CYP2C9

Functionⁱ

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (PubMed:25994031). This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).1 Publication

Catalytic activityⁱ

⁺-(R)-limonene + [reduced NADPH--hemoprotein reductase] + O₂ = (+)-trans-carveol + [oxidized NADPH--hemoprotein reductase] + H₂O.1 Publication

(S)-limonene + [reduced NADPH--hemoprotein reductase] + O₂ = (-)-trans-carveol + [oxidized NADPH--hemoprotein reductase] + H₂O.1 Publication

(S)-limonene + [reduced NADPH--hemoprotein reductase] + O₂ = (-)-perillyl alcohol + [oxidized NADPH--hemoprotein reductase] + H₂O.1 Publication

Cholesterol + [reduced NADPH--hemoprotein reductase] + O₂ = 25-hydroxycholesterol + [oxidized NADPH--hemoprotein reductase] + H₂O.1 Publication

Cofactorⁱ

heme

Kineticsⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	435	Iron (heme axial ligand)		1

GO - Molecular functionⁱ

arachidonic acid epoxygenase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
caffeine oxidase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18619574
drug binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 19448135
heme binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
iron ion binding Source: InterPro
monooxygenase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19651758
oxidoreductase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 16401082
- 19219744
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
steroid hydroxylase activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18356043

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular amide metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 19651758
drug catabolic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18356043
drug metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 19219744
- 19651758
epoxygenase P450 pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
exogenous drug catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 18619574
long-chain fatty acid biosynthetic process Source: Reactome
monocarboxylic acid metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 19651758
monoterpenoid metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 16401082
omega-hydroxylase P450 pathway Source: Reactome
organic acid metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
oxidation-reduction process
Source: BHF-UCL
Inferred from direct assayⁱ
- 16401082
- 19219744
oxidative demethylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 18619574
steroid metabolic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18356043
urea metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 19029318
xenobiotic metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Biological process	Lipid metabolism, Steroid metabolism, Sterol metabolism
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06458-MONOMER
BRENDAⁱ	1.14.99.38 2681
Reactomeⁱ	R-HSA-211981 Xenobiotics R-HSA-211999 CYP2E1 reactions R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKⁱ	P11712
SIGNORⁱ	P11712

Chemistry databases

SwissLipidsⁱ	SLP:000001203

SwissLipidsⁱ

SLP:000001203

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450 2C9 (EC:1.14.14.-1 Publication) Alternative name(s): (R)-limonene 6-monooxygenase (EC:1.14.14.531 Publication) (S)-limonene 6-monooxygenase (EC:1.14.14.511 Publication) (S)-limonene 7-monooxygenase (EC:1.14.14.521 Publication) CYPIIC9 Cholesterol 25-hydroxylase1 Publication (EC:1.14.14.-1 Publication) Cytochrome P-450MP Cytochrome P450 MP-4 Cytochrome P450 MP-8 Cytochrome P450 PB-1 S-mephenytoin 4-hydroxylase1 Publication
Gene namesⁱ	Name:CYP2C9 Synonyms:CYP2C10
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000138109.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2623 CYP2C9
MIMⁱ	601130 gene
neXtProtⁱ	NX_P11712

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1559
MalaCards human disease database More...MalaCardsⁱ	CYP2C9
Open Targets More...OpenTargetsⁱ	ENSG00000138109
Orphanetⁱ	413681 Oral antidiabetic drugs toxicity or dose selection 413674 Vitamin K antagonists toxicity or dose selection
PharmGKBⁱ	PA126

Chemistry databases

ChEMBLⁱ	CHEMBL3397
Drug and drug target database More...DrugBankⁱ	DB02507 4-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-One DB05812 Abiraterone DB06736 Aceclofenac DB01418 Acenocoumarol DB00316 Acetaminophen DB00945 Acetylsalicylic acid DB06594 Agomelatine DB00969 Alosetron DB00404 Alprazolam DB01424 Aminophenazone DB01118 Amiodarone DB00321 Amitriptyline DB00381 Amlodipine DB00613 Amodiaquine DB00701 Amprenavir DB01217 Anastrozole DB01435 Antipyrine DB06605 Apixaban DB00673 Aprepitant DB04557 Arachidonic Acid DB01274 Arformoterol DB06413 Armodafinil DB06697 Artemether DB01072 Atazanavir DB01076 Atorvastatin DB01117 Atovaquone DB00972 Azelastine DB00307 Bexarotene DB01128 Bicalutamide DB00188 Bortezomib DB00559 Bosentan DB00835 Brompheniramine DB00921 Buprenorphine DB01156 Bupropion DB08875 Cabozantinib DB00201 Caffeine DB00796 Candesartan DB01101 Capecitabine DB00564 Carbamazepine DB00748 Carbinoxamine DB01136 Carvedilol DB00482 Celecoxib DB09063 Ceritinib DB00439 Cerivastatin DB00446 Chloramphenicol DB00672 Chlorpropamide DB00169 Cholecalciferol DB00501 Cimetidine DB00568 Cinnarizine DB00604 Cisapride DB00515 Cisplatin DB04920 Clevidipine DB00758 Clopidogrel DB00257 Clotrimazole DB00363 Clozapine DB00907 Cocaine DB01394 Colchicine DB05219 Crisaborole DB01176 Cyclizine DB00531 Cyclophosphamide DB00091 Cyclosporine DB06292 Dapagliflozin DB00250 Dapsone DB00705 Delavirdine DB00967 Desloratadine DB01234 Dexamethasone DB01191 Dexfenfluramine DB04856 Dexloxiglumide DB00514 Dextromethorphan DB00647 Dextropropoxyphene DB00829 Diazepam DB00586 Diclofenac DB01144 Diclofenamide DB00266 Dicoumarol DB00255 Diethylstilbestrol DB00343 Diltiazem DB01075 Diphenhydramine DB00822 Disulfiram DB00757 Dolasetron DB00843 Donepezil DB00988 Dopamine DB00869 Dorzolamide DB01142 Doxepin DB00470 Dronabinol DB00625 Efavirenz DB00216 Eletriptan DB08899 Enzalutamide DB00668 Epinephrine DB01240 Epoprostenol DB00876 Eprosartan DB00783 Estradiol DB00655 Estrone DB04574 Estrone sulfate DB00402 Eszopiclone DB00898 Ethanol DB00749 Etodolac DB01628 Etoricoxib DB06414 Etravirine DB01023 Felodipine DB01039 Fenofibrate DB01195 Flecainide DB00322 Floxuridine DB00196 Fluconazole DB04841 Flunarizine DB01544 Flunitrazepam DB00544 Fluorouracil DB00472 Fluoxetine DB00712 Flurbiprofen DB01095 Fluvastatin DB00176 Fluvoxamine DB00983 Formoterol DB01320 Fosphenytoin DB06741 Gavestinel DB00317 Gefitinib DB01241 Gemfibrozil DB01381 Ginkgo biloba DB01120 Gliclazide DB00222 Glimepiride DB01067 Glipizide DB01016 Glyburide DB01018 Guanfacine DB00502 Haloperidol DB01159 Halothane DB03317 Heme C DB01355 Hexobarbital DB05381 Histamine DB00062 Human Serum Albumin DB00327 Hydromorphone DB01050 Ibuprofen DB01177 Idarubicin DB01181 Ifosfamide DB00619 Imatinib DB00224 Indinavir DB00328 Indomethacin DB01029 Irbesartan DB00951 Isoniazid DB09570 Ixazomib DB01221 Ketamine DB06738 Ketobemidone DB01026 Ketoconazole DB01009 Ketoprofen DB00448 Lansoprazole DB01097 Leflunomide DB11560 Lesinurad DB04725 Licofelone DB00281 Lidocaine DB01601 Lopinavir DB00455 Loratadine DB06725 Lornoxicam DB00678 Losartan DB00227 Lovastatin DB09280 Lumacaftor DB01283 Lumiracoxib DB00603 Medroxyprogesterone acetate DB00784 Mefenamic acid DB01065 Melatonin DB00814 Meloxicam DB00532 Mephenytoin DB01357 Mestranol DB00333 Methadone DB00703 Methazolamide DB00763 Methimazole DB01028 Methoxyflurane DB00916 Metronidazole DB01110 Miconazole DB00370 Mirtazapine DB01171 Moclobemide DB00745 Modafinil DB00471 Montelukast DB11605 Myrrh DB00788 Naproxen DB00731 Nateglinide DB00220 Nelfinavir DB09048 Netupitant DB00238 Nevirapine DB00622 Nicardipine DB06803 Niclosamide DB00184 Nicotine DB01115 Nifedipine DB04868 Nilotinib DB00665 Nilutamide DB06712 Nilvadipine DB00540 Nortriptyline DB00334 Olanzapine DB09080 Olodaterol DB00338 Omeprazole DB00904 Ondansetron DB04938 Ospemifene DB00991 Oxaprozin DB01229 Paclitaxel DB00213 Pantoprazole DB00617 Paramethadione DB08439 Parecoxib DB00715 Paroxetine DB00850 Perphenazine DB03783 Phenacetin DB01174 Phenobarbital DB00946 Phenprocoumon DB00191 Phentermine DB00812 Phenylbutazone DB00252 Phenytoin DB01132 Pioglitazone DB00554 Piroxicam DB08860 Pitavastatin DB01411 Pranlukast DB06209 Prasugrel DB00175 Pravastatin DB00794 Primidone DB01032 Probenecid DB00396 Progesterone DB01131 Proguanil DB00420 Promazine DB01069 Promethazine DB01182 Propafenone DB00818 Propofol DB09396 Propoxyphene napsylate DB00205 Pyrimethamine DB01589 Quazepam DB00908 Quinidine DB00468 Quinine DB01129 Rabeprazole DB08896 Regorafenib DB01045 Rifampicin DB01201 Rifapentine DB00503 Ritonavir DB00533 Rofecoxib DB00412 Rosiglitazone DB01098 Rosuvastatin DB01698 Rutin DB00936 Salicylic acid DB01232 Saquinavir DB00418 Secobarbital DB01037 Selegiline DB01104 Sertraline DB00203 Sildenafil DB00641 Simvastatin DB06268 Sitaxentan DB00398 Sorafenib DB06820 Sulconazole DB00359 Sulfadiazine DB06150 Sulfadimethoxine DB00576 Sulfamethizole DB01015 Sulfamethoxazole DB08798 Sulfamoxole DB00259 Sulfanilamide DB06729 Sulfaphenazole DB00891 Sulfapyridine DB01138 Sulfinpyrazone DB00263 Sulfisoxazole DB00870 Suprofen DB00675 Tamoxifen DB06204 Tapentadol DB01079 Tegaserod DB00231 Temazepam DB00444 Teniposide DB00469 Tenoxicam DB00857 Terbinafine DB00342 Terfenadine DB00624 Testosterone DB01041 Thalidomide DB00277 Theophylline DB01154 Thiamylal DB00679 Thioridazine DB08816 Ticagrelor DB00208 Ticlopidine DB04831 Ticrynafen DB01007 Tioconazole DB01124 Tolbutamide DB00323 Tolcapone DB01036 Tolterodine DB00214 Torasemide DB05109 Trabectedin DB00752 Tranylcypromine DB00374 Treprostinil DB00755 Tretinoin DB00897 Triazolam DB00347 Trimethadione DB00440 Trimethoprim DB00726 Trimipramine DB00197 Troglitazone DB01361 Troleandomycin DB00580 Valdecoxib DB00313 Valproic Acid DB00177 Valsartan DB00285 Venlafaxine DB00661 Verapamil DB08828 Vismodegib DB00582 Voriconazole DB09068 Vortioxetine DB00682 Warfarin DB04898 Ximelagatran DB00549 Zafirlukast DB00943 Zalcitabine DB06737 Zaltoprofen DB00495 Zidovudine DB00744 Zileuton DB00425 Zolpidem DB01198 Zopiclone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1326

Polymorphism and mutation databases

BioMutaⁱ	CYP2C9
DMDMⁱ	6686268

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051700	1 – 490	Cytochrome P450 2C9Add BLAST		490

Proteomic databases

EPDⁱ	P11712
PaxDbⁱ	P11712
PeptideAtlas More...PeptideAtlasⁱ	P11712
PRIDEⁱ	P11712
ProteomicsDBⁱ	52801

PTM databases

iPTMnetⁱ	P11712
PhosphoSitePlusⁱ	P11712

Expressionⁱ

Inductionⁱ

By rifampicin.

Gene expression databases

Bgeeⁱ	ENSG00000138109 Expressed in 106 organ(s), highest expression level in liver
CleanExⁱ	HS_CYP2C9
ExpressionAtlasⁱ	P11712 baseline and differential
Genevisibleⁱ	P11712 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016123 HPA015066

HPAⁱ

CAB016123
HPA015066

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107937, 14 interactors
IntActⁱ	P11712, 6 interactors
STRINGⁱ	9606.ENSP00000260682

Chemistry databases

BindingDBⁱ

P11712

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	33 – 35	Combined sources	3
Turnⁱ	37 – 39	Combined sources	3
Helixⁱ	42 – 44	Combined sources	3
Helixⁱ	47 – 61	Combined sources	15
Beta strandⁱ	63 – 71	Combined sources	9
Beta strandⁱ	73 – 77	Combined sources	5
Helixⁱ	80 – 87	Combined sources	8
Turnⁱ	88 – 94	Combined sources	7
Beta strandⁱ	95 – 97	Combined sources	3
Turnⁱ	105 – 107	Combined sources	3
Beta strandⁱ	111 – 114	Combined sources	4
Helixⁱ	117 – 131	Combined sources	15
Beta strandⁱ	134 – 136	Combined sources	3
Beta strandⁱ	137 – 139	Combined sources	3
Helixⁱ	141 – 157	Combined sources	17
Turnⁱ	158 – 161	Combined sources	4
Helixⁱ	167 – 183	Combined sources	17
Helixⁱ	192 – 208	Combined sources	17
Helixⁱ	211 – 214	Combined sources	4
Helixⁱ	216 – 218	Combined sources	3
Helixⁱ	222 – 224	Combined sources	3
Turnⁱ	227 – 229	Combined sources	3
Helixⁱ	230 – 253	Combined sources	24
Helixⁱ	263 – 274	Combined sources	12
Beta strandⁱ	275 – 277	Combined sources	3
Helixⁱ	284 – 315	Combined sources	32
Helixⁱ	317 – 330	Combined sources	14
Beta strandⁱ	333 – 335	Combined sources	3
Helixⁱ	339 – 344	Combined sources	6
Helixⁱ	346 – 359	Combined sources	14
Beta strandⁱ	374 – 376	Combined sources	3
Beta strandⁱ	379 – 381	Combined sources	3
Beta strandⁱ	386 – 389	Combined sources	4
Helixⁱ	392 – 395	Combined sources	4
Turnⁱ	398 – 400	Combined sources	3
Beta strandⁱ	401 – 403	Combined sources	3
Helixⁱ	409 – 412	Combined sources	4
Beta strandⁱ	415 – 417	Combined sources	3
Helixⁱ	431 – 433	Combined sources	3
Helixⁱ	438 – 455	Combined sources	18
Beta strandⁱ	456 – 462	Combined sources	7
Helixⁱ	464 – 466	Combined sources	3
Beta strandⁱ	475 – 477	Combined sources	3
Beta strandⁱ	485 – 489	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P11712
SMRⁱ	P11712
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P11712

EvolutionaryTraceⁱ

P11712

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137861
HOGENOMⁱ	HOG000036992
HOVERGENⁱ	HBG061848
InParanoidⁱ	P11712
KEGG Orthology (KO) More...KOⁱ	K17719
OMAⁱ	LHEMTKV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BT8
PhylomeDBⁱ	P11712
TreeFamⁱ	TF352043

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P11712-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLVVLVLC LSCLLLLSLW RQSSGRGKLP PGPTPLPVIG NILQIGIKDI 
        60         70         80         90        100
SKSLTNLSKV YGPVFTLYFG LKPIVVLHGY EAVKEALIDL GEEFSGRGIF 
       110        120        130        140        150
PLAERANRGF GIVFSNGKKW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR 
       160        170        180        190        200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFHKRFDYK DQQFLNLMEK 
       210        220        230        240        250
LNENIKILSS PWIQICNNFS PIIDYFPGTH NKLLKNVAFM KSYILEKVKE 
       260        270        280        290        300
HQESMDMNNP QDFIDCFLMK MEKEKHNQPS EFTIESLENT AVDLFGAGTE 
       310        320        330        340        350
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRSHMPYTDA 
       360        370        380        390        400
VVHEVQRYID LLPTSLPHAV TCDIKFRNYL IPKGTTILIS LTSVLHDNKE 
       410        420        430        440        450
FPNPEMFDPH HFLDEGGNFK KSKYFMPFSA GKRICVGEAL AGMELFLFLT 
       460        470        480        490
SILQNFNLKS LVDPKNLDTT PVVNGFASVP PFYQLCFIPV

Length:490

Mass (Da):55,628

Last modified:May 30, 2000 - v3

Checksum:ⁱ4FDFC395303A4E3E

GO

Isoform 2 (identifier: P11712-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
161-162: AS → GG
163-490: Missing.

« Hide

        10         20         30         40         50
MDSLVVLVLC LSCLLLLSLW RQSSGRGKLP PGPTPLPVIG NILQIGIKDI 
        60         70         80         90        100
SKSLTNLSKV YGPVFTLYFG LKPIVVLHGY EAVKEALIDL GEEFSGRGIF 
       110        120        130        140        150
PLAERANRGF GIVFSNGKKW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR 
       160 
CLVEELRKTK GG

Note: No experimental confirmation available.

Show »

Length:162

Mass (Da):18,005

Checksum:ⁱB59C8888ED45AD09

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A2R8YF67	A0A2R8YF67_HUMAN		Cytochrome P450 2C9 Cytochrome P450 2C9	CYP2C9	282	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	4	L → I no nucleotide entry (PubMed:3697070).Curated	1
Sequence conflictⁱ	6	V → S no nucleotide entry (PubMed:3697070).Curated	1
Sequence conflictⁱ	14	L → M in AAB23864 (PubMed:1445376).Curated	1
Sequence conflictⁱ	175	C → Y no nucleotide entry (PubMed:2827463).Curated	1
Sequence conflictⁱ	239	F → L no nucleotide entry (PubMed:2827463).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018862	19	L → I in allele CYP2C9*7. Corresponds to variant dbSNP:rs67807361Ensembl.	1
Natural variantⁱVAR_075286	125	R → H in allele CYP2C9*35. 1 PublicationCorresponds to variant dbSNP:rs72558189Ensembl.	1
Natural variantⁱVAR_075287	125	R → L in allele CYP2C9*14. 1 Publication	1
Natural variantⁱVAR_008343	144	R → C in allele CYP2C9*2. 7 PublicationsCorresponds to variant dbSNP:rs1799853EnsemblClinVar.	1
Natural variantⁱVAR_018863	150	R → H in allele CYP2C9*8. 2 PublicationsCorresponds to variant dbSNP:rs7900194EnsemblClinVar.	1
Natural variantⁱVAR_075288	204	N → H in allele CYP2C9*57. 1 Publication	1
Natural variantⁱVAR_018864	251	H → R in allele CYP2C9*9. 2 PublicationsCorresponds to variant dbSNP:rs2256871Ensembl.	1
Natural variantⁱVAR_018865	272	E → G in allele CYP2C9*10. 1 PublicationCorresponds to variant dbSNP:rs9332130Ensembl.	1
Natural variantⁱVAR_018866	335	R → W in allele CYP2C9*11. 2 PublicationsCorresponds to variant dbSNP:rs28371685Ensembl.	1
Natural variantⁱVAR_008344	358	Y → C3 PublicationsCorresponds to variant dbSNP:rs1057909Ensembl.	1
Natural variantⁱVAR_008345	359	I → L in allele CYP2C9*3; responsible for the tolbutamide poor metabolizer phenotype. 4 PublicationsCorresponds to variant dbSNP:rs1057910EnsemblClinVar.	1
Natural variantⁱVAR_013515	359	I → T in allele CYP2C9*4. 1 PublicationCorresponds to variant dbSNP:rs56165452EnsemblClinVar.	1
Natural variantⁱVAR_013516	360	D → E in allele CYP2C9*5; increases the K(m) value for substrates tested. 2 PublicationsCorresponds to variant dbSNP:rs28371686EnsemblClinVar.	1
Natural variantⁱVAR_024717	413	L → P1 PublicationCorresponds to variant dbSNP:rs28371687Ensembl.	1
Natural variantⁱVAR_008346	417	G → D3 Publications	1
Natural variantⁱVAR_075289	434	I → F in allele CYP2C9*59; produces warfarin hypersensitivity; increases affinity but highly decreases enzymatic activity for tolbutamide; no effect on affinity but decreases enzymatic activity for diclofenac; decreases affinity and highly decreases enzymatic activity for losartan. 1 Publication	1
Natural variantⁱVAR_018867	489	P → S in allele CYP2C9*12. 1 PublicationCorresponds to variant dbSNP:rs9332239Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055573	161 – 162	AS → GG in isoform 2. 1 Publication		2
Alternative sequenceⁱVSP_055574	163 – 490	Missing in isoform 2. 1 PublicationAdd BLAST		328

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY341248 Genomic DNA Translation: AAP88931.1 AY702706 Genomic DNA Translation: AAT94065.1 AK289420 mRNA Translation: BAF82109.1 AL359672 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50019.1 CH471066 Genomic DNA Translation: EAW50020.1 BC020754 mRNA Translation: AAH20754.1 BC070317 mRNA Translation: AAH70317.1 BC125054 mRNA Translation: AAI25055.1 D00173 mRNA Translation: BAA00123.1 M15331 mRNA Translation: AAA52157.1 M21939 mRNA Translation: AAA52158.1 M21940 mRNA Translation: AAA52159.1 S46963 mRNA Translation: AAB23864.2 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7437.1 [P11712-1]
PIRⁱ	B38462 D28951
NCBI Reference Sequences More...RefSeqⁱ	NP_000762.2, NM_000771.3 [P11712-1] XP_016871247.1, XM_017015758.1
UniGeneⁱ	Hs.282624

Genome annotation databases

Ensemblⁱ	ENST00000260682; ENSP00000260682; ENSG00000138109 [P11712-1] ENST00000461906; ENSP00000495649; ENSG00000138109 [P11712-2]
GeneIDⁱ	1559
KEGGⁱ	hsa:1559

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P11712	Cytochrome P450 family 2 subfamily C polypeptide 9		HUMAN		490	UniRef100_P11712
Cytochrome P450 2C9 (Fragment)		HUMAN		49
Cytochrome P450 2C9 (Fragment)		HUMAN		26
Cytochrome P-450 2C (Fragment)		HUMAN		273
Cytochrome P450 2C9 (Fragment)		HUMAN		62
+1

Protein	Similar proteins		Species	Score	Length	Source
P11712	Cytochrome P450 family 2 subfamily C polypeptide 9		HUMAN		490	UniRef90_P11712
Cytochrome P450 2C43		MACFA		490
Uncharacterized protein		MANLE		490
Uncharacterized protein		CERAT		490
Uncharacterized protein		COLAP		490
+58
P11712-2	Uncharacterized protein		CERAT		164	UniRef90_P11712-2
Cytochrome P450 2C19		HUMAN		162
Uncharacterized protein		RHIRO		162
Uncharacterized protein		PAPAN		162
Uncharacterized protein		RHIBE		162

Protein	Similar proteins		Species	Score	Length	Source
P11712	Cytochrome P450 2C55		MOUSE		490	UniRef50_P11712
Cytochrome P450 2C27		MESAU		490
Cytochrome P450 2C20		MACFA		490
Cytochrome P450 2C8	)	HUMAN		490
Cytochrome P450 2C11		RAT		500
+311
P11712-2	Uncharacterized protein		CERAT		164	UniRef50_P11712-2
Uncharacterized protein		RHIBE		162
Cytochrome P450 2C19		HUMAN		162
Uncharacterized protein		RHIRO		162
Uncharacterized protein		PAPAN		162
+8

Cross-referencesⁱ

Web resourcesⁱ

Cytochrome P450 Allele Nomenclature Committee

CYP2C9 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY341248 Genomic DNA Translation: AAP88931.1 AY702706 Genomic DNA Translation: AAT94065.1 AK289420 mRNA Translation: BAF82109.1 AL359672 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50019.1 CH471066 Genomic DNA Translation: EAW50020.1 BC020754 mRNA Translation: AAH20754.1 BC070317 mRNA Translation: AAH70317.1 BC125054 mRNA Translation: AAI25055.1 D00173 mRNA Translation: BAA00123.1 M15331 mRNA Translation: AAA52157.1 M21939 mRNA Translation: AAA52158.1 M21940 mRNA Translation: AAA52159.1 S46963 mRNA Translation: AAB23864.2 Sequence problems.
CCDSⁱ	CCDS7437.1 [P11712-1]
PIRⁱ	B38462 D28951
RefSeqⁱ	NP_000762.2, NM_000771.3 [P11712-1] XP_016871247.1, XM_017015758.1
UniGeneⁱ	Hs.282624

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1OG2	X-ray	2.60	A/B	30-490	[»]
	1OG5	X-ray	2.55	A/B	30-490	[»]
	1R9O	X-ray	2.00	A	18-490	[»]
	4NZ2	X-ray	2.45	A/B	30-490	[»]
	5A5I	X-ray	2.00	A	23-489	[»]
	5A5J	X-ray	2.90	A	23-489	[»]
	5K7K	X-ray	2.30	A	23-489	[»]
	5W0C	X-ray	2.00	A	18-489	[»]
	5X23	X-ray	2.00	A	19-490	[»]
	5X24	X-ray	2.48	A	19-490	[»]
	5XXI	X-ray	2.30	A	28-489	[»]
ProteinModelPortalⁱ	P11712
SMRⁱ	P11712
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107937, 14 interactors
IntActⁱ	P11712, 6 interactors
STRINGⁱ	9606.ENSP00000260682

Chemistry databases

BindingDBⁱ	P11712
ChEMBLⁱ	CHEMBL3397
DrugBankⁱ	DB02507 4-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-One DB05812 Abiraterone DB06736 Aceclofenac DB01418 Acenocoumarol DB00316 Acetaminophen DB00945 Acetylsalicylic acid DB06594 Agomelatine DB00969 Alosetron DB00404 Alprazolam DB01424 Aminophenazone DB01118 Amiodarone DB00321 Amitriptyline DB00381 Amlodipine DB00613 Amodiaquine DB00701 Amprenavir DB01217 Anastrozole DB01435 Antipyrine DB06605 Apixaban DB00673 Aprepitant DB04557 Arachidonic Acid DB01274 Arformoterol DB06413 Armodafinil DB06697 Artemether DB01072 Atazanavir DB01076 Atorvastatin DB01117 Atovaquone DB00972 Azelastine DB00307 Bexarotene DB01128 Bicalutamide DB00188 Bortezomib DB00559 Bosentan DB00835 Brompheniramine DB00921 Buprenorphine DB01156 Bupropion DB08875 Cabozantinib DB00201 Caffeine DB00796 Candesartan DB01101 Capecitabine DB00564 Carbamazepine DB00748 Carbinoxamine DB01136 Carvedilol DB00482 Celecoxib DB09063 Ceritinib DB00439 Cerivastatin DB00446 Chloramphenicol DB00672 Chlorpropamide DB00169 Cholecalciferol DB00501 Cimetidine DB00568 Cinnarizine DB00604 Cisapride DB00515 Cisplatin DB04920 Clevidipine DB00758 Clopidogrel DB00257 Clotrimazole DB00363 Clozapine DB00907 Cocaine DB01394 Colchicine DB05219 Crisaborole DB01176 Cyclizine DB00531 Cyclophosphamide DB00091 Cyclosporine DB06292 Dapagliflozin DB00250 Dapsone DB00705 Delavirdine DB00967 Desloratadine DB01234 Dexamethasone DB01191 Dexfenfluramine DB04856 Dexloxiglumide DB00514 Dextromethorphan DB00647 Dextropropoxyphene DB00829 Diazepam DB00586 Diclofenac DB01144 Diclofenamide DB00266 Dicoumarol DB00255 Diethylstilbestrol DB00343 Diltiazem DB01075 Diphenhydramine DB00822 Disulfiram DB00757 Dolasetron DB00843 Donepezil DB00988 Dopamine DB00869 Dorzolamide DB01142 Doxepin DB00470 Dronabinol DB00625 Efavirenz DB00216 Eletriptan DB08899 Enzalutamide DB00668 Epinephrine DB01240 Epoprostenol DB00876 Eprosartan DB00783 Estradiol DB00655 Estrone DB04574 Estrone sulfate DB00402 Eszopiclone DB00898 Ethanol DB00749 Etodolac DB01628 Etoricoxib DB06414 Etravirine DB01023 Felodipine DB01039 Fenofibrate DB01195 Flecainide DB00322 Floxuridine DB00196 Fluconazole DB04841 Flunarizine DB01544 Flunitrazepam DB00544 Fluorouracil DB00472 Fluoxetine DB00712 Flurbiprofen DB01095 Fluvastatin DB00176 Fluvoxamine DB00983 Formoterol DB01320 Fosphenytoin DB06741 Gavestinel DB00317 Gefitinib DB01241 Gemfibrozil DB01381 Ginkgo biloba DB01120 Gliclazide DB00222 Glimepiride DB01067 Glipizide DB01016 Glyburide DB01018 Guanfacine DB00502 Haloperidol DB01159 Halothane DB03317 Heme C DB01355 Hexobarbital DB05381 Histamine DB00062 Human Serum Albumin DB00327 Hydromorphone DB01050 Ibuprofen DB01177 Idarubicin DB01181 Ifosfamide DB00619 Imatinib DB00224 Indinavir DB00328 Indomethacin DB01029 Irbesartan DB00951 Isoniazid DB09570 Ixazomib DB01221 Ketamine DB06738 Ketobemidone DB01026 Ketoconazole DB01009 Ketoprofen DB00448 Lansoprazole DB01097 Leflunomide DB11560 Lesinurad DB04725 Licofelone DB00281 Lidocaine DB01601 Lopinavir DB00455 Loratadine DB06725 Lornoxicam DB00678 Losartan DB00227 Lovastatin DB09280 Lumacaftor DB01283 Lumiracoxib DB00603 Medroxyprogesterone acetate DB00784 Mefenamic acid DB01065 Melatonin DB00814 Meloxicam DB00532 Mephenytoin DB01357 Mestranol DB00333 Methadone DB00703 Methazolamide DB00763 Methimazole DB01028 Methoxyflurane DB00916 Metronidazole DB01110 Miconazole DB00370 Mirtazapine DB01171 Moclobemide DB00745 Modafinil DB00471 Montelukast DB11605 Myrrh DB00788 Naproxen DB00731 Nateglinide DB00220 Nelfinavir DB09048 Netupitant DB00238 Nevirapine DB00622 Nicardipine DB06803 Niclosamide DB00184 Nicotine DB01115 Nifedipine DB04868 Nilotinib DB00665 Nilutamide DB06712 Nilvadipine DB00540 Nortriptyline DB00334 Olanzapine DB09080 Olodaterol DB00338 Omeprazole DB00904 Ondansetron DB04938 Ospemifene DB00991 Oxaprozin DB01229 Paclitaxel DB00213 Pantoprazole DB00617 Paramethadione DB08439 Parecoxib DB00715 Paroxetine DB00850 Perphenazine DB03783 Phenacetin DB01174 Phenobarbital DB00946 Phenprocoumon DB00191 Phentermine DB00812 Phenylbutazone DB00252 Phenytoin DB01132 Pioglitazone DB00554 Piroxicam DB08860 Pitavastatin DB01411 Pranlukast DB06209 Prasugrel DB00175 Pravastatin DB00794 Primidone DB01032 Probenecid DB00396 Progesterone DB01131 Proguanil DB00420 Promazine DB01069 Promethazine DB01182 Propafenone DB00818 Propofol DB09396 Propoxyphene napsylate DB00205 Pyrimethamine DB01589 Quazepam DB00908 Quinidine DB00468 Quinine DB01129 Rabeprazole DB08896 Regorafenib DB01045 Rifampicin DB01201 Rifapentine DB00503 Ritonavir DB00533 Rofecoxib DB00412 Rosiglitazone DB01098 Rosuvastatin DB01698 Rutin DB00936 Salicylic acid DB01232 Saquinavir DB00418 Secobarbital DB01037 Selegiline DB01104 Sertraline DB00203 Sildenafil DB00641 Simvastatin DB06268 Sitaxentan DB00398 Sorafenib DB06820 Sulconazole DB00359 Sulfadiazine DB06150 Sulfadimethoxine DB00576 Sulfamethizole DB01015 Sulfamethoxazole DB08798 Sulfamoxole DB00259 Sulfanilamide DB06729 Sulfaphenazole DB00891 Sulfapyridine DB01138 Sulfinpyrazone DB00263 Sulfisoxazole DB00870 Suprofen DB00675 Tamoxifen DB06204 Tapentadol DB01079 Tegaserod DB00231 Temazepam DB00444 Teniposide DB00469 Tenoxicam DB00857 Terbinafine DB00342 Terfenadine DB00624 Testosterone DB01041 Thalidomide DB00277 Theophylline DB01154 Thiamylal DB00679 Thioridazine DB08816 Ticagrelor DB00208 Ticlopidine DB04831 Ticrynafen DB01007 Tioconazole DB01124 Tolbutamide DB00323 Tolcapone DB01036 Tolterodine DB00214 Torasemide DB05109 Trabectedin DB00752 Tranylcypromine DB00374 Treprostinil DB00755 Tretinoin DB00897 Triazolam DB00347 Trimethadione DB00440 Trimethoprim DB00726 Trimipramine DB00197 Troglitazone DB01361 Troleandomycin DB00580 Valdecoxib DB00313 Valproic Acid DB00177 Valsartan DB00285 Venlafaxine DB00661 Verapamil DB08828 Vismodegib DB00582 Voriconazole DB09068 Vortioxetine DB00682 Warfarin DB04898 Ximelagatran DB00549 Zafirlukast DB00943 Zalcitabine DB06737 Zaltoprofen DB00495 Zidovudine DB00744 Zileuton DB00425 Zolpidem DB01198 Zopiclone
GuidetoPHARMACOLOGYⁱ	1326
SwissLipidsⁱ	SLP:000001203

PTM databases

iPTMnetⁱ	P11712
PhosphoSitePlusⁱ	P11712

Polymorphism and mutation databases

BioMutaⁱ	CYP2C9
DMDMⁱ	6686268

Proteomic databases

EPDⁱ	P11712
PaxDbⁱ	P11712
PeptideAtlasⁱ	P11712
PRIDEⁱ	P11712
ProteomicsDBⁱ	52801

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000260682; ENSP00000260682; ENSG00000138109 [P11712-1] ENST00000461906; ENSP00000495649; ENSG00000138109 [P11712-2]
GeneIDⁱ	1559
KEGGⁱ	hsa:1559

Organism-specific databases

CTDⁱ	1559
DisGeNETⁱ	1559
EuPathDBⁱ	HostDB:ENSG00000138109.9
GeneCardsⁱ	CYP2C9
HGNCⁱ	HGNC:2623 CYP2C9
HPAⁱ	CAB016123 HPA015066
MalaCardsⁱ	CYP2C9
MIMⁱ	601130 gene
neXtProtⁱ	NX_P11712
OpenTargetsⁱ	ENSG00000138109
Orphanetⁱ	413681 Oral antidiabetic drugs toxicity or dose selection 413674 Vitamin K antagonists toxicity or dose selection
PharmGKBⁱ	PA126
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
GeneTreeⁱ	ENSGT00880000137861
HOGENOMⁱ	HOG000036992
HOVERGENⁱ	HBG061848
InParanoidⁱ	P11712
KOⁱ	K17719
OMAⁱ	LHEMTKV
OrthoDBⁱ	EOG091G0BT8
PhylomeDBⁱ	P11712
TreeFamⁱ	TF352043

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06458-MONOMER
BRENDAⁱ	1.14.99.38 2681
Reactomeⁱ	R-HSA-211981 Xenobiotics R-HSA-211999 CYP2E1 reactions R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKⁱ	P11712
SIGNORⁱ	P11712

Miscellaneous databases

ChiTaRSⁱ	CYP2C9 human
EvolutionaryTraceⁱ	P11712
GeneWikiⁱ	CYP2C9
GenomeRNAiⁱ	1559
Protein Ontology More...PROⁱ	PR:P11712
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000138109 Expressed in 106 organ(s), highest expression level in liver
CleanExⁱ	HS_CYP2C9
ExpressionAtlasⁱ	P11712 baseline and differential
Genevisibleⁱ	P11712 HS

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf
Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP2C9_HUMAN
Accessionⁱ	P11712Primary (citable) accession number: P11712 Secondary accession number(s): P11713 , Q16756, Q16872, Q5VX92, Q6IRV8, Q8WW80
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
	Last sequence update:	May 30, 2000
	Last modified:	November 7, 2018
	This is version 210 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - P11712 (CP2C9_HUMAN)

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Cytochrome P450 2C9

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

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Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

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Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Keywords - Coding sequence diversityi

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Sequence databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ