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Protein

Properdin

Gene

Cfp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.

GO - Biological processi

Keywordsi

Biological processComplement alternate pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-173736 Alternative complement activation
R-MMU-174577 Activation of C3 and C5
R-MMU-5173214 O-glycosylation of TSR domain-containing proteins
R-MMU-6798695 Neutrophil degranulation
R-MMU-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Properdin
Alternative name(s):
Complement factor P
Gene namesi
Name:Cfp
Synonyms:Pfc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:97545 Cfp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004336923 – 464ProperdinAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 68PROSITE-ProRule annotation
Disulfide bondi39 ↔ 71PROSITE-ProRule annotation
Disulfide bondi85 ↔ 123PROSITE-ProRule annotation
Disulfide bondi89 ↔ 129PROSITE-ProRule annotation
Disulfide bondi100 ↔ 107PROSITE-ProRule annotation
Disulfide bondi144 ↔ 180PROSITE-ProRule annotation
Disulfide bondi148 ↔ 186PROSITE-ProRule annotation
Disulfide bondi159 ↔ 170PROSITE-ProRule annotation
Disulfide bondi201 ↔ 244PROSITE-ProRule annotation
Disulfide bondi205 ↔ 250PROSITE-ProRule annotation
Disulfide bondi220 ↔ 234PROSITE-ProRule annotation
Disulfide bondi265 ↔ 302PROSITE-ProRule annotation
Disulfide bondi269 ↔ 308PROSITE-ProRule annotation
Disulfide bondi280 ↔ 292PROSITE-ProRule annotation
Disulfide bondi323 ↔ 365PROSITE-ProRule annotation
Disulfide bondi332 ↔ 371PROSITE-ProRule annotation
Disulfide bondi345 ↔ 355PROSITE-ProRule annotation
Disulfide bondi386 ↔ 450PROSITE-ProRule annotation
Disulfide bondi390 ↔ 456PROSITE-ProRule annotation
Disulfide bondi402 ↔ 434PROSITE-ProRule annotation
Glycosylationi423N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP11680
PaxDbiP11680
PeptideAtlasiP11680
PRIDEiP11680

PTM databases

iPTMnetiP11680
PhosphoSitePlusiP11680
SwissPalmiP11680

Expressioni

Gene expression databases

BgeeiENSMUSG00000001128 Expressed in 177 organ(s), highest expression level in spleen
CleanExiMM_CFP
ExpressionAtlasiP11680 baseline and differential
GenevisibleiP11680 MM

Interactioni

Subunit structurei

In plasma, properdin exists as dimers, trimers or tetramers in the relative proportions of 26:54:20.By similarity

Protein-protein interaction databases

IntActiP11680, 3 interactors
STRINGi10090.ENSMUSP00000001156

Structurei

3D structure databases

ProteinModelPortaliP11680
SMRiP11680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 72TSP type-1 0PROSITE-ProRule annotationAdd BLAST49
Domaini73 – 130TSP type-1 1PROSITE-ProRule annotationAdd BLAST58
Domaini132 – 187TSP type-1 2PROSITE-ProRule annotationAdd BLAST56
Domaini189 – 251TSP type-1 3PROSITE-ProRule annotationAdd BLAST63
Domaini253 – 309TSP type-1 4PROSITE-ProRule annotationAdd BLAST57
Domaini311 – 372TSP type-1 5PROSITE-ProRule annotationAdd BLAST62
Domaini374 – 457TSP type-1 6PROSITE-ProRule annotationAdd BLAST84

Domaini

TSP type-1 domains 0 and 6 bind to each other and mediate multimerization.By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IUGK Eukaryota
ENOG410ZHSM LUCA
GeneTreeiENSGT00930000150838
HOGENOMiHOG000231326
HOVERGENiHBG008263
InParanoidiP11680
KOiK15412
OMAiVEEKRPC
OrthoDBiEOG091G07MO
PhylomeDBiP11680
TreeFamiTF315491

Family and domain databases

Gene3Di2.20.100.10, 6 hits
InterProiView protein in InterPro
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF00090 TSP_1, 6 hits
SMARTiView protein in SMART
SM00209 TSP1, 6 hits
SUPFAMiSSF82895 SSF82895, 6 hits
PROSITEiView protein in PROSITE
PS50092 TSP1, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11680-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAEMQAPQW LLLLLVILPA TGSDPVLCFT QYEESSGRCK GLLGRDIRVE
60 70 80 90 100
DCCLNAAYAF QEHDGGLCQA CRSPQWSAWS LWGPCSVTCS EGSQLRHRRC
110 120 130 140 150
VGRGGQCSEN VAPGTLEWQL QACEDQPCCP EMGGWSEWGP WGPCSVTCSK
160 170 180 190 200
GTQIRQRVCD NPAPKCGGHC PGEAQQSQAC DTQKTCPTHG AWASWGPWSP
210 220 230 240 250
CSGSCLGGAQ EPKETRSRSC SAPAPSHQPP GKPCSGPAYE HKACSGLPPC
260 270 280 290 300
PVAGGWGPWS PLSPCSVTCG LGQTLEQRTC DHPAPRHGGP FCAGDATRNQ
310 320 330 340 350
MCNKAVPCPV NGEWEAWGKW SDCSRLRMSI NCEGTPGQQS RSRSCGGRKF
360 370 380 390 400
NGKPCAGKLQ DIRHCYNIHN CIMKGSWSQW STWSLCTPPC SPNATRVRQR
410 420 430 440 450
LCTPLLPKYP PTVSMVEGQG EKNVTFWGTP RPLCEALQGQ KLVVEEKRSC
460
LHVPVCKDPE EKKP
Length:464
Mass (Da):50,327
Last modified:December 6, 2005 - v2
Checksum:iC787F5493042379A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58Y → N in BAE42416 (PubMed:16141072).Curated1
Sequence conflicti201C → R in CAA31389 (PubMed:3045564).Curated1
Sequence conflicti347G → D in CAA31389 (PubMed:3045564).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150212 mRNA Translation: BAE29382.1
AK152782 mRNA Translation: BAE31492.1
AK159291 mRNA Translation: BAE34967.1
AK171374 mRNA Translation: BAE42416.1
X12905 mRNA Translation: CAA31389.1
CCDSiCCDS30047.1
PIRiS05478
RefSeqiNP_032849.2, NM_008823.4
UniGeneiMm.3064

Genome annotation databases

EnsembliENSMUST00000001156; ENSMUSP00000001156; ENSMUSG00000001128
GeneIDi18636
KEGGimmu:18636
UCSCiuc009sub.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150212 mRNA Translation: BAE29382.1
AK152782 mRNA Translation: BAE31492.1
AK159291 mRNA Translation: BAE34967.1
AK171374 mRNA Translation: BAE42416.1
X12905 mRNA Translation: CAA31389.1
CCDSiCCDS30047.1
PIRiS05478
RefSeqiNP_032849.2, NM_008823.4
UniGeneiMm.3064

3D structure databases

ProteinModelPortaliP11680
SMRiP11680
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP11680, 3 interactors
STRINGi10090.ENSMUSP00000001156

PTM databases

iPTMnetiP11680
PhosphoSitePlusiP11680
SwissPalmiP11680

Proteomic databases

MaxQBiP11680
PaxDbiP11680
PeptideAtlasiP11680
PRIDEiP11680

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001156; ENSMUSP00000001156; ENSMUSG00000001128
GeneIDi18636
KEGGimmu:18636
UCSCiuc009sub.1 mouse

Organism-specific databases

CTDi5199
MGIiMGI:97545 Cfp

Phylogenomic databases

eggNOGiENOG410IUGK Eukaryota
ENOG410ZHSM LUCA
GeneTreeiENSGT00930000150838
HOGENOMiHOG000231326
HOVERGENiHBG008263
InParanoidiP11680
KOiK15412
OMAiVEEKRPC
OrthoDBiEOG091G07MO
PhylomeDBiP11680
TreeFamiTF315491

Enzyme and pathway databases

ReactomeiR-MMU-173736 Alternative complement activation
R-MMU-174577 Activation of C3 and C5
R-MMU-5173214 O-glycosylation of TSR domain-containing proteins
R-MMU-6798695 Neutrophil degranulation
R-MMU-977606 Regulation of Complement cascade

Miscellaneous databases

PROiPR:P11680
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001128 Expressed in 177 organ(s), highest expression level in spleen
CleanExiMM_CFP
ExpressionAtlasiP11680 baseline and differential
GenevisibleiP11680 MM

Family and domain databases

Gene3Di2.20.100.10, 6 hits
InterProiView protein in InterPro
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF00090 TSP_1, 6 hits
SMARTiView protein in SMART
SM00209 TSP1, 6 hits
SUPFAMiSSF82895 SSF82895, 6 hits
PROSITEiView protein in PROSITE
PS50092 TSP1, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPROP_MOUSE
AccessioniPrimary (citable) accession number: P11680
Secondary accession number(s): Q3TB98, Q3U779
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 6, 2005
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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