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Entry version 121 (08 May 2019)
Sequence version 1 (01 Oct 1989)
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Protein

Major cell-surface adhesin PAc

Gene

pac

Organism
Streptococcus mutans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Surface protein antigen implicated in dental caries.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major cell-surface adhesin PAc
Alternative name(s):
Antigen I/II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pac
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus mutans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1309 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell wall, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Dental caries

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 381 PublicationAdd BLAST38
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000564539 – 1535Major cell-surface adhesin PAcAdd BLAST1497
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000056461536 – 1565Removed by sortasePROSITE-ProRule annotationAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1535Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchor

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P11657

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
1198676.SMUGS5_02680

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11565
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P11657

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P11657

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati203 – 285A1Add BLAST83
Repeati286 – 367A2Add BLAST82
Repeati368 – 448A3Add BLAST81
Repeati848 – 887P1Add BLAST40
Repeati888 – 926P2Add BLAST39
Repeati927 – 964P3Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni203 – 448Heptad repeats of Y-[EQ]-X-X-L-A-XAdd BLAST246
Regioni461 – 834V-region (lectin-like)Add BLAST374

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1532 – 1536LPXTG sorting signalPROSITE-ProRule annotation5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi157 – 201Ala-richAdd BLAST45
Compositional biasi835 – 988Pro-richAdd BLAST154

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SpaP/Ssp5/SpaA family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.530.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026345 Adh_isopep-form_adh_dom
IPR041324 AgI/II_N
IPR032300 Antigen_C
IPR021197 Cross-wall-target_lipo_motif
IPR013574 Glucan-bd_C/Surface_Ag-I/II_V
IPR019948 Gram-positive_anchor
IPR019931 LPXTG_anchor
IPR036234 SA_I/II_PAC_V_sf
IPR009578 Surface_Ag_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18652 Adhesin_P1_N, 1 hit
PF17998 AgI_II_C2, 1 hit
PF16364 Antigen_C, 1 hit
PF08363 GbpC, 1 hit
PF00746 Gram_pos_anchor, 1 hit
PF06696 Strep_SA_rep, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74914 SSF74914, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04228 isopep_sspB_C2, 1 hit
TIGR03726 strep_RK_lipo, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P11657-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVKKTYGFR KSKISKTLCG AVLGTVAAVS VAGQKVFADE TTTTSDVDTK
60 70 80 90 100
VVGTQTGNPA TNLPEAQGSA SKEAEQSQTK LERQMVHTIE VPKTDLDQAA
110 120 130 140 150
KDAKSAGVNV VQDADVNKGT VKTPEEAVQK ETEIKEDYTK QAEDIKKTTD
160 170 180 190 200
QYKSDVAAHE AEVAKIKAKN QATKEQYEKD MAAHKAEVER INAANAASKT
210 220 230 240 250
AYEAKLAQYQ ADLAAVQKTN AANQAAYQKA LAAYQAELKR VQEANAAAKA
260 270 280 290 300
AYDTAVAANN AKNTEIAAAN EEIRKRNATA KAEYETKLAQ YQAELKRVQE
310 320 330 340 350
ANAANEADYQ AKLTAYQTEL ARVQKANADA KATYEAAVAA NNAKNAALTA
360 370 380 390 400
ENTAIKQRNE NAKATYEAAL KQYEADLAAV KKANAANEAD YQAKLTAYQT
410 420 430 440 450
ELARVQKANA DAKAAYEAAV AANNAANAAL TAENTAIKKR NADAKADYEA
460 470 480 490 500
KLAKYQADLA KYQKDLADYP VKLKAYEDEQ TSIKAALAEL EKHKNEDGNL
510 520 530 540 550
TEPSAQNLVY DLEPNANLSL TTDGKFLKAS AVDDAFSKST SKAKYDQKIL
560 570 580 590 600
QLDDLDITNL EQSNDVASSM ELYGNFGDKA GWSTTVSNNS QVKWGSVLLE
610 620 630 640 650
RGQSATATYT NLQNSYYNGK KISKIVYKYT VDPKSKFQGQ KVWLGIFTDP
660 670 680 690 700
TLGVFASAYT GQVEKNTSIF IKNEFTFYHE DEKPINFDNA LLSVTSLNRE
710 720 730 740 750
HNSIEMAKDY SGKFVKISGS SIGEKNGMIY ATDTLNFKQG EGGSRWTMYK
760 770 780 790 800
NSQAGSGWDS SDAPNSWYGA GAIKMSGPNN HVTVGATSAT NVMPVSDMPV
810 820 830 840 850
VPGKDNTDGK KPNIWYSLNG KIRAVNVPKV TKEKPTPPVK PTAPTKPTYE
860 870 880 890 900
TEKPLKPAPV APNYEKEPTP PTRTPDQAEP NKPTPPTYET EKPLEPAPVE
910 920 930 940 950
PSYEAEPTPP TRTPDQAEPN KPTPPTYETE KPLEPAPVEP SYEAEPTPPT
960 970 980 990 1000
PTPDQPEPNK PVEPTYEVIP TPPTDPVYQD LPTPPSDPTV HFHYFKLAVQ
1010 1020 1030 1040 1050
PQVNKEIRNN NDINIDRTLV AKQSVVKFQL KTADLPAGRD ETTSFVLVDP
1060 1070 1080 1090 1100
LPSGYQFNPE ATKAASPGFD VTYDNATNTV TFKATAATLA TFNADLTKSV
1110 1120 1130 1140 1150
ATIYPTVVGQ VLNDGATYKN NFTLTVNDAY GIKSNVVRVT TPGKPNDPDN
1160 1170 1180 1190 1200
PNNNYIKPTK VNKNENGVVI DGKTVLAGST NYYELTWDLD QYKNDRSSAD
1210 1220 1230 1240 1250
TIQKGFYYVD DYPEEALELR QDLVKITDAN GNEVTGVSVD NYTNLEAAPQ
1260 1270 1280 1290 1300
EIRDVLSKAG IRPKGAFQIF RADNPREFYD TYVKTGIDLK IVSPMVVKKQ
1310 1320 1330 1340 1350
MGQTGGSYEN QAYQIDFGNG YASNIVINNV PKINPKKDVT LTLDPADTNN
1360 1370 1380 1390 1400
VDGQTIPLNT VFNYRLIGGI IPANHSEELF EYNFYDDYDQ TGDHYTGQYK
1410 1420 1430 1440 1450
VFAKVDITLK NGVIIKSGTE LTQYTTAEVD TTKGAITIKF KEAFLRSVSI
1460 1470 1480 1490 1500
DSAFQAESYI QMKRIAVGTF ENTYINTVNG VTYSSNTVKT TTPEDPADPT
1510 1520 1530 1540 1550
DPQDPSSPRT STVIIYKPQS TAYQPSSVQE TLPNTGVTNN AYMPLLGIIG
1560
LVTSFSLLGL KAKKD
Length:1,565
Mass (Da):170,782
Last modified:October 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C3B05C809D0C32A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X14490 Genomic DNA Translation: CAA32652.1
AB040534 Genomic DNA Translation: BAC54564.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S04729

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14490 Genomic DNA Translation: CAA32652.1
AB040534 Genomic DNA Translation: BAC54564.1
PIRiS04729

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JMMX-ray2.40A463-839[»]
3OPUX-ray2.18A/B/C/D/E/F1154-1492[»]
3QE5X-ray2.50A/B991-1485[»]
5LO2NMR-A451-469[»]
SMRiP11657
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1198676.SMUGS5_02680

Proteomic databases

PRIDEiP11657

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP11657

Family and domain databases

Gene3Di2.60.530.10, 1 hit
InterProiView protein in InterPro
IPR026345 Adh_isopep-form_adh_dom
IPR041324 AgI/II_N
IPR032300 Antigen_C
IPR021197 Cross-wall-target_lipo_motif
IPR013574 Glucan-bd_C/Surface_Ag-I/II_V
IPR019948 Gram-positive_anchor
IPR019931 LPXTG_anchor
IPR036234 SA_I/II_PAC_V_sf
IPR009578 Surface_Ag_rpt
PfamiView protein in Pfam
PF18652 Adhesin_P1_N, 1 hit
PF17998 AgI_II_C2, 1 hit
PF16364 Antigen_C, 1 hit
PF08363 GbpC, 1 hit
PF00746 Gram_pos_anchor, 1 hit
PF06696 Strep_SA_rep, 7 hits
SUPFAMiSSF74914 SSF74914, 1 hit
TIGRFAMsiTIGR04228 isopep_sspB_C2, 1 hit
TIGR03726 strep_RK_lipo, 1 hit
PROSITEiView protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAC_STRMG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11657
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 8, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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