Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

B-lymphocyte antigen CD20

Gene

MS4A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein may be involved in the regulation of B-cell activation and proliferation.

Caution

Epitope 1, mapped in PubMed:16785532, is predicted to be buried in the membrane. Its accessibility to the extracellular space, and thus to antibody recognition, is not explained.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • B cell proliferation Source: UniProtKB
  • humoral immune response Source: UniProtKB
  • response to bacterium Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processB-cell activation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P11836

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.37.1.1 the cd20 ca(2+) channel (cd20) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
B-lymphocyte antigen CD20
Alternative name(s):
B-lymphocyte surface antigen B1
Bp35
Leukocyte surface antigen Leu-16
Membrane-spanning 4-domains subfamily A member 1
CD_antigen: CD20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MS4A1
Synonyms:CD20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000156738.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7315 MS4A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
112210 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11836

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 56CytoplasmicSequence analysisAdd BLAST56
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei57 – 78HelicalSequence analysisAdd BLAST22
Topological domaini79 – 84ExtracellularSequence analysis6
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 120CytoplasmicSequence analysisAdd BLAST15
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 188ExtracellularSequence analysisAdd BLAST47
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 297CytoplasmicSequence analysisAdd BLAST88

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency, common variable, 5 (CVID5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
See also OMIM:613495

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical usei

Monoclonal antibodies (mAb) against CD20 are used to treat B-cell non-Hodgkin lymphoma (NHL). These antibodies include Rituximab (Mabthera), Britumomab (Zevalin) and Tositumomab (Bexxar). CD20 engaged by mAb can generate transmembrane signals capable of directly controlling cell growth and triggering cell death in certain tumors. Alternatively, mAb can mediate complement-dependent cytotoxicity.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi159T → K: Abrogates recognition by some antibodies; when associated with D-163 and D-166. Slight decrease of rituximab binding; when associated with D-163 and D-166. 1 Publication1
Mutagenesisi163N → D: Decreased binding of some antibodies. No effect on rituximab binding. 1 Publication1
Mutagenesisi166N → D: Decreased binding of some antibodies. No effect on rituximab binding. 1 Publication1
Mutagenesisi170A → S: Abrogates recognition by therapeutic antibodies, including rituximab; when associated with S-172. 1 Publication1
Mutagenesisi172P → S: Marked reduction in rituximab binding. Abrogates recognition by antibodies, including rituximab; when associated with S-170. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
931

MalaCards human disease database

More...
MalaCardsi
MS4A1
MIMi613495 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000156738

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1572 Common variable immunodeficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31111

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2058

Drug and drug target database

More...
DrugBanki
DB00078 Ibritumomab tiuxetan
DB08935 Obinutuzumab
DB06650 Ofatumumab
DB00073 Rituximab
DB00081 Tositumomab

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2628

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MS4A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
115968

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001586271 – 297B-lymphocyte antigen CD20Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei36PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi111S-palmitoyl cysteine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi167 ↔ 1831 Publication
Lipidationi220S-palmitoyl cysteine1 Publication1
Modified residuei225PhosphoserineBy similarity1
Modified residuei239PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Might be functionally regulated by protein kinase(s).

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P11836

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P11836

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11836

PeptideAtlas

More...
PeptideAtlasi
P11836

PRoteomics IDEntifications database

More...
PRIDEi
P11836

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52807

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11836

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P11836

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P11836

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed on B-cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156738 Expressed in 140 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_MS4A1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P11836 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P11836 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000015
HPA014341
HPA014391

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-2808234,EBI-749265

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107369, 15 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P11836

Protein interaction database and analysis system

More...
IntActi
P11836, 21 interactors

Molecular INTeraction database

More...
MINTi
P11836

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000314620

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1297
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S8Bmodel-A1-297[»]
2OSLX-ray2.60P/Q163-187[»]
3BKYX-ray2.61P163-187[»]
3PP4X-ray1.60P163-187[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P11836

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11836

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P11836

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni74 – 80Epitope 17
Regioni146 – 160Epitope 2Add BLAST15
Regioni168 – 175Epitope 3 (recognized by antibodies, including Rituximab)8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFXM Eukaryota
ENOG41119VB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000048781

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111479

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG048815

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11836

KEGG Orthology (KO)

More...
KOi
K06466

Identification of Orthologs from Complete Genome Data

More...
OMAi
SHFFKME

Database of Orthologous Groups

More...
OrthoDBi
636718at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11836

TreeFam database of animal gene trees

More...
TreeFami
TF335157

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030418 MS4A1

The PANTHER Classification System

More...
PANTHERi
PTHR23320 PTHR23320, 1 hit
PTHR23320:SF79 PTHR23320:SF79, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04103 CD20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11836-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTPRNSVNG TFPAEPMKGP IAMQSGPKPL FRRMSSLVGP TQSFFMRESK
60 70 80 90 100
TLGAVQIMNG LFHIALGGLL MIPAGIYAPI CVTVWYPLWG GIMYIISGSL
110 120 130 140 150
LAATEKNSRK CLVKGKMIMN SLSLFAAISG MILSIMDILN IKISHFLKME
160 170 180 190 200
SLNFIRAHTP YINIYNCEPA NPSEKNSPST QYCYSIQSLF LGILSVMLIF
210 220 230 240 250
AFFQELVIAG IVENEWKRTC SRPKSNIVLL SAEEKKEQTI EIKEEVVGLT
260 270 280 290
ETSSQPKNEE DIEIIPIQEE EEEETETNFP EPPQDQESSP IENDSSP
Length:297
Mass (Da):33,077
Last modified:October 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC5420F8B626BDD1
GO
Isoform 2 (identifier: P11836-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-204: Missing.

Note: No experimental confirmation available.
Show »
Length:130
Mass (Da):14,581
Checksum:i7B38C8639E2D3744
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKH8E9PKH8_HUMAN
B-lymphocyte antigen CD20
MS4A1
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPL6E9PPL6_HUMAN
B-lymphocyte antigen CD20
MS4A1
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y8EK32A0A1Y8EK32_HUMAN
B-lymphocyte antigen CD20
MS4A1
7Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13P → L in CAA30179 (PubMed:2456210).Curated1
Sequence conflicti13P → L in CAA30180 (PubMed:2456210).Curated1
Sequence conflicti71M → I in AAA88911 (PubMed:2466899).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05705838 – 204Missing in isoform 2. 1 PublicationAdd BLAST167

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X12530 mRNA Translation: CAA31046.1
M27394 Genomic DNA Translation: AAA35581.1
X07203 mRNA Translation: CAA30179.1
X07204 mRNA Translation: CAA30180.1
L23419
, L23415, L23416, L23417 Genomic DNA Translation: AAA88911.1
M27395 Genomic DNA No translation available.
AP001034 Genomic DNA No translation available.
AK300025 mRNA Translation: BAG61836.1
AP003127 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73889.1
BC002807 mRNA Translation: AAH02807.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31570.1 [P11836-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A30586

NCBI Reference Sequences

More...
RefSeqi
NP_068769.2, NM_021950.3 [P11836-1]
NP_690605.1, NM_152866.2 [P11836-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.712553

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000345732; ENSP00000314620; ENSG00000156738 [P11836-1]
ENST00000389939; ENSP00000374589; ENSG00000156738 [P11836-1]
ENST00000528313; ENSP00000432270; ENSG00000156738 [P11836-2]
ENST00000534668; ENSP00000433277; ENSG00000156738 [P11836-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
931

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:931

UCSC genome browser

More...
UCSCi
uc001npq.3 human [P11836-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CD20 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12530 mRNA Translation: CAA31046.1
M27394 Genomic DNA Translation: AAA35581.1
X07203 mRNA Translation: CAA30179.1
X07204 mRNA Translation: CAA30180.1
L23419
, L23415, L23416, L23417 Genomic DNA Translation: AAA88911.1
M27395 Genomic DNA No translation available.
AP001034 Genomic DNA No translation available.
AK300025 mRNA Translation: BAG61836.1
AP003127 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73889.1
BC002807 mRNA Translation: AAH02807.1
CCDSiCCDS31570.1 [P11836-1]
PIRiA30586
RefSeqiNP_068769.2, NM_021950.3 [P11836-1]
NP_690605.1, NM_152866.2 [P11836-1]
UniGeneiHs.712553

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S8Bmodel-A1-297[»]
2OSLX-ray2.60P/Q163-187[»]
3BKYX-ray2.61P163-187[»]
3PP4X-ray1.60P163-187[»]
ProteinModelPortaliP11836
SMRiP11836
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107369, 15 interactors
CORUMiP11836
IntActiP11836, 21 interactors
MINTiP11836
STRINGi9606.ENSP00000314620

Chemistry databases

ChEMBLiCHEMBL2058
DrugBankiDB00078 Ibritumomab tiuxetan
DB08935 Obinutuzumab
DB06650 Ofatumumab
DB00073 Rituximab
DB00081 Tositumomab
GuidetoPHARMACOLOGYi2628

Protein family/group databases

TCDBi1.A.37.1.1 the cd20 ca(2+) channel (cd20) family

PTM databases

iPTMnetiP11836
PhosphoSitePlusiP11836
SwissPalmiP11836

Polymorphism and mutation databases

BioMutaiMS4A1
DMDMi115968

Proteomic databases

jPOSTiP11836
MaxQBiP11836
PaxDbiP11836
PeptideAtlasiP11836
PRIDEiP11836
ProteomicsDBi52807

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
931
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345732; ENSP00000314620; ENSG00000156738 [P11836-1]
ENST00000389939; ENSP00000374589; ENSG00000156738 [P11836-1]
ENST00000528313; ENSP00000432270; ENSG00000156738 [P11836-2]
ENST00000534668; ENSP00000433277; ENSG00000156738 [P11836-1]
GeneIDi931
KEGGihsa:931
UCSCiuc001npq.3 human [P11836-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
931
DisGeNETi931
EuPathDBiHostDB:ENSG00000156738.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MS4A1
HGNCiHGNC:7315 MS4A1
HPAiCAB000015
HPA014341
HPA014391
MalaCardsiMS4A1
MIMi112210 gene
613495 phenotype
neXtProtiNX_P11836
OpenTargetsiENSG00000156738
Orphaneti1572 Common variable immunodeficiency
PharmGKBiPA31111

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFXM Eukaryota
ENOG41119VB LUCA
GeneTreeiENSGT00510000048781
HOGENOMiHOG000111479
HOVERGENiHBG048815
InParanoidiP11836
KOiK06466
OMAiSHFFKME
OrthoDBi636718at2759
PhylomeDBiP11836
TreeFamiTF335157

Enzyme and pathway databases

SIGNORiP11836

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MS4A1 human
EvolutionaryTraceiP11836

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CD20

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
931

Protein Ontology

More...
PROi
PR:P11836

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156738 Expressed in 140 organ(s), highest expression level in blood
CleanExiHS_MS4A1
ExpressionAtlasiP11836 baseline and differential
GenevisibleiP11836 HS

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030418 MS4A1
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF79 PTHR23320:SF79, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD20_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11836
Secondary accession number(s): A6NMS4
, B4DT24, P08984, Q13963
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: January 16, 2019
This is version 186 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Pharmaceutical, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again