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UniProtKB - P11766 (ADHX_HUMAN)

Entry version 211 (18 Sep 2019)
Sequence version 4 (23 Jan 2007)
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Protein

Alcohol dehydrogenase class-3

Gene

ADH5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164).2 Publications

Miscellaneous

There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+1 PublicationNote: Binds 2 Zn2+ ions per subunit.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=21 µM for 20-HETE1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi45Zinc 1; catalytic1 Publication1
    Metal bindingi67Zinc 1; catalytic1 Publication1
    Metal bindingi97Zinc 21 Publication1
    Metal bindingi100Zinc 21 Publication1
    Metal bindingi103Zinc 21 Publication1
    Metal bindingi111Zinc 21 Publication1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei115Important for FDH activity and activation by fatty acids2 Publications1
    Metal bindingi174Zinc 1; catalytic1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandMetal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:HS10601-MONOMER

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-71384 Ethanol oxidation

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P11766

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...    SwissLipidsi    		SLP:000000500

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Alcohol dehydrogenase class-3Curated (EC:1.1.1.11 Publication)
    Alternative name(s):
    Alcohol dehydrogenase 5
    Alcohol dehydrogenase class chi chain
    Alcohol dehydrogenase class-III
    Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
    Short name:
    FALDH
    Short name:
    FDH
    Short name:
    GSH-FDH
    S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.2841 Publication)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ADH5Imported
    Synonyms:ADHX, FDH
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:253 ADH5

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		103710 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P11766

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi115R → A or D: Loss of FDH activity and loss of activation by fatty acids. 2 Publications1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		128

    Open Targets

    More...    OpenTargetsi    		ENSG00000197894

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA24574

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P11766

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL4116

    Drug and drug target database

    More...    DrugBanki    		DB03704 12-Hydroxydodecanoic Acid
    DB00898 Ethanol
    DB03017 Lauric acid
    DB00157 NADH
    DB11077 Polyethylene glycol 400
    DB04153 S-Hydroxymethyl Glutathione

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		ADH5

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		113408

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001607592 – 374Alcohol dehydrogenase class-3Add BLAST373

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
    Modified residuei233N6-succinyllysineBy similarity1
    Modified residuei247PhosphoserineCombined sources1
    Modified residuei315N6-succinyllysineBy similarity1
    Modified residuei324PhosphoserineCombined sources1
    Modified residuei351PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		P11766

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P11766

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P11766

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P11766

    PeptideAtlas

    More...    PeptideAtlasi    		P11766

    PRoteomics IDEntifications database

    More...    PRIDEi    		P11766

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		52803

    2D gel databases

    REPRODUCTION-2DPAGE

    More...    REPRODUCTION-2DPAGEi    		IPI00746777

    PTM databases

    CarbonylDB database of protein carbonylation sites

    More...    CarbonylDBi    		P11766

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P11766

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P11766

    SwissPalm database of S-palmitoylation events

    More...    SwissPalmi    		P11766

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000197894 Expressed in 235 organ(s), highest expression level in lower esophagus

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P11766 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P11766 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		HPA044578
    HPA061919

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		106640, 22 interactors

    Protein interaction database and analysis system

    More...    IntActi    		P11766, 9 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000296412

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P11766

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1374
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P11766

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		P11766

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG0022 Eukaryota
    COG1062 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000155196

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		HOG000294674

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P11766

    KEGG Orthology (KO)

    More...    KOi    		K00121

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		ATHKGWG

    Database of Orthologous Groups

    More...    OrthoDBi    		664798at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P11766

    TreeFam database of animal gene trees

    More...    TreeFami    		TF300429

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd08300 alcohol_DH_class_III, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR014183 ADH_3
    IPR013149 ADH_C
    IPR013154 ADH_N
    IPR002328 ADH_Zn_CS
    IPR011032 GroES-like_sf
    IPR036291 NAD(P)-bd_dom_sf

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF08240 ADH_N, 1 hit
    PF00107 ADH_zinc_N, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF50129 SSF50129, 2 hits
    SSF51735 SSF51735, 1 hit

    TIGRFAMs; a protein family database

    More...    TIGRFAMsi    		TIGR02818 adh_III_F_hyde, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00059 ADH_ZINC, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

    P11766-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MANEVIKCKA AVAWEAGKPL SIEEIEVAPP KAHEVRIKII ATAVCHTDAY 
            60         70         80         90        100
    TLSGADPEGC FPVILGHEGA GIVESVGEGV TKLKAGDTVI PLYIPQCGEC 
           110        120        130        140        150
    KFCLNPKTNL CQKIRVTQGK GLMPDGTSRF TCKGKTILHY MGTSTFSEYT 
           160        170        180        190        200
    VVADISVAKI DPLAPLDKVC LLGCGISTGY GAAVNTAKLE PGSVCAVFGL 
           210        220        230        240        250
    GGVGLAVIMG CKVAGASRII GVDINKDKFA RAKEFGATEC INPQDFSKPI 
           260        270        280        290        300
    QEVLIEMTDG GVDYSFECIG NVKVMRAALE ACHKGWGVSV VVGVAASGEE 
           310        320        330        340        350
    IATRPFQLVT GRTWKGTAFG GWKSVESVPK LVSEYMSKKI KVDEFVTHNL 
           360        370 
    SFDEINKAFE LMHSGKSIRT VVKI
    Length:374
    Mass (Da):39,724
    Last modified:January 23, 2007 - v4
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4F823B4A609C952
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    H0YAG8H0YAG8_HUMAN
    Alcohol dehydrogenase class-3
    ADH5
    		262Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RFE4D6RFE4_HUMAN
    Alcohol dehydrogenase class-3
    ADH5
    		115Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6R9G2D6R9G2_HUMAN
    Alcohol dehydrogenase class-3
    ADH5
    		95Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RAY0D6RAY0_HUMAN
    Alcohol dehydrogenase class-3
    ADH5
    		56Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti167D → Y in AAA51597 (PubMed:2679557).Curated1
    Sequence conflicti246F → L in AAA51597 (PubMed:2679557).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025823163L → S1 PublicationCorresponds to variant dbSNP:rs28730623Ensembl.1
    Natural variantiVAR_025824309V → I1 PublicationCorresponds to variant dbSNP:rs28730628Ensembl.1
    Natural variantiVAR_048199353D → E. Corresponds to variant dbSNP:rs16996593Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		M30471 mRNA Translation: AAA79018.1
    M29872 mRNA Translation: AAA51597.1
    M81118
    , M81112, M81113, M81114, M81115, M81116, M81117 Genomic DNA Translation: AAA51596.1
    CR541689 mRNA Translation: CAG46490.1
    BT019832 mRNA Translation: AAV38635.1
    AY987960 Genomic DNA Translation: AAX81412.1
    BC014665 mRNA Translation: AAH14665.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS47111.1

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		JH0789 DEHUC2

    NCBI Reference Sequences

    More...    RefSeqi    		NP_000662.3, NM_000671.4

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000296412; ENSP00000296412; ENSG00000197894

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		128

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:128

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		M30471 mRNA Translation: AAA79018.1
    M29872 mRNA Translation: AAA51597.1
    M81118
    , M81112, M81113, M81114, M81115, M81116, M81117 Genomic DNA Translation: AAA51596.1
    CR541689 mRNA Translation: CAG46490.1
    BT019832 mRNA Translation: AAV38635.1
    AY987960 Genomic DNA Translation: AAX81412.1
    BC014665 mRNA Translation: AAH14665.1
    CCDSiCCDS47111.1
    PIRiJH0789 DEHUC2
    RefSeqiNP_000662.3, NM_000671.4

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1M6HX-ray2.00A/B2-374[»]
    1M6WX-ray2.30A/B2-374[»]
    1MA0X-ray2.30A/B2-374[»]
    1MC5X-ray2.60A/B1-374[»]
    1MP0X-ray2.20A/B2-374[»]
    1TEHX-ray2.70A/B2-374[»]
    2FZEX-ray1.90A/B2-374[»]
    2FZWX-ray1.84A/B2-374[»]
    3QJ5X-ray1.90A/B2-374[»]
    SMRiP11766
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi106640, 22 interactors
    IntActiP11766, 9 interactors
    STRINGi9606.ENSP00000296412

    Chemistry databases

    BindingDBiP11766
    ChEMBLiCHEMBL4116
    DrugBankiDB03704 12-Hydroxydodecanoic Acid
    DB00898 Ethanol
    DB03017 Lauric acid
    DB00157 NADH
    DB11077 Polyethylene glycol 400
    DB04153 S-Hydroxymethyl Glutathione
    SwissLipidsiSLP:000000500

    PTM databases

    CarbonylDBiP11766
    iPTMnetiP11766
    PhosphoSitePlusiP11766
    SwissPalmiP11766

    Polymorphism and mutation databases

    BioMutaiADH5
    DMDMi113408

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00746777

    Proteomic databases

    EPDiP11766
    jPOSTiP11766
    MassIVEiP11766
    PaxDbiP11766
    PeptideAtlasiP11766
    PRIDEiP11766
    ProteomicsDBi52803

    Protocols and materials databases

    The DNASU plasmid repository

    More...    DNASUi    		128

    Genome annotation databases

    EnsembliENST00000296412; ENSP00000296412; ENSG00000197894
    GeneIDi128
    KEGGihsa:128

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		128
    DisGeNETi128

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		ADH5
    HGNCiHGNC:253 ADH5
    HPAiHPA044578
    HPA061919
    MIMi103710 gene
    neXtProtiNX_P11766
    OpenTargetsiENSG00000197894
    PharmGKBiPA24574

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG0022 Eukaryota
    COG1062 LUCA
    GeneTreeiENSGT00940000155196
    HOGENOMiHOG000294674
    InParanoidiP11766
    KOiK00121
    OMAiATHKGWG
    OrthoDBi664798at2759
    PhylomeDBiP11766
    TreeFamiTF300429

    Enzyme and pathway databases

    BioCyciMetaCyc:HS10601-MONOMER
    ReactomeiR-HSA-71384 Ethanol oxidation
    SABIO-RKiP11766

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		ADH5 human
    EvolutionaryTraceiP11766

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		ADH5

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		128
    PharosiP11766

    Protein Ontology

    More...    PROi    		PR:P11766

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000197894 Expressed in 235 organ(s), highest expression level in lower esophagus
    ExpressionAtlasiP11766 baseline and differential
    GenevisibleiP11766 HS

    Family and domain databases

    CDDicd08300 alcohol_DH_class_III, 1 hit
    InterProiView protein in InterPro
    IPR014183 ADH_3
    IPR013149 ADH_C
    IPR013154 ADH_N
    IPR002328 ADH_Zn_CS
    IPR011032 GroES-like_sf
    IPR036291 NAD(P)-bd_dom_sf
    PfamiView protein in Pfam
    PF08240 ADH_N, 1 hit
    PF00107 ADH_zinc_N, 1 hit
    SUPFAMiSSF50129 SSF50129, 2 hits
    SSF51735 SSF51735, 1 hit
    TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
    PROSITEiView protein in PROSITE
    PS00059 ADH_ZINC, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADHX_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11766
    Secondary accession number(s): Q6FHR2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: January 23, 2007
    Last modified: September 18, 2019
    This is version 211 of the entry and version 4 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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