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Protein

Serine/threonine-protein kinase H1

Gene

PSKH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Activity depends on Ca2+ concentration.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127ATPPROSITE-ProRule annotation1
Active sitei218Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 112ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiP11801

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase H1 (EC:2.7.11.1)
Alternative name(s):
Protein serine kinase H1
Short name:
PSK-H1
Gene namesi
Name:PSKH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000159792.9
HGNCiHGNC:9529 PSKH1
MIMi177015 gene
neXtProtiNX_P11801

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi218D → A: Loss of autophosphorylation. 1 Publication1

Organism-specific databases

DisGeNETi5681
OpenTargetsiENSG00000159792
PharmGKBiPA33874

Polymorphism and mutation databases

BioMutaiPSKH1
DMDMi17379144

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00000861672 – 424Serine/threonine-protein kinase H1Add BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Lipidationi3S-palmitoyl cysteine1 Publication1
Modified residuei380Phosphoserine; by autocatalysisSequence analysis1
Modified residuei381Phosphoserine; by autocatalysisSequence analysis1

Post-translational modificationi

Autophosphorylated on serine residues.1 Publication
Myristoylated. Required for membrane association. Prerequisite for palmitoylation to occur.1 Publication
Palmitoylated.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP11801
PeptideAtlasiP11801
PRIDEiP11801
ProteomicsDBi52804

PTM databases

iPTMnetiP11801
PhosphoSitePlusiP11801
SwissPalmiP11801

Expressioni

Tissue specificityi

Expressed in all tissues and cell lines tested with the highest level of abundance in testis.1 Publication

Gene expression databases

BgeeiENSG00000159792 Expressed in 177 organ(s), highest expression level in heart left ventricle
CleanExiHS_PSKH1
ExpressionAtlasiP11801 baseline and differential
GenevisibleiP11801 HS

Organism-specific databases

HPAiHPA053927

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AB1P082382EBI-3922781,EBI-352572

Protein-protein interaction databases

BioGridi111654, 6 interactors
IntActiP11801, 2 interactors
STRINGi9606.ENSP00000291041

Structurei

3D structure databases

ProteinModelPortaliP11801
SMRiP11801
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 355Protein kinasePROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118944
HOGENOMiHOG000233016
HOVERGENiHBG108055
InParanoidiP11801
KOiK08808
OMAiKHPWVVS
OrthoDBiEOG091G0HK9
PhylomeDBiP11801
TreeFamiTF314166

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P11801-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCGTSKVLP EPPKDVQLDL VKKVEPFSGT KSDVYKHFIT EVDSVGPVKA
60 70 80 90 100
GFPAASQYAH PCPGPPTAGH TEPPSEPPRR ARVAKYRAKF DPRVTAKYDI
110 120 130 140 150
KALIGRGSFS RVVRVEHRAT RQPYAIKMIE TKYREGREVC ESELRVLRRV
160 170 180 190 200
RHANIIQLVE VFETQERVYM VMELATGGEL FDRIIAKGSF TERDATRVLQ
210 220 230 240 250
MVLDGVRYLH ALGITHRDLK PENLLYYHPG TDSKIIITDF GLASARKKGD
260 270 280 290 300
DCLMKTTCGT PEYIAPEVLV RKPYTNSVDM WALGVIAYIL LSGTMPFEDD
310 320 330 340 350
NRTRLYRQIL RGKYSYSGEP WPSVSNLAKD FIDRLLTVDP GARMTALQAL
360 370 380 390 400
RHPWVVSMAA SSSMKNLHRS ISQNLLKRAS SRCQSTKSAQ STRSSRSTRS
410 420
NKSRRVRERE LRELNLRYQQ QYNG
Length:424
Mass (Da):48,035
Last modified:January 23, 2007 - v4
Checksum:iB357757DDC12388D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZT9A0A087WZT9_HUMAN
Serine/threonine-protein kinase H1
PSKH1
353Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040614301N → S1 PublicationCorresponds to variant dbSNP:rs35552721Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272212 mRNA Translation: CAB91984.1
BC062616 mRNA Translation: AAH62616.1
M14504 mRNA Translation: AAA36519.1
CCDSiCCDS10851.1
PIRiB26368
I38138
RefSeqiNP_006733.1, NM_006742.2
UniGeneiHs.513683

Genome annotation databases

EnsembliENST00000291041; ENSP00000291041; ENSG00000159792
GeneIDi5681
KEGGihsa:5681
UCSCiuc002euv.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272212 mRNA Translation: CAB91984.1
BC062616 mRNA Translation: AAH62616.1
M14504 mRNA Translation: AAA36519.1
CCDSiCCDS10851.1
PIRiB26368
I38138
RefSeqiNP_006733.1, NM_006742.2
UniGeneiHs.513683

3D structure databases

ProteinModelPortaliP11801
SMRiP11801
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111654, 6 interactors
IntActiP11801, 2 interactors
STRINGi9606.ENSP00000291041

PTM databases

iPTMnetiP11801
PhosphoSitePlusiP11801
SwissPalmiP11801

Polymorphism and mutation databases

BioMutaiPSKH1
DMDMi17379144

Proteomic databases

PaxDbiP11801
PeptideAtlasiP11801
PRIDEiP11801
ProteomicsDBi52804

Protocols and materials databases

DNASUi5681
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291041; ENSP00000291041; ENSG00000159792
GeneIDi5681
KEGGihsa:5681
UCSCiuc002euv.3 human

Organism-specific databases

CTDi5681
DisGeNETi5681
EuPathDBiHostDB:ENSG00000159792.9
GeneCardsiPSKH1
HGNCiHGNC:9529 PSKH1
HPAiHPA053927
MIMi177015 gene
neXtProtiNX_P11801
OpenTargetsiENSG00000159792
PharmGKBiPA33874
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118944
HOGENOMiHOG000233016
HOVERGENiHBG108055
InParanoidiP11801
KOiK08808
OMAiKHPWVVS
OrthoDBiEOG091G0HK9
PhylomeDBiP11801
TreeFamiTF314166

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiP11801

Miscellaneous databases

ChiTaRSiPSKH1 human
GeneWikiiPSKH1
GenomeRNAii5681
PROiPR:P11801
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159792 Expressed in 177 organ(s), highest expression level in heart left ventricle
CleanExiHS_PSKH1
ExpressionAtlasiP11801 baseline and differential
GenevisibleiP11801 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKPSH1_HUMAN
AccessioniPrimary (citable) accession number: P11801
Secondary accession number(s): Q9NY19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 177 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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