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UniProtKB - P11989 (BGLG_ECOLI)
Protein
Cryptic beta-glucoside bgl operon antiterminator
Gene
bglG
Organism
Escherichia coli (strain K12)
Status
Functioni
Mediates the positive regulation of the beta-glucoside (bgl) operon by functioning as a transcriptional antiterminator. This is an RNA-binding protein that recognizes a specific sequence located just upstream of two termination sites within the operon.
GO - Molecular functioni
- RNA binding Source: EcoCyc
GO - Biological processi
- positive regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | Activator, RNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10116-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cryptic beta-glucoside bgl operon antiterminator |
Gene namesi | Name:bglG Synonyms:bglC Ordered Locus Names:b3723, JW3701 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204244 | 1 – 278 | Cryptic beta-glucoside bgl operon antiterminatorAdd BLAST | 278 |
Post-translational modificationi
Phosphorylated and inactivated by BglF (eII-bgl). The degree of phosphorylation is dependent on the presence or absence of beta-glucosides which act as inducers of the operon expression. Addition of inducer result in the rapid dephosphorylation of BglG.
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P11989 |
PRIDEi | P11989 |
Interactioni
Binary interactionsi
P11989
With | #Exp. | IntAct |
---|---|---|
dnaX [P06710] | 3 | EBI-545674,EBI-549140 |
ptsH [P0AA04] | 5 | EBI-545674,EBI-902853 |
ptsI [P08839] | 3 | EBI-545674,EBI-551533 |
yahB [P77700] | 4 | EBI-545674,EBI-545731 |
Protein-protein interaction databases
BioGRIDi | 4262138, 6 interactors 852537, 7 interactors |
DIPi | DIP-9216N |
IntActi | P11989, 14 interactors |
MINTi | P11989 |
STRINGi | 511145.b3723 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 67 – 171 | PRD 1PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 172 – 278 | PRD 2PROSITE-ProRule annotationAdd BLAST | 107 |
Sequence similaritiesi
Belongs to the transcriptional antiterminator BglG family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | COG3711, Bacteria |
HOGENOMi | CLU_078802_0_0_6 |
InParanoidi | P11989 |
OMAi | VMQEILN |
PhylomeDBi | P11989 |
Family and domain databases
Gene3Di | 2.30.24.10, 1 hit |
InterProi | View protein in InterPro IPR004341, CAT_RNA-bd_dom IPR036650, CAT_RNA-bd_dom_sf IPR011608, PRD IPR036634, PRD_sf IPR001550, Transcrpt_antitermin_CS |
Pfami | View protein in Pfam PF03123, CAT_RBD, 1 hit PF00874, PRD, 2 hits |
SMARTi | View protein in SMART SM01061, CAT_RBD, 1 hit |
SUPFAMi | SSF50151, SSF50151, 1 hit SSF63520, SSF63520, 2 hits |
PROSITEi | View protein in PROSITE PS00654, PRD_1, 1 hit PS51372, PRD_2, 2 hits |
i Sequence
Sequence statusi: Complete.
P11989-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNMQITKILN NNVVVVIDDQ QREKVVMGRG IGFQKRAGER INSSGIEKEY
60 70 80 90 100
ALSSHELNGR LSELLSHIPL EVMATCDRII SLAQERLGKL QDSIYISLTD
110 120 130 140 150
HCQFAIKRFQ QNVLLPNPLL WDIQRLYPKE FQLGEEALTI IDKRLGVQLP
160 170 180 190 200
KDEVGFIAMH LVSAQMSGNM EDVAGVTQLM REMLQLIKFQ FSLNYQEESL
210 220 230 240 250
SYQRLVTHLK FLSWRILEHA SINDSDESLQ QAVKQNYPQA WQCAERIAIF
260 270
IGLQYQRKIS PAEIMFLAIN IERVRKEH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16487 Genomic DNA Translation: AAA23509.1 L10328 Genomic DNA Translation: AAA62074.1 U00096 Genomic DNA Translation: AAC76746.1 AP009048 Genomic DNA Translation: BAE77565.1 M17098 Genomic DNA Translation: AAA23512.1 M15746 Genomic DNA Translation: AAA83836.1 Sequence problems. |
PIRi | B25977 |
RefSeqi | NP_418179.1, NC_000913.3 WP_001295251.1, NZ_SSZK01000036.1 |
Genome annotation databases
EnsemblBacteriai | AAC76746; AAC76746; b3723 BAE77565; BAE77565; BAE77565 |
GeneIDi | 948235 |
KEGGi | ecj:JW3701 eco:b3723 |
PATRICi | fig|1411691.4.peg.2978 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16487 Genomic DNA Translation: AAA23509.1 L10328 Genomic DNA Translation: AAA62074.1 U00096 Genomic DNA Translation: AAC76746.1 AP009048 Genomic DNA Translation: BAE77565.1 M17098 Genomic DNA Translation: AAA23512.1 M15746 Genomic DNA Translation: AAA83836.1 Sequence problems. |
PIRi | B25977 |
RefSeqi | NP_418179.1, NC_000913.3 WP_001295251.1, NZ_SSZK01000036.1 |
3D structure databases
AlphaFoldDBi | P11989 |
SMRi | P11989 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262138, 6 interactors 852537, 7 interactors |
DIPi | DIP-9216N |
IntActi | P11989, 14 interactors |
MINTi | P11989 |
STRINGi | 511145.b3723 |
Proteomic databases
PaxDbi | P11989 |
PRIDEi | P11989 |
Genome annotation databases
EnsemblBacteriai | AAC76746; AAC76746; b3723 BAE77565; BAE77565; BAE77565 |
GeneIDi | 948235 |
KEGGi | ecj:JW3701 eco:b3723 |
PATRICi | fig|1411691.4.peg.2978 |
Organism-specific databases
EchoBASEi | EB0114 |
Phylogenomic databases
eggNOGi | COG3711, Bacteria |
HOGENOMi | CLU_078802_0_0_6 |
InParanoidi | P11989 |
OMAi | VMQEILN |
PhylomeDBi | P11989 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10116-MONOMER |
Miscellaneous databases
PHI-basei | PHI:4630 |
PROi | PR:P11989 |
Family and domain databases
Gene3Di | 2.30.24.10, 1 hit |
InterProi | View protein in InterPro IPR004341, CAT_RNA-bd_dom IPR036650, CAT_RNA-bd_dom_sf IPR011608, PRD IPR036634, PRD_sf IPR001550, Transcrpt_antitermin_CS |
Pfami | View protein in Pfam PF03123, CAT_RBD, 1 hit PF00874, PRD, 2 hits |
SMARTi | View protein in SMART SM01061, CAT_RBD, 1 hit |
SUPFAMi | SSF50151, SSF50151, 1 hit SSF63520, SSF63520, 2 hits |
PROSITEi | View protein in PROSITE PS00654, PRD_1, 1 hit PS51372, PRD_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | BGLG_ECOLI | |
Accessioni | P11989Primary (citable) accession number: P11989 Secondary accession number(s): Q2M841, Q47078 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | May 25, 2022 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families