UniProtKB - P11712 (CP2C9_HUMAN)
Protein
Cytochrome P450 2C9
Gene
CYP2C9
Organism
Homo sapiens (Human)
Status
Functioni
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:7574697, PubMed:15766564, PubMed:19965576, PubMed:9866708). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) (PubMed:9866708, PubMed:9435160). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).9 Publications
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]4 PublicationsEC:1.14.14.14 PublicationsThis reaction proceeds in the forward4 Publications direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH—hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH—hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH—hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- cholesterol + O2 + reduced [NADPH—hemoprotein reductase] = 25-hydroxycholesterol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 17β-estradiol + O2 + reduced [NADPH—hemoprotein reductase] = 2-hydroxy-17β-estradiol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- estrone + O2 + reduced [NADPH—hemoprotein reductase] = 2-hydroxyestrone + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH—hemoprotein reductase] = (13R)-hydroxy-(9Z,11E)-octadecadienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH—hemoprotein reductase] = 9(R)-hydroxy-(10E,12Z)-octadecadienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (4R)-limonene + O2 + reduced [NADPH—hemoprotein reductase] = (1R,5S)-carveol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationEC:1.14.14.531 Publication
- (4S)-limonene + O2 + reduced [NADPH—hemoprotein reductase] = (1S,5R)-carveol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationEC:1.14.14.511 Publication
- (4S)-limonene + O2 + reduced [NADPH—hemoprotein reductase] = (4S)-perillyl alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationEC:1.14.14.521 Publication
Cofactori
Kineticsi
- KM=12.2 µM for (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate (epoxygenation)1 Publication
- KM=14.3 µM for (5Z,8Z,11Z,14Z)-eicosatetraenoate (epoxygenation)1 Publication
- KM=1.25 mM for S-mephenytoin1 Publication
- KM=46.24 µM for tolbutamide1 Publication
- KM=4.73 µM for diclofenac1 Publication
- KM=1.58 µM for losartan1 Publication
- Vmax=210.30 pmol/min/pmol enzyme with losartan as substrate1 Publication
- Vmax=29.1 nmol/min/nmol enzyme toward (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate (epoxidation)1 Publication
- Vmax=29.2 nmol/min/nmol enzyme toward (5Z,8Z,11Z,14Z)-eicosatetraenoate (epoxidation)1 Publication
- Vmax=9.22 pmol/min/pmol enzyme with tolbutamide as substrate1 Publication
- Vmax=17.16 pmol/min/pmol enzyme with diclofenac as substrate1 Publication
: arachidonate metabolism Pathwayi
This protein is involved in the pathway arachidonate metabolism, which is part of Lipid metabolism.4 PublicationsView all proteins of this organism that are known to be involved in the pathway arachidonate metabolism and in Lipid metabolism.
Pathwayi: cholesterol metabolism
This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.
Pathwayi: (4R)-limonene degradation
This protein is involved in the pathway (4R)-limonene degradation, which is part of Terpene metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway (4R)-limonene degradation and in Terpene metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 435 | Iron (heme axial ligand) | 1 |
GO - Molecular functioni
- (R)-limonene 6-monooxygenase activity Source: UniProtKB-EC
- (S)-limonene 6-monooxygenase activity Source: UniProtKB-EC
- (S)-limonene 7-monooxygenase activity Source: UniProtKB-EC
- arachidonic acid epoxygenase activity Source: UniProtKB
- aromatase activity Source: UniProtKB-EC
- caffeine oxidase activity Source: BHF-UCL
- drug binding Source: BHF-UCL
- heme binding Source: GO_Central
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB
- oxidoreductase activity Source: BHF-UCL
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
- steroid hydroxylase activity Source: BHF-UCL
GO - Biological processi
- cellular amide metabolic process Source: BHF-UCL
- cholesterol metabolic process Source: UniProtKB-UniPathway
- drug catabolic process Source: BHF-UCL
- drug metabolic process Source: BHF-UCL
- epoxygenase P450 pathway Source: UniProtKB
- estrogen metabolic process Source: UniProtKB
- exogenous drug catabolic process Source: BHF-UCL
- icosanoid biosynthetic process Source: UniProtKB
- long-chain fatty acid biosynthetic process Source: Reactome
- monocarboxylic acid metabolic process Source: BHF-UCL
- monoterpenoid metabolic process Source: BHF-UCL
- omega-hydroxylase P450 pathway Source: Reactome
- organic acid metabolic process Source: GO_Central
- oxidation-reduction process Source: BHF-UCL
- oxidative demethylation Source: BHF-UCL
- steroid metabolic process Source: BHF-UCL
- urea metabolic process Source: BHF-UCL
- xenobiotic metabolic process Source: GO_Central
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Lipid metabolism, Steroid metabolism, Sterol metabolism |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS06458-MONOMER |
BRENDAi | 1.14.99.38, 2681 |
PathwayCommonsi | P11712 |
Reactomei | R-HSA-211981, Xenobiotics R-HSA-211999, CYP2E1 reactions R-HSA-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816, Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-9027307, Biosynthesis of maresin-like SPMs |
SABIO-RKi | P11712 |
SIGNORi | P11712 |
UniPathwayi | UPA00296 UPA00383 UPA00987 |
Chemistry databases
SwissLipidsi | SLP:000001203 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 2C91 Publication (EC:1.14.14.14 Publications)Alternative name(s): (R)-limonene 6-monooxygenase (EC:1.14.14.531 Publication) (S)-limonene 6-monooxygenase (EC:1.14.14.511 Publication) (S)-limonene 7-monooxygenase (EC:1.14.14.521 Publication) CYPIIC9 Cholesterol 25-hydroxylase1 Publication Cytochrome P-450MP Cytochrome P450 MP-4 Cytochrome P450 MP-8 Cytochrome P450 PB-1 S-mephenytoin 4-hydroxylase1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138109.9 |
HGNCi | HGNC:2623, CYP2C9 |
MIMi | 601130, gene |
neXtProti | NX_P11712 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: UniProtKB
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 1559 |
MalaCardsi | CYP2C9 |
OpenTargetsi | ENSG00000138109 |
Orphaneti | 413681, Oral antidiabetic drugs toxicity or dose selection 413674, Vitamin K antagonists toxicity or dose selection |
PharmGKBi | PA126 |
Miscellaneous databases
Pharosi | P11712, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3397 |
DrugBanki | DB08496, (R)-warfarin DB14055, (S)-Warfarin DB12001, Abemaciclib DB05812, Abiraterone DB06736, Aceclofenac DB01418, Acenocoumarol DB00414, Acetohexamide DB14033, Acetyl sulfisoxazole DB00945, Acetylsalicylic acid DB06594, Agomelatine DB00969, Alosetron DB12015, Alpelisib DB00404, Alprazolam DB01424, Aminophenazone DB01118, Amiodarone DB00321, Amitriptyline DB00613, Amodiaquine DB00701, Amprenavir DB01217, Anastrozole DB01435, Antipyrine DB11901, Apalutamide DB06605, Apixaban DB00673, Aprepitant DB04557, Arachidonic Acid DB01274, Arformoterol DB06413, Armodafinil DB06697, Artemether DB11586, Asunaprevir DB01072, Atazanavir DB01076, Atorvastatin DB01117, Atovaquone DB15233, Avapritinib DB06442, Avasimibe DB11995, Avatrombopag DB00972, Azelastine DB05015, Belinostat DB12319, Benzbromarone DB00443, Betamethasone DB01128, Bicalutamide DB13746, Bioallethrin DB13975, Black cohosh DB00188, Bortezomib DB00559, Bosentan DB05541, Brivaracetam DB01222, Budesonide DB00921, Buprenorphine DB01156, Bupropion DB08875, Cabozantinib DB00201, Caffeine DB13919, Candesartan DB00796, Candesartan cilexetil DB09061, Cannabidiol DB01101, Capecitabine DB08502, Capravirine DB00564, Carbamazepine DB13406, Carbutamide DB01136, Carvedilol DB00482, Celecoxib DB09063, Ceritinib DB00439, Cerivastatin DB00672, Chlorpropamide DB00501, Cimetidine DB00568, Cinnarizine DB00604, Cisapride DB00515, Cisplatin DB04920, Clevidipine DB14025, Clinafloxacin DB00758, Clopidogrel DB00257, Clotrimazole DB00363, Clozapine DB04665, Coumarin DB05219, Crisaborole DB11672, Curcumin DB14635, Curcumin sulfate DB01176, Cyclizine DB00531, Cyclophosphamide DB08912, Dabrafenib DB11963, Dacomitinib DB06292, Dapagliflozin DB00250, Dapsone DB11943, Delafloxacin DB00705, Delavirdine DB00304, Desogestrel DB09213, Dexibuprofen DB04856, Dexloxiglumide DB00514, Dextromethorphan DB11994, Diacerein DB00829, Diazepam DB00586, Diclofenac DB00266, Dicoumarol DB00255, Diethylstilbestrol DB01075, Diphenhydramine DB03756, Doconexent DB00757, Dolasetron DB00843, Donepezil DB00869, Dorzolamide DB09167, Dosulepin DB00590, Doxazosin DB01142, Doxepin DB00470, Dronabinol DB00476, Duloxetine DB00625, Efavirenz DB00216, Eletriptan DB15444, Elexacaftor DB13874, Enasidenib DB08899, Enzalutamide DB00668, Epinephrine DB12147, Erdafitinib DB11823, Esketamine DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB00655, Estrone DB04574, Estrone sulfate DB00898, Ethanol DB00977, Ethinylestradiol DB00749, Etodolac DB01628, Etoricoxib DB06414, Etravirine DB00949, Felbamate DB01023, Felodipine DB01039, Fenofibrate DB03317, Ferroheme C DB01195, Flecainide DB00322, Floxuridine DB00196, Fluconazole DB13136, Fluindione DB04841, Flunarizine DB01544, Flunitrazepam DB00544, Fluorouracil DB00472, Fluoxetine DB00712, Flurbiprofen DB01095, Fluvastatin DB00176, Fluvoxamine DB00983, Formoterol DB06717, Fosaprepitant DB01320, Fosphenytoin DB00317, Gefitinib DB01241, Gemfibrozil DB01645, Genistein DB01381, Ginkgo biloba DB08962, Glibornuride DB01120, Gliclazide DB00222, Glimepiride DB01067, Glipizide DB01251, Gliquidone DB01289, Glisoxepide DB01016, Glyburide DB00502, Haloperidol DB01159, Halothane DB01355, Hexobarbital DB00741, Hydrocortisone DB00327, Hydromorphone DB01050, Ibuprofen DB01177, Idarubicin DB01181, Ifosfamide DB00619, Imatinib DB06370, Indisulam DB00328, Indomethacin DB04818, Iproniazid DB01029, Irbesartan DB11633, Isavuconazole DB00951, Isoniazid DB11757, Istradefylline DB14568, Ivosidenib DB09570, Ixazomib DB01221, Ketamine DB06738, Ketobemidone DB01026, Ketoconazole DB01009, Ketoprofen DB00465, Ketorolac DB06218, Lacosamide DB00448, Lansoprazole DB01097, Leflunomide DB09078, Lenvatinib DB11560, Lesinurad DB12070, Letermovir DB01137, Levofloxacin DB04725, Licofelone DB00281, Lidocaine DB11611, Lifitegrast DB09198, Lobeglitazone DB01601, Lopinavir DB00455, Loratadine DB06725, Lornoxicam DB00678, Losartan DB09280, Lumacaftor DB01283, Lumiracoxib DB12474, Lynestrenol DB09238, Manidipine DB14009, Medical Cannabis DB00603, Medroxyprogesterone acetate DB00784, Mefenamic acid DB01065, Melatonin DB00814, Meloxicam DB00532, Mephenytoin DB01357, Mestranol DB13675, Metahexamide DB00333, Methadone DB00763, Methimazole DB01028, Methoxyflurane DB09241, Methylene blue DB00959, Methylprednisolone DB00916, Metronidazole DB01110, Miconazole DB06595, Midostaurin DB00834, Mifepristone DB01171, Moclobemide DB00745, Modafinil DB00471, Montelukast DB00486, Nabilone DB14011, Nabiximols DB00461, Nabumetone DB00788, Naproxen DB00731, Nateglinide DB00220, Nelfinavir DB09048, Netupitant DB00238, Nevirapine DB00622, Nicardipine DB06803, Niclosamide DB00184, Nicotine DB01115, Nifedipine DB04868, Nilotinib DB00957, Norgestimate DB06174, Noscapine DB00334, Olanzapine DB09080, Olodaterol DB00338, Omeprazole DB00904, Ondansetron DB04911, Oritavancin DB04938, Ospemifene DB00621, Oxandrolone DB00617, Paramethadione DB08439, Parecoxib DB00715, Paroxetine DB00022, Peginterferon alfa-2b DB00850, Perphenazine DB12978, Pexidartinib DB03783, Phenacetin DB01174, Phenobarbital DB00946, Phenprocoumon DB00812, Phenylbutazone DB00252, Phenytoin DB13941, Piperaquine DB00554, Piroxicam DB08860, Pitavastatin DB01411, Pranlukast DB06209, Prasugrel DB14631, Prednisolone phosphate DB00635, Prednisone DB00794, Primidone DB01032, Probenecid DB00396, Progesterone DB01131, Proguanil DB00420, Promazine DB01069, Promethazine DB09288, Propacetamol DB00818, Propofol DB01589, Quazepam DB00908, Quinidine DB00468, Quinine DB01129, Rabeprazole DB00980, Ramelteon DB08896, Regorafenib DB13174, Rhein DB00615, Rifabutin DB01045, Rifampicin DB11753, Rifamycin DB01201, Rifapentine DB12457, Rimegepant DB00503, Ritonavir DB00533, Rofecoxib DB00412, Rosiglitazone DB01098, Rosuvastatin DB12332, Rucaparib DB11614, Rupatadine DB06654, Safinamide DB00936, Salicylic acid DB00418, Secobarbital DB01037, Selegiline DB11689, Selumetinib DB06731, Seproxetine DB06739, Seratrodast DB01104, Sertraline DB00203, Sildenafil DB00641, Simvastatin DB12371, Siponimod DB06268, Sitaxentan DB00398, Sorafenib DB09118, Stiripentol DB06820, Sulconazole DB00359, Sulfadiazine DB06150, Sulfadimethoxine DB00576, Sulfamethizole DB01015, Sulfamethoxazole DB08798, Sulfamoxole DB06729, Sulfaphenazole DB00891, Sulfapyridine DB01138, Sulfinpyrazone DB00263, Sulfisoxazole DB00870, Suprofen DB00675, Tamoxifen DB06204, Tapentadol DB00231, Temazepam DB00444, Teniposide DB00469, Tenoxicam DB00857, Terbinafine DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate DB01041, Thalidomide DB01154, Thiamylal DB08816, Ticagrelor DB00208, Ticlopidine DB04831, Tienilic acid DB00839, Tolazamide DB01124, Tolbutamide DB00323, Tolcapone DB01036, Tolterodine DB01685, Topiroxostat DB00214, Torasemide DB05109, Trabectedin DB07615, Tranilast DB00752, Tranylcypromine DB00374, Treprostinil DB00755, Tretinoin DB12245, Triclabendazole DB12808, Trifarotene DB00347, Trimethadione DB00440, Trimethoprim DB00726, Trimipramine DB00197, Troglitazone DB15328, Ubrogepant DB13609, Umifenovir DB00580, Valdecoxib DB00313, Valproic acid DB00177, Valsartan DB08881, Vemurafenib DB00661, Verapamil DB06652, Vicriviroc DB01080, Vigabatrin DB08828, Vismodegib DB00582, Voriconazole DB09068, Vortioxetine DB14975, Voxelotor DB00682, Warfarin DB04898, Ximelagatran DB00549, Zafirlukast DB06737, Zaltoprofen DB00495, Zidovudine DB00744, Zileuton DB00425, Zolpidem DB01198, Zopiclone DB09120, Zucapsaicin |
DrugCentrali | P11712 |
GuidetoPHARMACOLOGYi | 1326 |
Polymorphism and mutation databases
BioMutai | CYP2C9 |
DMDMi | 6686268 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051700 | 1 – 490 | Cytochrome P450 2C9Add BLAST | 490 |
Proteomic databases
EPDi | P11712 |
jPOSTi | P11712 |
MassIVEi | P11712 |
PaxDbi | P11712 |
PeptideAtlasi | P11712 |
PRIDEi | P11712 |
ProteomicsDBi | 52801 [P11712-1] |
PTM databases
iPTMneti | P11712 |
PhosphoSitePlusi | P11712 |
Expressioni
Inductioni
By rifampicin.
Gene expression databases
Bgeei | ENSG00000138109, Expressed in right lobe of liver and 126 other tissues |
ExpressionAtlasi | P11712, baseline and differential |
Genevisiblei | P11712, HS |
Organism-specific databases
HPAi | ENSG00000138109, Tissue enriched (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 107937, 14 interactors |
IntActi | P11712, 12 interactors |
STRINGi | 9606.ENSP00000260682 |
Chemistry databases
BindingDBi | P11712 |
Miscellaneous databases
RNActi | P11712, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P11712 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P11712 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00940000163209 |
HOGENOMi | CLU_001570_22_3_1 |
InParanoidi | P11712 |
OMAi | AAYTCGG |
PhylomeDBi | P11712 |
TreeFami | TF352043 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P11712-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSLVVLVLC LSCLLLLSLW RQSSGRGKLP PGPTPLPVIG NILQIGIKDI
60 70 80 90 100
SKSLTNLSKV YGPVFTLYFG LKPIVVLHGY EAVKEALIDL GEEFSGRGIF
110 120 130 140 150
PLAERANRGF GIVFSNGKKW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFHKRFDYK DQQFLNLMEK
210 220 230 240 250
LNENIKILSS PWIQICNNFS PIIDYFPGTH NKLLKNVAFM KSYILEKVKE
260 270 280 290 300
HQESMDMNNP QDFIDCFLMK MEKEKHNQPS EFTIESLENT AVDLFGAGTE
310 320 330 340 350
TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRSHMPYTDA
360 370 380 390 400
VVHEVQRYID LLPTSLPHAV TCDIKFRNYL IPKGTTILIS LTSVLHDNKE
410 420 430 440 450
FPNPEMFDPH HFLDEGGNFK KSKYFMPFSA GKRICVGEAL AGMELFLFLT
460 470 480 490
SILQNFNLKS LVDPKNLDTT PVVNGFASVP PFYQLCFIPV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8YF67 | A0A2R8YF67_HUMAN | Cytochrome P450 2C9 | CYP2C9 | 282 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 | L → I no nucleotide entry (PubMed:3697070).Curated | 1 | |
Sequence conflicti | 6 | V → S no nucleotide entry (PubMed:3697070).Curated | 1 | |
Sequence conflicti | 14 | L → M in AAB23864 (PubMed:1445376).Curated | 1 | |
Sequence conflicti | 175 | C → Y no nucleotide entry (PubMed:2827463).Curated | 1 | |
Sequence conflicti | 239 | F → L no nucleotide entry (PubMed:2827463).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018862 | 19 | L → I in allele CYP2C9*7. Corresponds to variant dbSNP:rs67807361Ensembl. | 1 | |
Natural variantiVAR_075286 | 125 | R → H in allele CYP2C9*35. 1 PublicationCorresponds to variant dbSNP:rs72558189Ensembl. | 1 | |
Natural variantiVAR_075287 | 125 | R → L in allele CYP2C9*14. 1 PublicationCorresponds to variant dbSNP:rs72558189Ensembl. | 1 | |
Natural variantiVAR_008343 | 144 | R → C in allele CYP2C9*2. 7 PublicationsCorresponds to variant dbSNP:rs1799853Ensembl. | 1 | |
Natural variantiVAR_018863 | 150 | R → H in allele CYP2C9*8. 2 PublicationsCorresponds to variant dbSNP:rs7900194Ensembl. | 1 | |
Natural variantiVAR_075288 | 204 | N → H in allele CYP2C9*57. 1 Publication | 1 | |
Natural variantiVAR_018864 | 251 | H → R in allele CYP2C9*9. 2 PublicationsCorresponds to variant dbSNP:rs2256871EnsemblClinVar. | 1 | |
Natural variantiVAR_018865 | 272 | E → G in allele CYP2C9*10. 1 PublicationCorresponds to variant dbSNP:rs9332130Ensembl. | 1 | |
Natural variantiVAR_018866 | 335 | R → W in allele CYP2C9*11. 2 PublicationsCorresponds to variant dbSNP:rs28371685Ensembl. | 1 | |
Natural variantiVAR_008344 | 358 | Y → C3 PublicationsCorresponds to variant dbSNP:rs1057909Ensembl. | 1 | |
Natural variantiVAR_008345 | 359 | I → L in allele CYP2C9*3; responsible for the tolbutamide poor metabolizer phenotype. 4 PublicationsCorresponds to variant dbSNP:rs1057910Ensembl. | 1 | |
Natural variantiVAR_013515 | 359 | I → T in allele CYP2C9*4. 1 PublicationCorresponds to variant dbSNP:rs56165452EnsemblClinVar. | 1 | |
Natural variantiVAR_013516 | 360 | D → E in allele CYP2C9*5; increases the K(m) value for substrates tested. 2 PublicationsCorresponds to variant dbSNP:rs28371686Ensembl. | 1 | |
Natural variantiVAR_024717 | 413 | L → P1 PublicationCorresponds to variant dbSNP:rs28371687Ensembl. | 1 | |
Natural variantiVAR_008346 | 417 | G → D3 Publications | 1 | |
Natural variantiVAR_075289 | 434 | I → F in allele CYP2C9*59; produces warfarin hypersensitivity; increases affinity but highly decreases enzymatic activity for tolbutamide; no effect on affinity but decreases enzymatic activity for diclofenac; decreases affinity and highly decreases enzymatic activity for losartan. 1 Publication | 1 | |
Natural variantiVAR_018867 | 489 | P → S in allele CYP2C9*12. 1 PublicationCorresponds to variant dbSNP:rs9332239Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055573 | 161 – 162 | AS → GG in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_055574 | 163 – 490 | Missing in isoform 2. 1 PublicationAdd BLAST | 328 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY341248 Genomic DNA Translation: AAP88931.1 AY702706 Genomic DNA Translation: AAT94065.1 AK289420 mRNA Translation: BAF82109.1 AL359672 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50019.1 CH471066 Genomic DNA Translation: EAW50020.1 BC020754 mRNA Translation: AAH20754.1 BC070317 mRNA Translation: AAH70317.1 BC125054 mRNA Translation: AAI25055.1 D00173 mRNA Translation: BAA00123.1 M15331 mRNA Translation: AAA52157.1 M21939 mRNA Translation: AAA52158.1 M21940 mRNA Translation: AAA52159.1 S46963 mRNA Translation: AAB23864.2 Sequence problems. |
CCDSi | CCDS7437.1 [P11712-1] |
PIRi | B38462 D28951 |
RefSeqi | NP_000762.2, NM_000771.3 [P11712-1] XP_016871247.1, XM_017015758.1 |
Genome annotation databases
Ensembli | ENST00000260682; ENSP00000260682; ENSG00000138109 [P11712-1] ENST00000461906; ENSP00000495649; ENSG00000138109 [P11712-2] |
GeneIDi | 1559 |
KEGGi | hsa:1559 |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Cytochrome P450 Allele Nomenclature Committee CYP2C9 alleles |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY341248 Genomic DNA Translation: AAP88931.1 AY702706 Genomic DNA Translation: AAT94065.1 AK289420 mRNA Translation: BAF82109.1 AL359672 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50019.1 CH471066 Genomic DNA Translation: EAW50020.1 BC020754 mRNA Translation: AAH20754.1 BC070317 mRNA Translation: AAH70317.1 BC125054 mRNA Translation: AAI25055.1 D00173 mRNA Translation: BAA00123.1 M15331 mRNA Translation: AAA52157.1 M21939 mRNA Translation: AAA52158.1 M21940 mRNA Translation: AAA52159.1 S46963 mRNA Translation: AAB23864.2 Sequence problems. |
CCDSi | CCDS7437.1 [P11712-1] |
PIRi | B38462 D28951 |
RefSeqi | NP_000762.2, NM_000771.3 [P11712-1] XP_016871247.1, XM_017015758.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OG2 | X-ray | 2.60 | A/B | 30-490 | [»] | |
1OG5 | X-ray | 2.55 | A/B | 30-490 | [»] | |
1R9O | X-ray | 2.00 | A | 18-490 | [»] | |
4NZ2 | X-ray | 2.45 | A/B | 30-490 | [»] | |
5A5I | X-ray | 2.00 | A | 23-489 | [»] | |
5A5J | X-ray | 2.90 | A | 23-489 | [»] | |
5K7K | X-ray | 2.30 | A | 23-489 | [»] | |
5W0C | X-ray | 2.00 | A | 18-489 | [»] | |
5X23 | X-ray | 2.00 | A | 19-490 | [»] | |
5X24 | X-ray | 2.48 | A | 19-490 | [»] | |
5XXI | X-ray | 2.30 | A | 28-489 | [»] | |
SMRi | P11712 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107937, 14 interactors |
IntActi | P11712, 12 interactors |
STRINGi | 9606.ENSP00000260682 |
Chemistry databases
BindingDBi | P11712 |
ChEMBLi | CHEMBL3397 |
DrugBanki | DB08496, (R)-warfarin DB14055, (S)-Warfarin DB12001, Abemaciclib DB05812, Abiraterone DB06736, Aceclofenac DB01418, Acenocoumarol DB00414, Acetohexamide DB14033, Acetyl sulfisoxazole DB00945, Acetylsalicylic acid DB06594, Agomelatine DB00969, Alosetron DB12015, Alpelisib DB00404, Alprazolam DB01424, Aminophenazone DB01118, Amiodarone DB00321, Amitriptyline DB00613, Amodiaquine DB00701, Amprenavir DB01217, Anastrozole DB01435, Antipyrine DB11901, Apalutamide DB06605, Apixaban DB00673, Aprepitant DB04557, Arachidonic Acid DB01274, Arformoterol DB06413, Armodafinil DB06697, Artemether DB11586, Asunaprevir DB01072, Atazanavir DB01076, Atorvastatin DB01117, Atovaquone DB15233, Avapritinib DB06442, Avasimibe DB11995, Avatrombopag DB00972, Azelastine DB05015, Belinostat DB12319, Benzbromarone DB00443, Betamethasone DB01128, Bicalutamide DB13746, Bioallethrin DB13975, Black cohosh DB00188, Bortezomib DB00559, Bosentan DB05541, Brivaracetam DB01222, Budesonide DB00921, Buprenorphine DB01156, Bupropion DB08875, Cabozantinib DB00201, Caffeine DB13919, Candesartan DB00796, Candesartan cilexetil DB09061, Cannabidiol DB01101, Capecitabine DB08502, Capravirine DB00564, Carbamazepine DB13406, Carbutamide DB01136, Carvedilol DB00482, Celecoxib DB09063, Ceritinib DB00439, Cerivastatin DB00672, Chlorpropamide DB00501, Cimetidine DB00568, Cinnarizine DB00604, Cisapride DB00515, Cisplatin DB04920, Clevidipine DB14025, Clinafloxacin DB00758, Clopidogrel DB00257, Clotrimazole DB00363, Clozapine DB04665, Coumarin DB05219, Crisaborole DB11672, Curcumin DB14635, Curcumin sulfate DB01176, Cyclizine DB00531, Cyclophosphamide DB08912, Dabrafenib DB11963, Dacomitinib DB06292, Dapagliflozin DB00250, Dapsone DB11943, Delafloxacin DB00705, Delavirdine DB00304, Desogestrel DB09213, Dexibuprofen DB04856, Dexloxiglumide DB00514, Dextromethorphan DB11994, Diacerein DB00829, Diazepam DB00586, Diclofenac DB00266, Dicoumarol DB00255, Diethylstilbestrol DB01075, Diphenhydramine DB03756, Doconexent DB00757, Dolasetron DB00843, Donepezil DB00869, Dorzolamide DB09167, Dosulepin DB00590, Doxazosin DB01142, Doxepin DB00470, Dronabinol DB00476, Duloxetine DB00625, Efavirenz DB00216, Eletriptan DB15444, Elexacaftor DB13874, Enasidenib DB08899, Enzalutamide DB00668, Epinephrine DB12147, Erdafitinib DB11823, Esketamine DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB00655, Estrone DB04574, Estrone sulfate DB00898, Ethanol DB00977, Ethinylestradiol DB00749, Etodolac DB01628, Etoricoxib DB06414, Etravirine DB00949, Felbamate DB01023, Felodipine DB01039, Fenofibrate DB03317, Ferroheme C DB01195, Flecainide DB00322, Floxuridine DB00196, Fluconazole DB13136, Fluindione DB04841, Flunarizine DB01544, Flunitrazepam DB00544, Fluorouracil DB00472, Fluoxetine DB00712, Flurbiprofen DB01095, Fluvastatin DB00176, Fluvoxamine DB00983, Formoterol DB06717, Fosaprepitant DB01320, Fosphenytoin DB00317, Gefitinib DB01241, Gemfibrozil DB01645, Genistein DB01381, Ginkgo biloba DB08962, Glibornuride DB01120, Gliclazide DB00222, Glimepiride DB01067, Glipizide DB01251, Gliquidone DB01289, Glisoxepide DB01016, Glyburide DB00502, Haloperidol DB01159, Halothane DB01355, Hexobarbital DB00741, Hydrocortisone DB00327, Hydromorphone DB01050, Ibuprofen DB01177, Idarubicin DB01181, Ifosfamide DB00619, Imatinib DB06370, Indisulam DB00328, Indomethacin DB04818, Iproniazid DB01029, Irbesartan DB11633, Isavuconazole DB00951, Isoniazid DB11757, Istradefylline DB14568, Ivosidenib DB09570, Ixazomib DB01221, Ketamine DB06738, Ketobemidone DB01026, Ketoconazole DB01009, Ketoprofen DB00465, Ketorolac DB06218, Lacosamide DB00448, Lansoprazole DB01097, Leflunomide DB09078, Lenvatinib DB11560, Lesinurad DB12070, Letermovir DB01137, Levofloxacin DB04725, Licofelone DB00281, Lidocaine DB11611, Lifitegrast DB09198, Lobeglitazone DB01601, Lopinavir DB00455, Loratadine DB06725, Lornoxicam DB00678, Losartan DB09280, Lumacaftor DB01283, Lumiracoxib DB12474, Lynestrenol DB09238, Manidipine DB14009, Medical Cannabis DB00603, Medroxyprogesterone acetate DB00784, Mefenamic acid DB01065, Melatonin DB00814, Meloxicam DB00532, Mephenytoin DB01357, Mestranol DB13675, Metahexamide DB00333, Methadone DB00763, Methimazole DB01028, Methoxyflurane DB09241, Methylene blue DB00959, Methylprednisolone DB00916, Metronidazole DB01110, Miconazole DB06595, Midostaurin DB00834, Mifepristone DB01171, Moclobemide DB00745, Modafinil DB00471, Montelukast DB00486, Nabilone DB14011, Nabiximols DB00461, Nabumetone DB00788, Naproxen DB00731, Nateglinide DB00220, Nelfinavir DB09048, Netupitant DB00238, Nevirapine DB00622, Nicardipine DB06803, Niclosamide DB00184, Nicotine DB01115, Nifedipine DB04868, Nilotinib DB00957, Norgestimate DB06174, Noscapine DB00334, Olanzapine DB09080, Olodaterol DB00338, Omeprazole DB00904, Ondansetron DB04911, Oritavancin DB04938, Ospemifene DB00621, Oxandrolone DB00617, Paramethadione DB08439, Parecoxib DB00715, Paroxetine DB00022, Peginterferon alfa-2b DB00850, Perphenazine DB12978, Pexidartinib DB03783, Phenacetin DB01174, Phenobarbital DB00946, Phenprocoumon DB00812, Phenylbutazone DB00252, Phenytoin DB13941, Piperaquine DB00554, Piroxicam DB08860, Pitavastatin DB01411, Pranlukast DB06209, Prasugrel DB14631, Prednisolone phosphate DB00635, Prednisone DB00794, Primidone DB01032, Probenecid DB00396, Progesterone DB01131, Proguanil DB00420, Promazine DB01069, Promethazine DB09288, Propacetamol DB00818, Propofol DB01589, Quazepam DB00908, Quinidine DB00468, Quinine DB01129, Rabeprazole DB00980, Ramelteon DB08896, Regorafenib DB13174, Rhein DB00615, Rifabutin DB01045, Rifampicin DB11753, Rifamycin DB01201, Rifapentine DB12457, Rimegepant DB00503, Ritonavir DB00533, Rofecoxib DB00412, Rosiglitazone DB01098, Rosuvastatin DB12332, Rucaparib DB11614, Rupatadine DB06654, Safinamide DB00936, Salicylic acid DB00418, Secobarbital DB01037, Selegiline DB11689, Selumetinib DB06731, Seproxetine DB06739, Seratrodast DB01104, Sertraline DB00203, Sildenafil DB00641, Simvastatin DB12371, Siponimod DB06268, Sitaxentan DB00398, Sorafenib DB09118, Stiripentol DB06820, Sulconazole DB00359, Sulfadiazine DB06150, Sulfadimethoxine DB00576, Sulfamethizole DB01015, Sulfamethoxazole DB08798, Sulfamoxole DB06729, Sulfaphenazole DB00891, Sulfapyridine DB01138, Sulfinpyrazone DB00263, Sulfisoxazole DB00870, Suprofen DB00675, Tamoxifen DB06204, Tapentadol DB00231, Temazepam DB00444, Teniposide DB00469, Tenoxicam DB00857, Terbinafine DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate DB01041, Thalidomide DB01154, Thiamylal DB08816, Ticagrelor DB00208, Ticlopidine DB04831, Tienilic acid DB00839, Tolazamide DB01124, Tolbutamide DB00323, Tolcapone DB01036, Tolterodine DB01685, Topiroxostat DB00214, Torasemide DB05109, Trabectedin DB07615, Tranilast DB00752, Tranylcypromine DB00374, Treprostinil DB00755, Tretinoin DB12245, Triclabendazole DB12808, Trifarotene DB00347, Trimethadione DB00440, Trimethoprim DB00726, Trimipramine DB00197, Troglitazone DB15328, Ubrogepant DB13609, Umifenovir DB00580, Valdecoxib DB00313, Valproic acid DB00177, Valsartan DB08881, Vemurafenib DB00661, Verapamil DB06652, Vicriviroc DB01080, Vigabatrin DB08828, Vismodegib DB00582, Voriconazole DB09068, Vortioxetine DB14975, Voxelotor DB00682, Warfarin DB04898, Ximelagatran DB00549, Zafirlukast DB06737, Zaltoprofen DB00495, Zidovudine DB00744, Zileuton DB00425, Zolpidem DB01198, Zopiclone DB09120, Zucapsaicin |
DrugCentrali | P11712 |
GuidetoPHARMACOLOGYi | 1326 |
SwissLipidsi | SLP:000001203 |
PTM databases
iPTMneti | P11712 |
PhosphoSitePlusi | P11712 |
Polymorphism and mutation databases
BioMutai | CYP2C9 |
DMDMi | 6686268 |
Proteomic databases
EPDi | P11712 |
jPOSTi | P11712 |
MassIVEi | P11712 |
PaxDbi | P11712 |
PeptideAtlasi | P11712 |
PRIDEi | P11712 |
ProteomicsDBi | 52801 [P11712-1] |
Protocols and materials databases
Antibodypediai | 4244, 289 antibodies |
Genome annotation databases
Ensembli | ENST00000260682; ENSP00000260682; ENSG00000138109 [P11712-1] ENST00000461906; ENSP00000495649; ENSG00000138109 [P11712-2] |
GeneIDi | 1559 |
KEGGi | hsa:1559 |
Organism-specific databases
CTDi | 1559 |
DisGeNETi | 1559 |
EuPathDBi | HostDB:ENSG00000138109.9 |
GeneCardsi | CYP2C9 |
HGNCi | HGNC:2623, CYP2C9 |
HPAi | ENSG00000138109, Tissue enriched (liver) |
MalaCardsi | CYP2C9 |
MIMi | 601130, gene |
neXtProti | NX_P11712 |
OpenTargetsi | ENSG00000138109 |
Orphaneti | 413681, Oral antidiabetic drugs toxicity or dose selection 413674, Vitamin K antagonists toxicity or dose selection |
PharmGKBi | PA126 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00940000163209 |
HOGENOMi | CLU_001570_22_3_1 |
InParanoidi | P11712 |
OMAi | AAYTCGG |
PhylomeDBi | P11712 |
TreeFami | TF352043 |
Enzyme and pathway databases
UniPathwayi | UPA00296 UPA00383 UPA00987 |
BioCyci | MetaCyc:HS06458-MONOMER |
BRENDAi | 1.14.99.38, 2681 |
PathwayCommonsi | P11712 |
Reactomei | R-HSA-211981, Xenobiotics R-HSA-211999, CYP2E1 reactions R-HSA-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816, Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-9027307, Biosynthesis of maresin-like SPMs |
SABIO-RKi | P11712 |
SIGNORi | P11712 |
Miscellaneous databases
BioGRID-ORCSi | 1559, 9 hits in 841 CRISPR screens |
ChiTaRSi | CYP2C9, human |
EvolutionaryTracei | P11712 |
GeneWikii | CYP2C9 |
GenomeRNAii | 1559 |
Pharosi | P11712, Tchem |
PROi | PR:P11712 |
RNActi | P11712, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138109, Expressed in right lobe of liver and 126 other tissues |
ExpressionAtlasi | P11712, baseline and differential |
Genevisiblei | P11712, HS |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CP2C9_HUMAN | |
Accessioni | P11712Primary (citable) accession number: P11712 Secondary accession number(s): P11713 Q8WW80 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | May 30, 2000 | |
Last modified: | December 2, 2020 | |
This is version 226 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations