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Protein

Tyrosine 3-monooxygenase

Gene

TH

Organism
Phasianidae sp. (Quail)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the physiology of adrenergic neurons.

Catalytic activityi

L-tyrosine + tetrahydrobiopterin + O2 = L-dopa + 4a-hydroxytetrahydrobiopterin.

Cofactori

Enzyme regulationi

Phosphorylation leads to an increase in the catalytic activity.

Pathwayi: dopamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dopamine from L-tyrosine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tyrosine 3-monooxygenase (TH)
  2. no protein annotated in this organism
This subpathway is part of the pathway dopamine biosynthesis, which is itself part of Catecholamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dopamine from L-tyrosine, the pathway dopamine biosynthesis and in Catecholamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi324IronBy similarity1
Metal bindingi329IronBy similarity1
Metal bindingi369IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processCatecholamine biosynthesis, Neurotransmitter biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00747; UER00733

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine 3-monooxygenase (EC:1.14.16.2)
Alternative name(s):
Tyrosine 3-hydroxylase
Short name:
TH
Gene namesi
Name:TH
OrganismiPhasianidae sp. (Quail)
Taxonomic identifieri9006 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidae

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002055631 – 491Tyrosine 3-monooxygenaseAdd BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei40Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP11982

Structurei

3D structure databases

ProteinModelPortaliP11982
SMRiP11982
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 55Poly-Ala5

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG006841

Family and domain databases

Gene3Di1.10.800.10, 1 hit
InterProiView protein in InterPro
IPR001273 ArAA_hydroxylase
IPR018301 ArAA_hydroxylase_Fe/CU_BS
IPR036951 ArAA_hydroxylase_sf
IPR036329 Aro-AA_hydroxylase_C_sf
IPR019774 Aromatic-AA_hydroxylase_C
IPR005962 Tyr_3_mOase
IPR019773 Tyrosine_3-monooxygenase-like
IPR021164 Tyrosine_hydroxylase_CS
PANTHERiPTHR11473 PTHR11473, 1 hit
PfamiView protein in Pfam
PF00351 Biopterin_H, 1 hit
PF12549 TOH_N, 2 hits
PIRSFiPIRSF000336 TH, 1 hit
PRINTSiPR00372 FYWHYDRXLASE
SUPFAMiSSF56534 SSF56534, 1 hit
TIGRFAMsiTIGR01269 Tyr_3_monoox, 1 hit
PROSITEiView protein in PROSITE
PS00367 BH4_AAA_HYDROXYL_1, 1 hit
PS51410 BH4_AAA_HYDROXYL_2, 1 hit

Sequencei

Sequence statusi: Complete.

P11982-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTPNISTSA AKGFRRAVSE LDSKQAEAIM SPRFIGRRQS LIEDARKERE
60 70 80 90 100
AAAAATDAAE STETIVFEEK DGRAMLNLFF MLKGVKTSPL SRALKVFETF
110 120 130 140 150
EAKIHHLETR LSRKPREGTA ELEYFVRCEV HSSDLNTFIS SIKRVAEDVR
160 170 180 190 200
TTKEDKFHWF PRKICELDKC HHLVTKFDPD LDLDHPGYSD QVYRQRRKSI
210 220 230 240 250
AEIAFHYKHG DPIPRVEYTA EETATWKEVY STLKSLYPTH ACKEYLEAFN
260 270 280 290 300
LLEKFCGYNE NNIPQLEEVS RFLKERTGFQ LRPVRGLLSA RDFLASLAFR
310 320 330 340 350
VFQCTQYIRH ASSPMHSPEP DCCHELLGHV PMLADKTFAQ FSQDIGLASL
360 370 380 390 400
GATDEEIEKL ATLYWFTVEF GLCRQNGIVK AYGAGLLSSY GELIHSLSDE
410 420 430 440 450
PEVRDFDPDA AAVQPCQDQP YQPVYFVSES FSDAKNKLRN YAAHIKRPFS
460 470 480 490
VKYEPYTHSI ELLDSPQTIC HSLESVRDEL HTLINALNVI S
Length:491
Mass (Da):56,066
Last modified:October 1, 1989 - v1
Checksum:iAFB363220F70C0A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24778 Genomic DNA Translation: AAA49514.1
S50878 Genomic DNA No translation available.
PIRiA28582

Similar proteinsi

Entry informationi

Entry nameiTY3H_PHASP
AccessioniPrimary (citable) accession number: P11982
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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