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Protein

T-complex protein 1 subunit alpha

Gene

Tcp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-complex protein 1 subunit alpha
Short name:
TCP-1-alpha
Alternative name(s):
CCT-alpha
Tailless complex polypeptide 1A
Short name:
TCP-1-A
Tailless complex polypeptide 1B
Short name:
TCP-1-B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tcp1
Synonyms:Cct1, Ccta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:98535 Tcp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001283051 – 556T-complex protein 1 subunit alphaAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1
Modified residuei6PhosphoserineBy similarity1
Modified residuei181PhosphotyrosineBy similarity1
Modified residuei199N6-acetyllysineBy similarity1
Modified residuei400N6-acetyllysineCombined sources1
Modified residuei494N6-acetyllysineCombined sources1
Modified residuei544PhosphoserineCombined sources1
Modified residuei551PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P11983

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P11983

MaxQB - The MaxQuant DataBase

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MaxQBi
P11983

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P11983

PeptideAtlas

More...
PeptideAtlasi
P11983

PRoteomics IDEntifications database

More...
PRIDEi
P11983

2D gel databases

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00459493
P11983

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P11983

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P11983

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P11983

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000068039 Expressed in 51 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

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CleanExi
MM_TCP1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P11983 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P11983 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Interacts with GBA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
204044, 16 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P11983

Database of interacting proteins

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DIPi
DIP-32342N

Protein interaction database and analysis system

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IntActi
P11983, 12 interactors

Molecular INTeraction database

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MINTi
P11983

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000116108

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P11983

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P11983

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0360 Eukaryota
COG0459 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00550000074878

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001052

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P11983

KEGG Orthology (KO)

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KOi
K09493

Identification of Orthologs from Complete Genome Data

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OMAi
KNYKNYG

Database of Orthologous Groups

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OrthoDBi
905324at2759

TreeFam database of animal gene trees

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TreeFami
TF106331

Family and domain databases

Conserved Domains Database

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CDDi
cd03335 TCP1_alpha, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012715 Chap_CCT_alpha
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00118 Cpn60_TCP1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00304 TCOMPLEXTCP1

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR02340 chap_CCT_alpha, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11983-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGPLSVFGD RSTGEAVRSQ NVMAAASIAN IVKSSFGPVG LDKMLVDDIG
60 70 80 90 100
DVTITNDGAT ILKLLEVEHP AAKVLCELAD LQDKEVGDGT TSVVIIAAEL
110 120 130 140 150
LKNADELVKQ KIHPTSVISG YRLACKEAVR YINENLIINT DELGRDCLIN
160 170 180 190 200
AAKTSMSSKI IGINGDYFAN MVVDAVLAVK YTDARGQPRY PVNSVNILKA
210 220 230 240 250
HGRSQIESML INGYALNCVV GSQGMPKRIV NAKIACLDFS LQKTKMKLGV
260 270 280 290 300
QVVITDPEKL DQIRQRESDI TKERIQKILA TGANVILTTG GIDDMYLKYF
310 320 330 340 350
VEAGAMAVRR VLKRDLKHVA KASGASILST LANLEGEETF EVTMLGQAEE
360 370 380 390 400
VVQERICDDE LILIKNTKAR TSASIILRGA NDFMCDEMER SLHDALCVVK
410 420 430 440 450
RVLELKSVVP GGGAVEAALS IYLENYATSM GSREQLAIAE FARSLLVIPN
460 470 480 490 500
TLAVNAAQDS TDLVAKLRAF HNEAQVNPER KNLKWIGLDL VHGKPRDNKQ
510 520 530 540 550
AGVFEPTIVK VKSLKFATEA AITILRIDDL IKLHPESKDD KHGSYENAVH

SGALDD
Length:556
Mass (Da):60,449
Last modified:October 1, 1996 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48F2387BE0F909A4
GO
Isoform 2 (identifier: P11983-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.
     50-50: G → M

Note: No experimental confirmation available.
Show »
Length:507
Mass (Da):55,459
Checksum:i1E169BE37404520B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z483F2Z483_MOUSE
T-complex protein 1 subunit alpha
Tcp1
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WDE2A0A3B2WDE2_MOUSE
T-complex protein 1 subunit alpha
Tcp1
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA40337 differs from that shown. Reason: Frameshift at position 528.Curated
The sequence AAA40338 differs from that shown. Reason: Frameshift at position 528.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17V → I in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti17V → I in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti17V → I in BAE30084 (PubMed:16141072).Curated1
Sequence conflicti36F → L in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti36F → L in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti140T → A in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti140T → A in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti149 – 151INA → TNT in AAA40337 (PubMed:3753900).Curated3
Sequence conflicti149 – 151INA → TNT in BAA14356 (PubMed:1937024).Curated3
Sequence conflicti151A → T in AAA40338 (PubMed:3753900).Curated1
Sequence conflicti177L → H in BAE31381 (PubMed:16141072).Curated1
Sequence conflicti192V → I in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti192V → I in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti217N → D in BAE39599 (PubMed:16141072).Curated1
Sequence conflicti259K → E in BAE31381 (PubMed:16141072).Curated1
Sequence conflicti296Y → C in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti296Y → C in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti318H → C in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti318H → C in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti326S → T in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti326S → T in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti378R → Q in BAE30084 (PubMed:16141072).Curated1
Sequence conflicti402V → I in BAE30407 (PubMed:16141072).Curated1
Sequence conflicti402V → I in BAE31988 (PubMed:16141072).Curated1
Sequence conflicti405L → S in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti405L → S in BAA14356 (PubMed:1937024).Curated1
Sequence conflicti429S → N in AAA40338 (PubMed:3753900).Curated1
Sequence conflicti439A → V in BAE31381 (PubMed:16141072).Curated1
Sequence conflicti454V → M in BAE39052 (PubMed:16141072).Curated1
Sequence conflicti494K → N in BAE30407 (PubMed:16141072).Curated1
Sequence conflicti537S → C in AAA40337 (PubMed:3753900).Curated1
Sequence conflicti537S → C in BAA14356 (PubMed:1937024).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0247341 – 49Missing in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_02473550G → M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M20130 mRNA Translation: AAA40337.1 Frameshift.
M12899 mRNA Translation: AAA40338.1 Frameshift.
D90344 mRNA Translation: BAA14356.1
D10606 Genomic DNA Translation: BAA01461.1
S46763 Genomic DNA Translation: AAB23855.1
AK149611 mRNA Translation: BAE28989.1
AK149755 mRNA Translation: BAE29063.1
AK151068 mRNA Translation: BAE30084.1
AK151445 mRNA Translation: BAE30407.1
AK152641 mRNA Translation: BAE31381.1
AK153430 mRNA Translation: BAE31988.1
AK165665 mRNA Translation: BAE38327.1
AK166828 mRNA Translation: BAE39052.1
AK166966 mRNA Translation: BAE39149.1
AK167529 mRNA Translation: BAE39599.1
BC003809 mRNA Translation: AAH03809.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28397.1 [P11983-1]
CCDS70760.1 [P11983-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
B24059
JC1443

NCBI Reference Sequences

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RefSeqi
NP_001277641.1, NM_001290712.1 [P11983-2]
NP_038714.2, NM_013686.4 [P11983-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.229342

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000089024; ENSMUSP00000086418; ENSMUSG00000068039 [P11983-2]
ENSMUST00000151287; ENSMUSP00000116108; ENSMUSG00000068039 [P11983-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
21454

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:21454

UCSC genome browser

More...
UCSCi
uc008all.2 mouse [P11983-1]
uc008alm.2 mouse [P11983-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20130 mRNA Translation: AAA40337.1 Frameshift.
M12899 mRNA Translation: AAA40338.1 Frameshift.
D90344 mRNA Translation: BAA14356.1
D10606 Genomic DNA Translation: BAA01461.1
S46763 Genomic DNA Translation: AAB23855.1
AK149611 mRNA Translation: BAE28989.1
AK149755 mRNA Translation: BAE29063.1
AK151068 mRNA Translation: BAE30084.1
AK151445 mRNA Translation: BAE30407.1
AK152641 mRNA Translation: BAE31381.1
AK153430 mRNA Translation: BAE31988.1
AK165665 mRNA Translation: BAE38327.1
AK166828 mRNA Translation: BAE39052.1
AK166966 mRNA Translation: BAE39149.1
AK167529 mRNA Translation: BAE39599.1
BC003809 mRNA Translation: AAH03809.1
CCDSiCCDS28397.1 [P11983-1]
CCDS70760.1 [P11983-2]
PIRiB24059
JC1443
RefSeqiNP_001277641.1, NM_001290712.1 [P11983-2]
NP_038714.2, NM_013686.4 [P11983-1]
UniGeneiMm.229342

3D structure databases

ProteinModelPortaliP11983
SMRiP11983
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204044, 16 interactors
CORUMiP11983
DIPiDIP-32342N
IntActiP11983, 12 interactors
MINTiP11983
STRINGi10090.ENSMUSP00000116108

PTM databases

iPTMnetiP11983
PhosphoSitePlusiP11983
SwissPalmiP11983

2D gel databases

REPRODUCTION-2DPAGEiIPI00459493
P11983

Proteomic databases

EPDiP11983
jPOSTiP11983
MaxQBiP11983
PaxDbiP11983
PeptideAtlasiP11983
PRIDEiP11983

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089024; ENSMUSP00000086418; ENSMUSG00000068039 [P11983-2]
ENSMUST00000151287; ENSMUSP00000116108; ENSMUSG00000068039 [P11983-1]
GeneIDi21454
KEGGimmu:21454
UCSCiuc008all.2 mouse [P11983-1]
uc008alm.2 mouse [P11983-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6950
MGIiMGI:98535 Tcp1

Phylogenomic databases

eggNOGiKOG0360 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074878
HOVERGENiHBG001052
InParanoidiP11983
KOiK09493
OMAiKNYKNYG
OrthoDBi905324at2759
TreeFamiTF106331

Enzyme and pathway databases

ReactomeiR-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tcp1 mouse

Protein Ontology

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PROi
PR:P11983

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000068039 Expressed in 51 organ(s), highest expression level in testis
CleanExiMM_TCP1
ExpressionAtlasiP11983 baseline and differential
GenevisibleiP11983 MM

Family and domain databases

CDDicd03335 TCP1_alpha, 1 hit
Gene3Di1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012715 Chap_CCT_alpha
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02340 chap_CCT_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCPA_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11983
Secondary accession number(s): P11984
, Q3TJ96, Q3TKU1, Q3U5T8, Q3U7I8, Q3UAA8, Q3UB80, Q3UE48
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1996
Last modified: January 16, 2019
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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