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Protein

Cation-independent mannose-6-phosphate receptor

Gene

IGF2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme binding Source: Ensembl
  • G-protein alpha-subunit binding Source: GO_Central
  • identical protein binding Source: IntAct
  • insulin-like growth factor-activated receptor activity Source: ProtInc
  • insulin-like growth factor binding Source: GO_Central
  • insulin-like growth factor II binding Source: GO_Central
  • kringle domain binding Source: GO_Central
  • mannose binding Source: GO_Central
  • phosphoprotein binding Source: UniProtKB
  • retinoic acid binding Source: GO_Central
  • signaling receptor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-6798695 Neutrophil degranulation
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P11717

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P11717

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.247.1.2 the mannose 6-phosphate receptor (m6pr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cation-independent mannose-6-phosphate receptor
Short name:
CI Man-6-P receptor
Short name:
CI-MPR
Short name:
M6PR
Alternative name(s):
300 kDa mannose 6-phosphate receptor
Short name:
MPR 300
Insulin-like growth factor 2 receptor
Insulin-like growth factor II receptor
Short name:
IGF-II receptor
M6P/IGF2 receptor
Short name:
M6P/IGF2R
CD_antigen: CD222
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGF2R
Synonyms:MPRI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197081.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5467 IGF2R

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147280 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11717

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini41 – 2304LumenalSequence analysisAdd BLAST2264
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2305 – 2327HelicalSequence analysisAdd BLAST23
Topological domaini2328 – 2491CytoplasmicSequence analysisAdd BLAST164

Keywords - Cellular componenti

Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3482

MalaCards human disease database

More...
MalaCardsi
IGF2R

Open Targets

More...
OpenTargetsi
ENSG00000197081

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29701

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3240

Drug and drug target database

More...
DrugBanki
DB02900 alpha-D-mannose 6-phosphate
DB01277 Mecasermin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IGF2R

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373416

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 40Add BLAST40
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001922941 – 2491Cation-independent mannose-6-phosphate receptorAdd BLAST2451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 69PROSITE-ProRule annotation
Disulfide bondi77 ↔ 84PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi112N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi117 ↔ 149PROSITE-ProRule annotation
Disulfide bondi134 ↔ 161PROSITE-ProRule annotation
Disulfide bondi174 ↔ 212PROSITE-ProRule annotation
Disulfide bondi228 ↔ 235PROSITE-ProRule annotation
Disulfide bondi275 ↔ 306PROSITE-ProRule annotation
Disulfide bondi288 ↔ 318PROSITE-ProRule annotation
Disulfide bondi328 ↔ 366PROSITE-ProRule annotation
Disulfide bondi374 ↔ 382PROSITE-ProRule annotation
Glycosylationi400N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi420 ↔ 454PROSITE-ProRule annotation
Disulfide bondi434 ↔ 466PROSITE-ProRule annotation
Glycosylationi435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi543N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi581N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi626N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi627 ↔ 664PROSITE-ProRule annotation
Disulfide bondi672 ↔ 679PROSITE-ProRule annotation
Disulfide bondi731 ↔ 760PROSITE-ProRule annotation
Glycosylationi747N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi871N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi951N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi957N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1246N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1312N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1516 ↔ 1553PROSITE-ProRule annotation1 Publication
Disulfide bondi1559 ↔ 1566PROSITE-ProRule annotation1 Publication
Disulfide bondi1598 ↔ 1634PROSITE-ProRule annotation1 Publication
Disulfide bondi1614 ↔ 1646PROSITE-ProRule annotation1 Publication
Disulfide bondi1652 ↔ 1695PROSITE-ProRule annotation1 Publication
Glycosylationi1656N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1706 ↔ 1713PROSITE-ProRule annotation1 Publication
Disulfide bondi1750 ↔ 1783PROSITE-ProRule annotation1 Publication
Glycosylationi1757N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1766 ↔ 1795PROSITE-ProRule annotation1 Publication
Disulfide bondi1804 ↔ 1839PROSITE-ProRule annotation1 Publication
Glycosylationi1816N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1850 ↔ 1856PROSITE-ProRule annotation1 Publication
Disulfide bondi1893 ↔ 1975PROSITE-ProRule annotation1 Publication
Disulfide bondi1903 ↔ 1927PROSITE-ProRule annotation1 Publication
Disulfide bondi1917 ↔ 1942PROSITE-ProRule annotation1 Publication
Disulfide bondi1957 ↔ 1987PROSITE-ProRule annotation1 Publication
Disulfide bondi1994 ↔ 2029PROSITE-ProRule annotation1 Publication
Disulfide bondi2039 ↔ 2046PROSITE-ProRule annotation1 Publication
Disulfide bondi2082 ↔ 2113PROSITE-ProRule annotation1 Publication
Glycosylationi2085N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2096 ↔ 2125PROSITE-ProRule annotation1 Publication
Glycosylationi2136N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2352N6-acetyllysineCombined sources1
Modified residuei2409PhosphoserineCombined sources1
Modified residuei2425Omega-N-methylarginineBy similarity1
Modified residuei2479PhosphoserineCombined sources1
Modified residuei2484PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P11717

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P11717

MaxQB - The MaxQuant DataBase

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MaxQBi
P11717

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P11717

PeptideAtlas

More...
PeptideAtlasi
P11717

PRoteomics IDEntifications database

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PRIDEi
P11717

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52802

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1084

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11717

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P11717

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P11717

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197081 Expressed in 230 organ(s), highest expression level in leukocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_IGF2R

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P11717 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P11717 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009661
HPA011332

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3.By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109703, 41 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P11717

Database of interacting proteins

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DIPi
DIP-6027N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P11717

Protein interaction database and analysis system

More...
IntActi
P11717, 42 interactors

Molecular INTeraction database

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MINTi
P11717

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000349437

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P11717

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12491
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E6FX-ray1.75A/B1508-1650[»]
1GP0X-ray1.40A1508-1650[»]
1GP3X-ray1.95A1508-1650[»]
1GQBX-ray1.80A/B1508-1650[»]
1JPLX-ray2.40E/F/G/H2480-2491[»]
1JWGX-ray2.00C/D2479-2491[»]
1LF8X-ray2.30E/F/G/H2480-2491[»]
2CNJNMR-D1508-1650[»]
2L29NMR-A1508-1647[»]
2L2ANMR-A1508-1647[»]
2M68NMR-A1508-1647[»]
2M6TNMR-A1508-1647[»]
2V5NX-ray3.20A1508-1799[»]
2V5OX-ray2.91A1508-2128[»]
2V5PX-ray4.10A/B1508-1992[»]
5IEIX-ray2.80A1508-1647[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P11717

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P11717

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P11717

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati40 – 1891Add BLAST150
Repeati190 – 3442Add BLAST155
Repeati345 – 4893Add BLAST145
Repeati490 – 6434Add BLAST154
Repeati644 – 7835Add BLAST140
Repeati784 – 9506Add BLAST167
Repeati951 – 10997Add BLAST149
Repeati1100 – 12438Add BLAST144
Repeati1244 – 13849Add BLAST141
Repeati1385 – 153210Add BLAST148
Repeati1533 – 166611Add BLAST134
Repeati1667 – 182012Add BLAST154
Repeati1821 – 200813Add BLAST188
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1898 – 1944Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST47
Repeati2009 – 213714Add BLAST129
Repeati2165 – 228915Add BLAST125

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MRL1/IGF2R family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4504 Eukaryota
ENOG410ZWHP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013943

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113638

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000334

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11717

KEGG Orthology (KO)

More...
KOi
K06564

Identification of Orthologs from Complete Genome Data

More...
OMAi
CPDQIRK

Database of Orthologous Groups

More...
OrthoDBi
290124at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11717

TreeFam database of animal gene trees

More...
TreeFami
TF328963

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00062 FN2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 1 hit
2.70.130.10, 15 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000479 CIMR
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00878 CIMR, 15 hits
PF00040 fn2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00059 FN2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57440 SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P11717-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAAAGRSPH LGPAPARRPQ RSLLLLQLLL LVAAPGSTQA QAAPFPELCS
60 70 80 90 100
YTWEAVDTKN NVLYKINICG SVDIVQCGPS SAVCMHDLKT RTYHSVGDSV
110 120 130 140 150
LRSATRSLLE FNTTVSCDQQ GTNHRVQSSI AFLCGKTLGT PEFVTATECV
160 170 180 190 200
HYFEWRTTAA CKKDIFKANK EVPCYVFDEE LRKHDLNPLI KLSGAYLVDD
210 220 230 240 250
SDPDTSLFIN VCRDIDTLRD PGSQLRACPP GTAACLVRGH QAFDVGQPRD
260 270 280 290 300
GLKLVRKDRL VLSYVREEAG KLDFCDGHSP AVTITFVCPS ERREGTIPKL
310 320 330 340 350
TAKSNCRYEI EWITEYACHR DYLESKTCSL SGEQQDVSID LTPLAQSGGS
360 370 380 390 400
SYISDGKEYL FYLNVCGETE IQFCNKKQAA VCQVKKSDTS QVKAAGRYHN
410 420 430 440 450
QTLRYSDGDL TLIYFGGDEC SSGFQRMSVI NFECNKTAGN DGKGTPVFTG
460 470 480 490 500
EVDCTYFFTW DTEYACVKEK EDLLCGATDG KKRYDLSALV RHAEPEQNWE
510 520 530 540 550
AVDGSQTETE KKHFFINICH RVLQEGKARG CPEDAAVCAV DKNGSKNLGK
560 570 580 590 600
FISSPMKEKG NIQLSYSDGD DCGHGKKIKT NITLVCKPGD LESAPVLRTS
610 620 630 640 650
GEGGCFYEFE WHTAAACVLS KTEGENCTVF DSQAGFSFDL SPLTKKNGAY
660 670 680 690 700
KVETKKYDFY INVCGPVSVS PCQPDSGACQ VAKSDEKTWN LGLSNAKLSY
710 720 730 740 750
YDGMIQLNYR GGTPYNNERH TPRATLITFL CDRDAGVGFP EYQEEDNSTY
760 770 780 790 800
NFRWYTSYAC PEEPLECVVT DPSTLEQYDL SSLAKSEGGL GGNWYAMDNS
810 820 830 840 850
GEHVTWRKYY INVCRPLNPV PGCNRYASAC QMKYEKDQGS FTEVVSISNL
860 870 880 890 900
GMAKTGPVVE DSGSLLLEYV NGSACTTSDG RQTTYTTRIH LVCSRGRLNS
910 920 930 940 950
HPIFSLNWEC VVSFLWNTEA ACPIQTTTDT DQACSIRDPN SGFVFNLNPL
960 970 980 990 1000
NSSQGYNVSG IGKIFMFNVC GTMPVCGTIL GKPASGCEAE TQTEELKNWK
1010 1020 1030 1040 1050
PARPVGIEKS LQLSTEGFIT LTYKGPLSAK GTADAFIVRF VCNDDVYSGP
1060 1070 1080 1090 1100
LKFLHQDIDS GQGIRNTYFE FETALACVPS PVDCQVTDLA GNEYDLTGLS
1110 1120 1130 1140 1150
TVRKPWTAVD TSVDGRKRTF YLSVCNPLPY IPGCQGSAVG SCLVSEGNSW
1160 1170 1180 1190 1200
NLGVVQMSPQ AAANGSLSIM YVNGDKCGNQ RFSTRITFEC AQISGSPAFQ
1210 1220 1230 1240 1250
LQDGCEYVFI WRTVEACPVV RVEGDNCEVK DPRHGNLYDL KPLGLNDTIV
1260 1270 1280 1290 1300
SAGEYTYYFR VCGKLSSDVC PTSDKSKVVS SCQEKREPQG FHKVAGLLTQ
1310 1320 1330 1340 1350
KLTYENGLLK MNFTGGDTCH KVYQRSTAIF FYCDRGTQRP VFLKETSDCS
1360 1370 1380 1390 1400
YLFEWRTQYA CPPFDLTECS FKDGAGNSFD LSSLSRYSDN WEAITGTGDP
1410 1420 1430 1440 1450
EHYLINVCKS LAPQAGTEPC PPEAAACLLG GSKPVNLGRV RDGPQWRDGI
1460 1470 1480 1490 1500
IVLKYVDGDL CPDGIRKKST TIRFTCSESQ VNSRPMFISA VEDCEYTFAW
1510 1520 1530 1540 1550
PTATACPMKS NEHDDCQVTN PSTGHLFDLS SLSGRAGFTA AYSEKGLVYM
1560 1570 1580 1590 1600
SICGENENCP PGVGACFGQT RISVGKANKR LRYVDQVLQL VYKDGSPCPS
1610 1620 1630 1640 1650
KSGLSYKSVI SFVCRPEARP TNRPMLISLD KQTCTLFFSW HTPLACEQAT
1660 1670 1680 1690 1700
ECSVRNGSSI VDLSPLIHRT GGYEAYDESE DDASDTNPDF YINICQPLNP
1710 1720 1730 1740 1750
MHGVPCPAGA AVCKVPIDGP PIDIGRVAGP PILNPIANEI YLNFESSTPC
1760 1770 1780 1790 1800
LADKHFNYTS LIAFHCKRGV SMGTPKLLRT SECDFVFEWE TPVVCPDEVR
1810 1820 1830 1840 1850
MDGCTLTDEQ LLYSFNLSSL STSTFKVTRD SRTYSVGVCT FAVGPEQGGC
1860 1870 1880 1890 1900
KDGGVCLLSG TKGASFGRLQ SMKLDYRHQD EAVVLSYVNG DRCPPETDDG
1910 1920 1930 1940 1950
VPCVFPFIFN GKSYEECIIE SRAKLWCSTT ADYDRDHEWG FCRHSNSYRT
1960 1970 1980 1990 2000
SSIIFKCDED EDIGRPQVFS EVRGCDVTFE WKTKVVCPPK KLECKFVQKH
2010 2020 2030 2040 2050
KTYDLRLLSS LTGSWSLVHN GVSYYINLCQ KIYKGPLGCS ERASICRRTT
2060 2070 2080 2090 2100
TGDVQVLGLV HTQKLGVIGD KVVVTYSKGY PCGGNKTASS VIELTCTKTV
2110 2120 2130 2140 2150
GRPAFKRFDI DSCTYYFSWD SRAACAVKPQ EVQMVNGTIT NPINGKSFSL
2160 2170 2180 2190 2200
GDIYFKLFRA SGDMRTNGDN YLYEIQLSSI TSSRNPACSG ANICQVKPND
2210 2220 2230 2240 2250
QHFSRKVGTS DKTKYYLQDG DLDVVFASSS KCGKDKTKSV SSTIFFHCDP
2260 2270 2280 2290 2300
LVEDGIPEFS HETADCQYLF SWYTSAVCPL GVGFDSENPG DDGQMHKGLS
2310 2320 2330 2340 2350
ERSQAVGAVL SLLLVALTCC LLALLLYKKE RRETVISKLT TCCRRSSNVS
2360 2370 2380 2390 2400
YKYSKVNKEE ETDENETEWL MEEIQLPPPR QGKEGQENGH ITTKSVKALS
2410 2420 2430 2440 2450
SLHGDDQDSE DEVLTIPEVK VHSGRGAGAE SSHPVRNAQS NALQEREDDR
2460 2470 2480 2490
VGLVRGEKAR KGKSSSAQQK TVSSTKLVSF HDDSDEDLLH I
Length:2,491
Mass (Da):274,375
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3841ADE559B48057
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R328S4R328_HUMAN
Cation-independent mannose-6-phosph...
IGF2R
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti254L → V in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti510E → K in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti612H → R in CAA68395 (PubMed:2957598).Curated1
Sequence conflicti612H → R in AAF16870 (Ref. 3) Curated1
Sequence conflicti845V → A in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti1489S → N in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti1703G → A in CAA68395 (PubMed:2957598).Curated1
Sequence conflicti1703G → A in AAF16870 (Ref. 3) Curated1
Sequence conflicti2026I → M in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2075T → M in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2156K → N in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2160A → E in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2176Q → L in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2330E → K in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2335V → M in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2341T → S in AAA59866 (PubMed:2963003).Curated1
Sequence conflicti2410E → T in AAA59866 (PubMed:2963003).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02130491R → H1 PublicationCorresponds to variant dbSNP:rs8191704Ensembl.1
Natural variantiVAR_020470203P → L1 PublicationCorresponds to variant dbSNP:rs8191746Ensembl.1
Natural variantiVAR_021305231G → D1 PublicationCorresponds to variant dbSNP:rs8191753Ensembl.1
Natural variantiVAR_020471252L → V1 PublicationCorresponds to variant dbSNP:rs8191754Ensembl.1
Natural variantiVAR_021306273D → G1 PublicationCorresponds to variant dbSNP:rs8191758Ensembl.1
Natural variantiVAR_021307512K → Q1 PublicationCorresponds to variant dbSNP:rs8191776Ensembl.1
Natural variantiVAR_020472529R → Q. Corresponds to variant dbSNP:rs6413489Ensembl.1
Natural variantiVAR_020473604G → S1 PublicationCorresponds to variant dbSNP:rs8191797Ensembl.1
Natural variantiVAR_020474724A → T1 PublicationCorresponds to variant dbSNP:rs6413491Ensembl.1
Natural variantiVAR_021308817L → V1 PublicationCorresponds to variant dbSNP:rs8191808Ensembl.1
Natural variantiVAR_020475856G → S1 PublicationCorresponds to variant dbSNP:rs8191819Ensembl.1
Natural variantiVAR_0204761107T → M1 PublicationCorresponds to variant dbSNP:rs8191842Ensembl.1
Natural variantiVAR_0213091124V → I1 PublicationCorresponds to variant dbSNP:rs8191843Ensembl.1
Natural variantiVAR_0204771184T → S1 PublicationCorresponds to variant dbSNP:rs8191844Ensembl.1
Natural variantiVAR_0504281254E → A. Corresponds to variant dbSNP:rs2230043Ensembl.1
Natural variantiVAR_0213101315G → E1 PublicationCorresponds to variant dbSNP:rs8191859Ensembl.1
Natural variantiVAR_0213111335R → H1 PublicationCorresponds to variant dbSNP:rs8191860Ensembl.1
Natural variantiVAR_0504291395T → S. Corresponds to variant dbSNP:rs2230048Ensembl.1
Natural variantiVAR_0213121619R → G4 PublicationsCorresponds to variant dbSNP:rs629849Ensembl.1
Natural variantiVAR_0504301696Q → R. Corresponds to variant dbSNP:rs11552587Ensembl.1
Natural variantiVAR_0213131832R → H1 PublicationCorresponds to variant dbSNP:rs8191904Ensembl.1
Natural variantiVAR_0213141860G → D1 PublicationCorresponds to variant dbSNP:rs8191905Ensembl.1
Natural variantiVAR_0213151908I → M1 PublicationCorresponds to variant dbSNP:rs8191908Ensembl.1
Natural variantiVAR_0147222020N → S1 PublicationCorresponds to variant dbSNP:rs1805075Ensembl.1
Natural variantiVAR_0213162459A → V1 PublicationCorresponds to variant dbSNP:rs8191955Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y00285 mRNA Translation: CAA68395.1
J03528 mRNA Translation: AAA59866.1
AF109291
, AF109244, AF109245, AF109246, AF109247, AF109248, AF109249, AF109250, AF109251, AF109252, AF109253, AF109254, AF109255, AF109256, AF109257, AF109258, AF109259, AF109260, AF109261, AF109262, AF109263, AF109264, AF109265, AF109266, AF109267, AF109268, AF109269, AF109270, AF109271, AF109272, AF109273, AF109274, AF109275, AF109276, AF109277, AF109278, AF109279, AF109280, AF109281, AF109282, AF109283, AF109284, AF109285, AF109286, AF109287, AF109288, AF109289, AF109290 Genomic DNA Translation: AAF16870.1
AF069333 Genomic DNA Translation: AAL04402.1
AY293855 Genomic DNA Translation: AAP37954.1
AL353625 Genomic DNA No translation available.
AL035691 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5273.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A28372

NCBI Reference Sequences

More...
RefSeqi
NP_000867.2, NM_000876.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.487062
Hs.673278

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356956; ENSP00000349437; ENSG00000197081
ENST00000647592; ENSP00000497964; ENSG00000197081

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3482

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3482

UCSC genome browser

More...
UCSCi
uc003qta.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00285 mRNA Translation: CAA68395.1
J03528 mRNA Translation: AAA59866.1
AF109291
, AF109244, AF109245, AF109246, AF109247, AF109248, AF109249, AF109250, AF109251, AF109252, AF109253, AF109254, AF109255, AF109256, AF109257, AF109258, AF109259, AF109260, AF109261, AF109262, AF109263, AF109264, AF109265, AF109266, AF109267, AF109268, AF109269, AF109270, AF109271, AF109272, AF109273, AF109274, AF109275, AF109276, AF109277, AF109278, AF109279, AF109280, AF109281, AF109282, AF109283, AF109284, AF109285, AF109286, AF109287, AF109288, AF109289, AF109290 Genomic DNA Translation: AAF16870.1
AF069333 Genomic DNA Translation: AAL04402.1
AY293855 Genomic DNA Translation: AAP37954.1
AL353625 Genomic DNA No translation available.
AL035691 Genomic DNA No translation available.
CCDSiCCDS5273.1
PIRiA28372
RefSeqiNP_000867.2, NM_000876.3
UniGeneiHs.487062
Hs.673278

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E6FX-ray1.75A/B1508-1650[»]
1GP0X-ray1.40A1508-1650[»]
1GP3X-ray1.95A1508-1650[»]
1GQBX-ray1.80A/B1508-1650[»]
1JPLX-ray2.40E/F/G/H2480-2491[»]
1JWGX-ray2.00C/D2479-2491[»]
1LF8X-ray2.30E/F/G/H2480-2491[»]
2CNJNMR-D1508-1650[»]
2L29NMR-A1508-1647[»]
2L2ANMR-A1508-1647[»]
2M68NMR-A1508-1647[»]
2M6TNMR-A1508-1647[»]
2V5NX-ray3.20A1508-1799[»]
2V5OX-ray2.91A1508-2128[»]
2V5PX-ray4.10A/B1508-1992[»]
5IEIX-ray2.80A1508-1647[»]
ProteinModelPortaliP11717
SMRiP11717
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109703, 41 interactors
CORUMiP11717
DIPiDIP-6027N
ELMiP11717
IntActiP11717, 42 interactors
MINTiP11717
STRINGi9606.ENSP00000349437

Chemistry databases

BindingDBiP11717
ChEMBLiCHEMBL3240
DrugBankiDB02900 alpha-D-mannose 6-phosphate
DB01277 Mecasermin

Protein family/group databases

TCDBi9.B.247.1.2 the mannose 6-phosphate receptor (m6pr) family

PTM databases

GlyConnecti1084
iPTMnetiP11717
PhosphoSitePlusiP11717
SwissPalmiP11717

Polymorphism and mutation databases

BioMutaiIGF2R
DMDMi317373416

Proteomic databases

EPDiP11717
jPOSTiP11717
MaxQBiP11717
PaxDbiP11717
PeptideAtlasiP11717
PRIDEiP11717
ProteomicsDBi52802

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3482
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356956; ENSP00000349437; ENSG00000197081
ENST00000647592; ENSP00000497964; ENSG00000197081
GeneIDi3482
KEGGihsa:3482
UCSCiuc003qta.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3482
DisGeNETi3482
EuPathDBiHostDB:ENSG00000197081.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IGF2R
HGNCiHGNC:5467 IGF2R
HPAiCAB009661
HPA011332
MalaCardsiIGF2R
MIMi147280 gene
neXtProtiNX_P11717
OpenTargetsiENSG00000197081
PharmGKBiPA29701

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4504 Eukaryota
ENOG410ZWHP LUCA
GeneTreeiENSGT00390000013943
HOGENOMiHOG000113638
HOVERGENiHBG000334
InParanoidiP11717
KOiK06564
OMAiCPDQIRK
OrthoDBi290124at2759
PhylomeDBiP11717
TreeFamiTF328963

Enzyme and pathway databases

ReactomeiR-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-6798695 Neutrophil degranulation
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkiP11717
SIGNORiP11717

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IGF2R human
EvolutionaryTraceiP11717

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Insulin-like_growth_factor_2_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3482

Protein Ontology

More...
PROi
PR:P11717

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197081 Expressed in 230 organ(s), highest expression level in leukocyte
CleanExiHS_IGF2R
ExpressionAtlasiP11717 baseline and differential
GenevisibleiP11717 HS

Family and domain databases

CDDicd00062 FN2, 1 hit
Gene3Di2.10.10.10, 1 hit
2.70.130.10, 15 hits
InterProiView protein in InterPro
IPR000479 CIMR
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
PfamiView protein in Pfam
PF00878 CIMR, 15 hits
PF00040 fn2, 1 hit
SMARTiView protein in SMART
SM00059 FN2, 1 hit
SUPFAMiSSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPRI_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11717
Secondary accession number(s): Q7Z7G9, Q96PT5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 11, 2011
Last modified: January 16, 2019
This is version 211 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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