UniProtKB - P11709 (BIK1_YEAST)
Protein
Nuclear fusion protein BIK1
Gene
BIK1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for nuclear fusion, chromosome disjunction, and nuclear segregation during mitosis. Probably required for the formation or stabilization of microtubules during mitosis and for spindle pole body fusion during conjugation.
Miscellaneous
Present with 300 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- microtubule binding Source: SGD
- microtubule plus-end binding Source: GO_Central
GO - Biological processi
- 2-micrometer plasmid partitioning Source: SGD
- cell division Source: UniProtKB-KW
- cytoplasmic microtubule organization Source: GO_Central
- establishment of mitotic spindle orientation Source: GO_Central
- karyogamy involved in conjugation with cellular fusion Source: SGD
- mitotic spindle elongation Source: SGD
- negative regulation of microtubule polymerization Source: SGD
- nuclear migration involved in conjugation with cellular fusion Source: SGD
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear fusion protein BIK1 |
Gene namesi | Name:BIK1 Ordered Locus Names:YCL029C ORF Names:YCL29C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YCL029C |
SGDi | S000000534, BIK1 |
Subcellular locationi
Cytoskeleton
Other locations
Note: And mitotic spindle.
Cytoskeleton
- microtubule associated complex Source: GO_Central
- microtubule plus-end Source: SGD
- spindle Source: SGD
- spindle microtubule Source: SGD
- spindle pole body Source: SGD
Nucleus
- condensed nuclear chromosome kinetochore Source: SGD
- nucleus Source: GO_Central
Other locations
- cell cortex Source: SGD
- cell tip Source: GO_Central
- cytoplasm Source: GO_Central
- kinetochore Source: SGD
- mating projection tip Source: SGD
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083513 | 1 – 440 | Nuclear fusion protein BIK1Add BLAST | 440 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 95 | PhosphoserineCombined sources | 1 | |
Modified residuei | 110 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P11709 |
PaxDbi | P11709 |
PRIDEi | P11709 |
TopDownProteomicsi | P11709 |
PTM databases
iPTMneti | P11709 |
Interactioni
GO - Molecular functioni
- microtubule binding Source: SGD
- microtubule plus-end binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 30954, 238 interactors |
DIPi | DIP-2341N |
IntActi | P11709, 5 interactors |
MINTi | P11709 |
STRINGi | 4932.YCL029C |
Miscellaneous databases
RNActi | P11709, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P11709 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 69 | CAP-GlyPROSITE-ProRule annotationAdd BLAST | 44 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 190 – 397 | Sequence analysisAdd BLAST | 208 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 416 – 429 | CCHC-boxAdd BLAST | 14 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4568, Eukaryota |
HOGENOMi | CLU_031641_0_0_1 |
InParanoidi | P11709 |
OMAi | NHPQRRQ |
Family and domain databases
Gene3Di | 2.30.30.190, 1 hit |
InterProi | View protein in InterPro IPR036859, CAP-Gly_dom_sf IPR000938, CAP-Gly_domain |
Pfami | View protein in Pfam PF01302, CAP_GLY, 1 hit |
SMARTi | View protein in SMART SM01052, CAP_GLY, 1 hit |
SUPFAMi | SSF74924, SSF74924, 1 hit |
PROSITEi | View protein in PROSITE PS00845, CAP_GLY_1, 1 hit PS50245, CAP_GLY_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P11709-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRYQRKIGC FIQIPNLGRG QLKYVGPVDT KAGMFAGVDL LANIGKNDGS
60 70 80 90 100
FMGKKYFQTE YPQSGLFIQL QKVASLIEKA SISQTSRRTT MEPLSIPKNR
110 120 130 140 150
SIVRLTNQFS PMDDPKSPTP MRSFRITSRH SGNQQSMDQE ASDHHQQQEF
160 170 180 190 200
GYDNREDRME VDSILSSDRK ANHNTTSDWK PDNGHMNDLN SSEVTIELRE
210 220 230 240 250
AQLTIEKLQR KQLHYKRLLD DQRMVLEEVQ PTFDRYEATI QEREKEIDHL
260 270 280 290 300
KQQLELERRQ QAKQKQFFDA ENEQLLAVVS QLHEEIKENE ERNLSHNQPT
310 320 330 340 350
GANEDVELLK KQLEQLRNIE DQFELHKTKW AKEREQLKMH NDSLSKEYQN
360 370 380 390 400
LSKELFLTKP QDSSSEEVAS LTKKLEEANE KIKQLEQAQA QTAVESLPIF
410 420 430 440
DPPAPVDTTA GRQQWCEHCD TMGHNTAECP HHNPDNQQFF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16717 Genomic DNA Translation: AAA34614.1 X59720 Genomic DNA Translation: CAA42356.1 BK006937 Genomic DNA Translation: DAA07455.1 |
PIRi | B27061 |
RefSeqi | NP_009901.1, NM_001178674.1 |
Genome annotation databases
EnsemblFungii | YCL029C_mRNA; YCL029C; YCL029C |
GeneIDi | 850328 |
KEGGi | sce:YCL029C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16717 Genomic DNA Translation: AAA34614.1 X59720 Genomic DNA Translation: CAA42356.1 BK006937 Genomic DNA Translation: DAA07455.1 |
PIRi | B27061 |
RefSeqi | NP_009901.1, NM_001178674.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6FC5 | X-ray | 1.88 | A | 1-100 | [»] | |
6FC6 | X-ray | 1.80 | A | 1-100 | [»] | |
SMRi | P11709 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 30954, 238 interactors |
DIPi | DIP-2341N |
IntActi | P11709, 5 interactors |
MINTi | P11709 |
STRINGi | 4932.YCL029C |
PTM databases
iPTMneti | P11709 |
Proteomic databases
MaxQBi | P11709 |
PaxDbi | P11709 |
PRIDEi | P11709 |
TopDownProteomicsi | P11709 |
Genome annotation databases
EnsemblFungii | YCL029C_mRNA; YCL029C; YCL029C |
GeneIDi | 850328 |
KEGGi | sce:YCL029C |
Organism-specific databases
EuPathDBi | FungiDB:YCL029C |
SGDi | S000000534, BIK1 |
Phylogenomic databases
eggNOGi | KOG4568, Eukaryota |
HOGENOMi | CLU_031641_0_0_1 |
InParanoidi | P11709 |
OMAi | NHPQRRQ |
Miscellaneous databases
PROi | PR:P11709 |
RNActi | P11709, protein |
Family and domain databases
Gene3Di | 2.30.30.190, 1 hit |
InterProi | View protein in InterPro IPR036859, CAP-Gly_dom_sf IPR000938, CAP-Gly_domain |
Pfami | View protein in Pfam PF01302, CAP_GLY, 1 hit |
SMARTi | View protein in SMART SM01052, CAP_GLY, 1 hit |
SUPFAMi | SSF74924, SSF74924, 1 hit |
PROSITEi | View protein in PROSITE PS00845, CAP_GLY_1, 1 hit PS50245, CAP_GLY_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BIK1_YEAST | |
Accessioni | P11709Primary (citable) accession number: P11709 Secondary accession number(s): D6VQY6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome III
Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names