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Protein

Metallothionein-2

Gene

MtnB

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis.

GO - Molecular functioni

  • copper ion binding Source: FlyBase
  • metal ion binding Source: FlyBase

GO - Biological processi

  • metal ion homeostasis Source: FlyBase
  • response to metal ion Source: FlyBase

Keywordsi

LigandCadmium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2
Short name:
MT-2
Alternative name(s):
Metallothionein B
Gene namesi
Name:MtnB
Synonyms:Mto
ORF Names:CG4312
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0002869 MtnB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973551 – 43Metallothionein-2Add BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Blocked amino end (Met)1

Proteomic databases

PaxDbiP11956
PRIDEiP11956

Expressioni

Developmental stagei

Expressed predominantly in embryonic and larval stages.

Inductioni

Strongly induced by cadmium, copper and mercury.

Gene expression databases

BgeeiFBgn0002869 Expressed in 22 organ(s), highest expression level in midgut
ExpressionAtlasiP11956 differential
GenevisibleiP11956 DM

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi67404, 6 interactors
DIPiDIP-20926N
IntActiP11956, 3 interactors
STRINGi7227.FBpp0083298

Structurei

3D structure databases

SMRiP11956
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4738 Eukaryota
ENOG410Z9YK LUCA
InParanoidiP11956
OrthoDBiEOG091G1AD9
PhylomeDBiP11956

Family and domain databases

InterProiView protein in InterPro
IPR000966 Metalthion_5
PfamiView protein in Pfam
PF02067 Metallothio_5, 1 hit
PRINTSiPR00872 MTDIPTERA

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P11956-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
MVCKGCGTNC QCSAQKCGDN CACNKDCQCV CKNGPKDQCC SNK
Length:43
Mass (Da):4,525
Last modified:October 1, 1989 - v1
Checksum:i5EE0CF9171BD9A97
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LHD1A0A0B4LHD1_DROME
Metallothionein B, isoform B
MtnB Dmel\CG4312, DrosMto, MTN, MtnA, mtnB
43Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16250 mRNA Translation: AAA28683.1
X52098 Genomic DNA Translation: CAA36318.1
AE014297 Genomic DNA Translation: AAF55768.1
BT025813 mRNA Translation: ABF85713.1
PIRiS14706 SMFF2
RefSeqiNP_001287425.1, NM_001300496.1
NP_001287426.1, NM_001300497.1
NP_524413.1, NM_079689.3
UniGeneiDm.2394

Genome annotation databases

EnsemblMetazoaiFBtr0083890; FBpp0083298; FBgn0002869
FBtr0346152; FBpp0311980; FBgn0002869
FBtr0346153; FBpp0311981; FBgn0002869
GeneIDi42424
KEGGidme:Dmel_CG4312

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16250 mRNA Translation: AAA28683.1
X52098 Genomic DNA Translation: CAA36318.1
AE014297 Genomic DNA Translation: AAF55768.1
BT025813 mRNA Translation: ABF85713.1
PIRiS14706 SMFF2
RefSeqiNP_001287425.1, NM_001300496.1
NP_001287426.1, NM_001300497.1
NP_524413.1, NM_079689.3
UniGeneiDm.2394

3D structure databases

SMRiP11956
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi67404, 6 interactors
DIPiDIP-20926N
IntActiP11956, 3 interactors
STRINGi7227.FBpp0083298

Proteomic databases

PaxDbiP11956
PRIDEiP11956

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083890; FBpp0083298; FBgn0002869
FBtr0346152; FBpp0311980; FBgn0002869
FBtr0346153; FBpp0311981; FBgn0002869
GeneIDi42424
KEGGidme:Dmel_CG4312

Organism-specific databases

CTDi42424
FlyBaseiFBgn0002869 MtnB

Phylogenomic databases

eggNOGiKOG4738 Eukaryota
ENOG410Z9YK LUCA
InParanoidiP11956
OrthoDBiEOG091G1AD9
PhylomeDBiP11956

Miscellaneous databases

GenomeRNAii42424
PROiPR:P11956

Gene expression databases

BgeeiFBgn0002869 Expressed in 22 organ(s), highest expression level in midgut
ExpressionAtlasiP11956 differential
GenevisibleiP11956 DM

Family and domain databases

InterProiView protein in InterPro
IPR000966 Metalthion_5
PfamiView protein in Pfam
PF02067 Metallothio_5, 1 hit
PRINTSiPR00872 MTDIPTERA
ProtoNetiSearch...

Entry informationi

Entry nameiMT2_DROME
AccessioniPrimary (citable) accession number: P11956
Secondary accession number(s): Q1ECC1, Q9VDM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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