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UniProtKB - P11868 (TDCD_ECOLI)

Entry version 165 (22 Apr 2020)
Sequence version 3 (01 Nov 1995)
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Protein

Propionate kinase

Gene

tdcD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor.UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-threonine degradation via propanoate pathway

This protein is involved in step 4 of the subpathway that synthesizes propanoate from L-threonine.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. L-threonine dehydratase catabolic TdcB (tdcB), L-threonine dehydratase catabolic TdcB (tdcB)
  2. PFL-like enzyme TdcE (tdcE)
  3. no protein annotated in this organism
  4. Propionate kinase (tdcD), Propionate kinase (tdcD)
This subpathway is part of the pathway L-threonine degradation via propanoate pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes propanoate from L-threonine, the pathway L-threonine degradation via propanoate pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi11MagnesiumUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei11ATPUniRule annotation1
Binding sitei18ATPUniRule annotation1
Binding sitei86SubstrateUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei143Proton donor/acceptorUniRule annotation1
Binding sitei175ATPUniRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei175Transition state stabilizerUniRule annotation1
Sitei236Transition state stabilizerUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi203 – 207ATPUniRule annotation5
Nucleotide bindingi278 – 280ATPUniRule annotation3
Nucleotide bindingi326 – 330ATPUniRule annotation5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:PROPKIN-MONOMER
ECOL316407:JW5806-MONOMER
MetaCyc:PROPKIN-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00052;UER00510

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Propionate kinaseUniRule annotation (EC:2.7.2.15UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tdcDUniRule annotation
Synonyms:yhaA
Ordered Locus Names:b3115, JW5806
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001076521 – 402Propionate kinaseAdd BLAST402

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P11868

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P11868

PRoteomics IDEntifications database

More...PRIDEi		P11868

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotation

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		4262417, 22 interactors

Database of interacting proteins

More...DIPi		DIP-10971N

Protein interaction database and analysis system

More...IntActi		P11868, 3 interactors

STRING: functional protein association networks

More...STRINGi		511145.b3115

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P11868

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the acetokinase family. TdcD subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4105C6H Bacteria
COG0282 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020352_0_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P11868

KEGG Orthology (KO)

More...KOi		K00932

Database for complete collections of gene phylogenies

More...PhylomeDBi		P11868

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_00020 Acetate_kinase, 1 hit
MF_01881 Propion_kin_subfam1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
IPR024917 Propionate_kinase

The PANTHER Classification System

More...PANTHERi		PTHR21060 PTHR21060, 1 hit
PTHR21060:SF17 PTHR21060:SF17, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00871 Acetate_kinase, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000722 Acetate_prop_kin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00471 ACETATEKNASE

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00016 ackA, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P11868-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEFPVVLVI NCGSSSIKFS VLDASDCEVL MSGIADGINS ENAFLSVNGG 
        60         70         80         90        100
EPAPLAHHSY EGALKAIAFE LEKRNLNDSV ALIGHRIAHG GSIFTESAII 
       110        120        130        140        150
TDEVIDNIRR VSPLAPLHNY ANLSGIESAQ QLFPGVTQVA VFDTSFHQTM 
       160        170        180        190        200
APEAYLYGLP WKYYEELGVR RYGFHGTSHR YVSQRAHSLL NLAEDDSGLV 
       210        220        230        240        250
VAHLGNGASI CAVRNGQSVD TSMGMTPLEG LMMGTRSGDV DFGAMSWVAS 
       260        270        280        290        300
QTNQSLGDLE RVVNKESGLL GISGLSSDLR VLEKAWHEGH ERAQLAIKTF 
       310        320        330        340        350
VHRIARHIAG HAASLRRLDG IIFTGGIGEN SSLIRRLVME HLAVLGLEID 
       360        370        380        390        400
TEMNNRSNSC GERIVSSENA RVICAVIPTN EEKMIALDAI HLGKVNAPAE 

FA
Length:402
Mass (Da):43,384
Last modified:November 1, 1995 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E49756262C77144
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA24663 differs from that shown. Reason: Frameshift.Curated
The sequence AAA57919 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAA32595 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti121A → P in CAA32595 (PubMed:2660107).Curated1
Sequence conflicti121A → P in AAA24663 (PubMed:3053659).Curated1
Sequence conflicti141V → L in CAA32595 (PubMed:2660107).Curated1
Sequence conflicti141V → L in AAA24663 (PubMed:3053659).Curated1
Sequence conflicti198G → A in CAA32595 (PubMed:2660107).Curated1
Sequence conflicti198G → A in AAA24663 (PubMed:3053659).Curated1
Sequence conflicti244A → P in CAA32595 (PubMed:2660107).Curated1
Sequence conflicti244A → P in AAA24663 (PubMed:3053659).Curated1
Sequence conflicti249 – 250AS → RR in CAA32595 (PubMed:2660107).Curated2
Sequence conflicti249 – 250AS → RR in AAA24663 (PubMed:3053659).Curated2
Sequence conflicti275L → H in CAA32595 (PubMed:2660107).Curated1
Sequence conflicti275L → H in AAA24663 (PubMed:3053659).Curated1
Sequence conflicti283E → G in CAA32595 (PubMed:2660107).Curated1
Sequence conflicti283E → G in AAA24663 (PubMed:3053659).Curated1
Sequence conflicti396 – 402NAPAEFA → KEGANKRGNSSRLTQSFHFF MFEPIFSPVNALNQPI in BAE77164 (PubMed:16738553).Curated7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA57919.1 Different initiation.
U00096 Genomic DNA Translation: AAC76150.2
AP009048 Genomic DNA Translation: BAE77164.1
X14430 Genomic DNA Translation: CAA32595.1 Frameshift.
M23638 Genomic DNA Translation: AAA24663.1 Frameshift.

Protein sequence database of the Protein Information Resource

More...PIRi		H65100 Q3ECTD

NCBI Reference Sequences

More...RefSeqi		NP_417585.2, NC_000913.3
WP_001295545.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC76150; AAC76150; b3115
BAE77164; BAE77164; BAE77164

Database of genes from NCBI RefSeq genomes

More...GeneIDi		947635

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW5806
eco:b3115

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|511145.12.peg.3209

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA57919.1 Different initiation.
U00096 Genomic DNA Translation: AAC76150.2
AP009048 Genomic DNA Translation: BAE77164.1
X14430 Genomic DNA Translation: CAA32595.1 Frameshift.
M23638 Genomic DNA Translation: AAA24663.1 Frameshift.
PIRiH65100 Q3ECTD
RefSeqiNP_417585.2, NC_000913.3
WP_001295545.1, NZ_LN832404.1

3D structure databases

SMRiP11868
ModBaseiSearch...

Protein-protein interaction databases

BioGridi4262417, 22 interactors
DIPiDIP-10971N
IntActiP11868, 3 interactors
STRINGi511145.b3115

Proteomic databases

jPOSTiP11868
PaxDbiP11868
PRIDEiP11868

Genome annotation databases

EnsemblBacteriaiAAC76150; AAC76150; b3115
BAE77164; BAE77164; BAE77164
GeneIDi947635
KEGGiecj:JW5806
eco:b3115
PATRICifig|511145.12.peg.3209

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1159

Phylogenomic databases

eggNOGiENOG4105C6H Bacteria
COG0282 LUCA
HOGENOMiCLU_020352_0_1_6
InParanoidiP11868
KOiK00932
PhylomeDBiP11868

Enzyme and pathway databases

UniPathwayiUPA00052;UER00510
BioCyciEcoCyc:PROPKIN-MONOMER
ECOL316407:JW5806-MONOMER
MetaCyc:PROPKIN-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P11868

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
MF_01881 Propion_kin_subfam1, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
IPR024917 Propionate_kinase
PANTHERiPTHR21060 PTHR21060, 1 hit
PTHR21060:SF17 PTHR21060:SF17, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDCD_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11868
Secondary accession number(s): P76666, Q2M992
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 1, 1995
Last modified: April 22, 2020
This is version 165 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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