Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor 5

Gene

FGF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cell proliferation Source: ProtInc
  • fibroblast growth factor receptor signaling pathway Source: MGI
  • glial cell differentiation Source: Ensembl
  • MAPK cascade Source: Reactome
  • nervous system development Source: ProtInc
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of protein kinase B signaling Source: Reactome
  • signal transduction involved in regulation of gene expression Source: Ensembl

Keywordsi

Molecular functionGrowth factor, Mitogen

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1839122 Signaling by activated point mutants of FGFR1
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-190373 FGFR1c ligand binding and activation
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
SIGNORiP12034

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 5
Short name:
FGF-5
Alternative name(s):
Heparin-binding growth factor 5
Short name:
HBGF-5
Smag-82
Gene namesi
Name:FGF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138675.16
HGNCiHGNC:3683 FGF5
MIMi165190 gene
neXtProtiNX_P12034

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Trichomegaly (TCMGLY)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA morphologic trait characterized by unusually long eyelashes and mild hypertrichosis of eyebrows. It can be observed in association with corneal irritation, cataracts, and hereditary spherocytosis.
See also OMIM:190330
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_072566174Y → H in TCMGLY. 1 PublicationCorresponds to variant dbSNP:rs587777581EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNETi2250
MalaCardsiFGF5
MIMi190330 phenotype
OpenTargetsiENSG00000138675
Orphaneti411788 Familial isolated trichomegaly
PharmGKBiPA28122

Polymorphism and mutation databases

BioMutaiFGF5
DMDMi85700417

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000895821 – 268Fibroblast growth factor 5Add BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP12034
PeptideAtlasiP12034
PRIDEiP12034
ProteomicsDBi52818
52819 [P12034-2]

PTM databases

iPTMnetiP12034
PhosphoSitePlusiP12034

Expressioni

Tissue specificityi

Expressed in neonatal brain.

Developmental stagei

Can transform NIH 3T3 cells.

Gene expression databases

BgeeiENSG00000138675
CleanExiHS_FGF5
ExpressionAtlasiP12034 baseline and differential
GenevisibleiP12034 HS

Organism-specific databases

HPAiCAB010313
HPA042442

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108541, 5 interactors
DIPiDIP-4018N
IntActiP12034, 4 interactors
STRINGi9606.ENSP00000311697

Structurei

3D structure databases

ProteinModelPortaliP12034
SMRiP12034
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 52Poly-Ser4
Compositional biasi55 – 62Poly-Ser8

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP12034
KOiK04358
OMAiLSAWAHG
OrthoDBiEOG091G0NAY
PhylomeDBiP12034
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028240 FGF5
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF23 PTHR11486:SF23, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P12034-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLSFLLLLF FSHLILSAWA HGEKRLAPKG QPGPAATDRN PRGSSSRQSS
60 70 80 90 100
SSAMSSSSAS SSPAASLGSQ GSGLEQSSFQ WSPSGRRTGS LYCRVGIGFH
110 120 130 140 150
LQIYPDGKVN GSHEANMLSV LEIFAVSQGI VGIRGVFSNK FLAMSKKGKL
160 170 180 190 200
HASAKFTDDC KFRERFQENS YNTYASAIHR TEKTGREWYV ALNKRGKAKR
210 220 230 240 250
GCSPRVKPQH ISTHFLPRFK QSEQPELSFT VTVPEKKKPP SPIKPKIPLS
260
APRKNTNSVK YRLKFRFG
Length:268
Mass (Da):29,551
Last modified:January 24, 2006 - v4
Checksum:i28B7268B26781BCF
GO
Isoform Short (identifier: P12034-2) [UniParc]FASTAAdd to basket
Also known as: FGF-5S

The sequence of this isoform differs from the canonical sequence as follows:
     120-123: VLEI → QVHR
     124-268: Missing.

Note: Seems to have an antagonistic effect compared to that of the isoform Long.
Show »
Length:123
Mass (Da):13,006
Checksum:iE77B31D2CECE1096
GO

Sequence cautioni

The sequence AAB60698 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42R → I in AAB06463 (PubMed:1700424).Curated1
Sequence conflicti83 – 86PSGR → LGA in AAB60699 (PubMed:3211147).Curated4
Sequence conflicti224Q → QQ in AAZ67914 (Ref. 6) Curated1
Sequence conflicti238K → N in AAB06463 (PubMed:1700424).Curated1
Sequence conflicti238K → N in AAB60699 (PubMed:3211147).Curated1
Sequence conflicti245P → S in AAB06463 (PubMed:1700424).Curated1
Sequence conflicti245P → S in AAB60699 (PubMed:3211147).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02517454M → V1 PublicationCorresponds to variant dbSNP:rs33950145Ensembl.1
Natural variantiVAR_072566174Y → H in TCMGLY. 1 PublicationCorresponds to variant dbSNP:rs587777581EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001518120 – 123VLEI → QVHR in isoform Short. 3 Publications4
Alternative sequenceiVSP_001519124 – 268Missing in isoform Short. 3 PublicationsAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37825 mRNA Translation: AAB06463.1
M23536, M23534, M23535 Genomic DNA Translation: AAB60699.1
M23534 Genomic DNA Translation: AAB60698.1 Sequence problems.
AB016517 mRNA Translation: BAA33738.1
AF171928 mRNA Translation: AAF89742.1
AF535149 mRNA Translation: AAN04097.1
DQ151636 Genomic DNA Translation: AAZ67914.1
AK291962 mRNA Translation: BAF84651.1
AK312065 mRNA Translation: BAG35001.1
CH471057 Genomic DNA Translation: EAX05859.1
CH471057 Genomic DNA Translation: EAX05860.1
BC074858 mRNA Translation: AAH74858.1
BC074859 mRNA Translation: AAH74859.1
BC131502 mRNA Translation: AAI31503.1
CCDSiCCDS34021.1 [P12034-1]
CCDS3586.1 [P12034-2]
PIRiA31194 TVHUF5
B31194
RefSeqiNP_004455.2, NM_004464.3 [P12034-1]
NP_149134.1, NM_033143.2 [P12034-2]
UniGeneiHs.37055

Genome annotation databases

EnsembliENST00000312465; ENSP00000311697; ENSG00000138675 [P12034-1]
ENST00000456523; ENSP00000398353; ENSG00000138675 [P12034-2]
GeneIDi2250
KEGGihsa:2250
UCSCiuc003hmd.4 human [P12034-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFGF5_HUMAN
AccessioniPrimary (citable) accession number: P12034
Secondary accession number(s): B2R554
, O75846, Q3Y8M3, Q8NF90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 24, 2006
Last modified: June 20, 2018
This is version 167 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health