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Protein

Polyadenylate-binding protein 1

Gene

PABPC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). Positively regulates the replication of dengue virus (DENV) (PubMed:26735137).6 Publications

Miscellaneous

Many viruses shutoff host mRNA translational machinery by inhibiting cellular PABPC1 activity using different mechanisms. Picornaviruses, caliciviruses or lentiviruses encode proteases that cleave PABPC1 at several defined sites in the proline-rich linker region between RRMs and the C-terminal domain. Rotaviruses, gammherpesviruses and bunyamwera virus relocalize PABPC1 from the cytoplasm to the nucleus thus altering its function. Many of these viruses translate their mRNA in a PABPC1-independent manner and are unaffected by host PABPC1 inhibition.

Caution

Was termed (Ref. 5) polyadenylate binding protein II.Curated

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: UniProtKB
  • poly(A) binding Source: MGI
  • poly(U) RNA binding Source: MGI
  • protein C-terminus binding Source: UniProtKB
  • RNA binding Source: CAFA
  • translation activator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, Nonsense-mediated mRNA decay

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-429947 Deadenylation of mRNA
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-72649 Translation initiation complex formation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP11940

Protein family/group databases

MoonDBiP11940 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein 1
Short name:
PABP-1
Short name:
Poly(A)-binding protein 1
Gene namesi
Name:PABPC1
Synonyms:PAB1, PABP1, PABPC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000070756.13
HGNCiHGNC:8554 PABPC1
MIMi604679 gene
neXtProtiNX_P11940

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi455R → A: Greatly reduces methylation by CARM1 (in vitro); when associated with A-460. 1 Publication1
Mutagenesisi460R → A: Greatly reduces methylation by CARM1 (in vitro); when associated with A-455. 1 Publication1

Organism-specific databases

DisGeNETi26986
OpenTargetsiENSG00000070756
PharmGKBiPA32880

Chemistry databases

ChEMBLiCHEMBL1293286

Polymorphism and mutation databases

BioMutaiPABPC1
DMDMi3183544

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816981 – 636Polyadenylate-binding protein 1Add BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei299N6-methyllysine1 Publication1
Modified residuei315PhosphoserineCombined sources1
Modified residuei319PhosphothreonineCombined sources1
Modified residuei385Omega-N-methylarginineCombined sources1
Modified residuei419Omega-N-methylarginineCombined sources1
Modified residuei432Omega-N-methylarginineCombined sources1
Modified residuei436Omega-N-methylarginineCombined sources1
Modified residuei455Omega-N-methylated arginine; by CARM1; partial1 Publication1
Modified residuei460Omega-N-methylated arginine; by CARM1; partial1 Publication1
Modified residuei475Omega-N-methylarginineBy similarity1
Modified residuei481Omega-N-methylarginineCombined sources1
Modified residuei493Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei493Dimethylated arginine; alternate2 Publications1
Modified residuei493Omega-N-methylarginine; alternateCombined sources2 Publications1
Modified residuei506Omega-N-methylarginineCombined sources1
Modified residuei512N6-acetyllysineCombined sources1
Modified residuei518Omega-N-methylarginineCombined sources1

Post-translational modificationi

Phosphorylated by MAPKAPK2.1 Publication
Methylated by CARM1. Arg-493 is dimethylated, probably to asymmetric dimethylarginine.3 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP11940
MaxQBiP11940
PaxDbiP11940
PeptideAtlasiP11940
PRIDEiP11940
ProteomicsDBi52814
52815 [P11940-2]

PTM databases

iPTMnetiP11940
PhosphoSitePlusiP11940
SwissPalmiP11940

Miscellaneous databases

PMAP-CutDBiP11940

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000070756 Expressed in 230 organ(s), highest expression level in testis
CleanExiHS_PABPC1
ExpressionAtlasiP11940 baseline and differential
GenevisibleiP11940 HS

Organism-specific databases

HPAiCAB011536
HPA045423
HPA067156

Interactioni

Subunit structurei

May interact with SETX (PubMed:21700224). May form homodimers. Component of a multisubunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1 (PubMed:16356927). Directly interacts with IGF2BP1. Part of a complex associated with the FOS mCRD domain and consisting of HNRPD, SYNCRIP, PAIP1 and CSDE1/UNR (PubMed:11051545). Interacts with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1 and PAIP2 (PubMed:9548260, PubMed:11172725, PubMed:11438674, PubMed:11997512, PubMed:11287632, PubMed:20096703). Interacts with PAIP1 with a 1:1 stoichiometry and with PAIP2 with a 1:2 stoichiometry. The interaction with CSDE1 is direct and RNA-independent. Found in a mRNP complex with YBX2 (By similarity). Interacts with TENT2/GLD2 (By similarity). Identified in the spliceosome C complex (PubMed:11991638). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with NFX1 (PubMed:17267499). Interacts with PIWIL1 (By similarity). Interacts with AGO1, AGO2, GSPT1 and GSPT2 (PubMed:17932509, PubMed:18447585, Ref. 51). Interacts with human cytomegalovirus/HHV-5 protein UL69 (PubMed:20133758). Interacts with LARP4B (Ref. 53). Interacts (via the second and third RRM domains and the C-terminus) with PAIP2B (via central acidic portion and C-terminus) (PubMed:16804161, PubMed:11287632). Interacts with LARP1 (PubMed:20430826, PubMed:24532714, PubMed:25940091). Interacts with RYDEN (PubMed:26735137). Found in a complex with RYDEN and LARP1 (PubMed:26735137). Interacts with LARP4 (PubMed:21098120). Interacts with ZFC3H1 in a RNase-sensitive manner (PubMed:27871484). Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361). Interacts with TENT5C; the interaction has no effect on TENT5C poly(A) polymerase function (PubMed:28931820).By similarity28 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117939, 255 interactors
ComplexPortaliCPX-1076 mCRD-poly(A)-bridging complex
CORUMiP11940
DIPiDIP-31613N
ELMiP11940
IntActiP11940, 123 interactors
MINTiP11940
STRINGi9606.ENSP00000313007

Chemistry databases

BindingDBiP11940

Structurei

Secondary structure

1636
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP11940
SMRiP11940
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11940

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 89RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini99 – 175RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini191 – 268RRM 3PROSITE-ProRule annotationAdd BLAST78
Domaini294 – 370RRM 4PROSITE-ProRule annotationAdd BLAST77
Domaini542 – 619PABCPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 289CSDE1-bindingAdd BLAST124

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi495 – 501Poly-Ala7

Domaini

The RNA-binding domains RRM1 and RRM2 and the C-terminus (last 138 amino acids) regions interact with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1, respectively.2 Publications
The RNA-binding domains RRM2 and RRM3 and the C-terminus (last 138 amino acids) regions interact with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP2, respectively.2 Publications

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0123 Eukaryota
ENOG410XR5X LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000217922
HOVERGENiHBG002295
InParanoidiP11940
KOiK13126
OMAiVTEALCV
OrthoDBiEOG091G03ZE
PhylomeDBiP11940
TreeFamiTF300458

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR036053 PABP-dom
IPR006515 PABP_1234
IPR002004 PABP_HYD
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00658 PABP, 1 hit
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00517 PolyA, 1 hit
SM00360 RRM, 4 hits
SM00361 RRM_1, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
SSF63570 SSF63570, 1 hit
TIGRFAMsiTIGR01628 PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS51309 PABC, 1 hit
PS50102 RRM, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11940-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPSAPSYPM ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RVCRDMITRR
60 70 80 90 100
SLGYAYVNFQ QPADAERALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN
110 120 130 140 150
IFIKNLDKSI DNKALYDTFS AFGNILSCKV VCDENGSKGY GFVHFETQEA
160 170 180 190 200
AERAIEKMNG MLLNDRKVFV GRFKSRKERE AELGARAKEF TNVYIKNFGE
210 220 230 240 250
DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER HEDAQKAVDE
260 270 280 290 300
MNGKELNGKQ IYVGRAQKKV ERQTELKRKF EQMKQDRITR YQGVNLYVKN
310 320 330 340 350
LDDGIDDERL RKEFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV
360 370 380 390 400
TEMNGRIVAT KPLYVALAQR KEERQAHLTN QYMQRMASVR AVPNPVINPY
410 420 430 440 450
QPAPPSGYFM AAIPQTQNRA AYYPPSQIAQ LRPSPRWTAQ GARPHPFQNM
460 470 480 490 500
PGAIRPAAPR PPFSTMRPAS SQVPRVMSTQ RVANTSTQTM GPRPAAAAAA
510 520 530 540 550
ATPAVRTVPQ YKYAAGVRNP QQHLNAQPQV TMQQPAVHVQ GQEPLTASML
560 570 580 590 600
ASAPPQEQKQ MLGERLFPLI QAMHPTLAGK ITGMLLEIDN SELLHMLESP
610 620 630
ESLRSKVDEA VAVLQAHQAK EAAQKAVNSA TGVPTV
Length:636
Mass (Da):70,671
Last modified:July 15, 1998 - v2
Checksum:i2EB1B02A346132EE
GO
Isoform 2 (identifier: P11940-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     447-535: Missing.

Note: No experimental confirmation available.
Show »
Length:547
Mass (Da):61,181
Checksum:i8088B4F7DFABAFB8
GO

Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQV3E7EQV3_HUMAN
Polyadenylate-binding protein
PABPC1
591Annotation score:
E7ERJ7E7ERJ7_HUMAN
Polyadenylate-binding protein
PABPC1
604Annotation score:
A0A087WTT1A0A087WTT1_HUMAN
Polyadenylate-binding protein
PABPC1
522Annotation score:
H0YB75H0YB75_HUMAN
Polyadenylate-binding protein 1
PABPC1
183Annotation score:
H0YAW6H0YAW6_HUMAN
Polyadenylate-binding protein 1
PABPC1
187Annotation score:
H0YAR2H0YAR2_HUMAN
Polyadenylate-binding protein 1
PABPC1
284Annotation score:
H0YB86H0YB86_HUMAN
Polyadenylate-binding protein 1
PABPC1
165Annotation score:
H0YAP2H0YAP2_HUMAN
Polyadenylate-binding protein 1
PABPC1
131Annotation score:
E5RJB9E5RJB9_HUMAN
Polyadenylate-binding protein 1
PABPC1
129Annotation score:
E5RHG7E5RHG7_HUMAN
Polyadenylate-binding protein 1
PABPC1
75Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211 – 213Missing in CAA68428 (PubMed:2885805).Curated3
Sequence conflicti410M → I in CAA88401 (Ref. 5) Curated1
Sequence conflicti428I → V in CAA68428 (PubMed:2885805).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009846447 – 535Missing in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00345 mRNA Translation: CAA68428.1
U68104
, U68093, U68094, U68095, U68097, U68098, U68099, U68100, U68101, U68102, U68103 Genomic DNA Translation: AAD08718.1
AP001205 Genomic DNA No translation available.
BC015958 mRNA Translation: AAH15958.1
BC023520 mRNA Translation: AAH23520.1
Z48501 mRNA Translation: CAA88401.1
CCDSiCCDS6289.1 [P11940-1]
PIRiA93668 DNHUPA
S52491
RefSeqiNP_002559.2, NM_002568.3 [P11940-1]
XP_005250918.1, XM_005250861.2 [P11940-1]
UniGeneiHs.387804

Genome annotation databases

EnsembliENST00000318607; ENSP00000313007; ENSG00000070756 [P11940-1]
GeneIDi26986
KEGGihsa:26986
UCSCiuc003yjs.2 human [P11940-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00345 mRNA Translation: CAA68428.1
U68104
, U68093, U68094, U68095, U68097, U68098, U68099, U68100, U68101, U68102, U68103 Genomic DNA Translation: AAD08718.1
AP001205 Genomic DNA No translation available.
BC015958 mRNA Translation: AAH15958.1
BC023520 mRNA Translation: AAH23520.1
Z48501 mRNA Translation: CAA88401.1
CCDSiCCDS6289.1 [P11940-1]
PIRiA93668 DNHUPA
S52491
RefSeqiNP_002559.2, NM_002568.3 [P11940-1]
XP_005250918.1, XM_005250861.2 [P11940-1]
UniGeneiHs.387804

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CVJX-ray2.60A/B/C/D/E/F/G/H1-190[»]
1G9LNMR-A498-636[»]
1JGNNMR-A544-636[»]
1JH4NMR-A544-636[»]
2K8GNMR-A90-182[»]
2RQGNMR-B541-623[»]
2RQHNMR-B541-623[»]
2X04X-ray1.49A/B545-619[»]
3KTPX-ray1.50A544-626[»]
3KTRX-ray1.70A544-626[»]
3KUIX-ray2.30A544-626[»]
3KUJX-ray1.40A544-626[»]
3KURX-ray2.50A/B/C/D/E/F/G/H544-617[»]
3KUSX-ray1.40A/B544-626[»]
3KUTX-ray1.50A/B544-626[»]
3PKNX-ray1.80A544-626[»]
3PTHX-ray1.70A543-621[»]
4F02X-ray2.00A/D1-190[»]
4F25X-ray1.90A99-199[»]
4F26X-ray2.00A99-199[»]
5DX1X-ray1.93F/G/H/I449-466[»]
5DX8X-ray1.94E/F/G/H449-466[»]
5DXAX-ray2.07F/G/I449-466[»]
5LGPX-ray2.04E/F/G/H447-458[»]
5LGQX-ray2.11E/F/G/H456-466[»]
5LGRX-ray2.00E/F/G/H447-458[»]
5LGSX-ray2.10E/F/G/H456-464[»]
ProteinModelPortaliP11940
SMRiP11940
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117939, 255 interactors
ComplexPortaliCPX-1076 mCRD-poly(A)-bridging complex
CORUMiP11940
DIPiDIP-31613N
ELMiP11940
IntActiP11940, 123 interactors
MINTiP11940
STRINGi9606.ENSP00000313007

Chemistry databases

BindingDBiP11940
ChEMBLiCHEMBL1293286

Protein family/group databases

MoonDBiP11940 Predicted

PTM databases

iPTMnetiP11940
PhosphoSitePlusiP11940
SwissPalmiP11940

Polymorphism and mutation databases

BioMutaiPABPC1
DMDMi3183544

Proteomic databases

EPDiP11940
MaxQBiP11940
PaxDbiP11940
PeptideAtlasiP11940
PRIDEiP11940
ProteomicsDBi52814
52815 [P11940-2]

Protocols and materials databases

DNASUi26986
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318607; ENSP00000313007; ENSG00000070756 [P11940-1]
GeneIDi26986
KEGGihsa:26986
UCSCiuc003yjs.2 human [P11940-1]

Organism-specific databases

CTDi26986
DisGeNETi26986
EuPathDBiHostDB:ENSG00000070756.13
GeneCardsiPABPC1
HGNCiHGNC:8554 PABPC1
HPAiCAB011536
HPA045423
HPA067156
MIMi604679 gene
neXtProtiNX_P11940
OpenTargetsiENSG00000070756
PharmGKBiPA32880
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0123 Eukaryota
ENOG410XR5X LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000217922
HOVERGENiHBG002295
InParanoidiP11940
KOiK13126
OMAiVTEALCV
OrthoDBiEOG091G03ZE
PhylomeDBiP11940
TreeFamiTF300458

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-429947 Deadenylation of mRNA
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-72649 Translation initiation complex formation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP11940

Miscellaneous databases

ChiTaRSiPABPC1 human
EvolutionaryTraceiP11940
GeneWikiiPABPC1
GenomeRNAii26986
PMAP-CutDBiP11940
PROiPR:P11940
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070756 Expressed in 230 organ(s), highest expression level in testis
CleanExiHS_PABPC1
ExpressionAtlasiP11940 baseline and differential
GenevisibleiP11940 HS

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR036053 PABP-dom
IPR006515 PABP_1234
IPR002004 PABP_HYD
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00658 PABP, 1 hit
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00517 PolyA, 1 hit
SM00360 RRM, 4 hits
SM00361 RRM_1, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
SSF63570 SSF63570, 1 hit
TIGRFAMsiTIGR01628 PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS51309 PABC, 1 hit
PS50102 RRM, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPABP1_HUMAN
AccessioniPrimary (citable) accession number: P11940
Secondary accession number(s): Q15097, Q93004
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 15, 1998
Last modified: November 7, 2018
This is version 229 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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