UniProtKB - P11909 (GPX1_RABIT)
Protein
Glutathione peroxidase 1
Gene
GPX1
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
Protects the hemoglobin in erythrocytes from oxidative breakdown. In platelets, plays a crucial role of glutathione peroxidase in the arachidonic acid metabolism.By similarity
Catalytic activityi
- EC:1.11.1.9By similarityThis reaction proceeds in the forwardBy similarity direction.
- (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2OBy similarityThis reaction proceeds in the forwardBy similarity direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 46 | 1 | ||
Sitei | 46 | Subject to oxidation and hydroselenide loss to dehydroalanineBy similarity | 1 |
GO - Molecular functioni
- glutathione peroxidase activity Source: UniProtKB
- phospholipid-hydroperoxide glutathione peroxidase activity Source: UniProtKB
GO - Biological processi
- arachidonic acid metabolic process Source: UniProtKB
- lipoxygenase pathway Source: UniProtKB
- response to oxidative stress Source: InterPro
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Protein family/group databases
PeroxiBasei | 3729, OcuGPx01 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione peroxidase 1Curated (EC:1.11.1.9By similarity)Short name: GPx-1 Short name: GSHPx-1 Alternative name(s): Cellular glutathione peroxidase |
Gene namesi | Name:GPX1 |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066616 | 1 – 200 | Glutathione peroxidase 1Add BLAST | 200 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 31 | PhosphoserineBy similarity | 1 | |
Modified residuei | 85 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 85 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 111 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 111 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 118 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 145 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 145 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 194 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
During periods of oxidative stress, Sec-46 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.By similarity
Keywords - PTMi
Acetylation, PhosphoproteinInteractioni
Subunit structurei
Homotetramer.
Interacts with MIEN1 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9986.ENSOCUP00000005141 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glutathione peroxidase family.Curated
Phylogenomic databases
eggNOGi | KOG1651, Eukaryota |
InParanoidi | P11909 |
OMAi | MNDLQRR |
OrthoDBi | 1483113at2759 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P11909-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCAARMAAAA QSVYSFSAHP LAGGEPVNLG SLRGKVLLIE NVASLUGTTV
60 70 80 90 100
RDYTQMNELQ ERLGPRALVV LGFPCNQFGH QENAKNEEIL NSLKYVRPGG
110 120 130 140 150
GFEPNFMLFQ KCEVNGAKAS PLFAFLREAL PPPSDDPTAL MTDPKFITWC
160 170 180 190 200
PVCRNDVSWS FEKFLVGPDG VPVRRYSRRF PTIDIEPDIQ ALLSKGSGGA
Non-standard residue
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-standard residuei | 46 | Selenocysteine | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13837 mRNA Translation: CAB43546.1 |
PIRi | S03723 |
RefSeqi | NP_001078913.1, NM_001085444.1 |
Genome annotation databases
GeneIDi | 100009258 |
KEGGi | ocu:100009258 |
Keywords - Coding sequence diversityi
SelenocysteineSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13837 mRNA Translation: CAB43546.1 |
PIRi | S03723 |
RefSeqi | NP_001078913.1, NM_001085444.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000005141 |
Protein family/group databases
PeroxiBasei | 3729, OcuGPx01 |
Genome annotation databases
GeneIDi | 100009258 |
KEGGi | ocu:100009258 |
Organism-specific databases
CTDi | 2876 |
Phylogenomic databases
eggNOGi | KOG1651, Eukaryota |
InParanoidi | P11909 |
OMAi | MNDLQRR |
OrthoDBi | 1483113at2759 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPX1_RABIT | |
Accessioni | P11909Primary (citable) accession number: P11909 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | February 26, 2008 | |
Last modified: | April 7, 2021 | |
This is version 121 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families