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UniProtKB - P12035 (K2C3_HUMAN)

Entry version 193 (10 Feb 2021)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
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Protein

Keratin, type II cytoskeletal 3

Gene

KRT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P12035

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type II cytoskeletal 3
Alternative name(s):
65 kDa cytokeratin
Cytokeratin-3
Short name:
CK-3
Keratin-3
Short name:
K3
Type-II keratin Kb3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6440, KRT3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		148043, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P12035

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000186442.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Corneal dystrophy, Meesmann 2 (MECD2)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of Meesmann corneal dystrophy, a corneal disease characterized by fragility of the anterior corneal epithelium. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. MECD2 inheritance is autosomal dominant.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031327503R → P in MECD2. 1 PublicationCorresponds to variant dbSNP:rs60410063EnsemblClinVar.1
Natural variantiVAR_003868509E → K in MECD2. 1 PublicationCorresponds to variant dbSNP:rs57872071EnsemblClinVar.1

Keywords - Diseasei

Corneal dystrophy, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		3850

MalaCards human disease database

More...MalaCardsi		KRT3
MIMi618767, phenotype

Open Targets

More...OpenTargetsi		ENSG00000186442

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		98954, Meesmann corneal dystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30228

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P12035, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KRT3

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104225

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000637161 – 628Keratin, type II cytoskeletal 3Add BLAST628

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei296N6,N6-dimethyllysineBy similarity1
Modified residuei364PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P12035

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P12035

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P12035

PeptideAtlas

More...PeptideAtlasi		P12035

PRoteomics IDEntifications database

More...PRIDEi		P12035

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52820

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P12035

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P12035

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P12035

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Cornea specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186442, Expressed in gingiva and 37 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P12035, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000186442, Group enriched (salivary gland, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-3 associates with keratin-12.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P12035
With#Exp.IntAct
BPIFA1 [Q9NP55]3EBI-2430095,EBI-953896
C3orf62 [Q6ZUJ4]3EBI-2430095,EBI-2837036
CCDC197 [Q8NCU1]3EBI-2430095,EBI-750686
DEUP1 [Q05D60]3EBI-2430095,EBI-748597
HAUS1 [Q96CS2]3EBI-2430095,EBI-2514791
HGS [O14964]3EBI-2430095,EBI-740220
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-2430095,EBI-14069005
KRT14 [P02533]3EBI-2430095,EBI-702178
KRT16 [P08779]3EBI-2430095,EBI-356410
KRT19 [P08727]3EBI-2430095,EBI-742756
KRT20 [P35900]3EBI-2430095,EBI-742094
KRT24 [Q2M2I5]3EBI-2430095,EBI-2952736
KRT25 [Q7Z3Z0]3EBI-2430095,EBI-11980019
KRT26 [Q7Z3Y9]3EBI-2430095,EBI-12084444
KRT27 [Q7Z3Y8]3EBI-2430095,EBI-3044087
KRT28 [Q7Z3Y7]5EBI-2430095,EBI-11980489
KRT31 [Q15323]3EBI-2430095,EBI-948001
KRT33B [Q14525]3EBI-2430095,EBI-1049638
KRT34 [O76011]5EBI-2430095,EBI-1047093
KRT35 [Q92764]3EBI-2430095,EBI-1058674
KRT36 - isoform 2 [O76013-2]5EBI-2430095,EBI-11958506
KRT37 [O76014]3EBI-2430095,EBI-1045716
KRT38 [O76015]3EBI-2430095,EBI-1047263
KRT39 [Q6A163]3EBI-2430095,EBI-11958242
KRT75 [O95678]3EBI-2430095,EBI-2949715
KRTAP13-2 [Q52LG2]3EBI-2430095,EBI-11953846
LHX3 - isoform B [Q9UBR4-2]3EBI-2430095,EBI-12039345
LURAP1 [Q96LR2]3EBI-2430095,EBI-741355
NUP62 [P37198]3EBI-2430095,EBI-347978
OIP5 [O43482]3EBI-2430095,EBI-536879
PLEKHG4 [Q58EX7]3EBI-2430095,EBI-949255
SAPCD2 [Q86UD0]3EBI-2430095,EBI-2561646
SPAG5 [Q96R06]3EBI-2430095,EBI-413317
TRAF1 [Q13077]3EBI-2430095,EBI-359224
TRIM27 [P14373]3EBI-2430095,EBI-719493
TRIM54 [Q9BYV2]3EBI-2430095,EBI-2130429
WWOX - isoform 5 [Q9NZC7-5]3EBI-2430095,EBI-12040603
ZNF426 [Q9BUY5]3EBI-2430095,EBI-743265
G4XUV33EBI-2430095,EBI-10177989

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110048, 65 interactors

Protein interaction database and analysis system

More...IntActi		P12035, 46 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000413479

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P12035, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P12035

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini198 – 513IF rodPROSITE-ProRule annotationAdd BLAST316

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 197HeadAdd BLAST197
Regioni198 – 233Coil 1AAdd BLAST36
Regioni234 – 254Linker 1Add BLAST21
Regioni255 – 346Coil 1BAdd BLAST92
Regioni347 – 370Linker 12Add BLAST24
Regioni371 – 509Coil 2Add BLAST139
Regioni510 – 628TailAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 169Gly-richAdd BLAST160
Compositional biasi536 – 612Gly-richAdd BLAST77

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QURK, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162629

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012560_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P12035

Identification of Orthologs from Complete Genome Data

More...OMAi		DSEMRNM

Database of Orthologous Groups

More...OrthoDBi		824246at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P12035

TreeFam database of animal gene trees

More...TreeFami		TF332742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR032444, Keratin_2_head
IPR003054, Keratin_II

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00038, Filament, 1 hit
PF16208, Keratin_2_head, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01276, TYPE2KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01391, Filament, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P12035-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRQASKTSG GGSQGFSGRS AVVSGSSRMS CVAHSGGAGG GAYGFRSGAG 
        60         70         80         90        100
GFGSRSLYNL GGNKSISISV AAGGSRAGGF GGGRSSCAFA GGYGGGFGSG 
       110        120        130        140        150
YGGGFGGGFG GGRGMGGGFG GAGGFGGAGG FGGAGGFGGP GGFGGSGGFG 
       160        170        180        190        200
GPGSLGSPGG FGPGGFPGGI QEVTINQSLL QPLNVEIDPQ IGQVKAQERE 
       210        220        230        240        250
QIKTLNNKFA SFIDKVRFLE QQNKVLETKW NLLQQQGTSS ISGTNNLEPL 
       260        270        280        290        300
FENHINYLRS YLDNILGERG RLDSELKNME DLVEDFKKKY EDEINKRTAA 
       310        320        330        340        350
ENEFVTLKKD VDSAYMNKVE LQAKVDALID EIDFLRTLYD AELSQMQSHI 
       360        370        380        390        400
SDTSVVLSMD NNRSLDLDSI IAEVRAQYED IAQRSKAEAE ALYQTKLGEL 
       410        420        430        440        450
QTTAGRHGDD LRNTKSEIIE LNRMIQRLRA EIEGVKKQNA NLQTAIAEAE 
       460        470        480        490        500
QHGEMALKDA NAKLQELQAA LQQAKDDLAR LLRDYQELMN VKLALDVEIA 
       510        520        530        540        550
TYRKLLEGEE YRMSGECPSA VSISVVSSST TSASAGGYGG GYGGGMGGGL 
       560        570        580        590        600
GGGFSAGGGS GSGFGRGGGG GIGGGFGGGS SGFSGGSGFG SISGARYGVS 
       610        620 
GGGFSSASNR GGSIKFSQSS QSSQRYSR
Length:628
Mass (Da):64,417
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65FDB8CAA7F3C960
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAF31522 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti162G → A in CAA28991 (PubMed:2439698).Curated1
Sequence conflicti175I → T in CAA28991 (PubMed:2439698).Curated1
Sequence conflicti184N → K in CAA28991 (PubMed:2439698).Curated1
Sequence conflicti187I → T in CAA28991 (PubMed:2439698).Curated1
Sequence conflicti298T → Y in CAA28993 (PubMed:2439698).Curated1
Sequence conflicti397L → M in CAA28996 (PubMed:2439698).Curated1
Sequence conflicti409D → G in CAF31522 (PubMed:15737194).Curated1
Sequence conflicti448E → Q in CAA28996 (PubMed:2439698).Curated1
Sequence conflicti511Y → YS in CAA28996 (PubMed:2439698).Curated1
Sequence conflicti562S → I in CAA28996 (PubMed:2439698).Curated1
Sequence conflicti580S → T in CAA28996 (PubMed:2439698).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06129744G → A. Corresponds to variant dbSNP:rs28721426Ensembl.1
Natural variantiVAR_056023375R → G1 PublicationCorresponds to variant dbSNP:rs3887954Ensembl.1
Natural variantiVAR_031327503R → P in MECD2. 1 PublicationCorresponds to variant dbSNP:rs60410063EnsemblClinVar.1
Natural variantiVAR_003868509E → K in MECD2. 1 PublicationCorresponds to variant dbSNP:rs57872071EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X05418 Genomic DNA Translation: CAA28991.1
X05419 Genomic DNA Translation: CAA28992.1
X05420 Genomic DNA Translation: CAA28993.1
X05420 Genomic DNA Translation: CAA28994.1
X05420 Genomic DNA Translation: CAA28995.1
X05421 Genomic DNA Translation: CAA28996.1
AC107016 Genomic DNA No translation available.
AJ628418 mRNA Translation: CAF31522.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44895.1

Protein sequence database of the Protein Information Resource

More...PIRi		A29666

NCBI Reference Sequences

More...RefSeqi		NP_476429.2, NM_057088.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000417996; ENSP00000413479; ENSG00000186442

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3850

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3850

UCSC genome browser

More...UCSCi		uc001say.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Human Intermediate Filament Mutation Database
Wikipedia

Keratin-3 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05418 Genomic DNA Translation: CAA28991.1
X05419 Genomic DNA Translation: CAA28992.1
X05420 Genomic DNA Translation: CAA28993.1
X05420 Genomic DNA Translation: CAA28994.1
X05420 Genomic DNA Translation: CAA28995.1
X05421 Genomic DNA Translation: CAA28996.1
AC107016 Genomic DNA No translation available.
AJ628418 mRNA Translation: CAF31522.1 Different initiation.
CCDSiCCDS44895.1
PIRiA29666
RefSeqiNP_476429.2, NM_057088.2

3D structure databases

SMRiP12035
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110048, 65 interactors
IntActiP12035, 46 interactors
STRINGi9606.ENSP00000413479

PTM databases

iPTMnetiP12035
PhosphoSitePlusiP12035
SwissPalmiP12035

Genetic variation databases

BioMutaiKRT3
DMDMi313104225

Proteomic databases

jPOSTiP12035
MassIVEiP12035
PaxDbiP12035
PeptideAtlasiP12035
PRIDEiP12035
ProteomicsDBi52820

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7889, 174 antibodies

The DNASU plasmid repository

More...DNASUi		3850

Genome annotation databases

EnsembliENST00000417996; ENSP00000413479; ENSG00000186442
GeneIDi3850
KEGGihsa:3850
UCSCiuc001say.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3850
DisGeNETi3850

GeneCards: human genes, protein and diseases

More...GeneCardsi		KRT3
HGNCiHGNC:6440, KRT3
HPAiENSG00000186442, Group enriched (salivary gland, tongue)
MalaCardsiKRT3
MIMi148043, gene
618767, phenotype
neXtProtiNX_P12035
OpenTargetsiENSG00000186442
Orphaneti98954, Meesmann corneal dystrophy
PharmGKBiPA30228
VEuPathDBiHostDB:ENSG00000186442.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QURK, Eukaryota
GeneTreeiENSGT00940000162629
HOGENOMiCLU_012560_6_0_1
InParanoidiP12035
OMAiDSEMRNM
OrthoDBi824246at2759
PhylomeDBiP12035
TreeFamiTF332742

Enzyme and pathway databases

PathwayCommonsiP12035
ReactomeiR-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3850, 5 hits in 870 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Keratin_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3850
PharosiP12035, Tbio

Protein Ontology

More...PROi		PR:P12035
RNActiP12035, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186442, Expressed in gingiva and 37 other tissues
GenevisibleiP12035, HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR032444, Keratin_2_head
IPR003054, Keratin_II
PfamiView protein in Pfam
PF00038, Filament, 1 hit
PF16208, Keratin_2_head, 1 hit
PRINTSiPR01276, TYPE2KERATIN
SMARTiView protein in SMART
SM01391, Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK2C3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12035
Secondary accession number(s): A6NIS2, Q701L8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 30, 2010
Last modified: February 10, 2021
This is version 193 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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