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Protein

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Gene

PDHB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle.By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei89Thiamine pyrophosphateBy similarity1
Sitei319Important for interaction with DLATBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism, Tricarboxylic acid cycle
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

ReactomeiR-BTA-204174 Regulation of pyruvate dehydrogenase (PDH) complex
R-BTA-389661 Glyoxylate metabolism and glycine degradation
R-BTA-5362517 Signaling by Retinoic Acid
R-BTA-70268 Pyruvate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (EC:1.2.4.1)
Short name:
PDHE1-B
Gene namesi
Name:PDHB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Organism-specific databases

VGNCiVGNC:49151 PDHB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30Mitochondrion1 PublicationAdd BLAST30
ChainiPRO_000016221631 – 359Pyruvate dehydrogenase E1 component subunit beta, mitochondrialAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67PhosphotyrosineBy similarity1
Modified residuei354N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP11966
PeptideAtlasiP11966
PRIDEiP11966

Expressioni

Gene expression databases

BgeeiENSBTAG00000021724 Expressed in 10 organ(s), highest expression level in heart

Interactioni

Subunit structurei

Heterotetramer of two PDHA1 and two PDHB subunits. The heterotetramer interacts with DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules. Interacts with DLAT.By similarity

Protein-protein interaction databases

CORUMiP11966
STRINGi9913.ENSBTAP00000028958

Structurei

3D structure databases

ProteinModelPortaliP11966
SMRiP11966
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0524 Eukaryota
COG0022 LUCA
GeneTreeiENSGT00530000063423
HOGENOMiHOG000281450
HOVERGENiHBG000917
InParanoidiP11966
KOiK00162
OMAiSRMRHHC
OrthoDBiEOG091G0D37
TreeFamiTF105674

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR033248 Transketolase_C
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
SSF52922 SSF52922, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11966-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVVAVLVRK PLEQVSGLLR RRFHRTAPAA LQVTVREAIN QGMDEELERD
60 70 80 90 100
EKVFLLGEEV AQYDGAYKVS RGLWKKYGDK RIIDTPISEM GFAGIAVGAA
110 120 130 140 150
MAGLRPICEF MTFNFSMQAI DQVINSAAKT YYMSGGLQSV PIVFRGPNGA
160 170 180 190 200
SAGVAAQHSQ CFAAWYGHCP GLKVVSPWSS EDAKGLIKSA IRDNNPVVVL
210 220 230 240 250
ENELMYGVPF ELPSEAQSKD FLIPIGKAKI ERQGTHVTIV AHSRPVGHCL
260 270 280 290 300
EAATVLSKEG IECEVINLRT IRPMDIETIE GSVMKTNHLV TVEGGWPQFG
310 320 330 340 350
VGAEICARIM EGPAFNFLDA PAVRVTGADV PMPYAKILED NSVPQVKDII

FAIKKTLNI
Length:359
Mass (Da):39,126
Last modified:October 17, 2006 - v2
Checksum:i584B86D36A233EFC
GO

Sequence cautioni

The sequence AAX46758 differs from that shown. Reason: Frameshift at position 201.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021911 mRNA Translation: AAX46758.1 Frameshift.
BC150020 mRNA Translation: AAI50021.1
PIRiB27712
RefSeqiNP_001030512.2, NM_001035435.3
UniGeneiBt.49794

Genome annotation databases

EnsembliENSBTAT00000028958; ENSBTAP00000028958; ENSBTAG00000021724
GeneIDi613610
KEGGibta:613610

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021911 mRNA Translation: AAX46758.1 Frameshift.
BC150020 mRNA Translation: AAI50021.1
PIRiB27712
RefSeqiNP_001030512.2, NM_001035435.3
UniGeneiBt.49794

3D structure databases

ProteinModelPortaliP11966
SMRiP11966
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP11966
STRINGi9913.ENSBTAP00000028958

Proteomic databases

PaxDbiP11966
PeptideAtlasiP11966
PRIDEiP11966

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028958; ENSBTAP00000028958; ENSBTAG00000021724
GeneIDi613610
KEGGibta:613610

Organism-specific databases

CTDi5162
VGNCiVGNC:49151 PDHB

Phylogenomic databases

eggNOGiKOG0524 Eukaryota
COG0022 LUCA
GeneTreeiENSGT00530000063423
HOGENOMiHOG000281450
HOVERGENiHBG000917
InParanoidiP11966
KOiK00162
OMAiSRMRHHC
OrthoDBiEOG091G0D37
TreeFamiTF105674

Enzyme and pathway databases

ReactomeiR-BTA-204174 Regulation of pyruvate dehydrogenase (PDH) complex
R-BTA-389661 Glyoxylate metabolism and glycine degradation
R-BTA-5362517 Signaling by Retinoic Acid
R-BTA-70268 Pyruvate metabolism

Gene expression databases

BgeeiENSBTAG00000021724 Expressed in 10 organ(s), highest expression level in heart

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR033248 Transketolase_C
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
SSF52922 SSF52922, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiODPB_BOVIN
AccessioniPrimary (citable) accession number: P11966
Secondary accession number(s): A6QQW6, Q58CN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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