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Protein

Cell division control protein KAR1

Gene

KAR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

KAR1 is required for function of both intranuclear and extranuclear microtubules. KAR1 helps localize CDC31 to the spindle pole body (SPB), CDC31 then initiates SPB duplication via interaction with a downstream effector.3 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • karyogamy involved in conjugation with cellular fusion Source: SGD
  • spindle pole body duplication Source: SGD

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-33199-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein KAR1
Gene namesi
Name:KAR1
Ordered Locus Names:YNL188W
ORF Names:N1611
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL188W
SGDiS000005132 KAR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000842951 – 433Cell division control protein KAR1Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP11927
PaxDbiP11927
PRIDEiP11927

PTM databases

iPTMnetiP11927

Interactioni

Subunit structurei

Interacts with SPC72.1 Publication

Protein-protein interaction databases

BioGridi35645, 29 interactors
DIPiDIP-2274N
IntActiP11927, 6 interactors
STRINGi4932.YNL188W

Structurei

Secondary structure

1433
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP11927
SMRiP11927
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11927

Family & Domainsi

Phylogenomic databases

InParanoidiP11927
OrthoDBiEOG092C2JPC

Sequencei

Sequence statusi: Complete.

P11927-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVTSPKDGN HSFSKKNRFN TNKPRFHKLN EQAQSINLPE DRDSIVSSNT
60 70 80 90 100
TSIMTDDAFD YNEGIASRTK NINSDSDRSN DTIKQNNYNK RETGYNPFYN
110 120 130 140 150
GSGINQRYTQ FRKREFEPTL AENKAEEYIS DEDNVKIDED NIENELQFTP
160 170 180 190 200
KIKEASILRS SLLGQRNVLN TRNPKSKESH IKVKPIINNK SSSQRKSSAA
210 220 230 240 250
LRKQLGKPLP LPYLNSPNSD STPTLQRKEE VFTDEVLQKK RELIESKWHR
260 270 280 290 300
LLFHDKKMVE KKLESLREYE RKRMPPRGTD VSSSEQDNSF KISTPTKSYV
310 320 330 340 350
SLEQKPLPNL SAMNNFNDVT DNKEKEETNN NILKFQAQRD PLQILQSEIE
360 370 380 390 400
MHTKKLDTII ELLKDDTDSK EKRKVVTNDN AAPEQMVNKG WRKNVMMIYK
410 420 430
KSGNIMKKYR EYFLWTICIL ILLYCNIYVY YRF
Length:433
Mass (Da):50,653
Last modified:October 1, 1996 - v2
Checksum:iD65331B3B2B068E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95Y → H in AAT92901 (PubMed:17322287).Curated1
Sequence conflicti199A → V in AAA34716 (PubMed:3030557).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15683 Genomic DNA Translation: AAA34716.1
Z71464 Genomic DNA Translation: CAA96082.1
AY692882 Genomic DNA Translation: AAT92901.1
BK006947 Genomic DNA Translation: DAA10365.1
PIRiS63143
RefSeqiNP_014211.1, NM_001183026.1

Genome annotation databases

EnsemblFungiiYNL188W; YNL188W; YNL188W
GeneIDi855533
KEGGisce:YNL188W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15683 Genomic DNA Translation: AAA34716.1
Z71464 Genomic DNA Translation: CAA96082.1
AY692882 Genomic DNA Translation: AAT92901.1
BK006947 Genomic DNA Translation: DAA10365.1
PIRiS63143
RefSeqiNP_014211.1, NM_001183026.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OQPNMR-B239-257[»]
ProteinModelPortaliP11927
SMRiP11927
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35645, 29 interactors
DIPiDIP-2274N
IntActiP11927, 6 interactors
STRINGi4932.YNL188W

PTM databases

iPTMnetiP11927

Proteomic databases

MaxQBiP11927
PaxDbiP11927
PRIDEiP11927

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL188W; YNL188W; YNL188W
GeneIDi855533
KEGGisce:YNL188W

Organism-specific databases

EuPathDBiFungiDB:YNL188W
SGDiS000005132 KAR1

Phylogenomic databases

InParanoidiP11927
OrthoDBiEOG092C2JPC

Enzyme and pathway databases

BioCyciYEAST:G3O-33199-MONOMER

Miscellaneous databases

EvolutionaryTraceiP11927
PROiPR:P11927

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiKAR1_YEAST
AccessioniPrimary (citable) accession number: P11927
Secondary accession number(s): D6W0Z9, E9P8Y4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1996
Last modified: October 10, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
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Main funding by: National Institutes of Health

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