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Entry version 197 (12 Aug 2020)
Sequence version 1 (01 Oct 1989)
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Protein

Mitochondrial-processing peptidase subunit alpha

Gene

MAS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.1 Publication

Miscellaneous

Present with 31400 molecules/cell in log phase SD medium.1 Publication

Caution

Was originally thought to be the catalytic subunit (PubMed:3061797). The low processing activity which was previously observed with alpha-MPP which has been purified from a mitochondrial extract is most likely due to contamination by the beta-subunit. Does not seem to have a protease activity as it lack the zinc-binding site (PubMed:9299349).Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • protein processing involved in protein targeting to mitochondrion Source: SGD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:G3O-31085-MONOMER
YEAST:G3O-31085-MONOMER

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P11914

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M16.971

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial-processing peptidase subunit alpha1 Publication
Alternative name(s):
Alpha-MPP
Inactive zinc metalloprotease alphaCurated
Matrix processing peptidase1 Publication
Short name:
MPP
Mitochondrial assembly protein 21 Publication
Mitochondrial import function protein 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAS21 Publication
Synonyms:MIF21 Publication
Ordered Locus Names:YHR024CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YHR024C

Saccharomyces Genome Database

More...
SGDi
S000001066, MAS2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 13Mitochondrion1 PublicationAdd BLAST13
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002677314 – 482Mitochondrial-processing peptidase subunit alphaAdd BLAST469

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P11914

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11914

PRoteomics IDEntifications database

More...
PRIDEi
P11914

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11914

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of MAS2 (alpha) and MAS1 (beta) subunits, forming the mitochondrial processing protease (MPP) in which MAS2 is involved in substrate recognition and binding and MAS1 is the catalytic subunit.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36455, 278 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1630, Mitochondrial processing peptidase complex

Database of interacting proteins

More...
DIPi
DIP-2401N

Protein interaction database and analysis system

More...
IntActi
P11914, 8 interactors

Molecular INTeraction database

More...
MINTi
P11914

STRING: functional protein association networks

More...
STRINGi
4932.YHR024C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P11914, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1482
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11914

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P11914

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2067, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156724

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009902_5_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11914

KEGG Orthology (KO)

More...
KOi
K01412

Identification of Orthologs from Complete Genome Data

More...
OMAi
YTHILNH

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011249, Metalloenz_LuxS/M16
IPR011765, Pept_M16_N
IPR001431, Pept_M16_Zn_BS
IPR007863, Peptidase_M16_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00675, Peptidase_M16, 1 hit
PF05193, Peptidase_M16_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63411, SSF63411, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00143, INSULINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P11914-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRNGVQRLY SNIARTDNFK LSSLANGLKV ATSNTPGHFS ALGLYIDAGS
60 70 80 90 100
RFEGRNLKGC THILDRLAFK STEHVEGRAM AETLELLGGN YQCTSSRENL
110 120 130 140 150
MYQASVFNQD VGKMLQLMSE TVRFPKITEQ ELQEQKLSAE YEIDEVWMKP
160 170 180 190 200
ELVLPELLHT AAYSGETLGS PLICPRELIP SISKYYLLDY RNKFYTPENT
210 220 230 240 250
VAAFVGVPHE KALELTEKYL GDWQSTHPPI TKKVAQYTGG ESCIPPAPVF
260 270 280 290 300
GNLPELFHIQ IGFEGLPIDH PDIYALATLQ TLLGGGGSFS AGGPGKGMYS
310 320 330 340 350
RLYTHVLNQY YFVENCVAFN HSYSDSGIFG ISLSCIPQAA PQAVEVIAQQ
360 370 380 390 400
MYNTFANKDL RLTEDEVSRA KNQLKSSLLM NLESKLVELE DMGRQVLMHG
410 420 430 440 450
RKIPVNEMIS KIEDLKPDDI SRVAEMIFTG NVNNAGNGKG RATVVMQGDR
460 470 480
GSFGDVENVL KAYGLGNSSS SKNDSPKKKG WF
Length:482
Mass (Da):53,338
Last modified:October 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FDCD157388A56C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti235A → P in CAA32262 (PubMed:3061808).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X13455 Genomic DNA Translation: CAA31804.1
X14105 Genomic DNA Translation: CAA32262.1
U10399 Genomic DNA Translation: AAB68877.1
BK006934 Genomic DNA Translation: DAA06715.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S05738, ZPBY

NCBI Reference Sequences

More...
RefSeqi
NP_011889.1, NM_001179154.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YHR024C_mRNA; YHR024C; YHR024C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856419

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YHR024C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13455 Genomic DNA Translation: CAA31804.1
X14105 Genomic DNA Translation: CAA32262.1
U10399 Genomic DNA Translation: AAB68877.1
BK006934 Genomic DNA Translation: DAA06715.1
PIRiS05738, ZPBY
RefSeqiNP_011889.1, NM_001179154.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HR6X-ray2.50A/C/E/G14-482[»]
1HR7X-ray2.55A/C/E/G14-482[»]
1HR8X-ray2.70A/C/E/G14-482[»]
1HR9X-ray3.01A/C/E/G14-482[»]
SMRiP11914
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi36455, 278 interactors
ComplexPortaliCPX-1630, Mitochondrial processing peptidase complex
DIPiDIP-2401N
IntActiP11914, 8 interactors
MINTiP11914
STRINGi4932.YHR024C

Protein family/group databases

MEROPSiM16.971

PTM databases

iPTMnetiP11914

Proteomic databases

MaxQBiP11914
PaxDbiP11914
PRIDEiP11914

Genome annotation databases

EnsemblFungiiYHR024C_mRNA; YHR024C; YHR024C
GeneIDi856419
KEGGisce:YHR024C

Organism-specific databases

EuPathDBiFungiDB:YHR024C
SGDiS000001066, MAS2

Phylogenomic databases

eggNOGiKOG2067, Eukaryota
GeneTreeiENSGT00940000156724
HOGENOMiCLU_009902_5_2_1
InParanoidiP11914
KOiK01412
OMAiYTHILNH

Enzyme and pathway databases

BioCyciMetaCyc:G3O-31085-MONOMER
YEAST:G3O-31085-MONOMER
SABIO-RKiP11914

Miscellaneous databases

EvolutionaryTraceiP11914

Protein Ontology

More...
PROi
PR:P11914
RNActiP11914, protein

Family and domain databases

InterProiView protein in InterPro
IPR011249, Metalloenz_LuxS/M16
IPR011765, Pept_M16_N
IPR001431, Pept_M16_Zn_BS
IPR007863, Peptidase_M16_C
PfamiView protein in Pfam
PF00675, Peptidase_M16, 1 hit
PF05193, Peptidase_M16_C, 1 hit
SUPFAMiSSF63411, SSF63411, 2 hits
PROSITEiView protein in PROSITE
PS00143, INSULINASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPPA_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11914
Secondary accession number(s): D3DKX1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: August 12, 2020
This is version 197 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names
  5. Peptidase families
    Classification of peptidase families and list of entries
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