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UniProtKB - P11927 (KAR1_YEAST)
Protein
Cell division control protein KAR1
Gene
KAR1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
KAR1 is required for function of both intranuclear and extranuclear microtubules. KAR1 helps localize CDC31 to the spindle pole body (SPB), CDC31 then initiates SPB duplication via interaction with a downstream effector.
3 PublicationsGO - Biological processi
- cell division Source: UniProtKB-KW
- karyogamy involved in conjugation with cellular fusion Source: SGD
- spindle pole body duplication Source: SGD
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division control protein KAR1 |
Gene namesi | Name:KAR1 Ordered Locus Names:YNL188W ORF Names:N1611 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005132, KAR1 |
VEuPathDBi | FungiDB:YNL188W |
Subcellular locationi
Cytoskeleton
Cytoskeleton
- half bridge of spindle pole body Source: SGD
- microtubule Source: UniProtKB-KW
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084295 | 1 – 433 | Cell division control protein KAR1Add BLAST | 433 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 233 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P11927 |
PaxDbi | P11927 |
PRIDEi | P11927 |
PTM databases
iPTMneti | P11927 |
Interactioni
Subunit structurei
Interacts with SPC72.
1 PublicationProtein-protein interaction databases
BioGRIDi | 35645, 29 interactors |
DIPi | DIP-2274N |
IntActi | P11927, 6 interactors |
STRINGi | 4932.YNL188W |
Miscellaneous databases
RNActi | P11927, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P11927 |
SMRi | P11927 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P11927 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 38 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 69 – 101 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 207 – 227 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | Polar residuesSequence analysisAdd BLAST | 17 |
Phylogenomic databases
eggNOGi | ENOG502S30N, Eukaryota |
HOGENOMi | CLU_051895_0_0_1 |
InParanoidi | P11927 |
OMAi | LIESKWH |
Family and domain databases
IDEALi | IID50070 |
i Sequence
Sequence statusi: Complete.
P11927-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNVTSPKDGN HSFSKKNRFN TNKPRFHKLN EQAQSINLPE DRDSIVSSNT
60 70 80 90 100
TSIMTDDAFD YNEGIASRTK NINSDSDRSN DTIKQNNYNK RETGYNPFYN
110 120 130 140 150
GSGINQRYTQ FRKREFEPTL AENKAEEYIS DEDNVKIDED NIENELQFTP
160 170 180 190 200
KIKEASILRS SLLGQRNVLN TRNPKSKESH IKVKPIINNK SSSQRKSSAA
210 220 230 240 250
LRKQLGKPLP LPYLNSPNSD STPTLQRKEE VFTDEVLQKK RELIESKWHR
260 270 280 290 300
LLFHDKKMVE KKLESLREYE RKRMPPRGTD VSSSEQDNSF KISTPTKSYV
310 320 330 340 350
SLEQKPLPNL SAMNNFNDVT DNKEKEETNN NILKFQAQRD PLQILQSEIE
360 370 380 390 400
MHTKKLDTII ELLKDDTDSK EKRKVVTNDN AAPEQMVNKG WRKNVMMIYK
410 420 430
KSGNIMKKYR EYFLWTICIL ILLYCNIYVY YRF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 95 | Y → H in AAT92901 (PubMed:17322287).Curated | 1 | |
Sequence conflicti | 199 | A → V in AAA34716 (PubMed:3030557).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15683 Genomic DNA Translation: AAA34716.1 Z71464 Genomic DNA Translation: CAA96082.1 AY692882 Genomic DNA Translation: AAT92901.1 BK006947 Genomic DNA Translation: DAA10365.1 |
PIRi | S63143 |
RefSeqi | NP_014211.1, NM_001183026.1 |
Genome annotation databases
EnsemblFungii | YNL188W_mRNA; YNL188W; YNL188W |
GeneIDi | 855533 |
KEGGi | sce:YNL188W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15683 Genomic DNA Translation: AAA34716.1 Z71464 Genomic DNA Translation: CAA96082.1 AY692882 Genomic DNA Translation: AAT92901.1 BK006947 Genomic DNA Translation: DAA10365.1 |
PIRi | S63143 |
RefSeqi | NP_014211.1, NM_001183026.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OQP | NMR | - | B | 239-257 | [»] | |
BMRBi | P11927 | |||||
SMRi | P11927 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 35645, 29 interactors |
DIPi | DIP-2274N |
IntActi | P11927, 6 interactors |
STRINGi | 4932.YNL188W |
PTM databases
iPTMneti | P11927 |
Proteomic databases
MaxQBi | P11927 |
PaxDbi | P11927 |
PRIDEi | P11927 |
Genome annotation databases
EnsemblFungii | YNL188W_mRNA; YNL188W; YNL188W |
GeneIDi | 855533 |
KEGGi | sce:YNL188W |
Organism-specific databases
SGDi | S000005132, KAR1 |
VEuPathDBi | FungiDB:YNL188W |
Phylogenomic databases
eggNOGi | ENOG502S30N, Eukaryota |
HOGENOMi | CLU_051895_0_0_1 |
InParanoidi | P11927 |
OMAi | LIESKWH |
Miscellaneous databases
EvolutionaryTracei | P11927 |
PROi | PR:P11927 |
RNActi | P11927, protein |
Family and domain databases
IDEALi | IID50070 |
MobiDBi | Search... |
Entry informationi
Entry namei | KAR1_YEAST | |
Accessioni | P11927Primary (citable) accession number: P11927 Secondary accession number(s): D6W0Z9, E9P8Y4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references