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UniProtKB - P11661 (NU5M_RAT)

Entry version 137 (23 Feb 2022)
Sequence version 3 (01 Apr 2015)
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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

Mtnd5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-611105, Respiratory electron transport
R-RNO-6799198, Complex I biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:7.1.1.2By similarity)
Alternative name(s):
NADH dehydrogenase subunit 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mtnd5
Synonyms:mt-Nd5, Nd5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniMitochondrion
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Mitochondrion

Organism-specific databases

Rat genome database

More...RGDi		620560, mt-Nd5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei116 – 138HelicalSequence analysisAdd BLAST23
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei300 – 319HelicalSequence analysisAdd BLAST20
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Transmembranei581 – 601HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001181411 – 609NADH-ubiquinone oxidoreductase chain 5Add BLAST609

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P11661

PRoteomics IDEntifications database

More...PRIDEi		P11661

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000029971, Expressed in cerebellum and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P11661, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000044573

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P11661

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4668, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111303

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007100_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P11661

Identification of Orthologs from Complete Genome Data

More...OMAi		GVGIMSF

Database of Orthologous Groups

More...OrthoDBi		526738at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010934, NADH_DH_su5_C
IPR003945, NADHpl_OxRdtase_5
IPR018393, NADHpl_OxRdtase_5_subgr
IPR001750, ND/Mrp_mem
IPR001516, Proton_antipo_N

The PANTHER Classification System

More...PANTHERi		PTHR42829, PTHR42829, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06455, NADH5_C, 1 hit
PF00361, Proton_antipo_M, 1 hit
PF00662, Proton_antipo_N, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01974, NDH_I_L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P11661-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNMMTSSILM ILILLTTPII ISMTNLPKLI DFPSYATSSI KFSFLLSLLP 
        60         70         80         90        100
LLLFFHHNTE YMITNWHWLT INSIKLTMSF KIDYFSILFL SVALFVTWSI 
       110        120        130        140        150
MQFSSWYMHS DPHINRFIKY LMMFLITMLI LTSANNLFQL FIGWEGVGIM 
       160        170        180        190        200
SFLLIGWWYG RADANTAALQ AILYNRVGDI GFILAMTWFC LNMNSWELQQ 
       210        220        230        240        250
IFLTNTNNLV PLTGLLIAAT GKSAQFGLHP WLPSAMEGPT PVSALLHSST 
       260        270        280        290        300
MVVAGIFLMI RFHPLTSNNS TIMTAMLCLG AITTLFTAIC ALTQNDIKKI 
       310        320        330        340        350
VAFSTSSQLG LMMVTLGINQ PYLAFLHICT HAFFKAMLFM CSGSIIHSLN 
       360        370        380        390        400
DEQDIRKMGN MMKAMPFTSS CLIIGSLALT GMPFLTGFYS KDLIIEAINT 
       410        420        430        440        450
CNTNAWALMI TLIATSMTAV YSMRIIYFVT MTKPRYSPLI TINENNPNLI 
       460        470        480        490        500
NPIKRLALGS ILAGFLISLN IPPTNIQILT MPWHLKMTAL LITILGFAIA 
       510        520        530        540        550
LELNNLTLNL SMSKPTKLSS FSTSLGYYPP IMHRIIPQKT LNSSYKLSLN 
       560        570        580        590        600
LLDLIWLEKT IPKSTSITQT QLSKMMSNQK GLIKLYFLSF LITISLIFIL 

HTLNPEWFQ
Length:609
Mass (Da):68,618
Last modified:April 1, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C876639DC556967
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6 – 7SS → IL in CAA32964 (PubMed:2504926).Curated2
Sequence conflicti13I → D in CAA32964 (PubMed:2504926).Curated1
Sequence conflicti20 – 38IISMT…SYATS → TFSMTILTKLMYFRHMLIT in CAA32964 (PubMed:2504926).CuratedAdd BLAST19
Sequence conflicti93A → S in CAA32964 (PubMed:2504926).Curated1
Sequence conflicti126 – 127IT → NN in CAA32964 (PubMed:2504926).Curated2
Sequence conflicti161R → L in CAA32964 (PubMed:2504926).Curated1
Sequence conflicti206T → TN in CAA32964 (PubMed:2504926).Curated1
Sequence conflicti348S → I in CAA32964 (PubMed:2504926).Curated1
Sequence conflicti533H → P in CAA32964 (PubMed:2504926).Curated1
Sequence conflicti557L → S in CAA32964 (PubMed:2504926).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X14848 Genomic DNA Translation: CAA32964.1
AY172581 Genomic DNA Translation: AAN77604.1

Protein sequence database of the Protein Information Resource

More...PIRi		S04757

NCBI Reference Sequences

More...RefSeqi		AP_004902.1, AC_000022.2
YP_665639.1, NC_001665.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000048767; ENSRNOP00000044573; ENSRNOG00000029971

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26202

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:26202

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14848 Genomic DNA Translation: CAA32964.1
AY172581 Genomic DNA Translation: AAN77604.1
PIRiS04757
RefSeqiAP_004902.1, AC_000022.2
YP_665639.1, NC_001665.2

3D structure databases

SMRiP11661
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044573

Proteomic databases

PaxDbiP11661
PRIDEiP11661

Genome annotation databases

EnsembliENSRNOT00000048767; ENSRNOP00000044573; ENSRNOG00000029971
GeneIDi26202
KEGGirno:26202

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4540
RGDi620560, mt-Nd5

Phylogenomic databases

eggNOGiKOG4668, Eukaryota
GeneTreeiENSGT00730000111303
HOGENOMiCLU_007100_6_0_1
InParanoidiP11661
OMAiGVGIMSF
OrthoDBi526738at2759

Enzyme and pathway databases

ReactomeiR-RNO-611105, Respiratory electron transport
R-RNO-6799198, Complex I biogenesis

Miscellaneous databases

Protein Ontology

More...PROi		PR:P11661

Gene expression databases

BgeeiENSRNOG00000029971, Expressed in cerebellum and 21 other tissues
ExpressionAtlasiP11661, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR010934, NADH_DH_su5_C
IPR003945, NADHpl_OxRdtase_5
IPR018393, NADHpl_OxRdtase_5_subgr
IPR001750, ND/Mrp_mem
IPR001516, Proton_antipo_N
PANTHERiPTHR42829, PTHR42829, 1 hit
PfamiView protein in Pfam
PF06455, NADH5_C, 1 hit
PF00361, Proton_antipo_M, 1 hit
PF00662, Proton_antipo_N, 1 hit
TIGRFAMsiTIGR01974, NDH_I_L, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU5M_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11661
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: April 1, 2015
Last modified: February 23, 2022
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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