UniProtKB - P11908 (PRPS2_HUMAN)
Ribose-phosphate pyrophosphokinase 2
PRPS2
Functioni
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Catalytic activityi
- EC:2.7.6.1
Cofactori
Activity regulationi
: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I). This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 128 | MagnesiumSequence analysis | 1 | |
Metal bindingi | 130 | MagnesiumSequence analysis | 1 | |
Binding sitei | 130 | ATPBy similarity | 1 | |
Metal bindingi | 139 | MagnesiumSequence analysis | 1 | |
Metal bindingi | 143 | MagnesiumSequence analysis | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 96 – 101 | ATPBy similarity | 6 |
GO - Molecular functioni
- ADP binding Source: Ensembl
- AMP binding Source: Ensembl
- ATP binding Source: UniProtKB
- carbohydrate binding Source: Ensembl
- GDP binding Source: Ensembl
- identical protein binding Source: IntAct
- kinase activity Source: UniProtKB-KW
- magnesium ion binding Source: Ensembl
- protein homodimerization activity Source: UniProtKB
- ribose phosphate diphosphokinase activity Source: UniProtKB
GO - Biological processi
- 5-phosphoribose 1-diphosphate biosynthetic process Source: GO_Central
- AMP biosynthetic process Source: Ensembl
- animal organ regeneration Source: Ensembl
- nucleobase-containing compound metabolic process Source: ProtInc
- nucleoside metabolic process Source: InterPro
- purine nucleotide biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Nucleotide biosynthesis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P11908 |
Reactomei | R-HSA-73843, 5-Phosphoribose 1-diphosphate biosynthesis |
SignaLinki | P11908 |
SIGNORi | P11908 |
UniPathwayi | UPA00087;UER00172 |
Names & Taxonomyi
Protein namesi | Recommended name: Ribose-phosphate pyrophosphokinase 2 (EC:2.7.6.1)Alternative name(s): PPRibP Phosphoribosyl pyrophosphate synthase II Short name: PRS-II |
Gene namesi | Name:PRPS2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9465, PRPS2 |
MIMi | 311860, gene |
neXtProti | NX_P11908 |
VEuPathDBi | HostDB:ENSG00000101911 |
Subcellular locationi
Other locations
- cytoplasm Source: GO_Central
- ribose phosphate diphosphokinase complex Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 5634 |
OpenTargetsi | ENSG00000101911 |
PharmGKBi | PA33820 |
Miscellaneous databases
Pharosi | P11908, Tbio |
Genetic variation databases
BioMutai | PRPS2 |
DMDMi | 125583 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000141074 | 2 – 318 | Ribose-phosphate pyrophosphokinase 2Add BLAST | 317 |
Proteomic databases
EPDi | P11908 |
jPOSTi | P11908 |
MassIVEi | P11908 |
MaxQBi | P11908 |
PaxDbi | P11908 |
PeptideAtlasi | P11908 |
PRIDEi | P11908 |
ProteomicsDBi | 52809 [P11908-1] 52810 [P11908-2] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00219617 P11908 |
PTM databases
GlyGeni | P11908, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P11908 |
MetOSitei | P11908 |
PhosphoSitePlusi | P11908 |
SwissPalmi | P11908 |
Expressioni
Gene expression databases
Bgeei | ENSG00000101911, Expressed in testis and 236 other tissues |
ExpressionAtlasi | P11908, baseline and differential |
Genevisiblei | P11908, HS |
Organism-specific databases
HPAi | ENSG00000101911, Tissue enhanced (ovary, parathyroid gland) |
Interactioni
Subunit structurei
Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).
By similarityBinary interactionsi
P11908
Isoform 2 [P11908-2]
With | #Exp. | IntAct |
---|---|---|
PRPS1 [P60891] | 4 | EBI-12063547,EBI-749195 |
PRPSAP1 [Q14558] | 3 | EBI-12063547,EBI-724449 |
PRPSAP2 [O60256] | 4 | EBI-12063547,EBI-724960 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111617, 210 interactors |
IntActi | P11908, 50 interactors |
MINTi | P11908 |
STRINGi | 9606.ENSP00000381504 |
Miscellaneous databases
RNActi | P11908, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 212 – 227 | Binding of phosphoribosylpyrophosphateSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1448, Eukaryota |
GeneTreei | ENSGT00950000182803 |
HOGENOMi | CLU_033546_4_0_1 |
InParanoidi | P11908 |
OMAi | EVHAYAT |
PhylomeDBi | P11908 |
TreeFami | TF106366 |
Family and domain databases
CDDi | cd06223, PRTases_typeI, 1 hit |
Gene3Di | 3.40.50.2020, 2 hits |
HAMAPi | MF_00583_B, RibP_PPkinase_B, 1 hit |
InterProi | View protein in InterPro IPR000842, PRib_PP_synth_CS IPR029099, Pribosyltran_N IPR000836, PRibTrfase_dom IPR029057, PRTase-like IPR005946, Rib-P_diPkinase IPR037515, Rib-P_diPkinase_bac |
PANTHERi | PTHR10210, PTHR10210, 1 hit |
Pfami | View protein in Pfam PF14572, Pribosyl_synth, 1 hit PF13793, Pribosyltran_N, 1 hit |
SUPFAMi | SSF53271, SSF53271, 1 hit |
TIGRFAMsi | TIGR01251, ribP_PPkin, 1 hit |
PROSITEi | View protein in PROSITE PS00114, PRPP_SYNTHASE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPNIVLFSGS SHQDLSQRVA DRLGLELGKV VTKKFSNQET SVEIGESVRG
60 70 80 90 100
EDVYIIQSGC GEINDNLMEL LIMINACKIA SSSRVTAVIP CFPYARQDKK
110 120 130 140 150
DKSRAPISAK LVANMLSVAG ADHIITMDLH ASQIQGFFDI PVDNLYAEPA
160 170 180 190 200
VLQWIRENIA EWKNCIIVSP DAGGAKRVTS IADRLNVEFA LIHKERKKAN
210 220 230 240 250
EVDRMVLVGD VKDRVAILVD DMADTCGTIC HAADKLLSAG ATKVYAILTH
260 270 280 290 300
GIFSGPAISR INNAAFEAVV VTNTIPQEDK MKHCTKIQVI DISMILAEAI
310
RRTHNGESVS YLFSHVPL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YTJ7 | D3YTJ7_HUMAN | Ribose-phosphate pyrophosphokinase ... | PRPS2 | 200 | Annotation score: | ||
H7C540 | H7C540_HUMAN | Ribose-phosphate pyrophosphokinase ... | PRPS2 | 173 | Annotation score: | ||
A6NMS2 | A6NMS2_HUMAN | Ribose-phosphate pyrophosphokinase ... | PRPS2 | 147 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027769 | 102 | K → KVGE in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00971 mRNA Translation: CAA68785.1 BC030019 mRNA Translation: AAH30019.2 Different initiation. BC040483 mRNA Translation: AAH40483.3 BC110875 mRNA Translation: AAI10876.2 BC119662 mRNA Translation: AAI19663.1 BC119663 mRNA Translation: AAI19664.1 D28134 Genomic DNA Translation: BAA05676.1 |
CCDSi | CCDS14150.1 [P11908-1] CCDS43918.1 [P11908-2] |
PIRi | S02778, KIHUR2 |
RefSeqi | NP_001034180.1, NM_001039091.2 [P11908-2] NP_002756.1, NM_002765.4 [P11908-1] |
Genome annotation databases
Ensembli | ENST00000380668; ENSP00000370043; ENSG00000101911 ENST00000398491; ENSP00000381504; ENSG00000101911 [P11908-2] |
GeneIDi | 5634 |
KEGGi | hsa:5634 |
MANE-Selecti | ENST00000380668.10; ENSP00000370043.5; NM_002765.5; NP_002756.1 |
UCSCi | uc004cva.4, human [P11908-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00971 mRNA Translation: CAA68785.1 BC030019 mRNA Translation: AAH30019.2 Different initiation. BC040483 mRNA Translation: AAH40483.3 BC110875 mRNA Translation: AAI10876.2 BC119662 mRNA Translation: AAI19663.1 BC119663 mRNA Translation: AAI19664.1 D28134 Genomic DNA Translation: BAA05676.1 |
CCDSi | CCDS14150.1 [P11908-1] CCDS43918.1 [P11908-2] |
PIRi | S02778, KIHUR2 |
RefSeqi | NP_001034180.1, NM_001039091.2 [P11908-2] NP_002756.1, NM_002765.4 [P11908-1] |
3D structure databases
SMRi | P11908 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111617, 210 interactors |
IntActi | P11908, 50 interactors |
MINTi | P11908 |
STRINGi | 9606.ENSP00000381504 |
PTM databases
GlyGeni | P11908, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P11908 |
MetOSitei | P11908 |
PhosphoSitePlusi | P11908 |
SwissPalmi | P11908 |
Genetic variation databases
BioMutai | PRPS2 |
DMDMi | 125583 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00219617 P11908 |
Proteomic databases
EPDi | P11908 |
jPOSTi | P11908 |
MassIVEi | P11908 |
MaxQBi | P11908 |
PaxDbi | P11908 |
PeptideAtlasi | P11908 |
PRIDEi | P11908 |
ProteomicsDBi | 52809 [P11908-1] 52810 [P11908-2] |
Protocols and materials databases
Antibodypediai | 8471, 247 antibodies from 29 providers |
DNASUi | 5634 |
Genome annotation databases
Ensembli | ENST00000380668; ENSP00000370043; ENSG00000101911 ENST00000398491; ENSP00000381504; ENSG00000101911 [P11908-2] |
GeneIDi | 5634 |
KEGGi | hsa:5634 |
MANE-Selecti | ENST00000380668.10; ENSP00000370043.5; NM_002765.5; NP_002756.1 |
UCSCi | uc004cva.4, human [P11908-1] |
Organism-specific databases
CTDi | 5634 |
DisGeNETi | 5634 |
GeneCardsi | PRPS2 |
HGNCi | HGNC:9465, PRPS2 |
HPAi | ENSG00000101911, Tissue enhanced (ovary, parathyroid gland) |
MIMi | 311860, gene |
neXtProti | NX_P11908 |
OpenTargetsi | ENSG00000101911 |
PharmGKBi | PA33820 |
VEuPathDBi | HostDB:ENSG00000101911 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1448, Eukaryota |
GeneTreei | ENSGT00950000182803 |
HOGENOMi | CLU_033546_4_0_1 |
InParanoidi | P11908 |
OMAi | EVHAYAT |
PhylomeDBi | P11908 |
TreeFami | TF106366 |
Enzyme and pathway databases
UniPathwayi | UPA00087;UER00172 |
PathwayCommonsi | P11908 |
Reactomei | R-HSA-73843, 5-Phosphoribose 1-diphosphate biosynthesis |
SignaLinki | P11908 |
SIGNORi | P11908 |
Miscellaneous databases
BioGRID-ORCSi | 5634, 14 hits in 671 CRISPR screens |
ChiTaRSi | PRPS2, human |
GenomeRNAii | 5634 |
Pharosi | P11908, Tbio |
PROi | PR:P11908 |
RNActi | P11908, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101911, Expressed in testis and 236 other tissues |
ExpressionAtlasi | P11908, baseline and differential |
Genevisiblei | P11908, HS |
Family and domain databases
CDDi | cd06223, PRTases_typeI, 1 hit |
Gene3Di | 3.40.50.2020, 2 hits |
HAMAPi | MF_00583_B, RibP_PPkinase_B, 1 hit |
InterProi | View protein in InterPro IPR000842, PRib_PP_synth_CS IPR029099, Pribosyltran_N IPR000836, PRibTrfase_dom IPR029057, PRTase-like IPR005946, Rib-P_diPkinase IPR037515, Rib-P_diPkinase_bac |
PANTHERi | PTHR10210, PTHR10210, 1 hit |
Pfami | View protein in Pfam PF14572, Pribosyl_synth, 1 hit PF13793, Pribosyltran_N, 1 hit |
SUPFAMi | SSF53271, SSF53271, 1 hit |
TIGRFAMsi | TIGR01251, ribP_PPkin, 1 hit |
PROSITEi | View protein in PROSITE PS00114, PRPP_SYNTHASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRPS2_HUMAN | |
Accessioni | P11908Primary (citable) accession number: P11908 Secondary accession number(s): Q0VDH9 Q2TAK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 219 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families