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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

Cyp17a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Catalytic activityi

A C(21)-steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 17-alpha-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity
17-alpha-hydroxyprogesterone + [reduced NADPH--hemoprotein reductase] + O2 = androstenedione + acetate + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity
17-alpha-hydroxypregnenolone + [reduced NADPH--hemoprotein reductase] + O2 = 3-beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity

Cofactori

hemeBy similarity

Enzyme regulationi

Regulated predominantly by intracellular cAMP levels.

Pathwayi: steroid biosynthesis

This protein is involved in the pathway steroid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway steroid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi441Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • adrenal gland development Source: RGD
  • androgen biosynthetic process Source: RGD
  • biphenyl metabolic process Source: RGD
  • cellular response to antibiotic Source: RGD
  • cellular response to gonadotropin stimulus Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • dibenzo-p-dioxin metabolic process Source: RGD
  • hippocampus development Source: RGD
  • hormone biosynthetic process Source: UniProtKB
  • Leydig cell differentiation Source: RGD
  • male gonad development Source: RGD
  • organic acid metabolic process Source: RGD
  • ovulation Source: RGD
  • phenol-containing compound metabolic process Source: RGD
  • phthalate metabolic process Source: RGD
  • positive regulation of steroid hormone biosynthetic process Source: RGD
  • progesterone metabolic process Source: UniProtKB
  • response to acetate Source: RGD
  • response to cAMP Source: RGD
  • response to cytokine Source: RGD
  • response to drug Source: RGD
  • response to fungicide Source: RGD
  • response to gonadotropin Source: RGD
  • response to herbicide Source: RGD
  • response to insecticide Source: RGD
  • response to ionizing radiation Source: RGD
  • response to methylmercury Source: RGD
  • response to nutrient levels Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organic substance Source: RGD
  • response to retinoic acid Source: RGD
  • response to steroid hormone Source: RGD
  • response to toxic substance Source: RGD
  • steroid biosynthetic process Source: RGD
  • steroid metabolic process Source: UniProtKB

Keywordsi

Molecular functionLyase, Monooxygenase, Oxidoreductase
Biological processSteroidogenesis
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00062

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.14.19By similarity, EC:1.14.14.32By similarity)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:Cyp17a1
Synonyms:Cyp17
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2456 Cyp17a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4430

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519411 – 507Steroid 17-alpha-hydroxylase/17,20 lyaseAdd BLAST507

Proteomic databases

PaxDbiP11715
PRIDEiP11715

PTM databases

iPTMnetiP11715
PhosphoSitePlusiP11715

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027160

Chemistry databases

BindingDBiP11715

Structurei

3D structure databases

ProteinModelPortaliP11715
SMRiP11715
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
HOGENOMiHOG000036991
HOVERGENiHBG106944
InParanoidiP11715
KOiK00512
PhylomeDBiP11715
TreeFamiTF105095

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P11715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWELVGLLLL ILAYFFWVKS KTPGAKLPRS LPSLPLVGSL PFLPRRGHMH
60 70 80 90 100
VNFFKLQEKY GPIYSLRLGT TTTVIIGHYQ LAREVLIKKG KEFSGRPQMV
110 120 130 140 150
TQSLLSDQGK GVAFADAGSS WHLHRKLVFS TFSLFKDGQK LEKLICQEAK
160 170 180 190 200
SLCDMMLAHD KESIDLSTPI FMSVTNIICA ICFNISYEKN DPKLTAIKTF
210 220 230 240 250
TEGIVDATGD RNLVDIFPWL TIFPNKGLEV IKGYAKVRNE VLTGIFEKCR
260 270 280 290 300
EKFDSQSISS LTDILIQAKM NSDNNNSCEG RDPDVFSDRH ILATVGDIFG
310 320 330 340 350
AGIETTTTVL KWILAFLVHN PEVKKKIQKE IDQYVGFSRT PTFNDRSHLL
360 370 380 390 400
MLEATIREVL RIRPVAPMLI PHKANVDSSI GEFTVPKDTH VVVNLWALHH
410 420 430 440 450
DENEWDQPDQ FMPERFLDPT GSHLITPTQS YLPFGAGPRS CIGEALARQE
460 470 480 490 500
LFVFTALLLQ RFDLDVSDDK QLPRLEGDPK VVFLIDPFKV KITVRQAWMD

AQAEVST
Length:507
Mass (Da):57,250
Last modified:August 1, 1990 - v2
Checksum:iA535600F7E6A399B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190N → K in AAH78898 (PubMed:15489334).Curated1
Sequence conflicti505 – 506VS → LT in AAA41050 (PubMed:3260774).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14086 mRNA Translation: CAA32248.1
X69816 Genomic DNA Translation: CAA49470.1
M31681 mRNA Translation: AAA41777.1
M22204 mRNA Translation: AAA41783.1
BC078898 mRNA Translation: AAH78898.1
Z11902 Genomic DNA Translation: CAA77954.1
M21208 mRNA Translation: AAA41050.1
M27282 mRNA Translation: AAA41779.1
PIRiA31359 A30828
RefSeqiNP_036885.1, NM_012753.2
XP_006231496.1, XM_006231434.3
XP_006231497.1, XM_006231435.3
UniGeneiRn.10172

Genome annotation databases

GeneIDi25146
KEGGirno:25146
UCSCiRGD:2456 rat

Similar proteinsi

Entry informationi

Entry nameiCP17A_RAT
AccessioniPrimary (citable) accession number: P11715
Secondary accession number(s): Q68FY2, Q6LAE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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