UniProtKB - P11927 (KAR1_YEAST)

BLAST

>sp|P11927|KAR1_YEAST Cell division control protein KAR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=KAR1 PE=1 SV=2
MNVTSPKDGNHSFSKKNRFNTNKPRFHKLNEQAQSINLPEDRDSIVSSNTTSIMTDDAFD
YNEGIASRTKNINSDSDRSNDTIKQNNYNKRETGYNPFYNGSGINQRYTQFRKREFEPTL
AENKAEEYISDEDNVKIDEDNIENELQFTPKIKEASILRSSLLGQRNVLNTRNPKSKESH
IKVKPIINNKSSSQRKSSAALRKQLGKPLPLPYLNSPNSDSTPTLQRKEEVFTDEVLQKK
RELIESKWHRLLFHDKKMVEKKLESLREYERKRMPPRGTDVSSSEQDNSFKISTPTKSYV
SLEQKPLPNLSAMNNFNDVTDNKEKEETNNNILKFQAQRDPLQILQSEIEMHTKKLDTII
ELLKDDTDSKEKRKVVTNDNAAPEQMVNKGWRKNVMMIYKKSGNIMKKYREYFLWTICIL
ILLYCNIYVYYRF

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History
Entry version 134 (10 Oct 2018)
Sequence version 2 (01 Oct 1996)
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Protein

Cell division control protein KAR1

Gene

KAR1

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

KAR1 is required for function of both intranuclear and extranuclear microtubules. KAR1 helps localize CDC31 to the spindle pole body (SPB), CDC31 then initiates SPB duplication via interaction with a downstream effector.3 Publications

GO - Biological processⁱ

cell division Source: UniProtKB-KW
karyogamy involved in conjugation with cellular fusion
Source: SGD
Inferred from mutant phenotypeⁱ
- 1607389
spindle pole body duplication
Source: SGD
Inferred from mutant phenotypeⁱ
- 3030557

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, Mitosis

Biological process

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-33199-MONOMER

BioCycⁱ

YEAST:G3O-33199-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell division control protein KAR1
Gene namesⁱ	Name:KAR1 Ordered Locus Names:YNL188W ORF Names:N1611
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XIV

Organism-specific databases

EuPathDBⁱ	FungiDB:YNL188W
Saccharomyces Genome Database More...SGDⁱ	S000005132 KAR1

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000084295	1 – 433	Cell division control protein KAR1Add BLAST		433

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	233	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P11927
PaxDbⁱ	P11927
PRIDEⁱ	P11927

PTM databases

iPTMnetⁱ	P11927

iPTMnetⁱ

P11927

Interactionⁱ

Subunit structureⁱ

Interacts with SPC72.1 Publication

Protein-protein interaction databases

BioGridⁱ	35645, 29 interactors
Database of interacting proteins More...DIPⁱ	DIP-2274N
IntActⁱ	P11927, 6 interactors
STRINGⁱ	4932.YNL188W

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	240 – 252	Combined sources		13

Show more details

3D structure databases

ProteinModelPortalⁱ	P11927
SMRⁱ	P11927
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P11927

Family & Domainsⁱ

Phylogenomic databases

InParanoidⁱ	P11927
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C2JPC

Sequenceⁱ

Sequence statusⁱ: Complete.

P11927-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNVTSPKDGN HSFSKKNRFN TNKPRFHKLN EQAQSINLPE DRDSIVSSNT 
        60         70         80         90        100
TSIMTDDAFD YNEGIASRTK NINSDSDRSN DTIKQNNYNK RETGYNPFYN 
       110        120        130        140        150
GSGINQRYTQ FRKREFEPTL AENKAEEYIS DEDNVKIDED NIENELQFTP 
       160        170        180        190        200
KIKEASILRS SLLGQRNVLN TRNPKSKESH IKVKPIINNK SSSQRKSSAA 
       210        220        230        240        250
LRKQLGKPLP LPYLNSPNSD STPTLQRKEE VFTDEVLQKK RELIESKWHR 
       260        270        280        290        300
LLFHDKKMVE KKLESLREYE RKRMPPRGTD VSSSEQDNSF KISTPTKSYV 
       310        320        330        340        350
SLEQKPLPNL SAMNNFNDVT DNKEKEETNN NILKFQAQRD PLQILQSEIE 
       360        370        380        390        400
MHTKKLDTII ELLKDDTDSK EKRKVVTNDN AAPEQMVNKG WRKNVMMIYK 
       410        420        430 
KSGNIMKKYR EYFLWTICIL ILLYCNIYVY YRF

Length:433

Mass (Da):50,653

Last modified:October 1, 1996 - v2

Checksum:ⁱD65331B3B2B068E4

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	95	Y → H in AAT92901 (PubMed:17322287).Curated		1
Sequence conflictⁱ	199	A → V in AAA34716 (PubMed:3030557).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M15683 Genomic DNA Translation: AAA34716.1 Z71464 Genomic DNA Translation: CAA96082.1 AY692882 Genomic DNA Translation: AAT92901.1 BK006947 Genomic DNA Translation: DAA10365.1
PIRⁱ	S63143
NCBI Reference Sequences More...RefSeqⁱ	NP_014211.1, NM_001183026.1

Genome annotation databases

EnsemblFungiⁱ	YNL188W; YNL188W; YNL188W
GeneIDⁱ	855533
KEGGⁱ	sce:YNL188W

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P11927	Cell division control protein KAR1		YEAS1		433	UniRef100_P11927
Kar1p		YEASC		433
YNL188Wp-like protein		YEAS6		433
Karyogamy protein		YEAS7		433
KAR1p Protein involved in karyogamy and spindle pole body duplication		Saccharomyces sp. 'boulardii'		380

Protein	Similar proteins		Species	Score	Length	Source
P11927	Cell division control protein KAR1		YEAS1		433	UniRef90_P11927
Kar1p		YEASC		433
YNL188Wp-like protein		YEAS6		433
Karyogamy protein		YEAS7		433
KAR1p Protein involved in karyogamy and spindle pole body duplication		Saccharomyces sp. 'boulardii'		380
+5

Protein	Similar proteins		Species	Score	Length	Source
P11927	Cell division control protein KAR1		YEAS1		433	UniRef50_P11927
Kar1p		YEASC		433
YNL188Wp-like protein		YEAS6		433
Karyogamy protein		YEAS7		433
KAR1p Protein involved in karyogamy and spindle pole body duplication		Saccharomyces sp. 'boulardii'		380
+8

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M15683 Genomic DNA Translation: AAA34716.1 Z71464 Genomic DNA Translation: CAA96082.1 AY692882 Genomic DNA Translation: AAT92901.1 BK006947 Genomic DNA Translation: DAA10365.1
PIRⁱ	S63143
RefSeqⁱ	NP_014211.1, NM_001183026.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1OQP	NMR	-	B	239-257	[»]
ProteinModelPortalⁱ	P11927
SMRⁱ	P11927
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35645, 29 interactors
DIPⁱ	DIP-2274N
IntActⁱ	P11927, 6 interactors
STRINGⁱ	4932.YNL188W

PTM databases

iPTMnetⁱ	P11927

iPTMnetⁱ

P11927

Proteomic databases

MaxQBⁱ	P11927
PaxDbⁱ	P11927
PRIDEⁱ	P11927

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YNL188W; YNL188W; YNL188W
GeneIDⁱ	855533
KEGGⁱ	sce:YNL188W

Organism-specific databases

EuPathDBⁱ	FungiDB:YNL188W
SGDⁱ	S000005132 KAR1

Phylogenomic databases

InParanoidⁱ	P11927
OrthoDBⁱ	EOG092C2JPC

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-33199-MONOMER

BioCycⁱ

YEAST:G3O-33199-MONOMER

Miscellaneous databases

EvolutionaryTraceⁱ	P11927
Protein Ontology More...PROⁱ	PR:P11927

Family and domain databases

ProtoNetⁱ	Search...

ProtoNetⁱ

Search...

Entry informationⁱ

Entry nameⁱ	KAR1_YEAST
Accessionⁱ	P11927Primary (citable) accession number: P11927 Secondary accession number(s): D6W0Z9, E9P8Y4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
	Last sequence update:	October 1, 1996
	Last modified:	October 10, 2018
	This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P11927 (KAR1_YEAST)

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Cell division control protein KAR1

KAR1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ