SCH9

Functionⁱ

Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. Regulates both BCY1 phosphorylation and MPK1 activity (PubMed:20702584). Regulates ribosome biogenesis, translation initiation, and entry into stationary phase in a TORC1-dependent manner (PubMed:17560372).2 Publications

Miscellaneous

Present with 3850 molecules/cell in log phase SD medium.1 Publication

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Activity regulationⁱ

Activated by cAMP.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	441	ATPPROSITE-ProRule annotation		1
Active siteⁱ	538	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	418 – 426	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein serine/threonine kinase activity
Source: SGD
Inferred from direct assayⁱ
- 17568771
- 25921291

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

age-dependent response to oxidative stress involved in chronological cell aging
Source: SGD
Inferred from mutant phenotypeⁱ
- 11292860
intracellular signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptidyl-serine phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of ribosomal protein gene transcription by RNA polymerase II
Source: SGD
Inferred from mutant phenotypeⁱ
- 15466158
positive regulation of transcription by RNA polymerase I
Source: SGD
Inferred from mutant phenotypeⁱ
- 19684113
positive regulation of transcription by RNA polymerase III
Source: SGD
Inferred from mutant phenotypeⁱ
- 19684113
protein phosphorylation
Source: SGD
Inferred from mutant phenotypeⁱ
- 17568771
regulation of protein localization
Source: SGD
Inferred from mutant phenotypeⁱ
- 19684113
regulation of response to osmotic stress
Source: SGD
Inferred from mutant phenotypeⁱ
- 17568771
regulation of sphingolipid biosynthetic process
Source: SGD
Inferred from mutant phenotypeⁱ
- 24196832
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
Source: SGD
Inferred from mutant phenotypeⁱ
- 17568771
replicative cell aging
Source: SGD
Inferred from mutant phenotypeⁱ
- 15722108

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, cAMP, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31231-MONOMER
BRENDAⁱ	2.7.11.1 984
Reactomeⁱ	R-SCE-111933 Calmodulin induced events R-SCE-114508 Effects of PIP2 hydrolysis R-SCE-114516 Disinhibition of SNARE formation R-SCE-1169091 Activation of NF-kappaB in B cells R-SCE-1257604 PIP3 activates AKT signaling R-SCE-1358803 Downregulation of ERBB2:ERBB3 signaling R-SCE-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-SCE-1489509 DAG and IP3 signaling R-SCE-165158 Activation of AKT2 R-SCE-198323 AKT phosphorylates targets in the cytosol R-SCE-198693 AKT phosphorylates targets in the nucleus R-SCE-199418 Negative regulation of the PI3K/AKT network R-SCE-202424 Downstream TCR signaling R-SCE-2029485 Role of phospholipids in phagocytosis R-SCE-203615 eNOS activation R-SCE-2179392 EGFR Transactivation by Gastrin R-SCE-2871837 FCERI mediated NF-kB activation R-SCE-389357 CD28 dependent PI3K/Akt signaling R-SCE-389513 CTLA4 inhibitory signaling R-SCE-392451 G beta:gamma signalling through PI3Kgamma R-SCE-399997 Acetylcholine regulates insulin secretion R-SCE-4419969 Depolymerisation of the Nuclear Lamina R-SCE-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-SCE-450520 HuR (ELAVL1) binds and stabilizes mRNA R-SCE-5218920 VEGFR2 mediated vascular permeability R-SCE-5218921 VEGFR2 mediated cell proliferation R-SCE-5607764 CLEC7A (Dectin-1) signaling R-SCE-6798695 Neutrophil degranulation R-SCE-6804757 Regulation of TP53 Degradation R-SCE-6804758 Regulation of TP53 Activity through Acetylation R-SCE-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-SCE-76005 Response to elevated platelet cytosolic Ca2+

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase SCH9 (EC:2.7.11.1)
Gene namesⁱ	Name:SCH9 Synonyms:KOM1 Ordered Locus Names:YHR205W
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome VIII

Organism-specific databases

Saccharomyces Genome Database More...SGDⁱ	S000001248 SCH9

SGDⁱ

S000001248 SCH9

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086638	1 – 824	Serine/threonine-protein kinase SCH9Add BLAST		824

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	570	Phosphothreonine; by PKH1 or PKH21 Publication	1
Modified residueⁱ	711	Phosphoserine; by TORC11 Publication	1
Modified residueⁱ	723	Phosphothreonine; by TORC1Combined sources1 Publication	1
Modified residueⁱ	726	Phosphoserine; by TORC1Combined sources1 Publication	1
Modified residueⁱ	737	Phosphothreonine; by TORC11 Publication	1
Modified residueⁱ	758	Phosphoserine; by TORC11 Publication	1
Modified residueⁱ	765	Phosphoserine; by TORC11 Publication	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P11792
PaxDbⁱ	P11792
PRIDEⁱ	P11792

PTM databases

iPTMnetⁱ	P11792

iPTMnetⁱ

P11792

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	36639, 693 interactors
ELMⁱ	P11792
IntActⁱ	P11792, 10 interactors
Molecular INTeraction database More...MINTⁱ	P11792
STRINGⁱ	4932.YHR205W

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P11792
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	185 – 361	C2Add BLAST	177
Domainⁱ	412 – 671	Protein kinasePROSITE-ProRule annotationAdd BLAST	260
Domainⁱ	672 – 748	AGC-kinase C-terminalAdd BLAST	77

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	227 – 267	Asn-richAdd BLAST		41

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150811
HOGENOMⁱ	HOG000233033
InParanoidⁱ	P11792
KEGG Orthology (KO) More...KOⁱ	K19800
OMAⁱ	HMDDEFV
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C0HH3

Family and domain databases

InterProⁱ	View protein in InterPro IPR000961 AGC-kinase_C IPR000008 C2_dom IPR011009 Kinase-like_dom_sf IPR017892 Pkinase_C IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168 C2, 2 hits PF00069 Pkinase, 1 hit PF00433 Pkinase_C, 1 hit
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit SM00133 S_TK_X, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51285 AGC_KINASE_CTER, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P11792-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMNFFTSKSS NQDTGFSSQH QHPNGQNNGN NNSSTAGNDN GYPCKLVSSG 
        60         70         80         90        100
PCASSNNGAL FTNFTLQTAT PTTAISQDLY AMGTTGITSE NALFQMKSMN 
       110        120        130        140        150
NGISSVNNNN SNTPTIITTS QEETNAGNVH GDTGGNSLQN SEDDNFSSSS 
       160        170        180        190        200
TTKCLLSSTS SLSINQREAA AAAYGPDTDI PRGKLEVTII EARDLVTRSK 
       210        220        230        240        250
DSQPYVVCTF ESSEFISNGP ESLGAINNNN NNNNNNQHNQ NQHINNNNEN 
       260        270        280        290        300
TNPDAASQHH NNNSGWNGSQ LPSIKEHLKK KPLYTHRSSS QLDQLNSCSS 
       310        320        330        340        350
VTDPSKRSSN SSSGSSNGPK NDSSHPIWHH KTTFDVLGSH SELDISVYDA 
       360        370        380        390        400
AHDHMFLGQV RLYPMIHNLA HASQHQWHSL KPRVIDEVVS GDILIKWTYK 
       410        420        430        440        450
QTKKRHYGPQ DFEVLRLLGK GTFGQVYQVK KKDTQRIYAM KVLSKKVIVK 
       460        470        480        490        500
KNEIAHTIGE RNILVTTASK SSPFIVGLKF SFQTPTDLYL VTDYMSGGEL 
       510        520        530        540        550
FWHLQKEGRF SEDRAKFYIA ELVLALEHLH DNDIVYRDLK PENILLDANG 
       560        570        580        590        600
NIALCDFGLS KADLKDRTNT FCGTTEYLAP ELLLDETGYT KMVDFWSLGV 
       610        620        630        640        650
LIFEMCCGWS PFFAENNQKM YQKIAFGKVK FPRDVLSQEG RSFVKGLLNR 
       660        670        680        690        700
NPKHRLGAID DGRELRAHPF FADIDWEALK QKKIPPPFKP HLVSETDTSN 
       710        720        730        740        750
FDPEFTTAST SYMNKHQPMM TATPLSPAMQ AKFAGFTFVD ESAIDEHVNN 
       760        770        780        790        800
NRKFLQNSYF MEPGSFIPGN PNLPPDEDVI DDDGDEDIND GFNQEKNMNN 
       810        820 
SHSQMDFDGD QHMDDEFVSG RFEI

Length:824

Mass (Da):91,812

Last modified:September 5, 2006 - v3

Checksum:ⁱBA84BE0F27143AB5

GO

Sequence cautionⁱ

The sequence AAB69735 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	366	I → S in CAA31073 (PubMed:3290050).Curated		1
Sequence conflictⁱ	751	N → K in CAA31073 (PubMed:3290050).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X12560 Genomic DNA Translation: CAA31073.1 X57629 Genomic DNA Translation: CAA40853.1 U00029 Genomic DNA Translation: AAB69735.1 Different initiation. BK006934 Genomic DNA Translation: DAA06898.1
PIRⁱ	S48986
NCBI Reference Sequences More...RefSeqⁱ	NP_012075.1, NM_001179336.1

Genome annotation databases

EnsemblFungiⁱ	YHR205W; YHR205W; YHR205W
GeneIDⁱ	856612
KEGGⁱ	sce:YHR205W

Protein	Similar proteins		Species	Score	Length	Source
P11792	Non-specific serine/threonine protein kinase		YEAS1		824	UniRef100_P11792
Non-specific serine/threonine protein kinase		YEASC		824

Protein	Similar proteins		Species	Score	Length	Source
P11792	Non-specific serine/threonine protein kinase		YEAS1		824	UniRef90_P11792
Non-specific serine/threonine protein kinase		YEASC		824
Non-specific serine/threonine protein kinase		YEAS6		840
Non-specific serine/threonine protein kinase		SACCK		825
Non-specific serine/threonine protein kinase		YEASK		824
+6

Protein	Similar proteins		Species	Score	Length	Source
P11792	Non-specific serine/threonine protein kinase		YEAS1		824	UniRef50_P11792
Non-specific serine/threonine protein kinase		YEASC		824
Non-specific serine/threonine protein kinase		YEAS6		840
Non-specific serine/threonine protein kinase		SACCK		825
Non-specific serine/threonine protein kinase		YEAS2		824
+14

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X12560 Genomic DNA Translation: CAA31073.1 X57629 Genomic DNA Translation: CAA40853.1 U00029 Genomic DNA Translation: AAB69735.1 Different initiation. BK006934 Genomic DNA Translation: DAA06898.1
PIRⁱ	S48986
RefSeqⁱ	NP_012075.1, NM_001179336.1

3D structure databases

ProteinModelPortalⁱ	P11792
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	36639, 693 interactors
ELMⁱ	P11792
IntActⁱ	P11792, 10 interactors
MINTⁱ	P11792
STRINGⁱ	4932.YHR205W

PTM databases

iPTMnetⁱ	P11792

iPTMnetⁱ

P11792

Proteomic databases

MaxQBⁱ	P11792
PaxDbⁱ	P11792
PRIDEⁱ	P11792

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YHR205W; YHR205W; YHR205W
GeneIDⁱ	856612
KEGGⁱ	sce:YHR205W

Organism-specific databases

SGDⁱ	S000001248 SCH9

Phylogenomic databases

GeneTreeⁱ	ENSGT00930000150811
HOGENOMⁱ	HOG000233033
InParanoidⁱ	P11792
KOⁱ	K19800
OMAⁱ	HMDDEFV
OrthoDBⁱ	EOG092C0HH3

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31231-MONOMER
BRENDAⁱ	2.7.11.1 984
Reactomeⁱ	R-SCE-111933 Calmodulin induced events R-SCE-114508 Effects of PIP2 hydrolysis R-SCE-114516 Disinhibition of SNARE formation R-SCE-1169091 Activation of NF-kappaB in B cells R-SCE-1257604 PIP3 activates AKT signaling R-SCE-1358803 Downregulation of ERBB2:ERBB3 signaling R-SCE-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-SCE-1489509 DAG and IP3 signaling R-SCE-165158 Activation of AKT2 R-SCE-198323 AKT phosphorylates targets in the cytosol R-SCE-198693 AKT phosphorylates targets in the nucleus R-SCE-199418 Negative regulation of the PI3K/AKT network R-SCE-202424 Downstream TCR signaling R-SCE-2029485 Role of phospholipids in phagocytosis R-SCE-203615 eNOS activation R-SCE-2179392 EGFR Transactivation by Gastrin R-SCE-2871837 FCERI mediated NF-kB activation R-SCE-389357 CD28 dependent PI3K/Akt signaling R-SCE-389513 CTLA4 inhibitory signaling R-SCE-392451 G beta:gamma signalling through PI3Kgamma R-SCE-399997 Acetylcholine regulates insulin secretion R-SCE-4419969 Depolymerisation of the Nuclear Lamina R-SCE-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-SCE-450520 HuR (ELAVL1) binds and stabilizes mRNA R-SCE-5218920 VEGFR2 mediated vascular permeability R-SCE-5218921 VEGFR2 mediated cell proliferation R-SCE-5607764 CLEC7A (Dectin-1) signaling R-SCE-6798695 Neutrophil degranulation R-SCE-6804757 Regulation of TP53 Degradation R-SCE-6804758 Regulation of TP53 Activity through Acetylation R-SCE-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-SCE-76005 Response to elevated platelet cytosolic Ca2+

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P11792

PROⁱ

PR:P11792

Family and domain databases

InterProⁱ	View protein in InterPro IPR000961 AGC-kinase_C IPR000008 C2_dom IPR011009 Kinase-like_dom_sf IPR017892 Pkinase_C IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00168 C2, 2 hits PF00069 Pkinase, 1 hit PF00433 Pkinase_C, 1 hit
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit SM00133 S_TK_X, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51285 AGC_KINASE_CTER, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SCH9_YEAST
Accessionⁱ	P11792Primary (citable) accession number: P11792 Secondary accession number(s): D3DLF4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
	Last sequence update:	September 5, 2006
	Last modified:	November 7, 2018
	This is version 193 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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UniProtKB - P11792 (SCH9_YEAST)

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Serine/threonine-protein kinase SCH9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Caution

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Vacuole

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ