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Protein

Glycoprotein hormones alpha chain

Gene

Cga

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-193048 Androgen biosynthesis
R-RNO-193993 Mineralocorticoid biosynthesis
R-RNO-209822 Glycoprotein hormones
R-RNO-209968 Thyroxine biosynthesis
R-RNO-375281 Hormone ligand-binding receptors
R-RNO-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-RNO-975578 Reactions specific to the complex N-glycan synthesis pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chain
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Follicle-stimulating hormone alpha chain
Short name:
FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name:
LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name:
TSH-alpha
Thyrotropin alpha chain
Gene namesi
Name:Cga
Synonyms:Cga1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620436 Cga

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001165025 – 120Glycoprotein hormones alpha chainAdd BLAST96

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 59By similarity
Disulfide bondi38 ↔ 88By similarity
Disulfide bondi56 ↔ 110By similarity
Disulfide bondi60 ↔ 112By similarity
Glycosylationi80N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi87 ↔ 115By similarity
Glycosylationi106N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP11962
PRIDEiP11962

Expressioni

Gene expression databases

BgeeiENSRNOG00000009269 Expressed in 3 organ(s), highest expression level in testis
ExpressionAtlasiP11962 baseline and differential
GenevisibleiP11962 RN

Interactioni

Subunit structurei

Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP11962, 1 interactor
STRINGi10116.ENSRNOP00000012385

Structurei

3D structure databases

ProteinModelPortaliP11962
SMRiP11962
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWI0 Eukaryota
ENOG4111Q75 LUCA
GeneTreeiENSGT00390000012242
HOGENOMiHOG000232008
HOVERGENiHBG000452
InParanoidiP11962
OMAiFTKATVM
OrthoDBiEOG091G0TRG
PhylomeDBiP11962
TreeFamiTF332733

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000476 Glyco_hormone
PANTHERiPTHR11509 PTHR11509, 1 hit
PfamiView protein in Pfam
PF00236 Hormone_6, 1 hit
PRINTSiPR00274 GLYCOHORMONE
SMARTiView protein in SMART
SM00067 GHA, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit
PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11962-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDCYRRYAAV ILVMLSMVLH ILHSLPDGDL IIQGCPECKL KENKYFSKLG
60 70 80 90 100
APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KSFTKATVMG
110 120
NARVENHTDC HCSTCYYHKS
Length:120
Mass (Da):13,453
Last modified:October 1, 1989 - v1
Checksum:iBE0E7F3C44C69ECB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84E → Q in AAA97425 (PubMed:6177696).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00757 mRNA Translation: AAA97425.1
M25543, M22829 Genomic DNA Translation: AAB04669.1
M25544 Genomic DNA Translation: AAB04668.1
D00575 mRNA Translation: BAA00453.1
PIRiJT0408 TTRTA
RefSeqiXP_017448612.1, XM_017593123.1
UniGeneiRn.10589

Genome annotation databases

EnsembliENSRNOT00000012385; ENSRNOP00000012385; ENSRNOG00000009269
GeneIDi116700
UCSCiRGD:620436 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00757 mRNA Translation: AAA97425.1
M25543, M22829 Genomic DNA Translation: AAB04669.1
M25544 Genomic DNA Translation: AAB04668.1
D00575 mRNA Translation: BAA00453.1
PIRiJT0408 TTRTA
RefSeqiXP_017448612.1, XM_017593123.1
UniGeneiRn.10589

3D structure databases

ProteinModelPortaliP11962
SMRiP11962
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP11962, 1 interactor
STRINGi10116.ENSRNOP00000012385

Proteomic databases

PaxDbiP11962
PRIDEiP11962

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012385; ENSRNOP00000012385; ENSRNOG00000009269
GeneIDi116700
UCSCiRGD:620436 rat

Organism-specific databases

CTDi1081
RGDi620436 Cga

Phylogenomic databases

eggNOGiENOG410IWI0 Eukaryota
ENOG4111Q75 LUCA
GeneTreeiENSGT00390000012242
HOGENOMiHOG000232008
HOVERGENiHBG000452
InParanoidiP11962
OMAiFTKATVM
OrthoDBiEOG091G0TRG
PhylomeDBiP11962
TreeFamiTF332733

Enzyme and pathway databases

ReactomeiR-RNO-193048 Androgen biosynthesis
R-RNO-193993 Mineralocorticoid biosynthesis
R-RNO-209822 Glycoprotein hormones
R-RNO-209968 Thyroxine biosynthesis
R-RNO-375281 Hormone ligand-binding receptors
R-RNO-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-RNO-975578 Reactions specific to the complex N-glycan synthesis pathway

Miscellaneous databases

PROiPR:P11962

Gene expression databases

BgeeiENSRNOG00000009269 Expressed in 3 organ(s), highest expression level in testis
ExpressionAtlasiP11962 baseline and differential
GenevisibleiP11962 RN

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000476 Glyco_hormone
PANTHERiPTHR11509 PTHR11509, 1 hit
PfamiView protein in Pfam
PF00236 Hormone_6, 1 hit
PRINTSiPR00274 GLYCOHORMONE
SMARTiView protein in SMART
SM00067 GHA, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit
PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLHA_RAT
AccessioniPrimary (citable) accession number: P11962
Secondary accession number(s): P70516
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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