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Protein

Cytochrome P450 3A6

Gene

CYP3A6

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exhibits progesterone 6 beta-hydroxylase activity.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi440Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A6 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA6
Cytochrome P450-3C
Gene namesi
Name:CYP3A6
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1743541

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517891 – 501Cytochrome P450 3A6Add BLAST501

Proteomic databases

PRIDEiP11707

Expressioni

Inductioni

By rifampicin.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000016348

Chemistry databases

BindingDBiP11707

Structurei

3D structure databases

ProteinModelPortaliP11707
SMRiP11707
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
HOGENOMiHOG000039127
HOVERGENiHBG108567
InParanoidiP11707
KOiK07424

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P11707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLIFSLETW VLLAASLVLL YLYGTSTHGL FKKMGIPGPT PLPFIGTILE
60 70 80 90 100
YRKGIWDFDI ECRKKYGKMW GLFDGRQPLM VITDPDMIKT VLVKECYSVF
110 120 130 140 150
TNRRSFGPVG FMKKAVSISE DEDWKRVRTL LSPTFTSGKL KEMLPIIAQY
160 170 180 190 200
GDVLVKNLRQ EAEKGKPVDL KEIFGAYSMD VITGTSFGVN IDSLRNPQDP
210 220 230 240 250
FVKNVRRLLK FSFFDPLLLS ITLFPFLTPI FEALHISMFP KDVMDFLKTS
260 270 280 290 300
VEKIKDDRLK DKQKRRVDFL QLMINSQNSK EIDSHKALDD IEVVAQSIII
310 320 330 340 350
LFAGYETTSS TLSFIMHLLA THPDVQQKLQ EEIDTLLPNK ELATYDTLVK
360 370 380 390 400
MEYLDMVVNE TLRLYPIAGR LERVCKKDVD INGTFIPKGT IVMMPTYALH
410 420 430 440 450
RDPQHWTEPD EFRPERFSKK NKDNINPYIY HPFGAGPRNC LGMRFALMNI
460 470 480 490 500
KLALVRLMQN FSFKLCKETQ VPLKLGKQGL LQPEKPIVLK VVSRDGIIRG

A
Length:501
Mass (Da):57,450
Last modified:July 15, 1999 - v2
Checksum:i251D21061863ACFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54 – 55GI → VIN in AAA31430 (PubMed:3349903).Curated2
Sequence conflicti165 – 169GKPVD → ASPST in AAA31430 (PubMed:3349903).Curated5
Sequence conflicti393Missing in AAA31430 (PubMed:3349903).Curated1
Sequence conflicti494 – 495RD → ES in AAA31430 (PubMed:3349903).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19139 mRNA Translation: AAA31430.1
J05034 mRNA Translation: AAA31178.1
PIRiA29487
A34236
RefSeqiNP_001164739.1, NM_001171268.2
UniGeneiOcu.1831

Genome annotation databases

GeneIDi100328954
KEGGiocu:100328954

Similar proteinsi

Entry informationi

Entry nameiCP3A6_RABIT
AccessioniPrimary (citable) accession number: P11707
Secondary accession number(s): Q29506
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 15, 1999
Last modified: May 23, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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