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Entry version 193 (12 Aug 2020)
Sequence version 2 (01 Jun 1994)
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Protein

B-cell antigen receptor complex-associated protein alpha chain

Gene

CD79A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei210Required for binding to BLNKBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P11912

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5690714, CD22 mediated BCR regulation
R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P11912

SIGNOR Signaling Network Open Resource

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SIGNORi
P11912

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
B-cell antigen receptor complex-associated protein alpha chain
Alternative name(s):
Ig-alpha
MB-1 membrane glycoprotein
Membrane-bound immunoglobulin-associated protein
Surface IgM-associated protein
CD_antigen: CD79a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD79A
Synonyms:IGA, MB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000105369.9

Human Gene Nomenclature Database

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HGNCi
HGNC:1698, CD79A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
112205, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P11912

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 143ExtracellularSequence analysisAdd BLAST111
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei144 – 165HelicalSequence analysisAdd BLAST22
Topological domaini166 – 226CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Agammaglobulinemia 3, autosomal recessive (AGM3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein.
Disease descriptionA primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi197S → A: Increased phosphorylation of Y-188; when associated with A-203 and V-209. 1 Publication1
Mutagenesisi203S → A: Increased phosphorylation of Y-188; when associated with A-197 and V-209. 1 Publication1
Mutagenesisi209T → V: Increased phosphorylation of Y-188; when associated with A-197 and A-203. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
973

MalaCards human disease database

More...
MalaCardsi
CD79A
MIMi613501, phenotype

Open Targets

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OpenTargetsi
ENSG00000105369

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
33110, Autosomal agammaglobulinemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26237

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P11912, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CD79A

Domain mapping of disease mutations (DMDM)

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DMDMi
547896

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 321 PublicationAdd BLAST32
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001455833 – 226B-cell antigen receptor complex-associated protein alpha chainAdd BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi54 ↔ 106PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi119Interchain (with C-136 in beta chain)PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei188Phosphotyrosine; by SRC-type Tyr-kinasesPROSITE-ProRule annotationBy similarity1
Modified residuei199Phosphotyrosine; by SRC-type Tyr-kinasesPROSITE-ProRule annotationBy similarity1
Modified residuei204Asymmetric dimethylarginine; by PRMT1By similarity1
Modified residuei210Phosphotyrosine; by Tyr-kinasesPROSITE-ProRule annotationBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylated by LYN. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.2 Publications
Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-1178

Encyclopedia of Proteome Dynamics

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EPDi
P11912

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P11912

MaxQB - The MaxQuant DataBase

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MaxQBi
P11912

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P11912

PeptideAtlas

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PeptideAtlasi
P11912

PRoteomics IDEntifications database

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PRIDEi
P11912

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
52811 [P11912-1]
52812 [P11912-2]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1028, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P11912, 9 sites

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P11912

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P11912

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

B-cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105369, Expressed in lymph node and 162 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P11912, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P11912, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000105369, Group enriched (blood, intestine, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains.

Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation.

Also interacts, when phosphorylated on Tyr-210, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes.

Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P11912
With#Exp.IntAct
ADIPOQ [Q15848]3EBI-7797864,EBI-10827839
AGTRAP - isoform 2 [Q6RW13-2]3EBI-7797864,EBI-11522760
ALG10 [Q5BKT4]3EBI-7797864,EBI-13064220
ALG10B [Q5I7T1]3EBI-7797864,EBI-18075734
ALG3 [Q92685]3EBI-7797864,EBI-2848814
APOD [P05090]3EBI-7797864,EBI-715495
AQP1 [P29972]3EBI-7797864,EBI-745213
AQP3 [Q92482]3EBI-7797864,EBI-2808854
ATP6V0C [P27449]3EBI-7797864,EBI-721179
BCL2L2 [Q92843]3EBI-7797864,EBI-707714
BET1 [O15155]3EBI-7797864,EBI-749204
BRICD5 - isoform 2 [Q6PL45-2]3EBI-7797864,EBI-12244618
BTN2A2 [Q8WVV5]3EBI-7797864,EBI-8648738
C2CD2L [O14523]3EBI-7797864,EBI-12822627
C4orf3 - isoform 2 [Q8WVX3-2]3EBI-7797864,EBI-12003442
CCDC167 [Q9P0B6]3EBI-7797864,EBI-9083477
CDIPT [O14735]3EBI-7797864,EBI-358858
CLDN1 [O95832]3EBI-7797864,EBI-723889
CLN6 [Q9NWW5]3EBI-7797864,EBI-6165897
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-7797864,EBI-11522780
CMTM7 [Q96FZ5]3EBI-7797864,EBI-2807956
CNIH1 [O95406]3EBI-7797864,EBI-12172273
CNIH3 [Q8TBE1]3EBI-7797864,EBI-12208021
COL4A5 - isoform 2 [P29400-2]3EBI-7797864,EBI-12211159
CTXN3 [Q4LDR2]3EBI-7797864,EBI-12019274
CYB561 [P49447]3EBI-7797864,EBI-8646596
CYB561A3 [Q8NBI2]3EBI-7797864,EBI-10269179
CYB561D2 [O14569]3EBI-7797864,EBI-717654
CYB5B [O43169]3EBI-7797864,EBI-1058710
DEFB127 [Q9H1M4]3EBI-7797864,EBI-10305240
DOLK [Q9UPQ8]3EBI-7797864,EBI-8645574
EDDM3B [P56851]3EBI-7797864,EBI-10215665
EMC6 [Q9BV81]3EBI-7797864,EBI-2820492
EMP1 [P54849]3EBI-7797864,EBI-4319440
EMP3 [P54852]3EBI-7797864,EBI-3907816
FA2H [Q7L5A8]3EBI-7797864,EBI-11337888
FAM241B - isoform 2 [Q96D05-2]3EBI-7797864,EBI-12118888
FATE1 [Q969F0]6EBI-7797864,EBI-743099
FAXDC2 [Q96IV6]3EBI-7797864,EBI-12142299
FDFT1 [P37268]3EBI-7797864,EBI-714550
FFAR3 [O14843]3EBI-7797864,EBI-17762181
FKBP8 [Q14318]3EBI-7797864,EBI-724839
FUNDC2 [Q9BWH2]3EBI-7797864,EBI-714482
FXYD3 - isoform 3 [Q14802-3]3EBI-7797864,EBI-12175685
GALNT15 [Q8N3T1]3EBI-7797864,EBI-3925203
GIMAP1 [Q8WWP7]3EBI-7797864,EBI-11991950
GJB1 [P08034]3EBI-7797864,EBI-17565645
GPR42 [O15529]3EBI-7797864,EBI-18076404
HACD4 [Q5VWC8]3EBI-7797864,EBI-18076069
HMOX1 [P09601]3EBI-7797864,EBI-2806151
HMOX2 [P30519]3EBI-7797864,EBI-712096
IER3 [P46695]3EBI-7797864,EBI-1748945
INSIG2 [Q9Y5U4]3EBI-7797864,EBI-8503746
ITGAM [P11215]3EBI-7797864,EBI-2568251
JAGN1 [Q8N5M9]3EBI-7797864,EBI-10266796
LAMB1 [P07942]3EBI-7797864,EBI-949174
LEPROTL1 [O95214]3EBI-7797864,EBI-750776
LHFPL5 [Q8TAF8]3EBI-7797864,EBI-2820517
LPAR3 [Q9UBY5]3EBI-7797864,EBI-12033434
LTC4S [Q16873]3EBI-7797864,EBI-12241118
MALL [Q13021]3EBI-7797864,EBI-750078
MARCHF2 [Q9P0N8]3EBI-7797864,EBI-10317612
MFF - isoform 5 [Q9GZY8-5]3EBI-7797864,EBI-11956541
MFSD12 - isoform 2 [Q6NUT3-2]3EBI-7797864,EBI-17295698
MFSD5 [Q6N075]3EBI-7797864,EBI-3920969
MFSD6 [Q6ZSS7]3EBI-7797864,EBI-2858252
MGLL [A0A0C4DFN3]3EBI-7797864,EBI-12866138
MMD2 - isoform 2 [Q8IY49-2]3EBI-7797864,EBI-13349813
MOSPD3 [O75425]3EBI-7797864,EBI-12179105
MS4A13 [Q5J8X5]3EBI-7797864,EBI-12070086
MYADM [Q96S97]3EBI-7797864,EBI-13301517
MYADML2 [A6NDP7]3EBI-7797864,EBI-17641390
NAT8 [Q9UHE5]3EBI-7797864,EBI-2863634
NEU1 [Q99519]3EBI-7797864,EBI-721517
NINJ2 [Q9NZG7]3EBI-7797864,EBI-10317425
NIPAL3 [Q6P499]3EBI-7797864,EBI-10252783
NKG7 [Q16617]3EBI-7797864,EBI-3919611
NRAC [Q8N912]3EBI-7797864,EBI-12051377
ORMDL2 [Q53FV1]3EBI-7797864,EBI-11075081
OTOP2 [Q7RTS6]3EBI-7797864,EBI-7642372
PGAP2 - isoform 5 [Q9UHJ9-5]3EBI-7797864,EBI-12092917
PKMYT1 - isoform 2 [Q99640-2]3EBI-7797864,EBI-12257782
PLP2 [Q04941]3EBI-7797864,EBI-608347
PLPP6 [Q8IY26]3EBI-7797864,EBI-11721828
PLPPR2 [Q96GM1]3EBI-7797864,EBI-12955265
PNLIPRP1 [P54315]3EBI-7797864,EBI-8652812
PPGB [Q59EV6]3EBI-7797864,EBI-14210385
PRAF2 [O60831]3EBI-7797864,EBI-2506064
PTCH1 - isoform M [Q13635-3]3EBI-7797864,EBI-14199621
REEP6 - isoform 2 [Q96HR9-2]3EBI-7797864,EBI-14065960
RHO [P08100]3EBI-7797864,EBI-1394177
RTP2 [Q5QGT7]3EBI-7797864,EBI-10244780
SACM1L [Q9NTJ5]3EBI-7797864,EBI-3917235
SEC22B [O75396]3EBI-7797864,EBI-1058865
SERP1 [Q9Y6X1]3EBI-7797864,EBI-10329948
SFTPC [P11686]3EBI-7797864,EBI-10197617
SLC13A4 [Q9UKG4]6EBI-7797864,EBI-12808018
SLC13A5 [Q86YT5]3EBI-7797864,EBI-12002412
SLC16A12 [Q6ZSM3]3EBI-7797864,EBI-17460560
SLC16A13 [Q7RTY0]3EBI-7797864,EBI-12243266
SLC30A2 [Q9BRI3]3EBI-7797864,EBI-8644112
SLC35B1 [P78383]3EBI-7797864,EBI-12147661
SLC35B4 [Q969S0]3EBI-7797864,EBI-10281213
SLC38A1 [Q9H2H9]6EBI-7797864,EBI-9978441
SLC39A2 [Q9NP94]3EBI-7797864,EBI-12898013
SLC39A9 [Q9NUM3]3EBI-7797864,EBI-2823239
SLC41A1 [Q8IVJ1]3EBI-7797864,EBI-12266234
SLC41A2 [Q96JW4]3EBI-7797864,EBI-10290130
SLC46A3 - isoform 2 [Q7Z3Q1-2]3EBI-7797864,EBI-18074862
SLC66A2 [Q8N2U9]3EBI-7797864,EBI-3907610
SLC6A12 [P48065]3EBI-7797864,EBI-3843589
SLC7A1 [P30825]3EBI-7797864,EBI-4289564
SMCO4 [Q9NRQ5]3EBI-7797864,EBI-8640191
SMIM3 [Q9BZL3]3EBI-7797864,EBI-741850
STRIT1 [P0DN84]3EBI-7797864,EBI-12200293
STX12 [Q86Y82]3EBI-7797864,EBI-2691717
STX3 [Q13277]3EBI-7797864,EBI-1394295
STX8 [Q9UNK0]3EBI-7797864,EBI-727240
SYNJ2BP [P57105]3EBI-7797864,EBI-1049004
TECR [Q9NZ01]3EBI-7797864,EBI-2877718
THBD [P07204]3EBI-7797864,EBI-941422
TM4SF19 [Q96DZ7]3EBI-7797864,EBI-6448756
TM4SF4 [P48230]3EBI-7797864,EBI-8650934
TMBIM6 [P55061]3EBI-7797864,EBI-1045825
TMEM107 [Q6UX40]3EBI-7797864,EBI-12845616
TMEM11 [P17152]3EBI-7797864,EBI-723946
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-7797864,EBI-10694905
TMEM140 [Q9NV12]3EBI-7797864,EBI-2844246
TMEM147 [Q9BVK8]3EBI-7797864,EBI-348587
TMEM14B [Q9NUH8]3EBI-7797864,EBI-8638294
TMEM176A [Q96HP8]3EBI-7797864,EBI-2800645
TMEM187 [Q14656]3EBI-7797864,EBI-13046724
TMEM19 [Q96HH6]3EBI-7797864,EBI-741829
TMEM218 [A2RU14]3EBI-7797864,EBI-10173151
TMEM222 [Q9H0R3]3EBI-7797864,EBI-347385
TMEM229B [Q8NBD8]3EBI-7797864,EBI-12195227
TMEM239 - isoform 2 [Q8WW34-2]3EBI-7797864,EBI-11528917
TMEM243 [Q9BU79]3EBI-7797864,EBI-12887458
TMEM254 [Q8TBM7]3EBI-7797864,EBI-11956809
TMEM262 [E9PQX1]3EBI-7797864,EBI-17180389
TMEM42 [Q69YG0]3EBI-7797864,EBI-12038591
TMEM86A [Q8N2M4]3EBI-7797864,EBI-12015604
TMEM86B [Q8N661]3EBI-7797864,EBI-2548832
TMPPE [Q6ZT21]3EBI-7797864,EBI-11724433
TNFRSF10C [O14798]3EBI-7797864,EBI-717441
TRAM1L1 [Q8N609]3EBI-7797864,EBI-11996766
TSNARE1 [A0AVG3]3EBI-7797864,EBI-12003468
TSPAN2 [O60636]3EBI-7797864,EBI-3914288
TSPO2 [Q5TGU0]3EBI-7797864,EBI-12195249
TUSC5 [A5PKU2]3EBI-7797864,EBI-11988865
UBE2J1 [Q9Y385]3EBI-7797864,EBI-988826
UBIAD1 [Q9Y5Z9]3EBI-7797864,EBI-2819725
UNC93B1 [Q9H1C4]3EBI-7797864,EBI-4401271
VAMP3 [Q15836]3EBI-7797864,EBI-722343
VAPA [Q9P0L0]3EBI-7797864,EBI-1059156
VAPB [O95292]3EBI-7797864,EBI-1188298
VTI1B [Q9UEU0]3EBI-7797864,EBI-723716
WFDC2 [Q14508]3EBI-7797864,EBI-723529
WFS1 [O76024]3EBI-7797864,EBI-720609
YIF1A [O95070]3EBI-7797864,EBI-2799703
YIPF4 [Q9BSR8]3EBI-7797864,EBI-751253
YIPF6 [Q96EC8]3EBI-7797864,EBI-751210
ZDHHC15 [Q96MV8]3EBI-7797864,EBI-12837904
ZDHHC22 [Q8N966]3EBI-7797864,EBI-10268111

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
107411, 54 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P11912

Protein interaction database and analysis system

More...
IntActi
P11912, 198 interactors

Molecular INTeraction database

More...
MINTi
P11912

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000221972

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P11912, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11912

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P11912

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 116Ig-like C2-typeAdd BLAST84
Domaini177 – 205ITAMPROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S1DI, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154363

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_106774_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11912

KEGG Orthology (KO)

More...
KOi
K06506

Identification of Orthologs from Complete Genome Data

More...
OMAi
RWQNEKF

Database of Orthologous Groups

More...
OrthoDBi
1165385at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11912

TreeFam database of animal gene trees

More...
TreeFami
TF336032

Family and domain databases

Database of protein disorder

More...
DisProti
DP01486

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039695, CD79a/CD79b
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013151, Immunoglobulin
IPR003110, Phos_immunorcpt_sig_ITAM

The PANTHER Classification System

More...
PANTHERi
PTHR14334, PTHR14334, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00047, ig, 1 hit
PF02189, ITAM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00077, ITAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS51055, ITAM_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P11912-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGGPGVLQA LPATIFLLFL LSAVYLGPGC QALWMHKVPA SLMVSLGEDA
60 70 80 90 100
HFQCPHNSSN NANVTWWRVL HGNYTWPPEF LGPGEDPNGT LIIQNVNKSH
110 120 130 140 150
GGIYVCRVQE GNESYQQSCG TYLRVRQPPP RPFLDMGEGT KNRIITAEGI
160 170 180 190 200
ILLFCAVVPG TLLLFRKRWQ NEKLGLDAGD EYEDENLYEG LNLDDCSMYE
210 220
DISRGLQGTY QDVGSLNIGD VQLEKP
Length:226
Mass (Da):25,038
Last modified:June 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E5B837409969292
GO
Isoform 2 (identifier: P11912-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     89-127: GTLIIQNVNKSHGGIYVCRVQEGNESYQQSCGTYLRVRQ → E

Show »
Length:188
Mass (Da):20,786
Checksum:i176B170B710E6EEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QX61M0QX61_HUMAN
B-cell antigen receptor complex-ass...
CD79A
258Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti47G → V in BAD97091 (Ref. 10) Curated1
Sequence conflicti69V → I in AAA60270 (PubMed:1639443).Curated1
Sequence conflicti189E → G in BAD97091 (Ref. 10) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00247689 – 127GTLII…LRVRQ → E in isoform 2. 2 PublicationsAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S46706 mRNA Translation: AAB23558.1
M80462 mRNA Translation: AAA59556.1
M74721 mRNA Translation: AAA60270.1
S75217 mRNA Translation: AAB20812.1
M86921 mRNA Translation: AAA59557.1
U05259 Genomic DNA Translation: AAA20495.1
S79248 mRNA Translation: AAC60653.1
X83540 mRNA Translation: CAA58523.1
AK223371 mRNA Translation: BAD97091.1
X13451 mRNA Translation: CAA31802.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12589.1 [P11912-1]
CCDS46088.1 [P11912-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
I54539, A46477
S12504

NCBI Reference Sequences

More...
RefSeqi
NP_001774.1, NM_001783.3 [P11912-1]
NP_067612.1, NM_021601.3 [P11912-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000221972; ENSP00000221972; ENSG00000105369 [P11912-1]
ENST00000444740; ENSP00000400605; ENSG00000105369 [P11912-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
973

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:973

UCSC genome browser

More...
UCSCi
uc002oru.4, human [P11912-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

CD79Abase

CD79A mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S46706 mRNA Translation: AAB23558.1
M80462 mRNA Translation: AAA59556.1
M74721 mRNA Translation: AAA60270.1
S75217 mRNA Translation: AAB20812.1
M86921 mRNA Translation: AAA59557.1
U05259 Genomic DNA Translation: AAA20495.1
S79248 mRNA Translation: AAC60653.1
X83540 mRNA Translation: CAA58523.1
AK223371 mRNA Translation: BAD97091.1
X13451 mRNA Translation: CAA31802.1 Sequence problems.
CCDSiCCDS12589.1 [P11912-1]
CCDS46088.1 [P11912-2]
PIRiI54539, A46477
S12504
RefSeqiNP_001774.1, NM_001783.3 [P11912-1]
NP_067612.1, NM_021601.3 [P11912-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CV9NMR-A184-195[»]
SMRiP11912
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107411, 54 interactors
ELMiP11912
IntActiP11912, 198 interactors
MINTiP11912
STRINGi9606.ENSP00000221972

PTM databases

GlyConnecti1028, 1 N-Linked glycan (1 site)
GlyGeniP11912, 9 sites
iPTMnetiP11912
PhosphoSitePlusiP11912

Polymorphism and mutation databases

BioMutaiCD79A
DMDMi547896

Proteomic databases

CPTACiCPTAC-1178
EPDiP11912
MassIVEiP11912
MaxQBiP11912
PaxDbiP11912
PeptideAtlasiP11912
PRIDEiP11912
ProteomicsDBi52811 [P11912-1]
52812 [P11912-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2990, 2149 antibodies

The DNASU plasmid repository

More...
DNASUi
973

Genome annotation databases

EnsembliENST00000221972; ENSP00000221972; ENSG00000105369 [P11912-1]
ENST00000444740; ENSP00000400605; ENSG00000105369 [P11912-2]
GeneIDi973
KEGGihsa:973
UCSCiuc002oru.4, human [P11912-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
973
DisGeNETi973
EuPathDBiHostDB:ENSG00000105369.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CD79A
HGNCiHGNC:1698, CD79A
HPAiENSG00000105369, Group enriched (blood, intestine, lymphoid tissue)
MalaCardsiCD79A
MIMi112205, gene
613501, phenotype
neXtProtiNX_P11912
OpenTargetsiENSG00000105369
Orphaneti33110, Autosomal agammaglobulinemia
PharmGKBiPA26237

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S1DI, Eukaryota
GeneTreeiENSGT00940000154363
HOGENOMiCLU_106774_0_0_1
InParanoidiP11912
KOiK06506
OMAiRWQNEKF
OrthoDBi1165385at2759
PhylomeDBiP11912
TreeFamiTF336032

Enzyme and pathway databases

PathwayCommonsiP11912
ReactomeiR-HSA-5690714, CD22 mediated BCR regulation
R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiP11912
SIGNORiP11912

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
973, 18 hits in 870 CRISPR screens
EvolutionaryTraceiP11912

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CD79A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
973
PharosiP11912, Tbio

Protein Ontology

More...
PROi
PR:P11912
RNActiP11912, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105369, Expressed in lymph node and 162 other tissues
ExpressionAtlasiP11912, baseline and differential
GenevisibleiP11912, HS

Family and domain databases

DisProtiDP01486
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR039695, CD79a/CD79b
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013151, Immunoglobulin
IPR003110, Phos_immunorcpt_sig_ITAM
PANTHERiPTHR14334, PTHR14334, 1 hit
PfamiView protein in Pfam
PF00047, ig, 1 hit
PF02189, ITAM, 1 hit
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00077, ITAM, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS51055, ITAM_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD79A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11912
Secondary accession number(s): A0N775, Q53FB8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: June 1, 1994
Last modified: August 12, 2020
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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