The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P11868 (TDCD_ECOLI)
Protein
Propionate kinase
Gene
tdcD
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor.
UniRule annotation1 PublicationCatalytic activityi
- EC:2.7.2.15UniRule annotation
Cofactori
Mg2+UniRule annotation
: L-threonine degradation via propanoate pathway Pathwayi
This protein is involved in step 4 of the subpathway that synthesizes propanoate from L-threonine.UniRule annotation This subpathway is part of the pathway L-threonine degradation via propanoate pathway, which is itself part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes propanoate from L-threonine, the pathway L-threonine degradation via propanoate pathway and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 11 | MagnesiumUniRule annotation | 1 | |
Binding sitei | 11 | ATPUniRule annotation | 1 | |
Binding sitei | 18 | ATPUniRule annotation | 1 | |
Binding sitei | 86 | SubstrateUniRule annotation | 1 | |
Active sitei | 143 | Proton donor/acceptorUniRule annotation | 1 | |
Binding sitei | 175 | ATPUniRule annotation | 1 | |
Sitei | 175 | Transition state stabilizerUniRule annotation | 1 | |
Sitei | 236 | Transition state stabilizerUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 203 – 207 | ATPUniRule annotation | 5 | |
Nucleotide bindingi | 278 – 280 | ATPUniRule annotation | 3 | |
Nucleotide bindingi | 326 – 330 | ATPUniRule annotation | 5 |
GO - Molecular functioni
- acetate kinase activity Source: EcoCyc
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- propionate kinase activity Source: EcoCyc
GO - Biological processi
- acetate metabolic process Source: GO_Central
- anaerobic amino acid catabolic process Source: EcoCyc
- L-threonine catabolic process to propionate Source: UniProtKB-UniPathway
- threonine catabolic process Source: EcoCyc
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:PROPKIN-MONOMER |
UniPathwayi | UPA00052;UER00510 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:tdcDUniRule annotation Synonyms:yhaA Ordered Locus Names:b3115, JW5806 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000107652 | 1 – 402 | Propionate kinaseAdd BLAST | 402 |
Proteomic databases
PaxDbi | P11868 |
PRIDEi | P11868 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationBinary interactionsi
P11868
With | #Exp. | IntAct |
---|---|---|
glf [P37747] | 2 | EBI-553884,EBI-558730 |
Protein-protein interaction databases
BioGRIDi | 4262417, 22 interactors |
DIPi | DIP-10971N |
IntActi | P11868, 3 interactors |
STRINGi | 511145.b3115 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0282, Bacteria |
HOGENOMi | CLU_020352_0_1_6 |
InParanoidi | P11868 |
PhylomeDBi | P11868 |
Family and domain databases
HAMAPi | MF_00020, Acetate_kinase, 1 hit MF_01881, Propion_kin_subfam1, 1 hit |
InterProi | View protein in InterPro IPR004372, Ac/propionate_kinase IPR000890, Aliphatic_acid_kin_short-chain IPR023865, Aliphatic_acid_kinase_CS IPR043129, ATPase_NBD IPR024917, Propionate_kinase |
PANTHERi | PTHR21060, PTHR21060, 1 hit PTHR21060:SF17, PTHR21060:SF17, 1 hit |
Pfami | View protein in Pfam PF00871, Acetate_kinase, 1 hit |
PIRSFi | PIRSF000722, Acetate_prop_kin, 1 hit |
PRINTSi | PR00471, ACETATEKNASE |
SUPFAMi | SSF53067, SSF53067, 2 hits |
TIGRFAMsi | TIGR00016, ackA, 1 hit |
PROSITEi | View protein in PROSITE PS01075, ACETATE_KINASE_1, 1 hit PS01076, ACETATE_KINASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P11868-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNEFPVVLVI NCGSSSIKFS VLDASDCEVL MSGIADGINS ENAFLSVNGG
60 70 80 90 100
EPAPLAHHSY EGALKAIAFE LEKRNLNDSV ALIGHRIAHG GSIFTESAII
110 120 130 140 150
TDEVIDNIRR VSPLAPLHNY ANLSGIESAQ QLFPGVTQVA VFDTSFHQTM
160 170 180 190 200
APEAYLYGLP WKYYEELGVR RYGFHGTSHR YVSQRAHSLL NLAEDDSGLV
210 220 230 240 250
VAHLGNGASI CAVRNGQSVD TSMGMTPLEG LMMGTRSGDV DFGAMSWVAS
260 270 280 290 300
QTNQSLGDLE RVVNKESGLL GISGLSSDLR VLEKAWHEGH ERAQLAIKTF
310 320 330 340 350
VHRIARHIAG HAASLRRLDG IIFTGGIGEN SSLIRRLVME HLAVLGLEID
360 370 380 390 400
TEMNNRSNSC GERIVSSENA RVICAVIPTN EEKMIALDAI HLGKVNAPAE
FA
Sequence cautioni
The sequence AAA24663 differs from that shown. Reason: Frameshift.Curated
The sequence AAA57919 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAA32595 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 121 | A → P in CAA32595 (PubMed:2660107).Curated | 1 | |
Sequence conflicti | 121 | A → P in AAA24663 (PubMed:3053659).Curated | 1 | |
Sequence conflicti | 141 | V → L in CAA32595 (PubMed:2660107).Curated | 1 | |
Sequence conflicti | 141 | V → L in AAA24663 (PubMed:3053659).Curated | 1 | |
Sequence conflicti | 198 | G → A in CAA32595 (PubMed:2660107).Curated | 1 | |
Sequence conflicti | 198 | G → A in AAA24663 (PubMed:3053659).Curated | 1 | |
Sequence conflicti | 244 | A → P in CAA32595 (PubMed:2660107).Curated | 1 | |
Sequence conflicti | 244 | A → P in AAA24663 (PubMed:3053659).Curated | 1 | |
Sequence conflicti | 249 – 250 | AS → RR in CAA32595 (PubMed:2660107).Curated | 2 | |
Sequence conflicti | 249 – 250 | AS → RR in AAA24663 (PubMed:3053659).Curated | 2 | |
Sequence conflicti | 275 | L → H in CAA32595 (PubMed:2660107).Curated | 1 | |
Sequence conflicti | 275 | L → H in AAA24663 (PubMed:3053659).Curated | 1 | |
Sequence conflicti | 283 | E → G in CAA32595 (PubMed:2660107).Curated | 1 | |
Sequence conflicti | 283 | E → G in AAA24663 (PubMed:3053659).Curated | 1 | |
Sequence conflicti | 396 – 402 | NAPAEFA → KEGANKRGNSSRLTQSFHFF MFEPIFSPVNALNQPI in BAE77164 (PubMed:16738553).Curated | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA57919.1 Different initiation. U00096 Genomic DNA Translation: AAC76150.2 AP009048 Genomic DNA Translation: BAE77164.1 X14430 Genomic DNA Translation: CAA32595.1 Frameshift. M23638 Genomic DNA Translation: AAA24663.1 Frameshift. |
PIRi | H65100, Q3ECTD |
RefSeqi | NP_417585.2, NC_000913.3 WP_001295545.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC76150; AAC76150; b3115 BAE77164; BAE77164; BAE77164 |
GeneIDi | 947635 |
KEGGi | ecj:JW5806 eco:b3115 |
PATRICi | fig|511145.12.peg.3209 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA57919.1 Different initiation. U00096 Genomic DNA Translation: AAC76150.2 AP009048 Genomic DNA Translation: BAE77164.1 X14430 Genomic DNA Translation: CAA32595.1 Frameshift. M23638 Genomic DNA Translation: AAA24663.1 Frameshift. |
PIRi | H65100, Q3ECTD |
RefSeqi | NP_417585.2, NC_000913.3 WP_001295545.1, NZ_LN832404.1 |
3D structure databases
AlphaFoldDBi | P11868 |
SMRi | P11868 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262417, 22 interactors |
DIPi | DIP-10971N |
IntActi | P11868, 3 interactors |
STRINGi | 511145.b3115 |
Proteomic databases
PaxDbi | P11868 |
PRIDEi | P11868 |
Genome annotation databases
EnsemblBacteriai | AAC76150; AAC76150; b3115 BAE77164; BAE77164; BAE77164 |
GeneIDi | 947635 |
KEGGi | ecj:JW5806 eco:b3115 |
PATRICi | fig|511145.12.peg.3209 |
Organism-specific databases
EchoBASEi | EB1159 |
Phylogenomic databases
eggNOGi | COG0282, Bacteria |
HOGENOMi | CLU_020352_0_1_6 |
InParanoidi | P11868 |
PhylomeDBi | P11868 |
Enzyme and pathway databases
UniPathwayi | UPA00052;UER00510 |
BioCyci | EcoCyc:PROPKIN-MONOMER |
Miscellaneous databases
PROi | PR:P11868 |
Family and domain databases
HAMAPi | MF_00020, Acetate_kinase, 1 hit MF_01881, Propion_kin_subfam1, 1 hit |
InterProi | View protein in InterPro IPR004372, Ac/propionate_kinase IPR000890, Aliphatic_acid_kin_short-chain IPR023865, Aliphatic_acid_kinase_CS IPR043129, ATPase_NBD IPR024917, Propionate_kinase |
PANTHERi | PTHR21060, PTHR21060, 1 hit PTHR21060:SF17, PTHR21060:SF17, 1 hit |
Pfami | View protein in Pfam PF00871, Acetate_kinase, 1 hit |
PIRSFi | PIRSF000722, Acetate_prop_kin, 1 hit |
PRINTSi | PR00471, ACETATEKNASE |
SUPFAMi | SSF53067, SSF53067, 2 hits |
TIGRFAMsi | TIGR00016, ackA, 1 hit |
PROSITEi | View protein in PROSITE PS01075, ACETATE_KINASE_1, 1 hit PS01076, ACETATE_KINASE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TDCD_ECOLI | |
Accessioni | P11868Primary (citable) accession number: P11868 Secondary accession number(s): P76666, Q2M992 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | November 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 173 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families