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Entry version 190 (16 Jan 2019)
Sequence version 2 (15 Jul 1998)
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Protein

Myosin light chain kinase, smooth muscle

Gene

Mylk

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by phosphorylation on Tyr-478. Isoforms which lack this tyrosine residue are not regulated in this way. All catalytically active isoforms require binding to calcium and calmodulin for activation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1482ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1574Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1459 – 1467ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.18 1306

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin light chain kinase, smooth muscle (EC:2.7.11.18)
Short name:
MLCK
Alternative name(s):
Telokin
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mylk
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1762S → A: Decreases membrane translocation. 1 Publication1
Mutagenesisi1768S → A: Decreases membrane translocation. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3062

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000243611 – 1906Myosin light chain kinase, smooth muscleAdd BLAST1906
ChainiPRO_00004248671 – 1901Myosin light chain kinase, smooth muscle, deglutamylated formAdd BLAST1901

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1762Phosphoserine; by PKG1 Publication1
Modified residuei1768Phosphoserine; by MAPK1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The C-terminus is deglutamylated, leading to the formation of Myosin light chain kinase, smooth muscle, deglutamylated form. The C-terminus is variable, with one to five C-terminal glutamyl residues being removed producing five forms differring in their number of C-terminal glutamyl residues.1 Publication
Acetylated.1 Publication
Phosphorylation of telokin by PKG has no significant effect on its myosin binding activity, but promotes translocation to the membrane.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11799

PRoteomics IDEntifications database

More...
PRIDEi
P11799

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11799

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform telokin is expressed in gizzard, heart, lung, intestine, and skeletal muscle although the levels of the expression in the latter were much less than that in the gizzard.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

All isoforms including Telokin bind calmodulin.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
676694, 1 interactor

Protein interaction database and analysis system

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IntActi
P11799, 3 interactors

Molecular INTeraction database

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MINTi
P11799

STRING: functional protein association networks

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STRINGi
9031.ENSGALP00000019112

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P11799

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11906
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CDLX-ray2.00E/F/G/H1730-1749[»]
1QS7X-ray1.80B/D1731-1749[»]
1QTXX-ray1.65B1731-1749[»]
1VRKX-ray1.90B1731-1749[»]
2O5GX-ray1.08B1730-1748[»]
3EVUX-ray1.75A1731-1749[»]
3EVVX-ray2.60A1731-1749[»]
3O77X-ray2.35A1730-1749[»]
3O78X-ray2.60A/B1731-1749[»]
4OY4X-ray2.03A1715-1725[»]
A1731-1749[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P11799

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P11799

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P11799

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 117Ig-like C2-type 1Add BLAST90
Domaini156 – 244Ig-like C2-type 2Add BLAST89
Domaini429 – 517Ig-like C2-type 3Add BLAST89
Domaini521 – 613Ig-like C2-type 4Add BLAST93
Domaini637 – 725Ig-like C2-type 5Add BLAST89
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati660 – 676IIA-1Add BLAST17
Repeati693 – 708IIB-1Add BLAST16
Domaini735 – 830Ig-like C2-type 6Add BLAST96
Repeati758 – 774IIA-2Add BLAST17
Repeati791 – 807IIB-2Add BLAST17
Repeati970 – 987III-1Add BLAST18
Repeati999 – 1016III-2Add BLAST18
Repeati1061 – 1078III-3Add BLAST18
Domaini1084 – 1172Ig-like C2-type 7Add BLAST89
Repeati1107 – 1123IIA-3Add BLAST17
Repeati1140 – 1156IIB-3Add BLAST17
Repeati1209 – 1226III-4Add BLAST18
Domaini1225 – 1313Ig-like C2-type 8Add BLAST89
Repeati1281 – 1297IIB-4Add BLAST17
Domaini1321 – 1414Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST94
Domaini1453 – 1708Protein kinasePROSITE-ProRule annotationAdd BLAST256
Domaini1794 – 1885Ig-like C2-type 9Add BLAST92
Repeati1817 – 1833IIA-4Add BLAST17
Repeati1851 – 1866IIB-5Add BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni660 – 18334 X repeats, motif IIAAdd BLAST1174
Regioni693 – 18665 X repeats, motif IIBAdd BLAST1174
Regioni970 – 12264 X repeats, motif IIIAdd BLAST257
Regioni1317 – 1364Motif IAAdd BLAST48
Regioni1385 – 1402Motif IBAdd BLAST18
Regioni1700 – 1763Calmodulin-bindingAdd BLAST64
Regioni1716 – 1728Calmodulin autoinhibition (AM13) regionSequence analysisAdd BLAST13
Regioni1730 – 1749Calmodulin recognition (RS20) regionSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1896 – 1906Poly-GluAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0613 Eukaryota
ENOG410XQFD LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049287

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052551

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11799

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit
cd14191 STKc_MLCK1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR015725 MLCK1_kinase_dom
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 1 hit
PF07679 I-set, 9 hits
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 9 hits
SM00408 IGc2, 9 hits
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 9 hits
SSF49265 SSF49265, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket
Isoform 1 (identifier: P11799-1) [UniParc]FASTAAdd to basket
Also known as: MLCK-108, Smooth-muscle

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDVKLVTST RVSKTSLTLS PSVPAEAPAF TLPPRNIRVQ LGATARFEGK
60 70 80 90 100
VRGYPEPQIT WYRNGHPLPE GDHYVVDHSI RGIFSLVIKG VQEGDSGKYT
110 120 130 140 150
CEAANDGGVR QVTVELTVEG NSLKKYSLPS SAKTPGGRLS VPPVEHRPSI
160 170 180 190 200
WGESPPKFAT KPNRVVVREG QTGRFSCKIT GRPQPQVTWT KGDIHLQQNE
210 220 230 240 250
RFNMFEKTGI QYLEIQNVQL ADAGIYTCTV VNSAGKASVS AELTVQGPDK
260 270 280 290 300
TDTHAQPLCM PPKPTTLATK AIENSDFKQA TSNGIAKELK STSTELMVET
310 320 330 340 350
KDRLSAKKET FYTSREAKDG KQGQNQEANA VPLQESRGTK GPQVLQKTSS
360 370 380 390 400
TITLQAVKAQ PEPKAEPQTT FIRQAEDRKR TVQPLMTTTT QENPSLTGQV
410 420 430 440 450
SPRSRETENR AGVRKSVKEE KREPLGIPPQ FESRPQSLEA SEGQEIKFKS
460 470 480 490 500
KVSGKPKPDV EWFKEGVPIK TGEGIQIYEE DGTHCLWLKK ACLGDSGSYS
510 520 530 540 550
CAAFNPRGQT STSWLLTVKR PKVEEVAPCF SSVLKGCTVS EGQDFVLQCY
560 570 580 590 600
VGGVPVPEIT WLLNEQPIQY AHSTFEAGVA KLTVQDALPE DDGIYTCLAE
610 620 630 640 650
NNAGRASCSA QVTVKEKKSS KKAEGTQAAK LNKTFAPIFL KGLTDLKVMD
660 670 680 690 700
GSQVIMTVEV SANPCPEIIW LHNGKEIQET EDFHFEKKGN EYSLYIQEVF
710 720 730 740 750
PEDTGKYTCE AWNELGETQT QATLTVQEPQ DGIQPWFISK PRSVTAAAGQ
760 770 780 790 800
NVLISCAIAG DPFPTVHWFK DGQEITPGTG CEILQNEDIF TLILRNVQSR
810 820 830 840 850
HAGQYEIQLR NQVGECSCQV SLMLRESSAS RAEMLRDGRE SASSGERRDG
860 870 880 890 900
GNYGALTFGR TSGFKKSSSE TRAAEEEQED VRGVLKRRVE TREHTEESLR
910 920 930 940 950
QQEAEQLDFR DILGKKVSTK SFSEEDLKEI PAEQMDFRAN LQRQVKPKTL
960 970 980 990 1000
SEEERKVHAP QQVDFRSVLA KKGTPKTPLP EKVPPPKPAV TDFRSVLGAK
1010 1020 1030 1040 1050
KKPPAENGSA STPAPNARAG SEAQNATPNS EAPAPKPVVK KEEKNDRKCE
1060 1070 1080 1090 1100
HGCAVVDGGI IGKKAENKPA ASKPTPPPSK GTAPSFTEKL QDAKVADGEK
1110 1120 1130 1140 1150
LVLQCRISSD PPASVSWTLD SKAIKSSKSI VISQEGTLCS LTIEKVMPED
1160 1170 1180 1190 1200
GGEYKCIAEN AAGKAECACK VLVEDTSSTK AAKPAEKKTK KPKTTLPPVL
1210 1220 1230 1240 1250
STESSEATVK KKPAPKTPPK AATPPQITQF PEDRKVRAGE SVELFAKVVG
1260 1270 1280 1290 1300
TAPITCTWMK FRKQIQENEY IKIENAENSS KLTISSTKQE HCGCYTLVVE
1310 1320 1330 1340 1350
NKLGSRQAQV NLTVVDKPDP PAGTPCASDI RSSSLTLSWY GSSYDGGSAV
1360 1370 1380 1390 1400
QSYTVEIWNS VDNKWTDLTT CRSTSFNVQD LQADREYKFR VRAANVYGIS
1410 1420 1430 1440 1450
EPSQESEVVK VGEKQEEELK EEEAELSDDE GKETEVNYRT VTINTEQKVS
1460 1470 1480 1490 1500
DVYNIEERLG SGKFGQVFRL VEKKTGKVWA GKFFKAYSAK EKENIRDEIS
1510 1520 1530 1540 1550
IMNCLHHPKL VQCVDAFEEK ANIVMVLEMV SGGELFERII DEDFELTERE
1560 1570 1580 1590 1600
CIKYMRQISE GVEYIHKQGI VHLDLKPENI MCVNKTGTSI KLIDFGLARR
1610 1620 1630 1640 1650
LESAGSLKVL FGTPEFVAPE VINYEPIGYE TDMWSIGVIC YILVSGLSPF
1660 1670 1680 1690 1700
MGDNDNETLA NVTSATWDFD DEAFDEISDD AKDFISNLLK KDMKSRLNCT
1710 1720 1730 1740 1750
QCLQHPWLQK DTKNMEAKKL SKDRMKKYMA RRKWQKTGHA VRAIGRLSSM
1760 1770 1780 1790 1800
AMISGMSGRK ASGSSPTSPI NADKVENEDA FLEEVAEEKP HVKPYFTKTI
1810 1820 1830 1840 1850
LDMEVVEGSA ARFDCKIEGY PDPEVMWYKD DQPVKESRHF QIDYDEEGNC
1860 1870 1880 1890 1900
SLTISEVCGD DDAKYTCKAV NSLGEATCTA ELLVETMGKE GEGEGEGEED

EEEEEE
Length:1,906
Mass (Da):210,446
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD7D8A3B69EE3363
GO
Isoform 2 (identifier: P11799-2) [UniParc]FASTAAdd to basket
Also known as: MLCK-210, Non-muscle

The sequence of this isoform differs from the canonical sequence as follows:
     1-934: Missing.

Show »
Length:972
Mass (Da):107,547
Checksum:i375ED3627731EFFE
GO
Isoform 3 (identifier: P11799-3) [UniParc]FASTAAdd to basket
Also known as: Telokin

The sequence of this isoform differs from the canonical sequence as follows:
     1-1749: Missing.

Show »
Length:157
Mass (Da):17,337
Checksum:i557E7CD96C672E7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1439R → Q in AAA49069 (PubMed:3030394).Curated1
Sequence conflicti1439R → Q in AAA69964 (PubMed:3030394).Curated1
Sequence conflicti1776E → D AA sequence (PubMed:9283094).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0188521 – 1749Missing in isoform 3. 2 PublicationsAdd BLAST1749
Alternative sequenceiVSP_0188511 – 934Missing in isoform 2. 1 PublicationAdd BLAST934

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X52876 mRNA Translation: CAA37056.1
X52876 mRNA Translation: CAA37057.1
X52876 mRNA Translation: CAA37058.1
M31048 mRNA Translation: AAA49069.1
M14953 mRNA Translation: AAA69964.1
AF045285
, AF045255, AF045256, AF045257, AF045260, AF045259, AF045258, AF045261, AF045263, AF045265, AF045274, AF045273, AF045272, AF045271, AF045270, AF045269, AF045268, AF045267, AF045266, AF045283, AF045282, AF045281, AF045280, AF045279, AF045278, AF045277, AF045276, AF045275, AF045284, AF045264, AF045262 Genomic DNA Translation: AAC29031.1
M96655 mRNA Translation: AAA49083.1
M88283 mRNA Translation: AAA48647.1
M88284 Genomic DNA Translation: AAB53768.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S68235

NCBI Reference Sequences

More...
RefSeqi
XP_015145280.1, XM_015289794.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Gga.4091

Keywords - Coding sequence diversityi

Alternative promoter usage

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52876 mRNA Translation: CAA37056.1
X52876 mRNA Translation: CAA37057.1
X52876 mRNA Translation: CAA37058.1
M31048 mRNA Translation: AAA49069.1
M14953 mRNA Translation: AAA69964.1
AF045285
, AF045255, AF045256, AF045257, AF045260, AF045259, AF045258, AF045261, AF045263, AF045265, AF045274, AF045273, AF045272, AF045271, AF045270, AF045269, AF045268, AF045267, AF045266, AF045283, AF045282, AF045281, AF045280, AF045279, AF045278, AF045277, AF045276, AF045275, AF045284, AF045264, AF045262 Genomic DNA Translation: AAC29031.1
M96655 mRNA Translation: AAA49083.1
M88283 mRNA Translation: AAA48647.1
M88284 Genomic DNA Translation: AAB53768.1
PIRiS68235
RefSeqiXP_015145280.1, XM_015289794.1
UniGeneiGga.4091

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CDLX-ray2.00E/F/G/H1730-1749[»]
1QS7X-ray1.80B/D1731-1749[»]
1QTXX-ray1.65B1731-1749[»]
1VRKX-ray1.90B1731-1749[»]
2O5GX-ray1.08B1730-1748[»]
3EVUX-ray1.75A1731-1749[»]
3EVVX-ray2.60A1731-1749[»]
3O77X-ray2.35A1730-1749[»]
3O78X-ray2.60A/B1731-1749[»]
4OY4X-ray2.03A1715-1725[»]
A1731-1749[»]
ProteinModelPortaliP11799
SMRiP11799
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676694, 1 interactor
IntActiP11799, 3 interactors
MINTiP11799
STRINGi9031.ENSGALP00000019112

Chemistry databases

BindingDBiP11799
ChEMBLiCHEMBL3062

PTM databases

iPTMnetiP11799

Proteomic databases

PaxDbiP11799
PRIDEiP11799

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0613 Eukaryota
ENOG410XQFD LUCA
HOGENOMiHOG000049287
HOVERGENiHBG052551
PhylomeDBiP11799

Enzyme and pathway databases

BRENDAi2.7.11.18 1306

Miscellaneous databases

EvolutionaryTraceiP11799

Protein Ontology

More...
PROi
PR:P11799

Family and domain databases

CDDicd00063 FN3, 1 hit
cd14191 STKc_MLCK1, 1 hit
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR015725 MLCK1_kinase_dom
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF07679 I-set, 9 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 9 hits
SM00408 IGc2, 9 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48726 SSF48726, 9 hits
SSF49265 SSF49265, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYLK_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11799
Secondary accession number(s): P19038, Q549S2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 15, 1998
Last modified: January 16, 2019
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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