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Protein

Immunoglobulin iota chain

Gene

VPREB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.

GO - Biological processi

  • immune response Source: GO_Central
  • immunoglobulin production Source: GO_Central
  • leukocyte migration Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin iota chain
Alternative name(s):
CD179 antigen-like family member A
Protein VPreB1
V(pre)B protein
Short name:
VpreB protein
CD_antigen: CD179a
Gene namesi
Name:VPREB1
Synonyms:VPREB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000169575.4
HGNCiHGNC:12709 VPREB1
MIMi605141 gene
neXtProtiNX_P12018

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi7441
OpenTargetsiENSG00000169575
PharmGKBiPA37324

Polymorphism and mutation databases

BioMutaiVPREB1
DMDMi9911096

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001500020 – 145Immunoglobulin iota chainAdd BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 115PROSITE-ProRule annotation2 Publications

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP12018
PeptideAtlasiP12018
PRIDEiP12018
ProteomicsDBi52817
TopDownProteomicsiP12018

PTM databases

iPTMnetiP12018
PhosphoSitePlusiP12018

Expressioni

Tissue specificityi

Only expressed by pre-B-cells.

Gene expression databases

BgeeiENSG00000169575 Expressed in 8 organ(s), highest expression level in bone marrow
CleanExiHS_VPREB1
ExpressionAtlasiP12018 baseline and differential
GenevisibleiP12018 HS

Organism-specific databases

HPAiHPA055886

Interactioni

Subunit structurei

Associates non-covalently with IGLL1.1 Publication

Protein-protein interaction databases

CORUMiP12018
IntActiP12018, 1 interactor
STRINGi9606.ENSP00000385361

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP12018
SMRiP12018
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12018

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 132Ig-like V-typeAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 41Framework-1Add BLAST22
Regioni42 – 56Complementarity-determining-1Add BLAST15
Regioni57 – 70Framework-2Add BLAST14
Regioni71 – 81Complementarity-determining-2Add BLAST11
Regioni82 – 115Framework-3Add BLAST34

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IYZ1 Eukaryota
ENOG411181I LUCA
GeneTreeiENSGT00900000140867
HOGENOMiHOG000059537
HOVERGENiHBG018013
InParanoidiP12018
KOiK06553
OMAiVYSIYWY
OrthoDBiEOG091G0XV9
PhylomeDBiP12018
TreeFamiTF352061

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P12018-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWAPVLLML FVYCTGCGPQ PVLHQPPAMS SALGTTIRLT CTLRNDHDIG
60 70 80 90 100
VYSVYWYQQR PGHPPRFLLR YFSQSDKSQG PQVPPRFSGS KDVARNRGYL
110 120 130 140
SISELQPEDE AMYYCAMGAR SSEKEERERE WEEEMEPTAA RTRVP
Length:145
Mass (Da):16,605
Last modified:December 1, 2000 - v2
Checksum:i197665B13AF64D46
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W8C9F8W8C9_HUMAN
Immunoglobulin iota chain
VPREB1
144Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10L → H in AAA61292 (PubMed:3258819).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02450376D → N. Corresponds to variant dbSNP:rs1320Ensembl.1
Natural variantiVAR_029133122S → L. Corresponds to variant dbSNP:rs11089979Ensembl.1
Natural variantiVAR_029134132E → K. Corresponds to variant dbSNP:rs5995720Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74019 Genomic DNA Translation: AAB32118.1
D86992 Genomic DNA Translation: BAA19987.1
D88270 Genomic DNA Translation: BAA20030.1
CR456609 mRNA Translation: CAG30495.1
CH471095 Genomic DNA Translation: EAW59498.1
M34927 Genomic DNA Translation: AAA61292.1
CCDSiCCDS13798.1
PIRiI57832
S00258
RefSeqiNP_009059.1, NM_007128.3
UniGeneiHs.247979

Genome annotation databases

EnsembliENST00000403807; ENSP00000385361; ENSG00000169575
GeneIDi7441
KEGGihsa:7441
UCSCiuc002zvx.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

VPREB1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74019 Genomic DNA Translation: AAB32118.1
D86992 Genomic DNA Translation: BAA19987.1
D88270 Genomic DNA Translation: BAA20030.1
CR456609 mRNA Translation: CAG30495.1
CH471095 Genomic DNA Translation: EAW59498.1
M34927 Genomic DNA Translation: AAA61292.1
CCDSiCCDS13798.1
PIRiI57832
S00258
RefSeqiNP_009059.1, NM_007128.3
UniGeneiHs.247979

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H32X-ray2.70A20-145[»]
2H3NX-ray2.30A/C21-119[»]
3BJ9X-ray2.00122-121[»]
ProteinModelPortaliP12018
SMRiP12018
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP12018
IntActiP12018, 1 interactor
STRINGi9606.ENSP00000385361

PTM databases

iPTMnetiP12018
PhosphoSitePlusiP12018

Polymorphism and mutation databases

BioMutaiVPREB1
DMDMi9911096

Proteomic databases

PaxDbiP12018
PeptideAtlasiP12018
PRIDEiP12018
ProteomicsDBi52817
TopDownProteomicsiP12018

Protocols and materials databases

DNASUi7441
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000403807; ENSP00000385361; ENSG00000169575
GeneIDi7441
KEGGihsa:7441
UCSCiuc002zvx.2 human

Organism-specific databases

CTDi7441
DisGeNETi7441
EuPathDBiHostDB:ENSG00000169575.4
GeneCardsiVPREB1
HGNCiHGNC:12709 VPREB1
HPAiHPA055886
MIMi605141 gene
neXtProtiNX_P12018
OpenTargetsiENSG00000169575
PharmGKBiPA37324
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYZ1 Eukaryota
ENOG411181I LUCA
GeneTreeiENSGT00900000140867
HOGENOMiHOG000059537
HOVERGENiHBG018013
InParanoidiP12018
KOiK06553
OMAiVYSIYWY
OrthoDBiEOG091G0XV9
PhylomeDBiP12018
TreeFamiTF352061

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

EvolutionaryTraceiP12018
GeneWikiiVPREB1
GenomeRNAii7441
PROiPR:P12018
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169575 Expressed in 8 organ(s), highest expression level in bone marrow
CleanExiHS_VPREB1
ExpressionAtlasiP12018 baseline and differential
GenevisibleiP12018 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVPREB_HUMAN
AccessioniPrimary (citable) accession number: P12018
Secondary accession number(s): B5MCG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: December 1, 2000
Last modified: September 12, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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