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Protein

Galectin-1

Gene

Lgals1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53Beta-galactosideBy similarity1
Binding sitei62Beta-galactosideBy similarity1

GO - Molecular functioni

  • lactose binding Source: RGD
  • laminin binding Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandLectin

Enzyme and pathway databases

ReactomeiR-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation

Protein family/group databases

UniLectiniP11762

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-1
Short name:
Gal-1
Alternative name(s):
14 kDa lectin
Beta-galactoside-binding lectin L-14-I
Galaptin
Lactose-binding lectin 1
Lectin galactoside-binding soluble 1
RL 14.5
S-Lac lectin 1
Gene namesi
Name:Lgals1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi69355 Lgals1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000769202 – 135Galectin-1Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei13N6-acetyllysineBy similarity1
Modified residuei19N6-acetyllysineBy similarity1
Modified residuei29N6-acetyllysineBy similarity1
Modified residuei30PhosphoserineBy similarity1
Modified residuei108N6-acetyllysine; alternateBy similarity1
Modified residuei108N6-succinyllysine; alternateBy similarity1
Modified residuei128N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP11762
PRIDEiP11762

PTM databases

iPTMnetiP11762
PhosphoSitePlusiP11762

Expressioni

Gene expression databases

BgeeiENSRNOG00000009884 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiP11762 RN

Interactioni

Subunit structurei

Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Interacts with SUSD2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248567, 1 interactor
DIPiDIP-37188N
IntActiP11762, 2 interactors
STRINGi10116.ENSRNOP00000013538

Structurei

Secondary structure

1135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP11762
SMRiP11762
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11762

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 135GalectinPROSITE-ProRule annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 49Beta-galactoside bindingBy similarity5
Regioni69 – 72Beta-galactoside bindingBy similarity4

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00440000034263
HOGENOMiHOG000059539
HOVERGENiHBG006255
InParanoidiP11762
KOiK06830
OMAiCNSKEDG
OrthoDBiEOG091G0S7H
PhylomeDBiP11762

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11762-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACGLVASNL NLKPGECLKV RGELAPDAKS FVLNLGKDSN NLCLHFNPRF
60 70 80 90 100
NAHGDANTIV CNSKDDGTWG TEQRETAFPF QPGSITEVCI TFDQADLTIK
110 120 130
LPDGHEFKFP NRLNMEAINY MAADGDFKIK CVAFE
Length:135
Mass (Da):14,857
Last modified:January 23, 2007 - v2
Checksum:iA2C2DFB464FE81CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19036 mRNA Translation: AAA40822.1
BC058476 mRNA Translation: AAH58476.1
PIRiA28703 LNRTGB
RefSeqiNP_063969.1, NM_019904.1
UniGeneiRn.57

Genome annotation databases

EnsembliENSRNOT00000013538; ENSRNOP00000013538; ENSRNOG00000009884
GeneIDi56646
KEGGirno:56646
UCSCiRGD:69355 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19036 mRNA Translation: AAA40822.1
BC058476 mRNA Translation: AAH58476.1
PIRiA28703 LNRTGB
RefSeqiNP_063969.1, NM_019904.1
UniGeneiRn.57

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M2MX-ray2.95A/B/C/D/E/F/G/H2-135[»]
4GA9X-ray1.88A/B2-135[»]
4NO4X-ray1.40A/B/C/D/E/F2-135[»]
ProteinModelPortaliP11762
SMRiP11762
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248567, 1 interactor
DIPiDIP-37188N
IntActiP11762, 2 interactors
STRINGi10116.ENSRNOP00000013538

Protein family/group databases

UniLectiniP11762

PTM databases

iPTMnetiP11762
PhosphoSitePlusiP11762

Proteomic databases

PaxDbiP11762
PRIDEiP11762

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013538; ENSRNOP00000013538; ENSRNOG00000009884
GeneIDi56646
KEGGirno:56646
UCSCiRGD:69355 rat

Organism-specific databases

CTDi3956
RGDi69355 Lgals1

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00440000034263
HOGENOMiHOG000059539
HOVERGENiHBG006255
InParanoidiP11762
KOiK06830
OMAiCNSKEDG
OrthoDBiEOG091G0S7H
PhylomeDBiP11762

Enzyme and pathway databases

ReactomeiR-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation

Miscellaneous databases

EvolutionaryTraceiP11762
PROiPR:P11762

Gene expression databases

BgeeiENSRNOG00000009884 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiP11762 RN

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLEG1_RAT
AccessioniPrimary (citable) accession number: P11762
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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