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Protein

Integrin beta-2

Gene

Itgb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (By similarity). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (By similarity). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (By similarity). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). Alpha-M/beta-2 play a critical role in mast cell development and in immune complex-mediated glomerulonephritis. Mice expressing a null mutation of the alpha-M subunit gene demonstrate increase in neutrophil accumulation, in response to a impaired degranulation and phagocytosis, events that apparently accelerate apoptosis in neutrophils. These mice develop obesity.By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi139Calcium; via carbonyl oxygenBy similarity1
Metal bindingi142CalciumBy similarity1
Metal bindingi143CalciumBy similarity1
Metal bindingi348CalciumBy similarity1

GO - Molecular functioni

  • amyloid-beta binding Source: ARUK-UCL
  • cell adhesion molecule binding Source: MGI
  • complement component C3b binding Source: ARUK-UCL
  • heat shock protein binding Source: MGI
  • ICAM-3 receptor activity Source: MGI
  • integrin binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • protein-containing complex binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • protein kinase binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion, Phagocytosis
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-2
Alternative name(s):
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
Complement receptor C3 subunit beta
CD_antigen: CD18
Gene namesi
Name:Itgb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96611 Itgb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 702ExtracellularSequence analysisAdd BLAST679
Transmembranei703 – 725HelicalSequence analysisAdd BLAST23
Topological domaini726 – 771CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000001634224 – 771Integrin beta-2Add BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi26 ↔ 44By similarity
Disulfide bondi34 ↔ 448By similarity
Disulfide bondi37 ↔ 63By similarity
Disulfide bondi47 ↔ 74By similarity
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi192 ↔ 199By similarity
Disulfide bondi247 ↔ 287By similarity
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi387 ↔ 401By similarity
Disulfide bondi421 ↔ 446By similarity
Disulfide bondi450 ↔ 468By similarity
Disulfide bondi460 ↔ 471By similarity
Disulfide bondi473 ↔ 482By similarity
Disulfide bondi484 ↔ 515By similarity
Disulfide bondi498 ↔ 513By similarity
Glycosylationi502N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi507 ↔ 518By similarity
Disulfide bondi520 ↔ 535By similarity
Disulfide bondi537 ↔ 560By similarity
Disulfide bondi542 ↔ 558By similarity
Disulfide bondi550 ↔ 563By similarity
Disulfide bondi565 ↔ 574By similarity
Disulfide bondi576 ↔ 599By similarity
Disulfide bondi583 ↔ 597By similarity
Disulfide bondi591 ↔ 602By similarity
Disulfide bondi604 ↔ 613By similarity
Disulfide bondi616 ↔ 619By similarity
Disulfide bondi623 ↔ 664By similarity
Glycosylationi626N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi630 ↔ 649By similarity
Disulfide bondi633 ↔ 645By similarity
Glycosylationi644N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi672 ↔ 697By similarity
Modified residuei747PhosphoserineBy similarity1
Modified residuei758PhosphoserineBy similarity1
Modified residuei760PhosphothreonineBy similarity1
Modified residuei762PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP11835
MaxQBiP11835
PaxDbiP11835
PeptideAtlasiP11835
PRIDEiP11835

PTM databases

iPTMnetiP11835
PhosphoSitePlusiP11835
SwissPalmiP11835

Expressioni

Gene expression databases

CleanExiMM_ITGB2

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. ITGB2 associates with either ITGAL, ITGAM, ITGAX or ITGAD. Found in a complex with CD177 and ITGAM/CD11b (By similarity). Interacts with FGR (PubMed:19903482). Interacts with COPS5 and RANBP9 (By similarity). Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200828, 2 interactors
ComplexPortaliCPX-3126 Integrin alphaD-beta2 complex
CPX-3128 Integrin alphaL-beta2 complex
CPX-3129 Integrin alphaM-beta2 complex
CPX-3134 Integrin alphaX-beta2 complex
CORUMiP11835
DIPiDIP-37428N
IntActiP11835, 9 interactors
MINTiP11835
STRINGi10090.ENSMUSP00000000299

Structurei

3D structure databases

ProteinModelPortaliP11835
SMRiP11835
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 364VWFAAdd BLAST240
Repeati450 – 497IAdd BLAST48
Repeati498 – 541IIAdd BLAST44
Repeati542 – 582IIIAdd BLAST41
Repeati583 – 618IVAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni450 – 618Cysteine-rich tandem repeatsAdd BLAST169

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
HOGENOMiHOG000252936
HOVERGENiHBG006190
InParanoidiP11835
KOiK06464

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015439 Integrin_bsu-2
IPR014836 Integrin_bsu_cyt_dom
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF15 PTHR10082:SF15, 1 hit
PfamiView protein in Pfam
PF08725 Integrin_b_cyt, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PIRSFiPIRSF002512 Integrin_B, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit
SM00423 PSI, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 1 hit
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 3 hits
PS00243 INTEGRIN_BETA, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P11835-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGLRPSLLL ALAGLFFLGS AVSQECTKYK VSSCRDCIQS GPGCSWCQKL
60 70 80 90 100
NFTGPGEPDS LRCDTRAQLL LKGCPADDIM DPRSIANPEF DQRGQRKQLS
110 120 130 140 150
PQKVTLYLRP GQAAAFNVTF RRAKGYPIDL YYLMDLSYSM LDDLNNVKKL
160 170 180 190 200
GGDLLQALNE ITESGRIGFG SFVDKTVLPF VNTHPEKLRN PCPNKEKACQ
210 220 230 240 250
PPFAFRHVLK LTDNSNQFQT EVGKQLISGN LDAPEGGLDA IMQVAACPEE
260 270 280 290 300
IGWRNVTRLL VFATDDGFHF AGDGKLGAIL TPNDGRCHLE DNMYKRSNEF
310 320 330 340 350
DYPSVGQLAH KLSESNIQPI FAVTKKMVKT YEKLTEIIPK SAVGELSDDS
360 370 380 390 400
SNVVQLIKNA YYKLSSRVFL DHSTLPDTLK VTYDSFCSNG ASSIGKSRGD
410 420 430 440 450
CDGVQINNPV TFQVKVMASE CIQEQSFVIR ALGFTDTVTV QVRPQCECQC
460 470 480 490 500
RDQSREQSLC GGKGVMECGI CRCESGYIGK NCECQTQGRS SQELERNCRK
510 520 530 540 550
DNSSIVCSGL GDCICGQCVC HTSDVPNKEI FGQYCECDNV NCERYNSQVC
560 570 580 590 600
GGSDRGSCNC GKCSCKPGYE GSACQCQRST TGCLNARLVE CSGRGHCQCN
610 620 630 640 650
RCICDEGYQP PMCEDCPSCG SHCRDNHTSC AECLKFDKGP FEKNCSVQCA
660 670 680 690 700
GMTLQTIPLK KKPCKERDSE GCWITYTLQQ KDGRNIYNIH VEDSLECVKG
710 720 730 740 750
PNVAAIVGGT VVGVVLIGVL LLVIWKALTH LTDLREYRRF EKEKLKSQWN
760 770
NDNPLFKSAT TTVMNPKFAE S
Length:771
Mass (Da):85,026
Last modified:July 15, 1998 - v2
Checksum:i6FA51DA93AB40D8A
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q542I8Q542I8_MOUSE
Integrin beta
Itgb2 mCG_3383
770Annotation score:
M0QWA7M0QWA7_MOUSE
Integrin beta
Itgb2
480Annotation score:
D3YYP8D3YYP8_MOUSE
Integrin beta
Itgb2
130Annotation score:
M0QWJ6M0QWJ6_MOUSE
Integrin beta-2
Itgb2
56Annotation score:
D3Z1S4D3Z1S4_MOUSE
Integrin beta-2
Itgb2
54Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4 – 6LRP → PH in CAA33077 (PubMed:2569711).Curated3
Sequence conflicti449Q → H in AAA39325 (PubMed:1969385).Curated1
Sequence conflicti667R → K in AAA39325 (PubMed:1969385).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14951 mRNA Translation: CAA33077.1
M31039 mRNA Translation: AAA39325.1
PIRiA45839
S04847
RefSeqiNP_032430.2, NM_008404.4
UniGeneiMm.1137

Genome annotation databases

GeneIDi16414
KEGGimmu:16414

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14951 mRNA Translation: CAA33077.1
M31039 mRNA Translation: AAA39325.1
PIRiA45839
S04847
RefSeqiNP_032430.2, NM_008404.4
UniGeneiMm.1137

3D structure databases

ProteinModelPortaliP11835
SMRiP11835
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200828, 2 interactors
ComplexPortaliCPX-3126 Integrin alphaD-beta2 complex
CPX-3128 Integrin alphaL-beta2 complex
CPX-3129 Integrin alphaM-beta2 complex
CPX-3134 Integrin alphaX-beta2 complex
CORUMiP11835
DIPiDIP-37428N
IntActiP11835, 9 interactors
MINTiP11835
STRINGi10090.ENSMUSP00000000299

PTM databases

iPTMnetiP11835
PhosphoSitePlusiP11835
SwissPalmiP11835

Proteomic databases

EPDiP11835
MaxQBiP11835
PaxDbiP11835
PeptideAtlasiP11835
PRIDEiP11835

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16414
KEGGimmu:16414

Organism-specific databases

CTDi3689
MGIiMGI:96611 Itgb2

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
HOGENOMiHOG000252936
HOVERGENiHBG006190
InParanoidiP11835
KOiK06464

Miscellaneous databases

PROiPR:P11835
SOURCEiSearch...

Gene expression databases

CleanExiMM_ITGB2

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015439 Integrin_bsu-2
IPR014836 Integrin_bsu_cyt_dom
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF15 PTHR10082:SF15, 1 hit
PfamiView protein in Pfam
PF08725 Integrin_b_cyt, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PIRSFiPIRSF002512 Integrin_B, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit
SM00423 PSI, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 1 hit
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 3 hits
PS00243 INTEGRIN_BETA, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiITB2_MOUSE
AccessioniPrimary (citable) accession number: P11835
Secondary accession number(s): Q64482
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 15, 1998
Last modified: November 7, 2018
This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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