UniProtKB - P11661 (NU5M_RAT)
Protein
NADH-ubiquinone oxidoreductase chain 5
Gene
Mtnd5
Organism
Rattus norvegicus (Rat)
Status
Functioni
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity
Catalytic activityi
- EC:7.1.1.2
GO - Molecular functioni
- NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
- NADH dehydrogenase activity Source: RGD
GO - Biological processi
- ATP synthesis coupled electron transport Source: InterPro
- electron transport coupled proton transport Source: GO_Central
- response to hydrogen peroxide Source: RGD
- response to hypoxia Source: RGD
- response to organonitrogen compound Source: RGD
Keywordsi
Molecular function | Translocase |
Biological process | Electron transport, Respiratory chain, Transport |
Ligand | NAD, Ubiquinone |
Enzyme and pathway databases
Reactomei | R-RNO-611105, Respiratory electron transport R-RNO-6799198, Complex I biogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: NADH-ubiquinone oxidoreductase chain 5 (EC:7.1.1.2)Alternative name(s): NADH dehydrogenase subunit 5 |
Gene namesi | Name:Mtnd5 Synonyms:mt-Nd5, Nd5 |
Encoded oni | Mitochondrion |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620560, mt-Nd5 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial respiratory chain complex I Source: RGD
Other locations
- integral component of membrane Source: UniProtKB-KW
- neuron projection Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 26 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 35 – 55 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 84 – 104 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 116 – 138 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 140 – 160 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 171 – 191 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 240 – 260 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 272 – 292 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 300 – 319 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 330 – 350 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 365 – 385 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 409 – 429 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 456 – 476 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 481 – 501 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 581 – 601 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118141 | 1 – 609 | NADH-ubiquinone oxidoreductase chain 5Add BLAST | 609 |
Proteomic databases
PaxDbi | P11661 |
PRIDEi | P11661 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000029971, Expressed in cerebellum and 21 other tissues |
ExpressionAtlasi | P11661, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I subunit 5 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4668, Eukaryota |
GeneTreei | ENSGT00730000111303 |
HOGENOMi | CLU_007100_6_0_1 |
InParanoidi | P11661 |
OMAi | GVGIMSF |
OrthoDBi | 526738at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR010934, NADH_DH_su5_C IPR003945, NADHpl_OxRdtase_5 IPR001750, ND/Mrp_mem IPR001516, Proton_antipo_N |
Pfami | View protein in Pfam PF06455, NADH5_C, 1 hit PF00361, Proton_antipo_M, 1 hit PF00662, Proton_antipo_N, 1 hit |
TIGRFAMsi | TIGR01974, NDH_I_L, 1 hit |
i Sequence
Sequence statusi: Complete.
P11661-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNMMTSSILM ILILLTTPII ISMTNLPKLI DFPSYATSSI KFSFLLSLLP
60 70 80 90 100
LLLFFHHNTE YMITNWHWLT INSIKLTMSF KIDYFSILFL SVALFVTWSI
110 120 130 140 150
MQFSSWYMHS DPHINRFIKY LMMFLITMLI LTSANNLFQL FIGWEGVGIM
160 170 180 190 200
SFLLIGWWYG RADANTAALQ AILYNRVGDI GFILAMTWFC LNMNSWELQQ
210 220 230 240 250
IFLTNTNNLV PLTGLLIAAT GKSAQFGLHP WLPSAMEGPT PVSALLHSST
260 270 280 290 300
MVVAGIFLMI RFHPLTSNNS TIMTAMLCLG AITTLFTAIC ALTQNDIKKI
310 320 330 340 350
VAFSTSSQLG LMMVTLGINQ PYLAFLHICT HAFFKAMLFM CSGSIIHSLN
360 370 380 390 400
DEQDIRKMGN MMKAMPFTSS CLIIGSLALT GMPFLTGFYS KDLIIEAINT
410 420 430 440 450
CNTNAWALMI TLIATSMTAV YSMRIIYFVT MTKPRYSPLI TINENNPNLI
460 470 480 490 500
NPIKRLALGS ILAGFLISLN IPPTNIQILT MPWHLKMTAL LITILGFAIA
510 520 530 540 550
LELNNLTLNL SMSKPTKLSS FSTSLGYYPP IMHRIIPQKT LNSSYKLSLN
560 570 580 590 600
LLDLIWLEKT IPKSTSITQT QLSKMMSNQK GLIKLYFLSF LITISLIFIL
HTLNPEWFQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 – 7 | SS → IL in CAA32964 (PubMed:2504926).Curated | 2 | |
Sequence conflicti | 13 | I → D in CAA32964 (PubMed:2504926).Curated | 1 | |
Sequence conflicti | 20 – 38 | IISMT…SYATS → TFSMTILTKLMYFRHMLIT in CAA32964 (PubMed:2504926).CuratedAdd BLAST | 19 | |
Sequence conflicti | 93 | A → S in CAA32964 (PubMed:2504926).Curated | 1 | |
Sequence conflicti | 126 – 127 | IT → NN in CAA32964 (PubMed:2504926).Curated | 2 | |
Sequence conflicti | 161 | R → L in CAA32964 (PubMed:2504926).Curated | 1 | |
Sequence conflicti | 206 | T → TN in CAA32964 (PubMed:2504926).Curated | 1 | |
Sequence conflicti | 348 | S → I in CAA32964 (PubMed:2504926).Curated | 1 | |
Sequence conflicti | 533 | H → P in CAA32964 (PubMed:2504926).Curated | 1 | |
Sequence conflicti | 557 | L → S in CAA32964 (PubMed:2504926).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14848 Genomic DNA Translation: CAA32964.1 AY172581 Genomic DNA Translation: AAN77604.1 |
PIRi | S04757 |
RefSeqi | AP_004902.1, AC_000022.2 YP_665639.1, NC_001665.2 |
Genome annotation databases
Ensembli | ENSRNOT00000048767; ENSRNOP00000044573; ENSRNOG00000029971 |
GeneIDi | 26202 |
KEGGi | rno:26202 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14848 Genomic DNA Translation: CAA32964.1 AY172581 Genomic DNA Translation: AAN77604.1 |
PIRi | S04757 |
RefSeqi | AP_004902.1, AC_000022.2 YP_665639.1, NC_001665.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000044573 |
Proteomic databases
PaxDbi | P11661 |
PRIDEi | P11661 |
Genome annotation databases
Ensembli | ENSRNOT00000048767; ENSRNOP00000044573; ENSRNOG00000029971 |
GeneIDi | 26202 |
KEGGi | rno:26202 |
Organism-specific databases
CTDi | 4540 |
RGDi | 620560, mt-Nd5 |
Phylogenomic databases
eggNOGi | KOG4668, Eukaryota |
GeneTreei | ENSGT00730000111303 |
HOGENOMi | CLU_007100_6_0_1 |
InParanoidi | P11661 |
OMAi | GVGIMSF |
OrthoDBi | 526738at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-611105, Respiratory electron transport R-RNO-6799198, Complex I biogenesis |
Miscellaneous databases
PROi | PR:P11661 |
Gene expression databases
Bgeei | ENSRNOG00000029971, Expressed in cerebellum and 21 other tissues |
ExpressionAtlasi | P11661, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR010934, NADH_DH_su5_C IPR003945, NADHpl_OxRdtase_5 IPR001750, ND/Mrp_mem IPR001516, Proton_antipo_N |
Pfami | View protein in Pfam PF06455, NADH5_C, 1 hit PF00361, Proton_antipo_M, 1 hit PF00662, Proton_antipo_N, 1 hit |
TIGRFAMsi | TIGR01974, NDH_I_L, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NU5M_RAT | |
Accessioni | P11661Primary (citable) accession number: P11661 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | April 1, 2015 | |
Last modified: | December 2, 2020 | |
This is version 133 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families