PRPS2

Functionⁱ

Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

Catalytic activityⁱ

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactorⁱ

Activity regulationⁱ

Activated by magnesium and inorganic phosphate. Competitively or non-competitively inhibited by ADP, 2,3-bisphosphoglyceride or GDP.

Pathwayⁱ: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I).
Proteins known to be involved in this subpathway in this organism are:

Ribose-phosphate pyrophosphokinase 2 (PRPS2), Ribose-phosphate pyrophosphokinase 3 (PRPS1L1), Ribose-phosphate pyrophosphokinase 1 (PRPS1)

This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	128	MagnesiumSequence analysis	1
Metal bindingⁱ	130	MagnesiumSequence analysis	1
Binding siteⁱ	130	ATPBy similarity	1
Metal bindingⁱ	139	MagnesiumSequence analysis	1
Metal bindingⁱ	143	MagnesiumSequence analysis	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	96 – 101	ATPBy similarity		6

GO - Molecular functionⁱ

ADP binding Source: Ensembl
AMP binding Source: Ensembl
ATP binding Source: UniProtKB
carbohydrate binding Source: Ensembl
GDP binding Source: Ensembl
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956
kinase activity Source: UniProtKB-KW
magnesium ion binding Source: Ensembl
protein homodimerization activity Source: UniProtKB
ribose phosphate diphosphokinase activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

5-phosphoribose 1-diphosphate biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
AMP biosynthetic process Source: Ensembl
animal organ regeneration Source: Ensembl
nucleobase-containing compound metabolic process
Source: ProtInc
Traceable author statementⁱ
- 2538352
nucleoside metabolic process Source: InterPro
nucleotide biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
purine nucleotide biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS02317-MONOMER
Reactomeⁱ	R-HSA-73843 5-Phosphoribose 1-diphosphate biosynthesis
UniPathwayⁱ	UPA00087;UER00172

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ribose-phosphate pyrophosphokinase 2 (EC:2.7.6.1) Alternative name(s): PPRibP Phosphoribosyl pyrophosphate synthase II Short name: PRS-II
Gene namesⁱ	Name:PRPS2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101911.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9465 PRPS2
MIMⁱ	311860 gene
neXtProtⁱ	NX_P11908

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5634
Open Targets More...OpenTargetsⁱ	ENSG00000101911
PharmGKBⁱ	PA33820

Polymorphism and mutation databases

BioMutaⁱ	PRPS2
DMDMⁱ	125583

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000141074	2 – 318	Ribose-phosphate pyrophosphokinase 2Add BLAST		317

Proteomic databases

EPDⁱ	P11908
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P11908
PaxDbⁱ	P11908
PeptideAtlas More...PeptideAtlasⁱ	P11908
PRIDEⁱ	P11908
ProteomicsDBⁱ	52809 52810 [P11908-2]

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00219617 P11908

REPRODUCTION-2DPAGEⁱ

IPI00219617
P11908

PTM databases

iPTMnetⁱ	P11908
PhosphoSitePlusⁱ	P11908
SwissPalmⁱ	P11908

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000101911 Expressed in 222 organ(s), highest expression level in testis
CleanExⁱ	HS_PRPS2
ExpressionAtlasⁱ	P11908 baseline and differential
Genevisibleⁱ	P11908 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB070417

HPAⁱ

CAB070417

Interactionⁱ

Subunit structureⁱ

Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		4	EBI-4290895,EBI-4290895
NOTCH2NL	Q7Z3S9	3	EBI-4290895,EBI-945833
PRPS1	P60891	6	EBI-4290895,EBI-749195
PRPSAP1	Q14558	5	EBI-4290895,EBI-724449
WDYHV1	Q96HA8	3	EBI-4290895,EBI-741158

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956
protein homodimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111617, 24 interactors
IntActⁱ	P11908, 10 interactors
STRINGⁱ	9606.ENSP00000381504

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P11908
SMRⁱ	P11908
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	212 – 227	Binding of phosphoribosylpyrophosphateSequence analysisAdd BLAST		16

Sequence similaritiesⁱ

Belongs to the ribose-phosphate pyrophosphokinase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1448 Eukaryota COG0462 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074583
HOGENOMⁱ	HOG000210451
HOVERGENⁱ	HBG001520
InParanoidⁱ	P11908
KEGG Orthology (KO) More...KOⁱ	K00948
OMAⁱ	LLPEHKC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ZG8
PhylomeDBⁱ	P11908
TreeFamⁱ	TF106366

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06223 PRTases_typeI, 1 hit
HAMAPⁱ	MF_00583_B RibP_PPkinase_B, 1 hit
InterProⁱ	View protein in InterPro IPR000842 PRib_PP_synth_CS IPR029099 Pribosyltran_N IPR000836 PRibTrfase_dom IPR029057 PRTase-like IPR005946 Rib-P_diPkinase IPR037515 Rib-P_diPkinase_bac
PANTHERⁱ	PTHR10210 PTHR10210, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14572 Pribosyl_synth, 1 hit PF13793 Pribosyltran_N, 1 hit
SUPFAMⁱ	SSF53271 SSF53271, 1 hit
TIGRFAMsⁱ	TIGR01251 ribP_PPkin, 1 hit
PROSITEⁱ	View protein in PROSITE PS00114 PRPP_SYNTHASE, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P11908-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPNIVLFSGS SHQDLSQRVA DRLGLELGKV VTKKFSNQET SVEIGESVRG 
        60         70         80         90        100
EDVYIIQSGC GEINDNLMEL LIMINACKIA SSSRVTAVIP CFPYARQDKK 
       110        120        130        140        150
DKSRAPISAK LVANMLSVAG ADHIITMDLH ASQIQGFFDI PVDNLYAEPA 
       160        170        180        190        200
VLQWIRENIA EWKNCIIVSP DAGGAKRVTS IADRLNVEFA LIHKERKKAN 
       210        220        230        240        250
EVDRMVLVGD VKDRVAILVD DMADTCGTIC HAADKLLSAG ATKVYAILTH 
       260        270        280        290        300
GIFSGPAISR INNAAFEAVV VTNTIPQEDK MKHCTKIQVI DISMILAEAI 
       310 
RRTHNGESVS YLFSHVPL

Length:318

Mass (Da):34,769

Last modified:January 23, 2007 - v2

Checksum:ⁱ72A2873408250C31

GO

Isoform 2 (identifier: P11908-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
102-102: K → KVGE

« Hide

        10         20         30         40         50
MPNIVLFSGS SHQDLSQRVA DRLGLELGKV VTKKFSNQET SVEIGESVRG 
        60         70         80         90        100
EDVYIIQSGC GEINDNLMEL LIMINACKIA SSSRVTAVIP CFPYARQDKK 
       110        120        130        140        150
DKVGESRAPI SAKLVANMLS VAGADHIITM DLHASQIQGF FDIPVDNLYA 
       160        170        180        190        200
EPAVLQWIRE NIAEWKNCII VSPDAGGAKR VTSIADRLNV EFALIHKERK 
       210        220        230        240        250
KANEVDRMVL VGDVKDRVAI LVDDMADTCG TICHAADKLL SAGATKVYAI 
       260        270        280        290        300
LTHGIFSGPA ISRINNAAFE AVVVTNTIPQ EDKMKHCTKI QVIDISMILA 
       310        320 
EAIRRTHNGE SVSYLFSHVP L

Note: No experimental confirmation available.

Show »

Length:321

Mass (Da):35,054

Checksum:ⁱEDD88B9D33A55A37

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3YTJ7	D3YTJ7_HUMAN	Ribose-phosphate pyrophosphokinase ... Ribose-phosphate pyrophosphokinase 2	PRPS2	200	Annotation score:
H7C540	H7C540_HUMAN	Ribose-phosphate pyrophosphokinase ... Ribose-phosphate pyrophosphokinase 2	PRPS2	173	Annotation score:
A6NMS2	A6NMS2_HUMAN	Ribose-phosphate pyrophosphokinase ... Ribose-phosphate pyrophosphokinase 2	PRPS2	147	Annotation score:

Sequence cautionⁱ

The sequence AAH30019 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_027769	102	K → KVGE in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00971 mRNA Translation: CAA68785.1 BC030019 mRNA Translation: AAH30019.2 Different initiation. BC040483 mRNA Translation: AAH40483.3 BC110875 mRNA Translation: AAI10876.2 BC119662 mRNA Translation: AAI19663.1 BC119663 mRNA Translation: AAI19664.1 D28134 Genomic DNA Translation: BAA05676.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14150.1 [P11908-1] CCDS43918.1 [P11908-2]
PIRⁱ	S02778 KIHUR2
NCBI Reference Sequences More...RefSeqⁱ	NP_001034180.1, NM_001039091.2 [P11908-2] NP_002756.1, NM_002765.4 [P11908-1]
UniGeneⁱ	Hs.654581

Genome annotation databases

Ensemblⁱ	ENST00000380668; ENSP00000370043; ENSG00000101911 [P11908-1] ENST00000398491; ENSP00000381504; ENSG00000101911 [P11908-2]
GeneIDⁱ	5634
KEGGⁱ	hsa:5634
UCSC genome browser More...UCSCⁱ	uc004cva.4 human [P11908-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
P11908	Ribose-phosphate pyrophosphokinase 2		MACFA		318	UniRef100_P11908
Ribose-phosphate pyrophosphokinase 2		PONAB		318
Phosphoribosyl pyrophosphate synthetase 2		CALJA		497
Uncharacterized protein		NOMLE		251
Ribose-phosphate pyrophosphokinase 2 isoform 2		MACMU		318
+11
P11908-2	Testicular secretory protein Li 41		HUMAN		321	UniRef100_A0A140VK41
Ribose-phosphate pyrophosphokinase 2 isoform 1		MACMU		321
PRPS2 isoform 4		PANTR		321
Uncharacterized protein		COLAP		321
PRPS2 isoform 4		PONAB		321
+5

Protein	Similar proteins		Species	Score	Length	Source
P11908	Ribose-phosphate pyrophosphokinase 2		MACFA		318	UniRef90_P11908
Ribose-phosphate pyrophosphokinase 2		PONAB		318
Phosphoribosyl pyrophosphate synthetase 2		CALJA		497
Uncharacterized protein		NOMLE		251
Ribose-phosphate pyrophosphokinase 2 isoform 2		MACMU		318
+11
P11908-2	Ribose-phosphate pyrophosphokinase 1	)	HUMAN		318	UniRef90_P60891
Ribose-phosphate pyrophosphokinase 1		BOVIN		318
Ribose-phosphate pyrophosphokinase 1		MOUSE		318
Ribose-phosphate pyrophosphokinase 1		PONAB		318
Ribose-phosphate pyrophosphokinase 1		RAT		318
+594

Protein	Similar proteins		Species	Score	Length	Source
P11908	Ribose-phosphate pyrophosphokinase 2		MACFA		318	UniRef50_P11908
Ribose-phosphate pyrophosphokinase 2		PONAB		318
Phosphoribosyl pyrophosphate synthetase 2		CALJA		497
Uncharacterized protein		NOMLE		251
Ribose-phosphate pyrophosphokinase 2 isoform 2		MACMU		318
+261
P11908-2	Ribose-phosphate pyrophosphokinase 1	)	HUMAN		318	UniRef50_P60891
Ribose-phosphate pyrophosphokinase 1		BOVIN		318
Ribose-phosphate pyrophosphokinase 1		MOUSE		318
Ribose-phosphate pyrophosphokinase 1		PONAB		318
Ribose-phosphate pyrophosphokinase 1		RAT		318
+803

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00971 mRNA Translation: CAA68785.1 BC030019 mRNA Translation: AAH30019.2 Different initiation. BC040483 mRNA Translation: AAH40483.3 BC110875 mRNA Translation: AAI10876.2 BC119662 mRNA Translation: AAI19663.1 BC119663 mRNA Translation: AAI19664.1 D28134 Genomic DNA Translation: BAA05676.1
CCDSⁱ	CCDS14150.1 [P11908-1] CCDS43918.1 [P11908-2]
PIRⁱ	S02778 KIHUR2
RefSeqⁱ	NP_001034180.1, NM_001039091.2 [P11908-2] NP_002756.1, NM_002765.4 [P11908-1]
UniGeneⁱ	Hs.654581

3D structure databases

ProteinModelPortalⁱ	P11908
SMRⁱ	P11908
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111617, 24 interactors
IntActⁱ	P11908, 10 interactors
STRINGⁱ	9606.ENSP00000381504

PTM databases

iPTMnetⁱ	P11908
PhosphoSitePlusⁱ	P11908
SwissPalmⁱ	P11908

Polymorphism and mutation databases

BioMutaⁱ	PRPS2
DMDMⁱ	125583

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00219617 P11908

REPRODUCTION-2DPAGEⁱ

IPI00219617
P11908

Proteomic databases

EPDⁱ	P11908
MaxQBⁱ	P11908
PaxDbⁱ	P11908
PeptideAtlasⁱ	P11908
PRIDEⁱ	P11908
ProteomicsDBⁱ	52809 52810 [P11908-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5634
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000380668; ENSP00000370043; ENSG00000101911 [P11908-1] ENST00000398491; ENSP00000381504; ENSG00000101911 [P11908-2]
GeneIDⁱ	5634
KEGGⁱ	hsa:5634
UCSCⁱ	uc004cva.4 human [P11908-1]

Organism-specific databases

CTDⁱ	5634
DisGeNETⁱ	5634
EuPathDBⁱ	HostDB:ENSG00000101911.12
GeneCardsⁱ	PRPS2
HGNCⁱ	HGNC:9465 PRPS2
HPAⁱ	CAB070417
MIMⁱ	311860 gene
neXtProtⁱ	NX_P11908
OpenTargetsⁱ	ENSG00000101911
PharmGKBⁱ	PA33820
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1448 Eukaryota COG0462 LUCA
GeneTreeⁱ	ENSGT00550000074583
HOGENOMⁱ	HOG000210451
HOVERGENⁱ	HBG001520
InParanoidⁱ	P11908
KOⁱ	K00948
OMAⁱ	LLPEHKC
OrthoDBⁱ	EOG091G0ZG8
PhylomeDBⁱ	P11908
TreeFamⁱ	TF106366

Enzyme and pathway databases

UniPathwayⁱ	UPA00087;UER00172
BioCycⁱ	MetaCyc:HS02317-MONOMER
Reactomeⁱ	R-HSA-73843 5-Phosphoribose 1-diphosphate biosynthesis

Miscellaneous databases

ChiTaRSⁱ	PRPS2 human
GenomeRNAiⁱ	5634
Protein Ontology More...PROⁱ	PR:P11908
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101911 Expressed in 222 organ(s), highest expression level in testis
CleanExⁱ	HS_PRPS2
ExpressionAtlasⁱ	P11908 baseline and differential
Genevisibleⁱ	P11908 HS

Family and domain databases

CDDⁱ	cd06223 PRTases_typeI, 1 hit
HAMAPⁱ	MF_00583_B RibP_PPkinase_B, 1 hit
InterProⁱ	View protein in InterPro IPR000842 PRib_PP_synth_CS IPR029099 Pribosyltran_N IPR000836 PRibTrfase_dom IPR029057 PRTase-like IPR005946 Rib-P_diPkinase IPR037515 Rib-P_diPkinase_bac
PANTHERⁱ	PTHR10210 PTHR10210, 1 hit
Pfamⁱ	View protein in Pfam PF14572 Pribosyl_synth, 1 hit PF13793 Pribosyltran_N, 1 hit
SUPFAMⁱ	SSF53271 SSF53271, 1 hit
TIGRFAMsⁱ	TIGR01251 ribP_PPkin, 1 hit
PROSITEⁱ	View protein in PROSITE PS00114 PRPP_SYNTHASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRPS2_HUMAN
Accessionⁱ	P11908Primary (citable) accession number: P11908 Secondary accession number(s): Q0VDH9 , Q0VDI0, Q15245, Q2TAK7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 197 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM

UniProtKB

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Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P11908 (PRPS2_HUMAN)

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Ribose-phosphate pyrophosphokinase 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ