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UniProtKB - P11712 (CP2C9_HUMAN)

Entry version 226 (02 Dec 2020)
Sequence version 3 (30 May 2000)
Previous versions | rss
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Protein

Cytochrome P450 2C9

Gene

CYP2C9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:7574697, PubMed:15766564, PubMed:19965576, PubMed:9866708). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) (PubMed:9866708, PubMed:9435160). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).9 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

heme

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=12.2 µM for (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate (epoxygenation)1 Publication
  2. KM=14.3 µM for (5Z,8Z,11Z,14Z)-eicosatetraenoate (epoxygenation)1 Publication
  3. KM=1.25 mM for S-mephenytoin1 Publication
  4. KM=46.24 µM for tolbutamide1 Publication
  5. KM=4.73 µM for diclofenac1 Publication
  6. KM=1.58 µM for losartan1 Publication
  1. Vmax=210.30 pmol/min/pmol enzyme with losartan as substrate1 Publication
  2. Vmax=29.1 nmol/min/nmol enzyme toward (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate (epoxidation)1 Publication
  3. Vmax=29.2 nmol/min/nmol enzyme toward (5Z,8Z,11Z,14Z)-eicosatetraenoate (epoxidation)1 Publication
  4. Vmax=9.22 pmol/min/pmol enzyme with tolbutamide as substrate1 Publication
  5. Vmax=17.16 pmol/min/pmol enzyme with diclofenac as substrate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: arachidonate metabolism

This protein is involved in the pathway arachidonate metabolism, which is part of Lipid metabolism.4 Publications
View all proteins of this organism that are known to be involved in the pathway arachidonate metabolism and in Lipid metabolism.

Pathwayi: cholesterol metabolism

This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.

Pathwayi: (4R)-limonene degradation

This protein is involved in the pathway (4R)-limonene degradation, which is part of Terpene metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway (4R)-limonene degradation and in Terpene metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi435Iron (heme axial ligand)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processLipid metabolism, Steroid metabolism, Sterol metabolism
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS06458-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.14.99.38, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P11712

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-211981, Xenobiotics
R-HSA-211999, CYP2E1 reactions
R-HSA-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142816, Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-9027307, Biosynthesis of maresin-like SPMs

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P11712

SIGNOR Signaling Network Open Resource

More...SIGNORi		P11712

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00296
UPA00383
UPA00987

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001203

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 2C91 Publication (EC:1.14.14.14 Publications)
Alternative name(s):
(R)-limonene 6-monooxygenase (EC:1.14.14.531 Publication)
(S)-limonene 6-monooxygenase (EC:1.14.14.511 Publication)
(S)-limonene 7-monooxygenase (EC:1.14.14.521 Publication)
CYPIIC9
Cholesterol 25-hydroxylase1 Publication
Cytochrome P-450MP
Cytochrome P450 MP-4
Cytochrome P450 MP-8
Cytochrome P450 PB-1
S-mephenytoin 4-hydroxylase1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP2C91 PublicationImported
Synonyms:CYP2C101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000138109.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:2623, CYP2C9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601130, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P11712

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1559

MalaCards human disease database

More...MalaCardsi		CYP2C9

Open Targets

More...OpenTargetsi		ENSG00000138109

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		413681, Oral antidiabetic drugs toxicity or dose selection
413674, Vitamin K antagonists toxicity or dose selection

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA126

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P11712, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3397

Drug and drug target database

More...DrugBanki		DB08496, (R)-warfarin
DB14055, (S)-Warfarin
DB12001, Abemaciclib
DB05812, Abiraterone
DB06736, Aceclofenac
DB01418, Acenocoumarol
DB00414, Acetohexamide
DB14033, Acetyl sulfisoxazole
DB00945, Acetylsalicylic acid
DB06594, Agomelatine
DB00969, Alosetron
DB12015, Alpelisib
DB00404, Alprazolam
DB01424, Aminophenazone
DB01118, Amiodarone
DB00321, Amitriptyline
DB00613, Amodiaquine
DB00701, Amprenavir
DB01217, Anastrozole
DB01435, Antipyrine
DB11901, Apalutamide
DB06605, Apixaban
DB00673, Aprepitant
DB04557, Arachidonic Acid
DB01274, Arformoterol
DB06413, Armodafinil
DB06697, Artemether
DB11586, Asunaprevir
DB01072, Atazanavir
DB01076, Atorvastatin
DB01117, Atovaquone
DB15233, Avapritinib
DB06442, Avasimibe
DB11995, Avatrombopag
DB00972, Azelastine
DB05015, Belinostat
DB12319, Benzbromarone
DB00443, Betamethasone
DB01128, Bicalutamide
DB13746, Bioallethrin
DB13975, Black cohosh
DB00188, Bortezomib
DB00559, Bosentan
DB05541, Brivaracetam
DB01222, Budesonide
DB00921, Buprenorphine
DB01156, Bupropion
DB08875, Cabozantinib
DB00201, Caffeine
DB13919, Candesartan
DB00796, Candesartan cilexetil
DB09061, Cannabidiol
DB01101, Capecitabine
DB08502, Capravirine
DB00564, Carbamazepine
DB13406, Carbutamide
DB01136, Carvedilol
DB00482, Celecoxib
DB09063, Ceritinib
DB00439, Cerivastatin
DB00672, Chlorpropamide
DB00501, Cimetidine
DB00568, Cinnarizine
DB00604, Cisapride
DB00515, Cisplatin
DB04920, Clevidipine
DB14025, Clinafloxacin
DB00758, Clopidogrel
DB00257, Clotrimazole
DB00363, Clozapine
DB04665, Coumarin
DB05219, Crisaborole
DB11672, Curcumin
DB14635, Curcumin sulfate
DB01176, Cyclizine
DB00531, Cyclophosphamide
DB08912, Dabrafenib
DB11963, Dacomitinib
DB06292, Dapagliflozin
DB00250, Dapsone
DB11943, Delafloxacin
DB00705, Delavirdine
DB00304, Desogestrel
DB09213, Dexibuprofen
DB04856, Dexloxiglumide
DB00514, Dextromethorphan
DB11994, Diacerein
DB00829, Diazepam
DB00586, Diclofenac
DB00266, Dicoumarol
DB00255, Diethylstilbestrol
DB01075, Diphenhydramine
DB03756, Doconexent
DB00757, Dolasetron
DB00843, Donepezil
DB00869, Dorzolamide
DB09167, Dosulepin
DB00590, Doxazosin
DB01142, Doxepin
DB00470, Dronabinol
DB00476, Duloxetine
DB00625, Efavirenz
DB00216, Eletriptan
DB15444, Elexacaftor
DB13874, Enasidenib
DB08899, Enzalutamide
DB00668, Epinephrine
DB12147, Erdafitinib
DB11823, Esketamine
DB00783, Estradiol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB00655, Estrone
DB04574, Estrone sulfate
DB00898, Ethanol
DB00977, Ethinylestradiol
DB00749, Etodolac
DB01628, Etoricoxib
DB06414, Etravirine
DB00949, Felbamate
DB01023, Felodipine
DB01039, Fenofibrate
DB03317, Ferroheme C
DB01195, Flecainide
DB00322, Floxuridine
DB00196, Fluconazole
DB13136, Fluindione
DB04841, Flunarizine
DB01544, Flunitrazepam
DB00544, Fluorouracil
DB00472, Fluoxetine
DB00712, Flurbiprofen
DB01095, Fluvastatin
DB00176, Fluvoxamine
DB00983, Formoterol
DB06717, Fosaprepitant
DB01320, Fosphenytoin
DB00317, Gefitinib
DB01241, Gemfibrozil
DB01645, Genistein
DB01381, Ginkgo biloba
DB08962, Glibornuride
DB01120, Gliclazide
DB00222, Glimepiride
DB01067, Glipizide
DB01251, Gliquidone
DB01289, Glisoxepide
DB01016, Glyburide
DB00502, Haloperidol
DB01159, Halothane
DB01355, Hexobarbital
DB00741, Hydrocortisone
DB00327, Hydromorphone
DB01050, Ibuprofen
DB01177, Idarubicin
DB01181, Ifosfamide
DB00619, Imatinib
DB06370, Indisulam
DB00328, Indomethacin
DB04818, Iproniazid
DB01029, Irbesartan
DB11633, Isavuconazole
DB00951, Isoniazid
DB11757, Istradefylline
DB14568, Ivosidenib
DB09570, Ixazomib
DB01221, Ketamine
DB06738, Ketobemidone
DB01026, Ketoconazole
DB01009, Ketoprofen
DB00465, Ketorolac
DB06218, Lacosamide
DB00448, Lansoprazole
DB01097, Leflunomide
DB09078, Lenvatinib
DB11560, Lesinurad
DB12070, Letermovir
DB01137, Levofloxacin
DB04725, Licofelone
DB00281, Lidocaine
DB11611, Lifitegrast
DB09198, Lobeglitazone
DB01601, Lopinavir
DB00455, Loratadine
DB06725, Lornoxicam
DB00678, Losartan
DB09280, Lumacaftor
DB01283, Lumiracoxib
DB12474, Lynestrenol
DB09238, Manidipine
DB14009, Medical Cannabis
DB00603, Medroxyprogesterone acetate
DB00784, Mefenamic acid
DB01065, Melatonin
DB00814, Meloxicam
DB00532, Mephenytoin
DB01357, Mestranol
DB13675, Metahexamide
DB00333, Methadone
DB00763, Methimazole
DB01028, Methoxyflurane
DB09241, Methylene blue
DB00959, Methylprednisolone
DB00916, Metronidazole
DB01110, Miconazole
DB06595, Midostaurin
DB00834, Mifepristone
DB01171, Moclobemide
DB00745, Modafinil
DB00471, Montelukast
DB00486, Nabilone
DB14011, Nabiximols
DB00461, Nabumetone
DB00788, Naproxen
DB00731, Nateglinide
DB00220, Nelfinavir
DB09048, Netupitant
DB00238, Nevirapine
DB00622, Nicardipine
DB06803, Niclosamide
DB00184, Nicotine
DB01115, Nifedipine
DB04868, Nilotinib
DB00957, Norgestimate
DB06174, Noscapine
DB00334, Olanzapine
DB09080, Olodaterol
DB00338, Omeprazole
DB00904, Ondansetron
DB04911, Oritavancin
DB04938, Ospemifene
DB00621, Oxandrolone
DB00617, Paramethadione
DB08439, Parecoxib
DB00715, Paroxetine
DB00022, Peginterferon alfa-2b
DB00850, Perphenazine
DB12978, Pexidartinib
DB03783, Phenacetin
DB01174, Phenobarbital
DB00946, Phenprocoumon
DB00812, Phenylbutazone
DB00252, Phenytoin
DB13941, Piperaquine
DB00554, Piroxicam
DB08860, Pitavastatin
DB01411, Pranlukast
DB06209, Prasugrel
DB14631, Prednisolone phosphate
DB00635, Prednisone
DB00794, Primidone
DB01032, Probenecid
DB00396, Progesterone
DB01131, Proguanil
DB00420, Promazine
DB01069, Promethazine
DB09288, Propacetamol
DB00818, Propofol
DB01589, Quazepam
DB00908, Quinidine
DB00468, Quinine
DB01129, Rabeprazole
DB00980, Ramelteon
DB08896, Regorafenib
DB13174, Rhein
DB00615, Rifabutin
DB01045, Rifampicin
DB11753, Rifamycin
DB01201, Rifapentine
DB12457, Rimegepant
DB00503, Ritonavir
DB00533, Rofecoxib
DB00412, Rosiglitazone
DB01098, Rosuvastatin
DB12332, Rucaparib
DB11614, Rupatadine
DB06654, Safinamide
DB00936, Salicylic acid
DB00418, Secobarbital
DB01037, Selegiline
DB11689, Selumetinib
DB06731, Seproxetine
DB06739, Seratrodast
DB01104, Sertraline
DB00203, Sildenafil
DB00641, Simvastatin
DB12371, Siponimod
DB06268, Sitaxentan
DB00398, Sorafenib
DB09118, Stiripentol
DB06820, Sulconazole
DB00359, Sulfadiazine
DB06150, Sulfadimethoxine
DB00576, Sulfamethizole
DB01015, Sulfamethoxazole
DB08798, Sulfamoxole
DB06729, Sulfaphenazole
DB00891, Sulfapyridine
DB01138, Sulfinpyrazone
DB00263, Sulfisoxazole
DB00870, Suprofen
DB00675, Tamoxifen
DB06204, Tapentadol
DB00231, Temazepam
DB00444, Teniposide
DB00469, Tenoxicam
DB00857, Terbinafine
DB00624, Testosterone
DB13943, Testosterone cypionate
DB13944, Testosterone enanthate
DB13946, Testosterone undecanoate
DB01041, Thalidomide
DB01154, Thiamylal
DB08816, Ticagrelor
DB00208, Ticlopidine
DB04831, Tienilic acid
DB00839, Tolazamide
DB01124, Tolbutamide
DB00323, Tolcapone
DB01036, Tolterodine
DB01685, Topiroxostat
DB00214, Torasemide
DB05109, Trabectedin
DB07615, Tranilast
DB00752, Tranylcypromine
DB00374, Treprostinil
DB00755, Tretinoin
DB12245, Triclabendazole
DB12808, Trifarotene
DB00347, Trimethadione
DB00440, Trimethoprim
DB00726, Trimipramine
DB00197, Troglitazone
DB15328, Ubrogepant
DB13609, Umifenovir
DB00580, Valdecoxib
DB00313, Valproic acid
DB00177, Valsartan
DB08881, Vemurafenib
DB00661, Verapamil
DB06652, Vicriviroc
DB01080, Vigabatrin
DB08828, Vismodegib
DB00582, Voriconazole
DB09068, Vortioxetine
DB14975, Voxelotor
DB00682, Warfarin
DB04898, Ximelagatran
DB00549, Zafirlukast
DB06737, Zaltoprofen
DB00495, Zidovudine
DB00744, Zileuton
DB00425, Zolpidem
DB01198, Zopiclone
DB09120, Zucapsaicin

DrugCentral

More...DrugCentrali		P11712

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1326

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CYP2C9

Domain mapping of disease mutations (DMDM)

More...DMDMi		6686268

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000517001 – 490Cytochrome P450 2C9Add BLAST490

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P11712

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P11712

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P11712

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P11712

PeptideAtlas

More...PeptideAtlasi		P11712

PRoteomics IDEntifications database

More...PRIDEi		P11712

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52801 [P11712-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P11712

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P11712

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By rifampicin.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000138109, Expressed in right lobe of liver and 126 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P11712, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P11712, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000138109, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107937, 14 interactors

Protein interaction database and analysis system

More...IntActi		P11712, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000260682

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P11712

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P11712, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1490
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P11712

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P11712

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0156, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163209

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001570_22_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P11712

Identification of Orthologs from Complete Genome Data

More...OMAi		AAYTCGG

Database for complete collections of gene phylogenies

More...PhylomeDBi		P11712

TreeFam database of animal gene trees

More...TreeFami		TF352043

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR036396, Cyt_P450_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00067, p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00463, EP450I
PR00385, P450

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48264, SSF48264, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P11712-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSLVVLVLC LSCLLLLSLW RQSSGRGKLP PGPTPLPVIG NILQIGIKDI 
        60         70         80         90        100
SKSLTNLSKV YGPVFTLYFG LKPIVVLHGY EAVKEALIDL GEEFSGRGIF 
       110        120        130        140        150
PLAERANRGF GIVFSNGKKW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR 
       160        170        180        190        200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFHKRFDYK DQQFLNLMEK 
       210        220        230        240        250
LNENIKILSS PWIQICNNFS PIIDYFPGTH NKLLKNVAFM KSYILEKVKE 
       260        270        280        290        300
HQESMDMNNP QDFIDCFLMK MEKEKHNQPS EFTIESLENT AVDLFGAGTE 
       310        320        330        340        350
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRSHMPYTDA 
       360        370        380        390        400
VVHEVQRYID LLPTSLPHAV TCDIKFRNYL IPKGTTILIS LTSVLHDNKE 
       410        420        430        440        450
FPNPEMFDPH HFLDEGGNFK KSKYFMPFSA GKRICVGEAL AGMELFLFLT 
       460        470        480        490
SILQNFNLKS LVDPKNLDTT PVVNGFASVP PFYQLCFIPV
Length:490
Mass (Da):55,628
Last modified:May 30, 2000 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FDFC395303A4E3E
GO
Isoform 2 (identifier: P11712-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-162: AS → GG
     163-490: Missing.

Show »
Length:162
Mass (Da):18,005
Checksum:iB59C8888ED45AD09
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YF67A0A2R8YF67_HUMAN
Cytochrome P450 2C9
CYP2C9
282Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4L → I no nucleotide entry (PubMed:3697070).Curated1
Sequence conflicti6V → S no nucleotide entry (PubMed:3697070).Curated1
Sequence conflicti14L → M in AAB23864 (PubMed:1445376).Curated1
Sequence conflicti175C → Y no nucleotide entry (PubMed:2827463).Curated1
Sequence conflicti239F → L no nucleotide entry (PubMed:2827463).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01886219L → I in allele CYP2C9*7. Corresponds to variant dbSNP:rs67807361Ensembl.1
Natural variantiVAR_075286125R → H in allele CYP2C9*35. 1 PublicationCorresponds to variant dbSNP:rs72558189Ensembl.1
Natural variantiVAR_075287125R → L in allele CYP2C9*14. 1 PublicationCorresponds to variant dbSNP:rs72558189Ensembl.1
Natural variantiVAR_008343144R → C in allele CYP2C9*2. 7 PublicationsCorresponds to variant dbSNP:rs1799853Ensembl.1
Natural variantiVAR_018863150R → H in allele CYP2C9*8. 2 PublicationsCorresponds to variant dbSNP:rs7900194Ensembl.1
Natural variantiVAR_075288204N → H in allele CYP2C9*57. 1 Publication1
Natural variantiVAR_018864251H → R in allele CYP2C9*9. 2 PublicationsCorresponds to variant dbSNP:rs2256871EnsemblClinVar.1
Natural variantiVAR_018865272E → G in allele CYP2C9*10. 1 PublicationCorresponds to variant dbSNP:rs9332130Ensembl.1
Natural variantiVAR_018866335R → W in allele CYP2C9*11. 2 PublicationsCorresponds to variant dbSNP:rs28371685Ensembl.1
Natural variantiVAR_008344358Y → C3 PublicationsCorresponds to variant dbSNP:rs1057909Ensembl.1
Natural variantiVAR_008345359I → L in allele CYP2C9*3; responsible for the tolbutamide poor metabolizer phenotype. 4 PublicationsCorresponds to variant dbSNP:rs1057910Ensembl.1
Natural variantiVAR_013515359I → T in allele CYP2C9*4. 1 PublicationCorresponds to variant dbSNP:rs56165452EnsemblClinVar.1
Natural variantiVAR_013516360D → E in allele CYP2C9*5; increases the K(m) value for substrates tested. 2 PublicationsCorresponds to variant dbSNP:rs28371686Ensembl.1
Natural variantiVAR_024717413L → P1 PublicationCorresponds to variant dbSNP:rs28371687Ensembl.1
Natural variantiVAR_008346417G → D3 Publications1
Natural variantiVAR_075289434I → F in allele CYP2C9*59; produces warfarin hypersensitivity; increases affinity but highly decreases enzymatic activity for tolbutamide; no effect on affinity but decreases enzymatic activity for diclofenac; decreases affinity and highly decreases enzymatic activity for losartan. 1 Publication1
Natural variantiVAR_018867489P → S in allele CYP2C9*12. 1 PublicationCorresponds to variant dbSNP:rs9332239Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055573161 – 162AS → GG in isoform 2. 1 Publication2
Alternative sequenceiVSP_055574163 – 490Missing in isoform 2. 1 PublicationAdd BLAST328

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY341248 Genomic DNA Translation: AAP88931.1
AY702706 Genomic DNA Translation: AAT94065.1
AK289420 mRNA Translation: BAF82109.1
AL359672 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50019.1
CH471066 Genomic DNA Translation: EAW50020.1
BC020754 mRNA Translation: AAH20754.1
BC070317 mRNA Translation: AAH70317.1
BC125054 mRNA Translation: AAI25055.1
D00173 mRNA Translation: BAA00123.1
M15331 mRNA Translation: AAA52157.1
M21939 mRNA Translation: AAA52158.1
M21940 mRNA Translation: AAA52159.1
S46963 mRNA Translation: AAB23864.2 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7437.1 [P11712-1]

Protein sequence database of the Protein Information Resource

More...PIRi		B38462
D28951

NCBI Reference Sequences

More...RefSeqi		NP_000762.2, NM_000771.3 [P11712-1]
XP_016871247.1, XM_017015758.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000260682; ENSP00000260682; ENSG00000138109 [P11712-1]
ENST00000461906; ENSP00000495649; ENSG00000138109 [P11712-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1559

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1559

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2C9 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341248 Genomic DNA Translation: AAP88931.1
AY702706 Genomic DNA Translation: AAT94065.1
AK289420 mRNA Translation: BAF82109.1
AL359672 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50019.1
CH471066 Genomic DNA Translation: EAW50020.1
BC020754 mRNA Translation: AAH20754.1
BC070317 mRNA Translation: AAH70317.1
BC125054 mRNA Translation: AAI25055.1
D00173 mRNA Translation: BAA00123.1
M15331 mRNA Translation: AAA52157.1
M21939 mRNA Translation: AAA52158.1
M21940 mRNA Translation: AAA52159.1
S46963 mRNA Translation: AAB23864.2 Sequence problems.
CCDSiCCDS7437.1 [P11712-1]
PIRiB38462
D28951
RefSeqiNP_000762.2, NM_000771.3 [P11712-1]
XP_016871247.1, XM_017015758.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OG2X-ray2.60A/B30-490[»]
1OG5X-ray2.55A/B30-490[»]
1R9OX-ray2.00A18-490[»]
4NZ2X-ray2.45A/B30-490[»]
5A5IX-ray2.00A23-489[»]
5A5JX-ray2.90A23-489[»]
5K7KX-ray2.30A23-489[»]
5W0CX-ray2.00A18-489[»]
5X23X-ray2.00A19-490[»]
5X24X-ray2.48A19-490[»]
5XXIX-ray2.30A28-489[»]
SMRiP11712
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107937, 14 interactors
IntActiP11712, 12 interactors
STRINGi9606.ENSP00000260682

Chemistry databases

BindingDBiP11712
ChEMBLiCHEMBL3397
DrugBankiDB08496, (R)-warfarin
DB14055, (S)-Warfarin
DB12001, Abemaciclib
DB05812, Abiraterone
DB06736, Aceclofenac
DB01418, Acenocoumarol
DB00414, Acetohexamide
DB14033, Acetyl sulfisoxazole
DB00945, Acetylsalicylic acid
DB06594, Agomelatine
DB00969, Alosetron
DB12015, Alpelisib
DB00404, Alprazolam
DB01424, Aminophenazone
DB01118, Amiodarone
DB00321, Amitriptyline
DB00613, Amodiaquine
DB00701, Amprenavir
DB01217, Anastrozole
DB01435, Antipyrine
DB11901, Apalutamide
DB06605, Apixaban
DB00673, Aprepitant
DB04557, Arachidonic Acid
DB01274, Arformoterol
DB06413, Armodafinil
DB06697, Artemether
DB11586, Asunaprevir
DB01072, Atazanavir
DB01076, Atorvastatin
DB01117, Atovaquone
DB15233, Avapritinib
DB06442, Avasimibe
DB11995, Avatrombopag
DB00972, Azelastine
DB05015, Belinostat
DB12319, Benzbromarone
DB00443, Betamethasone
DB01128, Bicalutamide
DB13746, Bioallethrin
DB13975, Black cohosh
DB00188, Bortezomib
DB00559, Bosentan
DB05541, Brivaracetam
DB01222, Budesonide
DB00921, Buprenorphine
DB01156, Bupropion
DB08875, Cabozantinib
DB00201, Caffeine
DB13919, Candesartan
DB00796, Candesartan cilexetil
DB09061, Cannabidiol
DB01101, Capecitabine
DB08502, Capravirine
DB00564, Carbamazepine
DB13406, Carbutamide
DB01136, Carvedilol
DB00482, Celecoxib
DB09063, Ceritinib
DB00439, Cerivastatin
DB00672, Chlorpropamide
DB00501, Cimetidine
DB00568, Cinnarizine
DB00604, Cisapride
DB00515, Cisplatin
DB04920, Clevidipine
DB14025, Clinafloxacin
DB00758, Clopidogrel
DB00257, Clotrimazole
DB00363, Clozapine
DB04665, Coumarin
DB05219, Crisaborole
DB11672, Curcumin
DB14635, Curcumin sulfate
DB01176, Cyclizine
DB00531, Cyclophosphamide
DB08912, Dabrafenib
DB11963, Dacomitinib
DB06292, Dapagliflozin
DB00250, Dapsone
DB11943, Delafloxacin
DB00705, Delavirdine
DB00304, Desogestrel
DB09213, Dexibuprofen
DB04856, Dexloxiglumide
DB00514, Dextromethorphan
DB11994, Diacerein
DB00829, Diazepam
DB00586, Diclofenac
DB00266, Dicoumarol
DB00255, Diethylstilbestrol
DB01075, Diphenhydramine
DB03756, Doconexent
DB00757, Dolasetron
DB00843, Donepezil
DB00869, Dorzolamide
DB09167, Dosulepin
DB00590, Doxazosin
DB01142, Doxepin
DB00470, Dronabinol
DB00476, Duloxetine
DB00625, Efavirenz
DB00216, Eletriptan
DB15444, Elexacaftor
DB13874, Enasidenib
DB08899, Enzalutamide
DB00668, Epinephrine
DB12147, Erdafitinib
DB11823, Esketamine
DB00783, Estradiol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB00655, Estrone
DB04574, Estrone sulfate
DB00898, Ethanol
DB00977, Ethinylestradiol
DB00749, Etodolac
DB01628, Etoricoxib
DB06414, Etravirine
DB00949, Felbamate
DB01023, Felodipine
DB01039, Fenofibrate
DB03317, Ferroheme C
DB01195, Flecainide
DB00322, Floxuridine
DB00196, Fluconazole
DB13136, Fluindione
DB04841, Flunarizine
DB01544, Flunitrazepam
DB00544, Fluorouracil
DB00472, Fluoxetine
DB00712, Flurbiprofen
DB01095, Fluvastatin
DB00176, Fluvoxamine
DB00983, Formoterol
DB06717, Fosaprepitant
DB01320, Fosphenytoin
DB00317, Gefitinib
DB01241, Gemfibrozil
DB01645, Genistein
DB01381, Ginkgo biloba
DB08962, Glibornuride
DB01120, Gliclazide
DB00222, Glimepiride
DB01067, Glipizide
DB01251, Gliquidone
DB01289, Glisoxepide
DB01016, Glyburide
DB00502, Haloperidol
DB01159, Halothane
DB01355, Hexobarbital
DB00741, Hydrocortisone
DB00327, Hydromorphone
DB01050, Ibuprofen
DB01177, Idarubicin
DB01181, Ifosfamide
DB00619, Imatinib
DB06370, Indisulam
DB00328, Indomethacin
DB04818, Iproniazid
DB01029, Irbesartan
DB11633, Isavuconazole
DB00951, Isoniazid
DB11757, Istradefylline
DB14568, Ivosidenib
DB09570, Ixazomib
DB01221, Ketamine
DB06738, Ketobemidone
DB01026, Ketoconazole
DB01009, Ketoprofen
DB00465, Ketorolac
DB06218, Lacosamide
DB00448, Lansoprazole
DB01097, Leflunomide
DB09078, Lenvatinib
DB11560, Lesinurad
DB12070, Letermovir
DB01137, Levofloxacin
DB04725, Licofelone
DB00281, Lidocaine
DB11611, Lifitegrast
DB09198, Lobeglitazone
DB01601, Lopinavir
DB00455, Loratadine
DB06725, Lornoxicam
DB00678, Losartan
DB09280, Lumacaftor
DB01283, Lumiracoxib
DB12474, Lynestrenol
DB09238, Manidipine
DB14009, Medical Cannabis
DB00603, Medroxyprogesterone acetate
DB00784, Mefenamic acid
DB01065, Melatonin
DB00814, Meloxicam
DB00532, Mephenytoin
DB01357, Mestranol
DB13675, Metahexamide
DB00333, Methadone
DB00763, Methimazole
DB01028, Methoxyflurane
DB09241, Methylene blue
DB00959, Methylprednisolone
DB00916, Metronidazole
DB01110, Miconazole
DB06595, Midostaurin
DB00834, Mifepristone
DB01171, Moclobemide
DB00745, Modafinil
DB00471, Montelukast
DB00486, Nabilone
DB14011, Nabiximols
DB00461, Nabumetone
DB00788, Naproxen
DB00731, Nateglinide
DB00220, Nelfinavir
DB09048, Netupitant
DB00238, Nevirapine
DB00622, Nicardipine
DB06803, Niclosamide
DB00184, Nicotine
DB01115, Nifedipine
DB04868, Nilotinib
DB00957, Norgestimate
DB06174, Noscapine
DB00334, Olanzapine
DB09080, Olodaterol
DB00338, Omeprazole
DB00904, Ondansetron
DB04911, Oritavancin
DB04938, Ospemifene
DB00621, Oxandrolone
DB00617, Paramethadione
DB08439, Parecoxib
DB00715, Paroxetine
DB00022, Peginterferon alfa-2b
DB00850, Perphenazine
DB12978, Pexidartinib
DB03783, Phenacetin
DB01174, Phenobarbital
DB00946, Phenprocoumon
DB00812, Phenylbutazone
DB00252, Phenytoin
DB13941, Piperaquine
DB00554, Piroxicam
DB08860, Pitavastatin
DB01411, Pranlukast
DB06209, Prasugrel
DB14631, Prednisolone phosphate
DB00635, Prednisone
DB00794, Primidone
DB01032, Probenecid
DB00396, Progesterone
DB01131, Proguanil
DB00420, Promazine
DB01069, Promethazine
DB09288, Propacetamol
DB00818, Propofol
DB01589, Quazepam
DB00908, Quinidine
DB00468, Quinine
DB01129, Rabeprazole
DB00980, Ramelteon
DB08896, Regorafenib
DB13174, Rhein
DB00615, Rifabutin
DB01045, Rifampicin
DB11753, Rifamycin
DB01201, Rifapentine
DB12457, Rimegepant
DB00503, Ritonavir
DB00533, Rofecoxib
DB00412, Rosiglitazone
DB01098, Rosuvastatin
DB12332, Rucaparib
DB11614, Rupatadine
DB06654, Safinamide
DB00936, Salicylic acid
DB00418, Secobarbital
DB01037, Selegiline
DB11689, Selumetinib
DB06731, Seproxetine
DB06739, Seratrodast
DB01104, Sertraline
DB00203, Sildenafil
DB00641, Simvastatin
DB12371, Siponimod
DB06268, Sitaxentan
DB00398, Sorafenib
DB09118, Stiripentol
DB06820, Sulconazole
DB00359, Sulfadiazine
DB06150, Sulfadimethoxine
DB00576, Sulfamethizole
DB01015, Sulfamethoxazole
DB08798, Sulfamoxole
DB06729, Sulfaphenazole
DB00891, Sulfapyridine
DB01138, Sulfinpyrazone
DB00263, Sulfisoxazole
DB00870, Suprofen
DB00675, Tamoxifen
DB06204, Tapentadol
DB00231, Temazepam
DB00444, Teniposide
DB00469, Tenoxicam
DB00857, Terbinafine
DB00624, Testosterone
DB13943, Testosterone cypionate
DB13944, Testosterone enanthate
DB13946, Testosterone undecanoate
DB01041, Thalidomide
DB01154, Thiamylal
DB08816, Ticagrelor
DB00208, Ticlopidine
DB04831, Tienilic acid
DB00839, Tolazamide
DB01124, Tolbutamide
DB00323, Tolcapone
DB01036, Tolterodine
DB01685, Topiroxostat
DB00214, Torasemide
DB05109, Trabectedin
DB07615, Tranilast
DB00752, Tranylcypromine
DB00374, Treprostinil
DB00755, Tretinoin
DB12245, Triclabendazole
DB12808, Trifarotene
DB00347, Trimethadione
DB00440, Trimethoprim
DB00726, Trimipramine
DB00197, Troglitazone
DB15328, Ubrogepant
DB13609, Umifenovir
DB00580, Valdecoxib
DB00313, Valproic acid
DB00177, Valsartan
DB08881, Vemurafenib
DB00661, Verapamil
DB06652, Vicriviroc
DB01080, Vigabatrin
DB08828, Vismodegib
DB00582, Voriconazole
DB09068, Vortioxetine
DB14975, Voxelotor
DB00682, Warfarin
DB04898, Ximelagatran
DB00549, Zafirlukast
DB06737, Zaltoprofen
DB00495, Zidovudine
DB00744, Zileuton
DB00425, Zolpidem
DB01198, Zopiclone
DB09120, Zucapsaicin
DrugCentraliP11712
GuidetoPHARMACOLOGYi1326
SwissLipidsiSLP:000001203

PTM databases

iPTMnetiP11712
PhosphoSitePlusiP11712

Polymorphism and mutation databases

BioMutaiCYP2C9
DMDMi6686268

Proteomic databases

EPDiP11712
jPOSTiP11712
MassIVEiP11712
PaxDbiP11712
PeptideAtlasiP11712
PRIDEiP11712
ProteomicsDBi52801 [P11712-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4244, 289 antibodies

Genome annotation databases

EnsembliENST00000260682; ENSP00000260682; ENSG00000138109 [P11712-1]
ENST00000461906; ENSP00000495649; ENSG00000138109 [P11712-2]
GeneIDi1559
KEGGihsa:1559

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1559
DisGeNETi1559
EuPathDBiHostDB:ENSG00000138109.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		CYP2C9
HGNCiHGNC:2623, CYP2C9
HPAiENSG00000138109, Tissue enriched (liver)
MalaCardsiCYP2C9
MIMi601130, gene
neXtProtiNX_P11712
OpenTargetsiENSG00000138109
Orphaneti413681, Oral antidiabetic drugs toxicity or dose selection
413674, Vitamin K antagonists toxicity or dose selection
PharmGKBiPA126

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0156, Eukaryota
GeneTreeiENSGT00940000163209
HOGENOMiCLU_001570_22_3_1
InParanoidiP11712
OMAiAAYTCGG
PhylomeDBiP11712
TreeFamiTF352043

Enzyme and pathway databases

UniPathwayiUPA00296
UPA00383
UPA00987
BioCyciMetaCyc:HS06458-MONOMER
BRENDAi1.14.99.38, 2681
PathwayCommonsiP11712
ReactomeiR-HSA-211981, Xenobiotics
R-HSA-211999, CYP2E1 reactions
R-HSA-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142816, Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-HSA-9027307, Biosynthesis of maresin-like SPMs
SABIO-RKiP11712
SIGNORiP11712

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1559, 9 hits in 841 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CYP2C9, human
EvolutionaryTraceiP11712

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CYP2C9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1559
PharosiP11712, Tchem

Protein Ontology

More...PROi		PR:P11712
RNActiP11712, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000138109, Expressed in right lobe of liver and 126 other tissues
ExpressionAtlasiP11712, baseline and differential
GenevisibleiP11712, HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR036396, Cyt_P450_sf
PfamiView protein in Pfam
PF00067, p450, 1 hit
PRINTSiPR00463, EP450I
PR00385, P450
SUPFAMiSSF48264, SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP2C9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11712
Secondary accession number(s): P11713
, Q16756, Q16872, Q5VX92, Q6IRV8, Q8WW80
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 30, 2000
Last modified: December 2, 2020
This is version 226 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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