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Protein

Acyl-CoA-binding protein

Gene

DBI

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
DBI(32-86) has antibacterial properties.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14Acyl-CoABy similarity1
Binding sitei51Acyl-CoABy similarity1
Binding sitei55Acyl-CoABy similarity1
Binding sitei74Acyl-CoABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial
Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-SSC-77289 Mitochondrial Fatty Acid Beta-Oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding protein
Short name:
ACBP
Alternative name(s):
Diazepam-binding inhibitor
Short name:
DBI
Endozepine
Short name:
EP
Cleaved into the following chain:
Gene namesi
Name:DBI
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000451992 – 87Acyl-CoA-binding proteinAdd BLAST86
PeptideiPRO_000000028733 – 87DBI(32-86)Add BLAST55

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei8N6-acetyllysine; alternateBy similarity1
Modified residuei8N6-succinyllysine; alternateBy similarity1
Modified residuei17N6-succinyllysineBy similarity1
Modified residuei19N6-acetyllysineBy similarity1
Modified residuei29PhosphotyrosineBy similarity1
Modified residuei51N6-acetyllysineBy similarity1
Modified residuei55N6-acetyllysine; alternateBy similarity1
Modified residuei55N6-malonyllysine; alternateBy similarity1
Modified residuei55N6-succinyllysine; alternateBy similarity1
Modified residuei77N6-acetyllysine; alternateBy similarity1
Modified residuei77N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP12026
PeptideAtlasiP12026
PRIDEiP12026

PTM databases

iPTMnetiP12026

Expressioni

Gene expression databases

BgeeiENSSSCG00000023435 Expressed in 5 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiP12026 differential
GenevisibleiP12026 SS

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000021888

Structurei

3D structure databases

ProteinModelPortaliP12026
SMRiP12026
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 87ACBPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 33Acyl-CoA bindingBy similarity5

Sequence similaritiesi

Belongs to the ACBP family.Curated

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
GeneTreeiENSGT00840000129776
HOGENOMiHOG000261845
HOVERGENiHBG000398
InParanoidiP12026
KOiK08762
OMAiRYKFEAW
OrthoDBiEOG091G0NXJ
TreeFamiTF335802

Family and domain databases

CDDicd00435 ACBP, 1 hit
Gene3Di1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PRINTSiPR00689 ACOABINDINGP
SUPFAMiSSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P12026-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQAEFEKAA EEVKNLKTKP ADDEMLFIYS HYKQATVGDI NTERPGILDL
60 70 80
KGKAKWDAWN GLKGTSKEDA MKAYINKVEE LKKKYGI
Length:87
Mass (Da):9,896
Last modified:January 23, 2007 - v2
Checksum:i3225B53E8307DE38
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A287BJR8A0A287BJR8_PIG
Acyl-CoA-binding protein
DBI
70Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019792 mRNA Translation: BAA34531.1
DQ885192 mRNA Translation: ABM30147.1
PIRiS00805 NZPG
RefSeqiNP_999284.1, NM_214119.1
UniGeneiSsc.55858

Genome annotation databases

EnsembliENSSSCT00000060340; ENSSSCP00000049861; ENSSSCG00000032213
GeneIDi397212
KEGGissc:397212

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019792 mRNA Translation: BAA34531.1
DQ885192 mRNA Translation: ABM30147.1
PIRiS00805 NZPG
RefSeqiNP_999284.1, NM_214119.1
UniGeneiSsc.55858

3D structure databases

ProteinModelPortaliP12026
SMRiP12026
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000021888

PTM databases

iPTMnetiP12026

Proteomic databases

PaxDbiP12026
PeptideAtlasiP12026
PRIDEiP12026

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000060340; ENSSSCP00000049861; ENSSSCG00000032213
GeneIDi397212
KEGGissc:397212

Organism-specific databases

CTDi1622

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
GeneTreeiENSGT00840000129776
HOGENOMiHOG000261845
HOVERGENiHBG000398
InParanoidiP12026
KOiK08762
OMAiRYKFEAW
OrthoDBiEOG091G0NXJ
TreeFamiTF335802

Enzyme and pathway databases

ReactomeiR-SSC-77289 Mitochondrial Fatty Acid Beta-Oxidation

Gene expression databases

BgeeiENSSSCG00000023435 Expressed in 5 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiP12026 differential
GenevisibleiP12026 SS

Family and domain databases

CDDicd00435 ACBP, 1 hit
Gene3Di1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PRINTSiPR00689 ACOABINDINGP
SUPFAMiSSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACBP_PIG
AccessioniPrimary (citable) accession number: P12026
Secondary accession number(s): A7YB23, Q9TSG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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