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Protein

N5-carboxyaminoimidazole ribonucleotide mutase

Gene

purE

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).UniRule annotation

Catalytic activityi

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. N5-carboxyaminoimidazole ribonucleotide synthase (purK)
  2. N5-carboxyaminoimidazole ribonucleotide mutase (purE)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11SubstrateUniRule annotation1
Binding sitei14SubstrateUniRule annotation1
Binding sitei41SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPurine biosynthesis

Enzyme and pathway databases

BioCyciBSUB:BSU06420-MONOMER
UniPathwayi
UPA00074;UER00943

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide mutaseUniRule annotation (EC:5.4.99.18UniRule annotation)
Short name:
N5-CAIR mutaseUniRule annotation
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide mutaseUniRule annotation
Gene namesi
Name:purEUniRule annotation
Ordered Locus Names:BSU06420
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000749691 – 162N5-carboxyaminoimidazole ribonucleotide mutaseAdd BLAST162

Proteomic databases

PaxDbiP12044
PRIDEiP12044

Interactioni

Protein-protein interaction databases

IntActiP12044, 1 interactor
MINTiP12044
STRINGi224308.Bsubs1_010100003628

Structurei

3D structure databases

ProteinModelPortaliP12044
SMRiP12044
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR carboxylase family. Class I subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UM6 Bacteria
COG0041 LUCA
HOGENOMiHOG000034141
InParanoidiP12044
KOiK01588
OMAiSNSIDGW
PhylomeDBiP12044

Family and domain databases

Gene3Di3.40.50.7700, 1 hit
HAMAPiMF_01929 PurE_classI, 1 hit
InterProiView protein in InterPro
IPR033747 PurE_ClassI
IPR000031 PurE_dom
IPR024694 PurE_prokaryotes
IPR035893 PurE_sf
PfamiView protein in Pfam
PF00731 AIRC, 1 hit
PIRSFiPIRSF001338 AIR_carboxylase, 1 hit
SMARTiView protein in SMART
SM01001 AIRC, 1 hit
SUPFAMiSSF52255 SSF52255, 1 hit
TIGRFAMsiTIGR01162 purE, 1 hit

Sequencei

Sequence statusi: Complete.

P12044-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPLVGIIMG STSDWETMKH ACDILDELNV PYEKKVVSAH RTPDFMFEYA
60 70 80 90 100
ETARERGIKV IIAGAGGAAH LPGMTAAKTT LPVIGVPVQS KALNGMDSLL
110 120 130 140 150
SIVQMPGGVP VATTSIGKAG AVNAGLLAAQ ILSAFDEDLA RKLDERRENT
160
KQTVLESSDQ LV
Length:162
Mass (Da):17,174
Last modified:October 1, 1989 - v1
Checksum:i9257EDF0253B4666
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02732 Genomic DNA Translation: AAA22674.1
AL009126 Genomic DNA Translation: CAB12462.1
U51115 Genomic DNA Translation: AAB62318.1
PIRiA29326 DEBSPE
RefSeqiNP_388524.1, NC_000964.3
WP_003244134.1, NZ_JNCM01000032.1

Genome annotation databases

EnsemblBacteriaiCAB12462; CAB12462; BSU06420
GeneIDi939481
KEGGibsu:BSU06420
PATRICifig|224308.179.peg.698

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02732 Genomic DNA Translation: AAA22674.1
AL009126 Genomic DNA Translation: CAB12462.1
U51115 Genomic DNA Translation: AAB62318.1
PIRiA29326 DEBSPE
RefSeqiNP_388524.1, NC_000964.3
WP_003244134.1, NZ_JNCM01000032.1

3D structure databases

ProteinModelPortaliP12044
SMRiP12044
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP12044, 1 interactor
MINTiP12044
STRINGi224308.Bsubs1_010100003628

Proteomic databases

PaxDbiP12044
PRIDEiP12044

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12462; CAB12462; BSU06420
GeneIDi939481
KEGGibsu:BSU06420
PATRICifig|224308.179.peg.698

Phylogenomic databases

eggNOGiENOG4108UM6 Bacteria
COG0041 LUCA
HOGENOMiHOG000034141
InParanoidiP12044
KOiK01588
OMAiSNSIDGW
PhylomeDBiP12044

Enzyme and pathway databases

UniPathwayi
UPA00074;UER00943

BioCyciBSUB:BSU06420-MONOMER

Family and domain databases

Gene3Di3.40.50.7700, 1 hit
HAMAPiMF_01929 PurE_classI, 1 hit
InterProiView protein in InterPro
IPR033747 PurE_ClassI
IPR000031 PurE_dom
IPR024694 PurE_prokaryotes
IPR035893 PurE_sf
PfamiView protein in Pfam
PF00731 AIRC, 1 hit
PIRSFiPIRSF001338 AIR_carboxylase, 1 hit
SMARTiView protein in SMART
SM01001 AIRC, 1 hit
SUPFAMiSSF52255 SSF52255, 1 hit
TIGRFAMsiTIGR01162 purE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPURE_BACSU
AccessioniPrimary (citable) accession number: P12044
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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