Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 133 (07 Oct 2020)
Sequence version 2 (23 Nov 2004)
Previous versions | rss
Add a publicationFeedback
Protein

Invasin

Gene

YPTB1668

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Invasin is a protein that allows enteric bacteria to penetrate cultured mammalian cells. The entry of invasin in the cell is mediated by binding several beta-1 chain integrins.

Caution

It is uncertain whether Met-1, Met-17 or Met-19 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.B.54.1.2, the intimin/invasin (int/inv) or autotransporter-3 (at-3) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Invasin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:YPTB1668
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri273123 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001011 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini494 – 985ExtracellularAdd BLAST492

GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB04272, Citric acid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002118311 – 985InvasinAdd BLAST985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi906 ↔ 981

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bond

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1985
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11922

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P11922

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini503 – 594Big-1 1PROSITE-ProRule annotationAdd BLAST92
Domaini601 – 691Big-1 2PROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni494 – 594D1Add BLAST101
Regioni595 – 694D2Add BLAST100
Regioni695 – 794D3Add BLAST100
Regioni795 – 985Integrin-bindingAdd BLAST191
Regioni795 – 886D4Add BLAST92
Regioni887 – 985D5Add BLAST99

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intimin/invasin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
GEYWVKK

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.160.160, 1 hit
2.60.40.10, 3 hits
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003344, Big_1_dom
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR024519, IAT_beta
IPR038177, IAT_beta_sf
IPR013783, Ig-like_fold
IPR003535, Intimin/invasin_bac
IPR013117, Intimin_C
IPR008964, Invasin/intimin_cell_adhesion
IPR015217, Invasin_dom_3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02369, Big_1, 1 hit
PF11924, IAT_beta, 1 hit
PF07979, Intimin_C, 1 hit
PF09134, Invasin_D3, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01369, INTIMIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00634, BID_1, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49373, SSF49373, 4 hits
SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51127, BIG1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P11922-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVFQPISEFL LIRNAGMSMY FNKIISFNII SRIVICIFLI CGMFMAGASE
60 70 80 90 100
KYDANAPQQV QPYSVSSSAF ENLHPNNEME SSINPFSASD TERNAAIIDR
110 120 130 140 150
ANKEQETEAV NKMISTGARL AASGRASDVA HSMVGDAVNQ EIKQWLNRFG
160 170 180 190 200
TAQVNLNFDK NFSLKESSLD WLAPWYDSAS FLFFSQLGIR NKDSRNTLNL
210 220 230 240 250
GVGIRTLENG WLYGLNTFYD NDLTGHNHRI GLGAEAWTDY LQLAANGYFR
260 270 280 290 300
LNGWHSSRDF SDYKERPATG GDLRANAYLP ALPQLGGKLM YEQYTGERVA
310 320 330 340 350
LFGKDNLQRN PYAVTAGINY TPVPLLTVGV DQRMGKSSKH ETQWNLQMNY
360 370 380 390 400
RLGESFQSQL SPSAVAGTRL LAESRYNLVD RNNNIVLEYQ KQQVVKLTLS
410 420 430 440 450
PATISGLPGQ VYQVNAQVQG ASAVREIVWS DAELIAAGGT LTPLSTTQFN
460 470 480 490 500
LVLPPYKRTA QVSRVTDDLT ANFYSLSALA VDHQGNRSNS FTLSVTVQQP
510 520 530 540 550
QLTLTAAVIG DGAPANGKTA ITVEFTVADF EGKPLAGQEV VITTNNGALP
560 570 580 590 600
NKITEKTDAN GVARIALTNT TDGVTVVTAE VEGQRQSVDT HFVKGTIAAD
610 620 630 640 650
KSTLAAVPTS IIADGLMAST ITLELKDTYG DPQAGANVAF DTTLGNMGVI
660 670 680 690 700
TDHNDGTYSA PLTSTTLGVA TVTVKVDGAA FSVPSVTVNF TADPIPDAGR
710 720 730 740 750
SSFTVSTPDI LADGTMSSTL SFVPVDKNGH FISGMQGLSF TQNGVPVSIS
760 770 780 790 800
PITEQPDSYT ATVVGNTAGD VTITPQVDTL ILSTLQKKIS LFPVPTLTGI
810 820 830 840 850
LVNGQNFATD KGFPKTIFKN ATFQLQMDND VANNTQYEWS SSFTPNVSVN
860 870 880 890 900
DQGQVTITYQ TYSEVAVTAK SKKFPSYSVS YRFYPNRWIY DGGTSLVSSL
910 920 930 940 950
EASRQCQGSD MSAVLESSRA TNGTRAPDGT LWGEWGSLTA YSSDWQSGEY
960 970 980
WVKKTSTDFE TMNMDTGALV QGPAYLAFPL CALAI
Length:985
Mass (Da):106,544
Last modified:November 23, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42007F9EEB984D50
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA27632 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA27634 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA27635 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti767 – 768TA → SV in AAA27633 (PubMed:3304658).Curated2
Sequence conflicti767 – 768TA → SV in AAA27632 (PubMed:3304658).Curated2
Sequence conflicti894T → R in AAA27633 (PubMed:3304658).Curated1
Sequence conflicti894T → R in AAA27632 (PubMed:3304658).Curated1
Sequence conflicti970 – 971VQ → QP in AAA27633 (PubMed:3304658).Curated2
Sequence conflicti970 – 971VQ → QP in AAA27632 (PubMed:3304658).Curated2
Sequence conflicti984A → S in AAA27633 (PubMed:3304658).Curated1
Sequence conflicti984A → S in AAA27632 (PubMed:3304658).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M17448 Genomic DNA Translation: AAA27633.1
M17448 Genomic DNA Translation: AAA27632.1 Different initiation.
M17448 Genomic DNA Translation: AAA27634.1 Different initiation.
M17448 Genomic DNA Translation: AAA27635.1 Different initiation.
BX936398 Genomic DNA Translation: CAH20907.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A29646

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAH20907; CAH20907; YPTB1668

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
yps:YPTB1668

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17448 Genomic DNA Translation: AAA27633.1
M17448 Genomic DNA Translation: AAA27632.1 Different initiation.
M17448 Genomic DNA Translation: AAA27634.1 Different initiation.
M17448 Genomic DNA Translation: AAA27635.1 Different initiation.
BX936398 Genomic DNA Translation: CAH20907.1
PIRiA29646

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CWVX-ray2.30A494-983[»]
4E1TX-ray2.26A147-390[»]
SMRiP11922
ModBaseiSearch...
PDBe-KBiSearch...

Chemistry databases

DrugBankiDB04272, Citric acid

Protein family/group databases

TCDBi1.B.54.1.2, the intimin/invasin (int/inv) or autotransporter-3 (at-3) family

Genome annotation databases

EnsemblBacteriaiCAH20907; CAH20907; YPTB1668
KEGGiyps:YPTB1668

Phylogenomic databases

OMAiGEYWVKK

Miscellaneous databases

EvolutionaryTraceiP11922

Family and domain databases

Gene3Di2.40.160.160, 1 hit
2.60.40.10, 3 hits
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR003344, Big_1_dom
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR024519, IAT_beta
IPR038177, IAT_beta_sf
IPR013783, Ig-like_fold
IPR003535, Intimin/invasin_bac
IPR013117, Intimin_C
IPR008964, Invasin/intimin_cell_adhesion
IPR015217, Invasin_dom_3
PfamiView protein in Pfam
PF02369, Big_1, 1 hit
PF11924, IAT_beta, 1 hit
PF07979, Intimin_C, 1 hit
PF09134, Invasin_D3, 2 hits
PRINTSiPR01369, INTIMIN
SMARTiView protein in SMART
SM00634, BID_1, 3 hits
SUPFAMiSSF49373, SSF49373, 4 hits
SSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS51127, BIG1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINVA_YERPS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11922
Secondary accession number(s): Q66BU9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 23, 2004
Last modified: October 7, 2020
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again