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Protein

Serine/threonine-protein kinase SCH9

Gene

SCH9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. Regulates both BCY1 phosphorylation and MPK1 activity (PubMed:20702584). Regulates ribosome biogenesis, translation initiation, and entry into stationary phase in a TORC1-dependent manner (PubMed:17560372).2 Publications

Miscellaneous

Present with 3850 molecules/cell in log phase SD medium.1 Publication

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by cAMP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei441ATPPROSITE-ProRule annotation1
Active sitei538Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi418 – 426ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • age-dependent response to oxidative stress involved in chronological cell aging Source: SGD
  • intracellular signal transduction Source: GO_Central
  • peptidyl-serine phosphorylation Source: GO_Central
  • positive regulation of ribosomal protein gene transcription by RNA polymerase II Source: SGD
  • positive regulation of transcription by RNA polymerase I Source: SGD
  • positive regulation of transcription by RNA polymerase III Source: SGD
  • protein phosphorylation Source: SGD
  • regulation of protein localization Source: SGD
  • regulation of response to osmotic stress Source: SGD
  • regulation of sphingolipid biosynthetic process Source: SGD
  • regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: SGD
  • replicative cell aging Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, cAMP, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31231-MONOMER
BRENDAi2.7.11.1 984
ReactomeiR-SCE-1257604 PIP3 activates AKT signaling
R-SCE-1358803 Downregulation of ERBB2:ERBB3 signaling
R-SCE-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-SCE-165158 Activation of AKT2
R-SCE-166208 mTORC1-mediated signalling
R-SCE-198323 AKT phosphorylates targets in the cytosol
R-SCE-198693 AKT phosphorylates targets in the nucleus
R-SCE-198753 ERK/MAPK targets
R-SCE-199418 Negative regulation of the PI3K/AKT network
R-SCE-203615 eNOS activation
R-SCE-211163 AKT-mediated inactivation of FOXO1A
R-SCE-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-SCE-375165 NCAM signaling for neurite out-growth
R-SCE-389357 CD28 dependent PI3K/Akt signaling
R-SCE-389513 CTLA4 inhibitory signaling
R-SCE-392451 G beta:gamma signalling through PI3Kgamma
R-SCE-444257 RSK activation
R-SCE-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-SCE-5218920 VEGFR2 mediated vascular permeability
R-SCE-6804757 Regulation of TP53 Degradation
R-SCE-6804758 Regulation of TP53 Activity through Acetylation
R-SCE-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-SCE-881907 Gastrin-CREB signalling pathway via PKC and MAPK

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SCH9 (EC:2.7.11.1)
Gene namesi
Name:SCH9
Synonyms:KOM1
Ordered Locus Names:YHR205W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR205W
SGDiS000001248 SCH9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000866381 – 824Serine/threonine-protein kinase SCH9Add BLAST824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei570Phosphothreonine; by PKH1 or PKH21 Publication1
Modified residuei711Phosphoserine; by TORC11 Publication1
Modified residuei723Phosphothreonine; by TORC1Combined sources1 Publication1
Modified residuei726Phosphoserine; by TORC1Combined sources1 Publication1
Modified residuei737Phosphothreonine; by TORC11 Publication1
Modified residuei758Phosphoserine; by TORC11 Publication1
Modified residuei765Phosphoserine; by TORC11 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP11792
PaxDbiP11792
PRIDEiP11792

PTM databases

iPTMnetiP11792

Interactioni

Protein-protein interaction databases

BioGridi36639, 691 interactors
ELMiP11792
IntActiP11792, 21 interactors
MINTiP11792
STRINGi4932.YHR205W

Structurei

3D structure databases

ProteinModelPortaliP11792
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 361C2Add BLAST177
Domaini412 – 671Protein kinasePROSITE-ProRule annotationAdd BLAST260
Domaini672 – 748AGC-kinase C-terminalAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi227 – 267Asn-richAdd BLAST41

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00920000148938
HOGENOMiHOG000233033
InParanoidiP11792
KOiK19800
OMAiVLIFEMC
OrthoDBiEOG092C0HH3

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000008 C2_dom
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P11792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNFFTSKSS NQDTGFSSQH QHPNGQNNGN NNSSTAGNDN GYPCKLVSSG
60 70 80 90 100
PCASSNNGAL FTNFTLQTAT PTTAISQDLY AMGTTGITSE NALFQMKSMN
110 120 130 140 150
NGISSVNNNN SNTPTIITTS QEETNAGNVH GDTGGNSLQN SEDDNFSSSS
160 170 180 190 200
TTKCLLSSTS SLSINQREAA AAAYGPDTDI PRGKLEVTII EARDLVTRSK
210 220 230 240 250
DSQPYVVCTF ESSEFISNGP ESLGAINNNN NNNNNNQHNQ NQHINNNNEN
260 270 280 290 300
TNPDAASQHH NNNSGWNGSQ LPSIKEHLKK KPLYTHRSSS QLDQLNSCSS
310 320 330 340 350
VTDPSKRSSN SSSGSSNGPK NDSSHPIWHH KTTFDVLGSH SELDISVYDA
360 370 380 390 400
AHDHMFLGQV RLYPMIHNLA HASQHQWHSL KPRVIDEVVS GDILIKWTYK
410 420 430 440 450
QTKKRHYGPQ DFEVLRLLGK GTFGQVYQVK KKDTQRIYAM KVLSKKVIVK
460 470 480 490 500
KNEIAHTIGE RNILVTTASK SSPFIVGLKF SFQTPTDLYL VTDYMSGGEL
510 520 530 540 550
FWHLQKEGRF SEDRAKFYIA ELVLALEHLH DNDIVYRDLK PENILLDANG
560 570 580 590 600
NIALCDFGLS KADLKDRTNT FCGTTEYLAP ELLLDETGYT KMVDFWSLGV
610 620 630 640 650
LIFEMCCGWS PFFAENNQKM YQKIAFGKVK FPRDVLSQEG RSFVKGLLNR
660 670 680 690 700
NPKHRLGAID DGRELRAHPF FADIDWEALK QKKIPPPFKP HLVSETDTSN
710 720 730 740 750
FDPEFTTAST SYMNKHQPMM TATPLSPAMQ AKFAGFTFVD ESAIDEHVNN
760 770 780 790 800
NRKFLQNSYF MEPGSFIPGN PNLPPDEDVI DDDGDEDIND GFNQEKNMNN
810 820
SHSQMDFDGD QHMDDEFVSG RFEI
Length:824
Mass (Da):91,812
Last modified:September 5, 2006 - v3
Checksum:iBA84BE0F27143AB5
GO

Sequence cautioni

The sequence AAB69735 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti366I → S in CAA31073 (PubMed:3290050).Curated1
Sequence conflicti751N → K in CAA31073 (PubMed:3290050).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12560 Genomic DNA Translation: CAA31073.1
X57629 Genomic DNA Translation: CAA40853.1
U00029 Genomic DNA Translation: AAB69735.1 Different initiation.
BK006934 Genomic DNA Translation: DAA06898.1
PIRiS48986
RefSeqiNP_012075.1, NM_001179336.1

Genome annotation databases

EnsemblFungiiYHR205W; YHR205W; YHR205W
GeneIDi856612
KEGGisce:YHR205W

Similar proteinsi

Entry informationi

Entry nameiSCH9_YEAST
AccessioniPrimary (citable) accession number: P11792
Secondary accession number(s): D3DLF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 5, 2006
Last modified: July 18, 2018
This is version 190 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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