UniProtKB - P11802 (CDK4_HUMAN)
Cyclin-dependent kinase 4
CDK4
Functioni
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
3 PublicationsCatalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 35 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 140 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 20 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cyclin binding Source: UniProtKB
- cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
- cyclin-dependent protein serine/threonine kinase regulator activity Source: Reactome
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine kinase activity Source: RHEA
- RNA polymerase II CTD heptapeptide repeat kinase activity Source: GO_Central
GO - Biological processi
- adipose tissue development Source: Ensembl
- cell division Source: UniProtKB-KW
- cellular response to insulin stimulus Source: Ensembl
- cellular response to interleukin-4 Source: Ensembl
- cellular response to ionomycin Source: Ensembl
- cellular response to lipopolysaccharide Source: Ensembl
- cellular response to phorbol 13-acetate 12-myristate Source: Ensembl
- G1/S transition of mitotic cell cycle Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of fibroblast proliferation Source: BHF-UCL
- positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
- protein phosphorylation Source: BHF-UCL
- regulation of cell cycle Source: UniProtKB
- regulation of gene expression Source: BHF-UCL
- regulation of insulin receptor signaling pathway Source: Ensembl
- regulation of lipid biosynthetic process Source: Ensembl
- regulation of lipid catabolic process Source: Ensembl
- regulation of multicellular organism growth Source: Ensembl
- regulation of transcription initiation from RNA polymerase II promoter Source: Reactome
- response to xenobiotic stimulus Source: UniProtKB
- signal transduction Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle, Cell division |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.22, 2681 |
PathwayCommonsi | P11802 |
Reactomei | R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559585, Oncogene Induced Senescence R-HSA-3214858, RMTs methylate histone arginines R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-69231, Cyclin D associated events in G1 R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8849470, PTK6 Regulates Cell Cycle R-HSA-8878166, Transcriptional regulation by RUNX2 R-HSA-912446, Meiotic recombination R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-9630791, Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630794, Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632697, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632700, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9661069, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) |
SignaLinki | P11802 |
SIGNORi | P11802 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinase 4 (EC:2.7.11.22)Alternative name(s): Cell division protein kinase 4 PSK-J3 |
Gene namesi | Name:CDK4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1773, CDK4 |
MIMi | 123829, gene |
neXtProti | NX_P11802 |
VEuPathDBi | HostDB:ENSG00000135446 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus 3 Publications
- Nucleus membrane 1 Publication
Note: Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G1 phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G1 to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.1 Publication
Cytosol
- cytosol Source: UniProtKB
Nucleus
- mediator complex Source: GO_Central
- nuclear membrane Source: UniProtKB
- nucleolus Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- bicellular tight junction Source: Ensembl
- chromatin Source: UniProtKB
- cyclin D1-CDK4 complex Source: ComplexPortal
- cyclin D2-CDK4 complex Source: ComplexPortal
- cyclin D3-CDK4 complex Source: ComplexPortal
- cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Melanoma, cutaneous malignant 3 (CMM3)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006200 | 24 | R → C in CMM3; somatic and familial; generates a dominant oncogene resistant to inhibition by p16(INK4a). 2 PublicationsCorresponds to variant dbSNP:rs11547328EnsemblClinVar. | 1 | |
Natural variantiVAR_006201 | 24 | R → H in CMM3. 1 PublicationCorresponds to variant dbSNP:rs104894340EnsemblClinVar. | 1 | |
Natural variantiVAR_021152 | 41 | N → S in CMM3; sporadic. 1 PublicationCorresponds to variant dbSNP:rs144890720EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 172 | T → A: Weak enzyme activity towards RB1, but no effect on binding of CCDN1 nor CCDN3. 1 Publication | 1 | |
Mutagenesisi | 172 | T → E: Retains moderate enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 173 | P → S: No effect on in vitro phosphorylation by CDK7. Greatly reduced T-172 phosphorylation and enzyme activity. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 1019 |
MalaCardsi | CDK4 |
MIMi | 609048, phenotype |
OpenTargetsi | ENSG00000135446 |
Orphaneti | 99970, Dedifferentiated liposarcoma 618, Familial melanoma 99971, Well-differentiated liposarcoma |
PharmGKBi | PA102 |
Miscellaneous databases
Pharosi | P11802, Tclin |
Chemistry databases
ChEMBLi | CHEMBL331 |
DrugBanki | DB12001, Abemaciclib DB03496, Alvocidib DB12010, Fostamatinib DB09073, Palbociclib DB02733, Purvalanol DB11730, Ribociclib DB15442, Trilaciclib |
DrugCentrali | P11802 |
GuidetoPHARMACOLOGYi | 1976 |
Genetic variation databases
BioMutai | CDK4 |
DMDMi | 1168867 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000085778 | 2 – 303 | Cyclin-dependent kinase 4Add BLAST | 302 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 172 | PhosphothreonineCombined sources4 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P11802 |
jPOSTi | P11802 |
MassIVEi | P11802 |
MaxQBi | P11802 |
PaxDbi | P11802 |
PeptideAtlasi | P11802 |
PRIDEi | P11802 |
ProteomicsDBi | 4694 52805 [P11802-1] |
PTM databases
GlyGeni | P11802, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P11802 |
MetOSitei | P11802 |
PhosphoSitePlusi | P11802 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135446, Expressed in subventricular zone (inner) (primate) and 237 other tissues |
ExpressionAtlasi | P11802, baseline and differential |
Genevisiblei | P11802, HS |
Organism-specific databases
HPAi | ENSG00000135446, Low tissue specificity |
Interactioni
Subunit structurei
Component of the D-CDK4 complex, composed of CDK4 and some D-type G1 cyclin (CCND1, CCND2 or CCND3).
Interacts directly in the complex with CCND1, CCND2 or CCND3.
Interacts with SEI1 and ZNF655.
Forms a ternary complex, cyclin D-CDK4-CDKN1B, involved in modulating CDK4 enzymatic activity.
Interacts directly with CDKN1B (phosphorylated on 'Tyr-88' and 'Tyr-89'); the interaction allows assembly of the cyclin D-CDK4 complex, Thr-172 phosphorylation, nuclear translocation and enhances the cyclin D-CDK4 complex activity. CDK4 activity is either inhibited or enhanced depending on stoichiometry of complex. The non-tyrosine-phosphorylated form of CDKN1B prevents T-loop phosphorylation of CDK4 producing inactive CDK4.
Interacts (unphosphorylated form) with CDK2. Also forms ternary complexes with CDKN1A or CDKN2A.
Interacts directly with CDKN1A (via its N-terminal); the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4.
Interacts with CCND1; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (PubMed:29127155).
Interacts with CEBPA (when phosphorylated) (PubMed:15107404).
Interacts with FNIP1 and FNIP2 (PubMed:27353360).
By similarity13 PublicationsBinary interactionsi
P11802
GO - Molecular functioni
- cyclin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107454, 274 interactors |
ComplexPortali | CPX-2010, Cyclin D1-CDK4 complex CPX-2011, Cyclin D2-CDK4 complex CPX-2012, Cyclin D3-CDK4 complex |
CORUMi | P11802 |
DIPi | DIP-875N |
ELMi | P11802 |
IntActi | P11802, 128 interactors |
MINTi | P11802 |
STRINGi | 9606.ENSP00000257904 |
Chemistry databases
BindingDBi | P11802 |
Miscellaneous databases
RNActi | P11802, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P11802 |
SMRi | P11802 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P11802 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 295 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 290 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 50 – 56 | Required for binding D-type cyclins | 7 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0594, Eukaryota |
GeneTreei | ENSGT00940000154770 |
InParanoidi | P11802 |
OMAi | THTHCWH |
PhylomeDBi | P11802 |
TreeFami | TF101022 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATSRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGGGGGGLP
60 70 80 90 100
ISTVREVALL RRLEAFEHPN VVRLMDVCAT SRTDREIKVT LVFEHVDQDL
110 120 130 140 150
RTYLDKAPPP GLPAETIKDL MRQFLRGLDF LHANCIVHRD LKPENILVTS
160 170 180 190 200
GGTVKLADFG LARIYSYQMA LTPVVVTLWY RAPEVLLQST YATPVDMWSV
210 220 230 240 250
GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR DVSLPRGAFP
260 270 280 290 300
PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISAFRAL QHSYLHKDEG
NPE
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VWX7 | F8VWX7_HUMAN | Cyclin-dependent kinase 4 | CDK4 | 203 | Annotation score: | ||
F8VYH9 | F8VYH9_HUMAN | Cyclin-dependent kinase 4 | CDK4 | 170 | Annotation score: | ||
F8VTV8 | F8VTV8_HUMAN | Cyclin-dependent kinase 4 | CDK4 | 201 | Annotation score: | ||
F8W1L8 | F8W1L8_HUMAN | Cyclin-dependent kinase 4 | CDK4 | 115 | Annotation score: | ||
F8VYY1 | F8VYY1_HUMAN | Cyclin-dependent kinase 4 | CDK4 | 74 | Annotation score: | ||
Q96BE9 | Q96BE9_HUMAN | CDK4 protein | CDK4 hCG_40151 | 111 | Annotation score: | ||
F8VXD2 | F8VXD2_HUMAN | Cyclin-dependent kinase 4 | CDK4 | 132 | Annotation score: | ||
F8VZ51 | F8VZ51_HUMAN | Cyclin-dependent kinase 4 | CDK4 | 208 | Annotation score: | ||
F8VZZ0 | F8VZZ0_HUMAN | Cyclin-dependent kinase 4 | CDK4 | 186 | Annotation score: | ||
F8VZ13 | F8VZ13_HUMAN | Cyclin-dependent kinase 4 | CDK4 | 40 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 117 | I → L in BAG36447 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006200 | 24 | R → C in CMM3; somatic and familial; generates a dominant oncogene resistant to inhibition by p16(INK4a). 2 PublicationsCorresponds to variant dbSNP:rs11547328EnsemblClinVar. | 1 | |
Natural variantiVAR_006201 | 24 | R → H in CMM3. 1 PublicationCorresponds to variant dbSNP:rs104894340EnsemblClinVar. | 1 | |
Natural variantiVAR_021152 | 41 | N → S in CMM3; sporadic. 1 PublicationCorresponds to variant dbSNP:rs144890720EnsemblClinVar. | 1 | |
Natural variantiVAR_029153 | 82 | R → Q1 PublicationCorresponds to variant dbSNP:rs3211612EnsemblClinVar. | 1 | |
Natural variantiVAR_041976 | 122 | R → H1 PublicationCorresponds to variant dbSNP:rs34386532EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056487 | 1 – 120 | Missing in isoform 2. 1 PublicationAdd BLAST | 120 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14505 mRNA Translation: AAA35673.1 U81031 Genomic DNA Translation: AAC39521.2 Z48970 mRNA Translation: CAA88834.1 U37022 Genomic DNA Translation: AAC50506.1 AF507942 Genomic DNA Translation: AAM23014.1 AK297901 mRNA Translation: BAG60221.1 AK313701 mRNA Translation: BAG36447.1 CR407668 mRNA Translation: CAG28596.1 CR542247 mRNA Translation: CAG47043.1 AC025165 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW97058.1 BC003644 mRNA Translation: AAH03644.1 BC005864 mRNA Translation: AAH05864.1 BC010153 mRNA Translation: AAH10153.1 S67448 Genomic DNA Translation: AAD13991.1 |
CCDSi | CCDS8953.1 [P11802-1] |
PIRi | I52695 S52841 |
RefSeqi | NP_000066.1, NM_000075.3 [P11802-1] |
Genome annotation databases
Ensembli | ENST00000257904.11; ENSP00000257904.5; ENSG00000135446.17 |
GeneIDi | 1019 |
KEGGi | hsa:1019 |
MANE-Selecti | ENST00000257904.11; ENSP00000257904.5; NM_000075.4; NP_000066.1 |
UCSCi | uc001spv.4, human [P11802-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14505 mRNA Translation: AAA35673.1 U81031 Genomic DNA Translation: AAC39521.2 Z48970 mRNA Translation: CAA88834.1 U37022 Genomic DNA Translation: AAC50506.1 AF507942 Genomic DNA Translation: AAM23014.1 AK297901 mRNA Translation: BAG60221.1 AK313701 mRNA Translation: BAG36447.1 CR407668 mRNA Translation: CAG28596.1 CR542247 mRNA Translation: CAG47043.1 AC025165 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW97058.1 BC003644 mRNA Translation: AAH03644.1 BC005864 mRNA Translation: AAH05864.1 BC010153 mRNA Translation: AAH10153.1 S67448 Genomic DNA Translation: AAD13991.1 |
CCDSi | CCDS8953.1 [P11802-1] |
PIRi | I52695 S52841 |
RefSeqi | NP_000066.1, NM_000075.3 [P11802-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2W96 | X-ray | 2.30 | B | 1-303 | [»] | |
2W99 | X-ray | 2.80 | B | 1-303 | [»] | |
2W9F | X-ray | 2.85 | B | 1-303 | [»] | |
2W9Z | X-ray | 2.45 | B | 1-303 | [»] | |
3G33 | X-ray | 3.00 | A/C | 1-303 | [»] | |
5FWK | electron microscopy | 3.90 | K | 1-303 | [»] | |
5FWL | electron microscopy | 9.00 | K | 1-303 | [»] | |
5FWM | electron microscopy | 8.00 | K | 1-303 | [»] | |
5FWP | electron microscopy | 7.20 | K | 1-303 | [»] | |
6P8E | X-ray | 2.30 | B | 2-303 | [»] | |
6P8F | X-ray | 2.89 | B | 2-303 | [»] | |
6P8G | X-ray | 2.80 | B | 2-303 | [»] | |
6P8H | X-ray | 3.19 | B | 2-303 | [»] | |
AlphaFoldDBi | P11802 | |||||
SMRi | P11802 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107454, 274 interactors |
ComplexPortali | CPX-2010, Cyclin D1-CDK4 complex CPX-2011, Cyclin D2-CDK4 complex CPX-2012, Cyclin D3-CDK4 complex |
CORUMi | P11802 |
DIPi | DIP-875N |
ELMi | P11802 |
IntActi | P11802, 128 interactors |
MINTi | P11802 |
STRINGi | 9606.ENSP00000257904 |
Chemistry databases
BindingDBi | P11802 |
ChEMBLi | CHEMBL331 |
DrugBanki | DB12001, Abemaciclib DB03496, Alvocidib DB12010, Fostamatinib DB09073, Palbociclib DB02733, Purvalanol DB11730, Ribociclib DB15442, Trilaciclib |
DrugCentrali | P11802 |
GuidetoPHARMACOLOGYi | 1976 |
PTM databases
GlyGeni | P11802, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P11802 |
MetOSitei | P11802 |
PhosphoSitePlusi | P11802 |
Genetic variation databases
BioMutai | CDK4 |
DMDMi | 1168867 |
Proteomic databases
EPDi | P11802 |
jPOSTi | P11802 |
MassIVEi | P11802 |
MaxQBi | P11802 |
PaxDbi | P11802 |
PeptideAtlasi | P11802 |
PRIDEi | P11802 |
ProteomicsDBi | 4694 52805 [P11802-1] |
Protocols and materials databases
Antibodypediai | 4190, 1097 antibodies from 47 providers |
DNASUi | 1019 |
Genome annotation databases
Ensembli | ENST00000257904.11; ENSP00000257904.5; ENSG00000135446.17 |
GeneIDi | 1019 |
KEGGi | hsa:1019 |
MANE-Selecti | ENST00000257904.11; ENSP00000257904.5; NM_000075.4; NP_000066.1 |
UCSCi | uc001spv.4, human [P11802-1] |
Organism-specific databases
CTDi | 1019 |
DisGeNETi | 1019 |
GeneCardsi | CDK4 |
HGNCi | HGNC:1773, CDK4 |
HPAi | ENSG00000135446, Low tissue specificity |
MalaCardsi | CDK4 |
MIMi | 123829, gene 609048, phenotype |
neXtProti | NX_P11802 |
OpenTargetsi | ENSG00000135446 |
Orphaneti | 99970, Dedifferentiated liposarcoma 618, Familial melanoma 99971, Well-differentiated liposarcoma |
PharmGKBi | PA102 |
VEuPathDBi | HostDB:ENSG00000135446 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0594, Eukaryota |
GeneTreei | ENSGT00940000154770 |
InParanoidi | P11802 |
OMAi | THTHCWH |
PhylomeDBi | P11802 |
TreeFami | TF101022 |
Enzyme and pathway databases
BRENDAi | 2.7.11.22, 2681 |
PathwayCommonsi | P11802 |
Reactomei | R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559585, Oncogene Induced Senescence R-HSA-3214858, RMTs methylate histone arginines R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-69231, Cyclin D associated events in G1 R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8849470, PTK6 Regulates Cell Cycle R-HSA-8878166, Transcriptional regulation by RUNX2 R-HSA-912446, Meiotic recombination R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-9630791, Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630794, Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632697, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632700, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9661069, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) |
SignaLinki | P11802 |
SIGNORi | P11802 |
Miscellaneous databases
BioGRID-ORCSi | 1019, 291 hits in 1124 CRISPR screens |
ChiTaRSi | CDK4, human |
EvolutionaryTracei | P11802 |
GeneWikii | Cyclin-dependent_kinase_4 |
GenomeRNAii | 1019 |
Pharosi | P11802, Tclin |
PROi | PR:P11802 |
RNActi | P11802, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135446, Expressed in subventricular zone (inner) (primate) and 237 other tissues |
ExpressionAtlasi | P11802, baseline and differential |
Genevisiblei | P11802, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDK4_HUMAN | |
Accessioni | P11802Primary (citable) accession number: P11802 Secondary accession number(s): B2R9A0 Q6FG61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | November 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 247 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families