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Protein

Midkine

Gene

Mdk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (By similarity). Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development.By similarity1 Publication

GO - Molecular functioni

  • growth factor activity Source: GO_Central
  • heparin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-MMU-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Midkine
Short name:
MK
Alternative name(s):
Retinoic acid-induced differentiation factor
Gene namesi
Name:Mdk
Synonyms:Mk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96949 Mdk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002466323 – 140MidkineAdd BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi42 ↔ 67By similarity
Disulfide bondi49 ↔ 71By similarity
Disulfide bondi81 ↔ 113By similarity
Disulfide bondi91 ↔ 123By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP12025
PaxDbiP12025
PeptideAtlasiP12025
PRIDEiP12025

PTM databases

iPTMnetiP12025
PhosphoSitePlusiP12025

Expressioni

Developmental stagei

Is expressed temporarily during the early stages of retinoic acid-induced differentiation of embryonal carcinoma cells and during the mid-gestation period of mouse embryogenesis. In late embryos and in adults expression is restricted to the kidney.

Inductioni

By retinoic acid.

Gene expression databases

BgeeiENSMUSG00000027239 Expressed in 118 organ(s), highest expression level in digestive tract
CleanExiMM_MDK
GenevisibleiP12025 MM

Interactioni

Subunit structurei

Homodimer. Interacts with ALK.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201369, 3 interactors
DIPiDIP-5791N
IntActiP12025, 3 interactors
STRINGi10090.ENSMUSP00000028672

Structurei

3D structure databases

ProteinModelPortaliP12025
SMRiP12025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pleiotrophin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0E8 Eukaryota
ENOG4111ZWP LUCA
GeneTreeiENSGT00390000007640
HOGENOMiHOG000231473
HOVERGENiHBG008317
InParanoidiP12025
KOiK06828
OMAiEWTWGPC
OrthoDBiEOG091G0VCN
PhylomeDBiP12025
TreeFamiTF332376

Family and domain databases

Gene3Di2.20.60.10, 1 hit
2.30.90.10, 1 hit
InterProiView protein in InterPro
IPR000762 Midkine_heparin-bd_GF
IPR020090 PTN/MK_C_dom
IPR038130 PTN/MK_C_dom_sf
IPR020091 PTN/MK_diS_sf
IPR020089 PTN/MK_N_dom
IPR037122 PTN/MK_N_dom_sf
IPR020092 PTN_MK_heparin-bd_GF_CS
PANTHERiPTHR13850 PTHR13850, 1 hit
PfamiView protein in Pfam
PF01091 PTN_MK_C, 1 hit
PF05196 PTN_MK_N, 1 hit
PRINTSiPR00269 PTNMIDKINE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005592 PTN_MK_hepar_bd, 1 hit
SMARTiView protein in SMART
SM00193 PTN, 1 hit
SUPFAMiSSF57288 SSF57288, 2 hits
PROSITEiView protein in PROSITE
PS00619 PTN_MK_1, 1 hit
PS00620 PTN_MK_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12025-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQHRGFFLLA LLALLVVTSA VAKKKEKVKK GSECSEWTWG PCTPSSKDCG
60 70 80 90 100
MGFREGTCGA QTQRVHCKVP CNWKKEFGAD CKYKFESWGA CDGSTGTKAR
110 120 130 140
QGTLKKARYN AQCQETIRVT KPCTSKTKSK TKAKKGKGKD
Length:140
Mass (Da):15,434
Last modified:August 1, 1991 - v2
Checksum:iDAE31FEC94B29CF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19662 mRNA Translation: AAA39710.1
M34327 mRNA Translation: AAA39712.1
M34328 mRNA Translation: AAA39715.1
M35833 mRNA Translation: AAA39714.1
M34094 Genomic DNA Translation: AAA39717.1
BC012244 mRNA Translation: AAH12244.1
CCDSiCCDS16440.1
PIRiA27684
A35305
RefSeqiNP_001012335.1, NM_001012335.2
NP_001012336.1, NM_001012336.2
NP_001278410.1, NM_001291481.1
NP_034914.1, NM_010784.5
UniGeneiMm.906

Genome annotation databases

EnsembliENSMUST00000028672; ENSMUSP00000028672; ENSMUSG00000027239
ENSMUST00000069423; ENSMUSP00000068413; ENSMUSG00000027239
ENSMUST00000090602; ENSMUSP00000088090; ENSMUSG00000027239
ENSMUST00000111309; ENSMUSP00000106941; ENSMUSG00000027239
GeneIDi17242
KEGGimmu:17242
UCSCiuc008kww.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19662 mRNA Translation: AAA39710.1
M34327 mRNA Translation: AAA39712.1
M34328 mRNA Translation: AAA39715.1
M35833 mRNA Translation: AAA39714.1
M34094 Genomic DNA Translation: AAA39717.1
BC012244 mRNA Translation: AAH12244.1
CCDSiCCDS16440.1
PIRiA27684
A35305
RefSeqiNP_001012335.1, NM_001012335.2
NP_001012336.1, NM_001012336.2
NP_001278410.1, NM_001291481.1
NP_034914.1, NM_010784.5
UniGeneiMm.906

3D structure databases

ProteinModelPortaliP12025
SMRiP12025
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201369, 3 interactors
DIPiDIP-5791N
IntActiP12025, 3 interactors
STRINGi10090.ENSMUSP00000028672

PTM databases

iPTMnetiP12025
PhosphoSitePlusiP12025

Proteomic databases

MaxQBiP12025
PaxDbiP12025
PeptideAtlasiP12025
PRIDEiP12025

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028672; ENSMUSP00000028672; ENSMUSG00000027239
ENSMUST00000069423; ENSMUSP00000068413; ENSMUSG00000027239
ENSMUST00000090602; ENSMUSP00000088090; ENSMUSG00000027239
ENSMUST00000111309; ENSMUSP00000106941; ENSMUSG00000027239
GeneIDi17242
KEGGimmu:17242
UCSCiuc008kww.2 mouse

Organism-specific databases

CTDi4192
MGIiMGI:96949 Mdk

Phylogenomic databases

eggNOGiENOG410J0E8 Eukaryota
ENOG4111ZWP LUCA
GeneTreeiENSGT00390000007640
HOGENOMiHOG000231473
HOVERGENiHBG008317
InParanoidiP12025
KOiK06828
OMAiEWTWGPC
OrthoDBiEOG091G0VCN
PhylomeDBiP12025
TreeFamiTF332376

Enzyme and pathway databases

ReactomeiR-MMU-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus

Miscellaneous databases

ChiTaRSiSlc11a2 mouse
PROiPR:P12025
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027239 Expressed in 118 organ(s), highest expression level in digestive tract
CleanExiMM_MDK
GenevisibleiP12025 MM

Family and domain databases

Gene3Di2.20.60.10, 1 hit
2.30.90.10, 1 hit
InterProiView protein in InterPro
IPR000762 Midkine_heparin-bd_GF
IPR020090 PTN/MK_C_dom
IPR038130 PTN/MK_C_dom_sf
IPR020091 PTN/MK_diS_sf
IPR020089 PTN/MK_N_dom
IPR037122 PTN/MK_N_dom_sf
IPR020092 PTN_MK_heparin-bd_GF_CS
PANTHERiPTHR13850 PTHR13850, 1 hit
PfamiView protein in Pfam
PF01091 PTN_MK_C, 1 hit
PF05196 PTN_MK_N, 1 hit
PRINTSiPR00269 PTNMIDKINE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005592 PTN_MK_hepar_bd, 1 hit
SMARTiView protein in SMART
SM00193 PTN, 1 hit
SUPFAMiSSF57288 SSF57288, 2 hits
PROSITEiView protein in PROSITE
PS00619 PTN_MK_1, 1 hit
PS00620 PTN_MK_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMK_MOUSE
AccessioniPrimary (citable) accession number: P12025
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 1, 1991
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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