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Protein

NADH-ubiquinone oxidoreductase chain 2

Gene

Mtnd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  • ionotropic glutamate receptor binding Source: RGD
  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  • protein kinase binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-RNO-611105 Respiratory electron transport
R-RNO-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 2 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 2
Gene namesi
Name:Mtnd2
Synonyms:mt-Nd2, Nd2
Encoded oniMitochondrion
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Mitochondrion

Organism-specific databases

RGDi620556 mt-Nd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001176331 – 346NADH-ubiquinone oxidoreductase chain 2Add BLAST346

Proteomic databases

PaxDbiP11662
PRIDEiP11662

Expressioni

Gene expression databases

BgeeiENSRNOG00000031033
ExpressionAtlasiP11662 baseline and differential
GenevisibleiP11662 RN

Interactioni

GO - Molecular functioni

  • ionotropic glutamate receptor binding Source: RGD
  • protein kinase binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043885

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPMV Eukaryota
COG1007 LUCA
GeneTreeiENSGT00730000111348
HOVERGENiHBG016692
InParanoidiP11662
KOiK03879
OMAiHFWVPEV
OrthoDBiEOG091G0J50
PhylomeDBiP11662

Family and domain databases

InterProiView protein in InterPro
IPR010933 NADH_DH_su2_C
IPR003917 NADH_UbQ_OxRdtase_chain2
IPR001750 ND/Mrp_mem
PfamiView protein in Pfam
PF06444 NADH_dehy_S2_C, 1 hit
PF00361 Proton_antipo_M, 1 hit
PRINTSiPR01436 NADHDHGNASE2

Sequencei

Sequence statusi: Complete.

P11662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPITLIIIY FTILMGPVIT MSSSNLLLMW VGLEMSLLAI IPLLANKKSP
60 70 80 90 100
RSTEAATKYF LTQATASMII LLVIILNYKQ SGMWTLQQQT NNMLLNMMLI
110 120 130 140 150
SLAMKLGLAP FHYWLPEVTQ GIPLHIGLIL LTWQKIAPLS ILYQFYQLLN
160 170 180 190 200
PTITTILAIS SVFVGAWGGL NQTQTRKIMA YSSIAHMGWM TAILPYNPNL
210 220 230 240 250
TLLNLTIYIL LTVPMFITLM TNSATTINTL SLAWNKTPMI LTMTSIILLS
260 270 280 290 300
LGGLPPLTGF LPKWAIISEL LKNNCSTLST LMAIMALLSL FFYTRLIYSM
310 320 330 340
SLTMFPTNNN SKMISHHHQN PKHNFILPTL TVLSTLTLPL SSQLIT
Length:346
Mass (Da):38,653
Last modified:April 1, 2015 - v3
Checksum:i2DD0FB68269A49D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7 – 28IIIYF…SNLLL → TIIYLTTFKGRLITTLSTNL PP in CAA32955 (PubMed:2504926).CuratedAdd BLAST22
Sequence conflicti217 – 219ITL → NYI in CAA32955 (PubMed:2504926).Curated3
Sequence conflicti244T → A in CAA32955 (PubMed:2504926).Curated1
Sequence conflicti304M → T in CAA32955 (PubMed:2504926).Curated1
Sequence conflicti316Missing in CAA32955 (PubMed:2504926).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14848 Genomic DNA Translation: CAA32955.1
AY172581 Genomic DNA Translation: AAN77595.1
V00676 Genomic DNA Translation: CAA24047.1
V00677 Genomic DNA Translation: CAA24049.1
V00678 Genomic DNA Translation: CAA24051.1
V00679 Genomic DNA Translation: CAA24053.1
PIRiS04748
RefSeqiAP_004893.1, AC_000022.2
YP_665630.1, NC_001665.2

Genome annotation databases

EnsembliENSRNOT00000040993; ENSRNOP00000043885; ENSRNOG00000031033
GeneIDi26194
KEGGirno:26194

Similar proteinsi

Entry informationi

Entry nameiNU2M_RAT
AccessioniPrimary (citable) accession number: P11662
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: April 1, 2015
Last modified: June 20, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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