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UniProtKB - P11792 (SCH9_YEAST)
Protein
Serine/threonine-protein kinase SCH9
Gene
SCH9
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. Regulates both BCY1 phosphorylation and MPK1 activity (PubMed:20702584).
Regulates ribosome biogenesis, translation initiation, and entry into stationary phase in a TORC1-dependent manner (PubMed:17560372).
2 PublicationsMiscellaneous
Present with 3850 molecules/cell in log phase SD medium.1 Publication
Caution
It is uncertain whether Met-1 or Met-2 is the initiator.Curated
Catalytic activityi
Activity regulationi
Activated by cAMP.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 441 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 538 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 418 – 426 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: SGD
- protein serine kinase activity Source: RHEA
GO - Biological processi
- intracellular signal transduction Source: GO_Central
- peptidyl-serine phosphorylation Source: GO_Central
- positive regulation of hydrogen sulfide biosynthetic process Source: SGD
- positive regulation of ribosomal protein gene transcription by RNA polymerase II Source: SGD
- positive regulation of transcription by RNA polymerase I Source: SGD
- positive regulation of transcription by RNA polymerase III Source: SGD
- protein phosphorylation Source: SGD
- regulation of cell size Source: SGD
- regulation of cysteine metabolic process Source: SGD
- regulation of protein localization Source: SGD
- regulation of response to osmotic stress Source: SGD
- regulation of sphingolipid biosynthetic process Source: SGD
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: SGD
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, cAMP, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 984 |
Reactomei | R-SCE-1257604, PIP3 activates AKT signaling R-SCE-1358803, Downregulation of ERBB2:ERBB3 signaling R-SCE-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-SCE-165158, Activation of AKT2 R-SCE-198323, AKT phosphorylates targets in the cytosol R-SCE-198693, AKT phosphorylates targets in the nucleus R-SCE-203615, eNOS activation R-SCE-389357, CD28 dependent PI3K/Akt signaling R-SCE-392451, G beta:gamma signalling through PI3Kgamma R-SCE-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-SCE-5218920, VEGFR2 mediated vascular permeability R-SCE-6804757, Regulation of TP53 Degradation R-SCE-6804758, Regulation of TP53 Activity through Acetylation R-SCE-9009391, Extra-nuclear estrogen signaling R-SCE-9031628, NGF-stimulated transcription |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SCH9 Synonyms:KOM1 Ordered Locus Names:YHR205W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001248, SCH9 |
VEuPathDBi | FungiDB:YHR205W |
Subcellular locationi
Nucleus
- nucleus Source: SGD
Vacuole
- fungal-type vacuole membrane Source: SGD
Other locations
- cytoplasm Source: SGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086638 | 1 – 824 | Serine/threonine-protein kinase SCH9Add BLAST | 824 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 570 | Phosphothreonine; by PKH1 or PKH21 Publication | 1 | |
Modified residuei | 711 | Phosphoserine; by TORC11 Publication | 1 | |
Modified residuei | 723 | Phosphothreonine; by TORC1Combined sources1 Publication | 1 | |
Modified residuei | 726 | Phosphoserine; by TORC1Combined sources1 Publication | 1 | |
Modified residuei | 737 | Phosphothreonine; by TORC11 Publication | 1 | |
Modified residuei | 758 | Phosphoserine; by TORC11 Publication | 1 | |
Modified residuei | 765 | Phosphoserine; by TORC11 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P11792 |
PaxDbi | P11792 |
PRIDEi | P11792 |
PTM databases
iPTMneti | P11792 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 36639, 698 interactors |
ELMi | P11792 |
IntActi | P11792, 10 interactors |
MINTi | P11792 |
STRINGi | 4932.YHR205W |
Miscellaneous databases
RNActi | P11792, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 166 – 378 | C2PROSITE-ProRule annotationAdd BLAST | 213 | |
Domaini | 412 – 671 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 260 | |
Domaini | 672 – 748 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 37 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 125 – 152 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 221 – 272 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 285 – 327 | DisorderedSequence analysisAdd BLAST | 43 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 221 – 271 | Polar residuesSequence analysisAdd BLAST | 51 | |
Compositional biasi | 285 – 323 | Polar residuesSequence analysisAdd BLAST | 39 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0598, Eukaryota |
GeneTreei | ENSGT00940000168810 |
HOGENOMi | CLU_000288_52_2_1 |
InParanoidi | P11792 |
OMAi | SYAMGTT |
Family and domain databases
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR000008, C2_dom IPR035892, C2_domain_sf IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00168, C2, 2 hits PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF49562, SSF49562, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50004, C2, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
P11792-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMNFFTSKSS NQDTGFSSQH QHPNGQNNGN NNSSTAGNDN GYPCKLVSSG
60 70 80 90 100
PCASSNNGAL FTNFTLQTAT PTTAISQDLY AMGTTGITSE NALFQMKSMN
110 120 130 140 150
NGISSVNNNN SNTPTIITTS QEETNAGNVH GDTGGNSLQN SEDDNFSSSS
160 170 180 190 200
TTKCLLSSTS SLSINQREAA AAAYGPDTDI PRGKLEVTII EARDLVTRSK
210 220 230 240 250
DSQPYVVCTF ESSEFISNGP ESLGAINNNN NNNNNNQHNQ NQHINNNNEN
260 270 280 290 300
TNPDAASQHH NNNSGWNGSQ LPSIKEHLKK KPLYTHRSSS QLDQLNSCSS
310 320 330 340 350
VTDPSKRSSN SSSGSSNGPK NDSSHPIWHH KTTFDVLGSH SELDISVYDA
360 370 380 390 400
AHDHMFLGQV RLYPMIHNLA HASQHQWHSL KPRVIDEVVS GDILIKWTYK
410 420 430 440 450
QTKKRHYGPQ DFEVLRLLGK GTFGQVYQVK KKDTQRIYAM KVLSKKVIVK
460 470 480 490 500
KNEIAHTIGE RNILVTTASK SSPFIVGLKF SFQTPTDLYL VTDYMSGGEL
510 520 530 540 550
FWHLQKEGRF SEDRAKFYIA ELVLALEHLH DNDIVYRDLK PENILLDANG
560 570 580 590 600
NIALCDFGLS KADLKDRTNT FCGTTEYLAP ELLLDETGYT KMVDFWSLGV
610 620 630 640 650
LIFEMCCGWS PFFAENNQKM YQKIAFGKVK FPRDVLSQEG RSFVKGLLNR
660 670 680 690 700
NPKHRLGAID DGRELRAHPF FADIDWEALK QKKIPPPFKP HLVSETDTSN
710 720 730 740 750
FDPEFTTAST SYMNKHQPMM TATPLSPAMQ AKFAGFTFVD ESAIDEHVNN
760 770 780 790 800
NRKFLQNSYF MEPGSFIPGN PNLPPDEDVI DDDGDEDIND GFNQEKNMNN
810 820
SHSQMDFDGD QHMDDEFVSG RFEI
Sequence cautioni
The sequence AAB69735 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 366 | I → S in CAA31073 (PubMed:3290050).Curated | 1 | |
Sequence conflicti | 751 | N → K in CAA31073 (PubMed:3290050).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12560 Genomic DNA Translation: CAA31073.1 X57629 Genomic DNA Translation: CAA40853.1 U00029 Genomic DNA Translation: AAB69735.1 Different initiation. BK006934 Genomic DNA Translation: DAA06898.1 |
PIRi | S48986 |
RefSeqi | NP_012075.1, NM_001179336.1 |
Genome annotation databases
EnsemblFungii | YHR205W_mRNA; YHR205W; YHR205W |
GeneIDi | 856612 |
KEGGi | sce:YHR205W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12560 Genomic DNA Translation: CAA31073.1 X57629 Genomic DNA Translation: CAA40853.1 U00029 Genomic DNA Translation: AAB69735.1 Different initiation. BK006934 Genomic DNA Translation: DAA06898.1 |
PIRi | S48986 |
RefSeqi | NP_012075.1, NM_001179336.1 |
3D structure databases
SMRi | P11792 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36639, 698 interactors |
ELMi | P11792 |
IntActi | P11792, 10 interactors |
MINTi | P11792 |
STRINGi | 4932.YHR205W |
PTM databases
iPTMneti | P11792 |
Proteomic databases
MaxQBi | P11792 |
PaxDbi | P11792 |
PRIDEi | P11792 |
Genome annotation databases
EnsemblFungii | YHR205W_mRNA; YHR205W; YHR205W |
GeneIDi | 856612 |
KEGGi | sce:YHR205W |
Organism-specific databases
SGDi | S000001248, SCH9 |
VEuPathDBi | FungiDB:YHR205W |
Phylogenomic databases
eggNOGi | KOG0598, Eukaryota |
GeneTreei | ENSGT00940000168810 |
HOGENOMi | CLU_000288_52_2_1 |
InParanoidi | P11792 |
OMAi | SYAMGTT |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 984 |
Reactomei | R-SCE-1257604, PIP3 activates AKT signaling R-SCE-1358803, Downregulation of ERBB2:ERBB3 signaling R-SCE-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-SCE-165158, Activation of AKT2 R-SCE-198323, AKT phosphorylates targets in the cytosol R-SCE-198693, AKT phosphorylates targets in the nucleus R-SCE-203615, eNOS activation R-SCE-389357, CD28 dependent PI3K/Akt signaling R-SCE-392451, G beta:gamma signalling through PI3Kgamma R-SCE-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-SCE-5218920, VEGFR2 mediated vascular permeability R-SCE-6804757, Regulation of TP53 Degradation R-SCE-6804758, Regulation of TP53 Activity through Acetylation R-SCE-9009391, Extra-nuclear estrogen signaling R-SCE-9031628, NGF-stimulated transcription |
Miscellaneous databases
PROi | PR:P11792 |
RNActi | P11792, protein |
Family and domain databases
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR000008, C2_dom IPR035892, C2_domain_sf IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00168, C2, 2 hits PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF49562, SSF49562, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50004, C2, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCH9_YEAST | |
Accessioni | P11792Primary (citable) accession number: P11792 Secondary accession number(s): D3DLF4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | September 5, 2006 | |
Last modified: | February 23, 2022 | |
This is version 212 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names - SIMILARITY comments
Index of protein domains and families