UniProtKB - P11766 (ADHX_HUMAN)

BLAST

>sp|P11766|ADHX_HUMAN Alcohol dehydrogenase class-3 OS=Homo sapiens OX=9606 GN=ADH5 PE=1 SV=4
MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGC
FPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGK
GLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGY
GAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATEC
INPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEE
IATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFE
LMHSGKSIRTVVKI

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History
Entry version 202 (12 Sep 2018)
Sequence version 4 (23 Jan 2007)
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Protein

Alcohol dehydrogenase class-3

Gene

ADH5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Miscellaneous

There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

Catalytic activityⁱ

A primary alcohol + NAD⁺ = an aldehyde + NADH.

A secondary alcohol + NAD⁺ = a ketone + NADH.

S-(hydroxymethyl)glutathione + NAD(P)⁺ = S-formylglutathione + NAD(P)H.

Cofactorⁱ

Zn²⁺1 PublicationNote: Binds 2 Zn²⁺ ions per subunit.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	45	Zinc 1; catalytic1 Publication	1
Metal bindingⁱ	67	Zinc 1; catalytic1 Publication	1
Metal bindingⁱ	97	Zinc 21 Publication	1
Metal bindingⁱ	100	Zinc 21 Publication	1
Metal bindingⁱ	103	Zinc 21 Publication	1
Metal bindingⁱ	111	Zinc 21 Publication	1
Siteⁱ	115	Important for FDH activity and activation by fatty acids	1
Metal bindingⁱ	174	Zinc 1; catalytic	1

GO - Molecular functionⁱ

alcohol dehydrogenase (NAD) activity Source: UniProtKB-EC
electron transfer activity
Source: UniProtKB
Traceable author statementⁱ
- 8460164
fatty acid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 8460164
formaldehyde dehydrogenase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8460164
protein homodimerization activity Source: Ensembl
S-(hydroxymethyl)glutathione dehydrogenase activity
Source: UniProtKB
Traceable author statementⁱ
- 8460164
zinc ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 6375718

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ethanol oxidation Source: Reactome
formaldehyde catabolic process Source: Ensembl
peptidyl-cysteine S-nitrosylation Source: Ensembl
positive regulation of blood pressure Source: Ensembl
respiratory system process Source: Ensembl
response to lipopolysaccharide Source: Ensembl
response to nitrosative stress Source: Ensembl
response to redox state
Source: UniProtKB
Inferred from direct assayⁱ
- 8460164
retinoid metabolic process Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS10601-MONOMER
Reactomeⁱ	R-HSA-71384 Ethanol oxidation
SABIO-RKⁱ	P11766

Chemistry databases

SwissLipidsⁱ	SLP:000000500

SwissLipidsⁱ

SLP:000000500

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alcohol dehydrogenase class-3 (EC:1.1.1.1) Alternative name(s): Alcohol dehydrogenase 5 Alcohol dehydrogenase class chi chain Alcohol dehydrogenase class-III Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-) Short name: FALDH Short name: FDH Short name: GSH-FDH S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
Gene namesⁱ	Name:ADH5Imported Synonyms:ADHX, FDH
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197894.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:253 ADH5
MIMⁱ	103710 gene
neXtProtⁱ	NX_P11766

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	115	R → A or D: Loss of FDH activity and loss of activation by fatty acids. 2 Publications		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	128
Open Targets More...OpenTargetsⁱ	ENSG00000197894
PharmGKBⁱ	PA24574

Chemistry databases

ChEMBLⁱ	CHEMBL4116
Drug and drug target database More...DrugBankⁱ	DB03704 12-Hydroxydodecanoic Acid DB00898 Ethanol DB03017 Lauric Acid DB00157 NADH DB04153 S-Hydroxymethyl Glutathione

Polymorphism and mutation databases

DMDMⁱ	113408

DMDMⁱ

113408

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000160759	2 – 374	Alcohol dehydrogenase class-3Add BLAST		373

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	233	N6-succinyllysineBy similarity	1
Modified residueⁱ	247	PhosphoserineCombined sources	1
Modified residueⁱ	315	N6-succinyllysineBy similarity	1
Modified residueⁱ	324	PhosphoserineCombined sources	1
Modified residueⁱ	351	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P11766
PaxDbⁱ	P11766
PeptideAtlas More...PeptideAtlasⁱ	P11766
PRIDEⁱ	P11766
ProteomicsDBⁱ	52803

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00746777

REPRODUCTION-2DPAGEⁱ

IPI00746777

PTM databases

CarbonylDBⁱ	P11766
iPTMnetⁱ	P11766
PhosphoSitePlusⁱ	P11766
SwissPalmⁱ	P11766

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000197894 Expressed in 235 organ(s), highest expression level in lower esophagus
CleanExⁱ	HS_ADH5
ExpressionAtlasⁱ	P11766 baseline and differential
Genevisibleⁱ	P11766 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044578 HPA061919

HPAⁱ

HPA044578
HPA061919

Interactionⁱ

Subunit structureⁱ

Homodimer.

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106640, 20 interactors
IntActⁱ	P11766, 8 interactors
STRINGⁱ	9606.ENSP00000296412

Chemistry databases

BindingDBⁱ

P11766

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	6 – 13	Combined sources	8
Beta strandⁱ	21 – 27	Combined sources	7
Beta strandⁱ	34 – 43	Combined sources	10
Helixⁱ	46 – 52	Combined sources	7
Beta strandⁱ	61 – 63	Combined sources	3
Beta strandⁱ	68 – 76	Combined sources	9
Beta strandⁱ	88 – 91	Combined sources	4
Beta strandⁱ	98 – 100	Combined sources	3
Helixⁱ	101 – 104	Combined sources	4
Helixⁱ	115 – 119	Combined sources	5
Beta strandⁱ	129 – 132	Combined sources	4
Beta strandⁱ	135 – 138	Combined sources	4
Turnⁱ	141 – 143	Combined sources	3
Beta strandⁱ	146 – 153	Combined sources	8
Helixⁱ	154 – 156	Combined sources	3
Beta strandⁱ	157 – 159	Combined sources	3
Helixⁱ	166 – 169	Combined sources	4
Helixⁱ	170 – 173	Combined sources	4
Helixⁱ	175 – 184	Combined sources	10
Turnⁱ	185 – 187	Combined sources	3
Beta strandⁱ	194 – 198	Combined sources	5
Helixⁱ	202 – 214	Combined sources	13
Beta strandⁱ	217 – 222	Combined sources	6
Helixⁱ	226 – 228	Combined sources	3
Helixⁱ	229 – 235	Combined sources	7
Beta strandⁱ	238 – 241	Combined sources	4
Helixⁱ	243 – 245	Combined sources	3
Helixⁱ	250 – 257	Combined sources	8
Beta strandⁱ	262 – 267	Combined sources	6
Helixⁱ	272 – 280	Combined sources	9
Turnⁱ	284 – 286	Combined sources	3
Beta strandⁱ	288 – 291	Combined sources	4
Beta strandⁱ	301 – 303	Combined sources	3
Helixⁱ	306 – 309	Combined sources	4
Beta strandⁱ	313 – 316	Combined sources	4
Helixⁱ	319 – 321	Combined sources	3
Helixⁱ	324 – 336	Combined sources	13
Helixⁱ	343 – 345	Combined sources	3
Beta strandⁱ	346 – 351	Combined sources	6
Helixⁱ	352 – 354	Combined sources	3
Helixⁱ	355 – 363	Combined sources	9
Beta strandⁱ	368 – 373	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	P11766
SMRⁱ	P11766
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P11766

EvolutionaryTraceⁱ

P11766

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0022 Eukaryota COG1062 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00430000030800
HOGENOMⁱ	HOG000294674
HOVERGENⁱ	HBG000195
InParanoidⁱ	P11766
KEGG Orthology (KO) More...KOⁱ	K00121
OMAⁱ	CIGNVNT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08N3
PhylomeDBⁱ	P11766
TreeFamⁱ	TF300429

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08300 alcohol_DH_class_III, 1 hit
InterProⁱ	View protein in InterPro IPR014183 ADH_3 IPR013149 ADH_C IPR013154 ADH_N IPR002328 ADH_Zn_CS IPR011032 GroES-like_sf IPR036291 NAD(P)-bd_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08240 ADH_N, 1 hit PF00107 ADH_zinc_N, 1 hit
SUPFAMⁱ	SSF50129 SSF50129, 2 hits SSF51735 SSF51735, 1 hit
TIGRFAMsⁱ	TIGR02818 adh_III_F_hyde, 1 hit
PROSITEⁱ	View protein in PROSITE PS00059 ADH_ZINC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.ⁱShow all

P11766-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MANEVIKCKA AVAWEAGKPL SIEEIEVAPP KAHEVRIKII ATAVCHTDAY 
        60         70         80         90        100
TLSGADPEGC FPVILGHEGA GIVESVGEGV TKLKAGDTVI PLYIPQCGEC 
       110        120        130        140        150
KFCLNPKTNL CQKIRVTQGK GLMPDGTSRF TCKGKTILHY MGTSTFSEYT 
       160        170        180        190        200
VVADISVAKI DPLAPLDKVC LLGCGISTGY GAAVNTAKLE PGSVCAVFGL 
       210        220        230        240        250
GGVGLAVIMG CKVAGASRII GVDINKDKFA RAKEFGATEC INPQDFSKPI 
       260        270        280        290        300
QEVLIEMTDG GVDYSFECIG NVKVMRAALE ACHKGWGVSV VVGVAASGEE 
       310        320        330        340        350
IATRPFQLVT GRTWKGTAFG GWKSVESVPK LVSEYMSKKI KVDEFVTHNL 
       360        370 
SFDEINKAFE LMHSGKSIRT VVKI

Length:374

Mass (Da):39,724

Last modified:January 23, 2007 - v4

Checksum:ⁱF4F823B4A609C952

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
H0YAG8	H0YAG8_HUMAN	Alcohol dehydrogenase class-3 Alcohol dehydrogenase class-3	ADH5	262	Annotation score:
D6R9G2	D6R9G2_HUMAN	Alcohol dehydrogenase class-3 Alcohol dehydrogenase class-3	ADH5	95	Annotation score:
D6RFE4	D6RFE4_HUMAN	Alcohol dehydrogenase class-3 Alcohol dehydrogenase class-3	ADH5	115	Annotation score:
D6RAY0	D6RAY0_HUMAN	Alcohol dehydrogenase class-3 Alcohol dehydrogenase class-3	ADH5	56	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	167	D → Y in AAA51597 (PubMed:2679557).Curated		1
Sequence conflictⁱ	246	F → L in AAA51597 (PubMed:2679557).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_025823	163	L → S1 PublicationCorresponds to variant dbSNP:rs28730623Ensembl.	1
Natural variantⁱVAR_025824	309	V → I1 PublicationCorresponds to variant dbSNP:rs28730628Ensembl.	1
Natural variantⁱVAR_048199	353	D → E. Corresponds to variant dbSNP:rs16996593Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M30471 mRNA Translation: AAA79018.1 M29872 mRNA Translation: AAA51597.1 M81118 M81117 Genomic DNA Translation: AAA51596.1 CR541689 mRNA Translation: CAG46490.1 BT019832 mRNA Translation: AAV38635.1 AY987960 Genomic DNA Translation: AAX81412.1 BC014665 mRNA Translation: AAH14665.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47111.1
PIRⁱ	JH0789 DEHUC2
NCBI Reference Sequences More...RefSeqⁱ	NP_000662.3, NM_000671.4
UniGeneⁱ	Hs.78989

Genome annotation databases

Ensemblⁱ	ENST00000296412; ENSP00000296412; ENSG00000197894
GeneIDⁱ	128
KEGGⁱ	hsa:128

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P11766	S-(hydroxymethyl)glutathione dehydrogenase		HUMAN		374	UniRef100_P11766
UPI0000112569		HUMAN		373

Protein	Similar proteins		Species	Score	Length	Source
P11766	Alcohol dehydrogenase class-3		BOVIN		374	UniRef90_P11766
Alcohol dehydrogenase class-3		HORSE		374
Alcohol dehydrogenase class-3	)	MOUSE		374
Alcohol dehydrogenase class-3		RABIT		374
Alcohol dehydrogenase class-3		RAT		374
+130

Protein	Similar proteins		Species	Score	Length	Source
P11766	Alcohol dehydrogenase class-3		HORSE		374	UniRef50_P11766
Alcohol dehydrogenase class-3		RAT		374
Alcohol dehydrogenase class-3	)	MOUSE		374
Alcohol dehydrogenase class-3		RABIT		374
Alcohol dehydrogenase class-3		BOVIN		374
+585

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M30471 mRNA Translation: AAA79018.1 M29872 mRNA Translation: AAA51597.1 M81118 M81117 Genomic DNA Translation: AAA51596.1 CR541689 mRNA Translation: CAG46490.1 BT019832 mRNA Translation: AAV38635.1 AY987960 Genomic DNA Translation: AAX81412.1 BC014665 mRNA Translation: AAH14665.1
CCDSⁱ	CCDS47111.1
PIRⁱ	JH0789 DEHUC2
RefSeqⁱ	NP_000662.3, NM_000671.4
UniGeneⁱ	Hs.78989

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1M6H	X-ray	2.00	A/B	2-374	[»]
	1M6W	X-ray	2.30	A/B	2-374	[»]
	1MA0	X-ray	2.30	A/B	2-374	[»]
	1MC5	X-ray	2.60	A/B	1-374	[»]
	1MP0	X-ray	2.20	A/B	2-374	[»]
	1TEH	X-ray	2.70	A/B	2-374	[»]
	2FZE	X-ray	1.90	A/B	2-374	[»]
	2FZW	X-ray	1.84	A/B	2-374	[»]
	3QJ5	X-ray	1.90	A/B	2-374	[»]
ProteinModelPortalⁱ	P11766
SMRⁱ	P11766
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106640, 20 interactors
IntActⁱ	P11766, 8 interactors
STRINGⁱ	9606.ENSP00000296412

Chemistry databases

BindingDBⁱ	P11766
ChEMBLⁱ	CHEMBL4116
DrugBankⁱ	DB03704 12-Hydroxydodecanoic Acid DB00898 Ethanol DB03017 Lauric Acid DB00157 NADH DB04153 S-Hydroxymethyl Glutathione
SwissLipidsⁱ	SLP:000000500

PTM databases

CarbonylDBⁱ	P11766
iPTMnetⁱ	P11766
PhosphoSitePlusⁱ	P11766
SwissPalmⁱ	P11766

Polymorphism and mutation databases

DMDMⁱ	113408

DMDMⁱ

113408

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00746777

REPRODUCTION-2DPAGEⁱ

IPI00746777

Proteomic databases

EPDⁱ	P11766
PaxDbⁱ	P11766
PeptideAtlasⁱ	P11766
PRIDEⁱ	P11766
ProteomicsDBⁱ	52803

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	128
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000296412; ENSP00000296412; ENSG00000197894
GeneIDⁱ	128
KEGGⁱ	hsa:128

Organism-specific databases

CTDⁱ	128
DisGeNETⁱ	128
EuPathDBⁱ	HostDB:ENSG00000197894.10
GeneCardsⁱ	ADH5
HGNCⁱ	HGNC:253 ADH5
HPAⁱ	HPA044578 HPA061919
MIMⁱ	103710 gene
neXtProtⁱ	NX_P11766
OpenTargetsⁱ	ENSG00000197894
PharmGKBⁱ	PA24574
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0022 Eukaryota COG1062 LUCA
GeneTreeⁱ	ENSGT00430000030800
HOGENOMⁱ	HOG000294674
HOVERGENⁱ	HBG000195
InParanoidⁱ	P11766
KOⁱ	K00121
OMAⁱ	CIGNVNT
OrthoDBⁱ	EOG091G08N3
PhylomeDBⁱ	P11766
TreeFamⁱ	TF300429

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS10601-MONOMER
Reactomeⁱ	R-HSA-71384 Ethanol oxidation
SABIO-RKⁱ	P11766

Miscellaneous databases

ChiTaRSⁱ	ADH5 human
EvolutionaryTraceⁱ	P11766
GeneWikiⁱ	ADH5
GenomeRNAiⁱ	128
Protein Ontology More...PROⁱ	PR:P11766
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197894 Expressed in 235 organ(s), highest expression level in lower esophagus
CleanExⁱ	HS_ADH5
ExpressionAtlasⁱ	P11766 baseline and differential
Genevisibleⁱ	P11766 HS

Family and domain databases

CDDⁱ	cd08300 alcohol_DH_class_III, 1 hit
InterProⁱ	View protein in InterPro IPR014183 ADH_3 IPR013149 ADH_C IPR013154 ADH_N IPR002328 ADH_Zn_CS IPR011032 GroES-like_sf IPR036291 NAD(P)-bd_dom_sf
Pfamⁱ	View protein in Pfam PF08240 ADH_N, 1 hit PF00107 ADH_zinc_N, 1 hit
SUPFAMⁱ	SSF50129 SSF50129, 2 hits SSF51735 SSF51735, 1 hit
TIGRFAMsⁱ	TIGR02818 adh_III_F_hyde, 1 hit
PROSITEⁱ	View protein in PROSITE PS00059 ADH_ZINC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADHX_HUMAN
Accessionⁱ	P11766Primary (citable) accession number: P11766 Secondary accession number(s): Q6FHR2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 202 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P11766 (ADHX_HUMAN)

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Alcohol dehydrogenase class-3

ADH5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ