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Protein

Gamma-crystallin A

Gene

CRYGA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

  • structural constituent of eye lens Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin A
Alternative name(s):
Gamma-A-crystallin
Gamma-crystallin 5
Gene namesi
Name:CRYGA
Synonyms:CRYG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000168582.4
HGNCiHGNC:2408 CRYGA
MIMi123660 gene
neXtProtiNX_P11844

Pathology & Biotechi

Organism-specific databases

DisGeNETi1418
OpenTargetsiENSG00000168582
PharmGKBiPA26915

Polymorphism and mutation databases

BioMutaiCRYGA
DMDMi148887193

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000575851 – 174Gamma-crystallin AAdd BLAST174

Proteomic databases

PaxDbiP11844
PeptideAtlasiP11844
PRIDEiP11844
ProteomicsDBi52808

Expressioni

Gene expression databases

BgeeiENSG00000168582 Expressed in 13 organ(s), highest expression level in hypothalamus
CleanExiHS_CRYGA
ExpressionAtlasiP11844 baseline and differential
GenevisibleiP11844 HS

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi107808, 1 interactor
STRINGi9606.ENSP00000302105

Structurei

3D structure databases

ProteinModelPortaliP11844
SMRiP11844
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 40Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini41 – 83Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini88 – 128Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini129 – 171Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 87Connecting peptide4

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWCR Eukaryota
ENOG411298R LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234389
HOVERGENiHBG003364
InParanoidiP11844
OMAiSCRAIPY
OrthoDBiEOG091G0L2P
PhylomeDBiP11844

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits

Sequencei

Sequence statusi: Complete.

P11844-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKITFYEDR DFQGRCYNCI SDCPNLRVYF SRCNSIRVDS GCWMLYERPN
60 70 80 90 100
YQGHQYFLRR GKYPDYQHWM GLSDSVQSCR IIPHTSSHKL RLYERDDYRG
110 120 130 140 150
LMSELTDDCA CVPELFRLPE IYSLHVLEGC WVLYEMPNYR GRQYLLRPGD
160 170
YRRYHDWGGA DAKVGSLRRV TDLY
Length:174
Mass (Da):20,877
Last modified:May 29, 2007 - v3
Checksum:i99889A7641728090
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021139148P → L2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17316, M17315 Genomic DNA Translation: AAA52108.1
EF426311 mRNA Translation: ABO14696.1
AC016697 Genomic DNA Translation: AAX93220.1
CCDSiCCDS33367.1
PIRiA26912
RefSeqiNP_055432.2, NM_014617.3
UniGeneiHs.122566

Genome annotation databases

EnsembliENST00000304502; ENSP00000302105; ENSG00000168582
GeneIDi1418
KEGGihsa:1418
UCSCiuc002vcq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17316, M17315 Genomic DNA Translation: AAA52108.1
EF426311 mRNA Translation: ABO14696.1
AC016697 Genomic DNA Translation: AAX93220.1
CCDSiCCDS33367.1
PIRiA26912
RefSeqiNP_055432.2, NM_014617.3
UniGeneiHs.122566

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LERmodel-A1-174[»]
ProteinModelPortaliP11844
SMRiP11844
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107808, 1 interactor
STRINGi9606.ENSP00000302105

Polymorphism and mutation databases

BioMutaiCRYGA
DMDMi148887193

Proteomic databases

PaxDbiP11844
PeptideAtlasiP11844
PRIDEiP11844
ProteomicsDBi52808

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304502; ENSP00000302105; ENSG00000168582
GeneIDi1418
KEGGihsa:1418
UCSCiuc002vcq.5 human

Organism-specific databases

CTDi1418
DisGeNETi1418
EuPathDBiHostDB:ENSG00000168582.4
GeneCardsiCRYGA
HGNCiHGNC:2408 CRYGA
MIMi123660 gene
neXtProtiNX_P11844
OpenTargetsiENSG00000168582
PharmGKBiPA26915
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWCR Eukaryota
ENOG411298R LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234389
HOVERGENiHBG003364
InParanoidiP11844
OMAiSCRAIPY
OrthoDBiEOG091G0L2P
PhylomeDBiP11844

Miscellaneous databases

GeneWikiiCRYGA
GenomeRNAii1418
PROiPR:P11844
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168582 Expressed in 13 organ(s), highest expression level in hypothalamus
CleanExiHS_CRYGA
ExpressionAtlasiP11844 baseline and differential
GenevisibleiP11844 HS

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRGA_HUMAN
AccessioniPrimary (citable) accession number: P11844
Secondary accession number(s): Q53ST5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 29, 2007
Last modified: September 12, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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