuclear genome (PubMed:30030519). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2) (PubMed:28844695).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107730, 51 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6123, Mitochondrial respiratory chain complex IV

Protein interaction database and analysis system

More...IntActi		P12074, 17 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000229379

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P12074, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P12074

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P12074

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 6A family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3469, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154612

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_122515_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P12074

Identification of Orthologs from Complete Genome Data

More...OMAi		GYEGHDE

Database of Orthologous Groups

More...OrthoDBi		1591077at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P12074

TreeFam database of animal gene trees

More...TreeFami		TF105064

Family and domain databases

Conserved Domains Database

More...CDDi		cd00925, Cyt_c_Oxidase_VIa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.95.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001349, Cyt_c_oxidase_su6a
IPR018507, Cyt_c_oxidase_su6a_CS
IPR036418, Cyt_c_oxidase_su6a_sf

The PANTHER Classification System

More...PANTHERi		PTHR11504, PTHR11504, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02046, COX6A, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000277, COX6A1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81411, SSF81411, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01329, COX6A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P12074-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVVGVSSVS RLLGRSRPQL GRPMSSGAHG EEGSARMWKT LTFFVALPGV 
        60         70         80         90        100
AVSMLNVYLK SHHGEHERPE FIAYPHLRIR TKPFPWGDGN HTLFHNPHVN 

PLPTGYEDE
Length:109
Mass (Da):12,155
Last modified:July 15, 1999 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0040F47CECE767B1
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA33392 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK312009 mRNA Translation: BAG34947.1
AL021546 Genomic DNA No translation available.
BC007723 mRNA Translation: AAH07723.1
BC070186 mRNA Translation: AAH70186.1
BC107861 mRNA Translation: AAI07862.1
X15341 mRNA Translation: CAA33392.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9197.1

NCBI Reference Sequences

More...RefSeqi		NP_004364.2, NM_004373.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000229379.3; ENSP00000229379.2; ENSG00000111775.3

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1337

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1337

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000229379.3; ENSP00000229379.2; NM_004373.4; NP_004364.2

UCSC genome browser

More...UCSCi		uc001tyf.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312009 mRNA Translation: BAG34947.1
AL021546 Genomic DNA No translation available.
BC007723 mRNA Translation: AAH07723.1
BC070186 mRNA Translation: AAH70186.1
BC107861 mRNA Translation: AAI07862.1
X15341 mRNA Translation: CAA33392.1 Frameshift.
CCDSiCCDS9197.1
RefSeqiNP_004364.2, NM_004373.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Z62electron microscopy3.60G34-108[»]
AlphaFoldDBiP12074
SMRiP12074
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107730, 51 interactors
ComplexPortaliCPX-6123, Mitochondrial respiratory chain complex IV
IntActiP12074, 17 interactors
STRINGi9606.ENSP00000229379

PTM databases

iPTMnetiP12074
PhosphoSitePlusiP12074

Genetic variation databases

BioMutaiCOX6A1
DMDMi6166030

2D gel databases

SWISS-2DPAGEiP12074

Proteomic databases

EPDiP12074
jPOSTiP12074
MassIVEiP12074
MaxQBiP12074
PaxDbiP12074
PeptideAtlasiP12074
PRIDEiP12074
ProteomicsDBi52823
TopDownProteomicsiP12074

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		45523, 347 antibodies from 29 providers

The DNASU plasmid repository

More...DNASUi		1337

Genome annotation databases

EnsembliENST00000229379.3; ENSP00000229379.2; ENSG00000111775.3
GeneIDi1337
KEGGihsa:1337
MANE-SelectiENST00000229379.3; ENSP00000229379.2; NM_004373.4; NP_004364.2
UCSCiuc001tyf.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1337
DisGeNETi1337

GeneCards: human genes, protein and diseases

More...GeneCardsi		COX6A1
HGNCiHGNC:2277, COX6A1
HPAiENSG00000111775, Low tissue specificity
MalaCardsiCOX6A1
MIMi602072, gene
616039, phenotype
neXtProtiNX_P12074
OpenTargetsiENSG00000111775
Orphaneti435998, Autosomal recessive intermediate Charcot-Marie-Tooth disease type D
PharmGKBiPA26794
VEuPathDBiHostDB:ENSG00000111775

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3469, Eukaryota
GeneTreeiENSGT00940000154612
HOGENOMiCLU_122515_1_1_1
InParanoidiP12074
OMAiGYEGHDE
OrthoDBi1591077at2759
PhylomeDBiP12074
TreeFamiTF105064

Enzyme and pathway databases

UniPathwayiUPA00705
PathwayCommonsiP12074
ReactomeiR-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-611105, Respiratory electron transport
R-HSA-9707564, Cytoprotection by HMOX1
SignaLinkiP12074
SIGNORiP12074

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1337, 119 hits in 1039 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		COX6A1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		COX6A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1337
PharosiP12074, Tbio

Protein Ontology

More...PROi		PR:P12074
RNActiP12074, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111775, Expressed in prefrontal cortex and 118 other tissues
ExpressionAtlasiP12074, baseline and differential
GenevisibleiP12074, HS

Family and domain databases

CDDicd00925, Cyt_c_Oxidase_VIa, 1 hit
Gene3Di4.10.95.10, 1 hit
InterProiView protein in InterPro
IPR001349, Cyt_c_oxidase_su6a
IPR018507, Cyt_c_oxidase_su6a_CS
IPR036418, Cyt_c_oxidase_su6a_sf
PANTHERiPTHR11504, PTHR11504, 1 hit
PfamiView protein in Pfam
PF02046, COX6A, 1 hit
PIRSFiPIRSF000277, COX6A1, 1 hit
SUPFAMiSSF81411, SSF81411, 1 hit
PROSITEiView protein in PROSITE
PS01329, COX6A, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCX6A1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12074
Secondary accession number(s): B2R500, O43714, Q32Q37
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 15, 1999
Last modified: May 25, 2022
This is version 197 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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