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Protein

Neural cell adhesion molecule L1

Gene

L1cam

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.By similarity

GO - Molecular functioni

  • identical protein binding Source: MGI
  • integrin binding Source: MGI
  • PDZ domain binding Source: MGI
  • protein domain specific binding Source: MGI
  • protein self-association Source: MGI
  • sialic acid binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion, Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neural cell adhesion molecule L1
Short name:
N-CAM-L1
Short name:
NCAM-L1
Alternative name(s):
CD_antigen: CD171
Gene namesi
Name:L1cam
Synonyms:Caml1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96721 L1cam

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1123ExtracellularSequence analysisAdd BLAST1104
Transmembranei1124 – 1146HelicalSequence analysisAdd BLAST23
Topological domaini1147 – 1260CytoplasmicSequence analysisAdd BLAST114

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001502320 – 1260Neural cell adhesion molecule L1Add BLAST1241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 113PROSITE-ProRule annotation
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 208PROSITE-ProRule annotation
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi263 ↔ 311PROSITE-ProRule annotation
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi353 ↔ 403PROSITE-ProRule annotation
Glycosylationi432N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi447 ↔ 496PROSITE-ProRule annotation
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi489N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi504N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi538 ↔ 590PROSITE-ProRule annotation
Glycosylationi587N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi670N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi725N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi776N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi824N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi848N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi875N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi968N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi978N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1022N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1030N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1073N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1107N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1166PhosphoserineBy similarity1
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1184PhosphoserineCombined sources1
Modified residuei1197PhosphoserineBy similarity1
Modified residuei1246PhosphoserineCombined sources1
Modified residuei1247PhosphoserineCombined sources1
Modified residuei1251PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP11627
PaxDbiP11627
PeptideAtlasiP11627
PRIDEiP11627

PTM databases

iPTMnetiP11627
PhosphoSitePlusiP11627

Miscellaneous databases

PMAP-CutDBiP11627

Expressioni

Tissue specificityi

Expressed in the brain, including in the molecular layer of the cerebellar cortex, the fiber-rich layers of the hippocampus (alveus, and strata lacunosum moleculare, radiatum, and oriens), the nerve fiber layer and the inner and outer plexiform layers of the retina, and in the molecular layer of the olfactory bulb (at protein level).1 Publication

Gene expression databases

CleanExiMM_L1CAM

Interactioni

Subunit structurei

Interacts with SHTN1; the interaction occurs in axonal growth cones.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

CORUMiP11627
IntActiP11627, 10 interactors
MINTiP11627
STRINGi10090.ENSMUSP00000099935

Structurei

3D structure databases

ProteinModelPortaliP11627
SMRiP11627
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 130Ig-like C2-type 1Add BLAST96
Domaini138 – 225Ig-like C2-type 2Add BLAST88
Domaini239 – 327Ig-like C2-type 3Add BLAST89
Domaini332 – 419Ig-like C2-type 4Add BLAST88
Domaini424 – 506Ig-like C2-type 5Add BLAST83
Domaini517 – 600Ig-like C2-type 6Add BLAST84
Domaini613 – 711Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini716 – 809Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94
Domaini811 – 916Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST106
Domaini919 – 1015Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST97
Domaini1014 – 1112Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST99

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi553 – 555Cell attachment siteSequence analysis3
Motifi562 – 564Cell attachment siteSequence analysis3

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
HOGENOMiHOG000231380
HOVERGENiHBG000144
InParanoidiP11627
PhylomeDBiP11627

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR026966 Neurofascin/L1/NrCAM_C
PfamiView protein in Pfam
PF13882 Bravo_FIGEY, 1 hit
PF00041 fn3, 4 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P11627-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVMLRYVWP LLLCSPCLLI QIPDEYKGHH VLEPPVITEQ SPRRLVVFPT
60 70 80 90 100
DDISLKCEAR GRPQVEFRWT KDGIHFKPKE ELGVVVHEAP YSGSFTIEGN
110 120 130 140 150
NSFAQRFQGI YRCYASNKLG TAMSHEIQLV AEGAPKWPKE TVKPVEVEEG
160 170 180 190 200
ESVVLPCNPP PSAAPPRIYW MNSKIFDIKQ DERVSMGQNG DLYFANVLTS
210 220 230 240 250
DNHSDYICNA HFPGTRTIIQ KEPIDLRVKP TNSMIDRKPR LLFPTNSSSR
260 270 280 290 300
LVALQGQSLI LECIAEGFPT PTIKWLHPSD PMPTDRVIYQ NHNKTLQLLN
310 320 330 340 350
VGEEDDGEYT CLAENSLGSA RHAYYVTVEA APYWLQKPQS HLYGPGETAR
360 370 380 390 400
LDCQVQGRPQ PEITWRINGM SMETVNKDQK YRIEQGSLIL SNVQPTDTMV
410 420 430 440 450
TQCEARNQHG LLLANAYIYV VQLPARILTK DNQTYMAVEG STAYLLCKAF
460 470 480 490 500
GAPVPSVQWL DEEGTTVLQD ERFFPYANGT LSIRDLQAND TGRYFCQAAN
510 520 530 540 550
DQNNVTILAN LQVKEATQIT QGPRSAIEKK GARVTFTCQA SFDPSLQASI
560 570 580 590 600
TWRGDGRDLQ ERGDSDKYFI EDGKLVIQSL DYSDQGNYSC VASTELDEVE
610 620 630 640 650
SRAQLLVVGS PGPVPHLELS DRHLLKQSQV HLSWSPAEDH NSPIEKYDIE
660 670 680 690 700
FEDKEMAPEK WFSLGKVPGN QTSTTLKLSP YVHYTFRVTA INKYGPGEPS
710 720 730 740 750
PVSESVVTPE AAPEKNPVDV RGEGNETNNM VITWKPLRWM DWNAPQIQYR
760 770 780 790 800
VQWRPQGKQE TWRKQTVSDP FLVVSNTSTF VPYEIKVQAV NNQGKGPEPQ
810 820 830 840 850
VTIGYSGEDY PQVSPELEDI TIFNSSTVLV RWRPVDLAQV KGHLKGYNVT
860 870 880 890 900
YWWKGSQRKH SKRHIHKSHI VVPANTTSAI LSGLRPYSSY HVEVQAFNGR
910 920 930 940 950
GLGPASEWTF STPEGVPGHP EALHLECQSD TSLLLHWQPP LSHNGVLTGY
960 970 980 990 1000
LLSYHPVEGE SKEQLFFNLS DPELRTHNLT NLNPDLQYRF QLQATTQQGG
1010 1020 1030 1040 1050
PGEAIVREGG TMALFGKPDF GNISATAGEN YSVVSWVPRK GQCNFRFHIL
1060 1070 1080 1090 1100
FKALPEGKVS PDHQPQPQYV SYNQSSYTQW NLQPDTKYEI HLIKEKVLLH
1110 1120 1130 1140 1150
HLDVKTNGTG PVRVSTTGSF ASEGWFIAFV SAIILLLLIL LILCFIKRSK
1160 1170 1180 1190 1200
GGKYSVKDKE DTQVDSEARP MKDETFGEYR SLESDNEEKA FGSSQPSLNG
1210 1220 1230 1240 1250
DIKPLGSDDS LADYGGSVDV QFNEDGSFIG QYSGKKEKEA AGGNDSSGAT
1260
SPINPAVALE
Length:1,260
Mass (Da):140,969
Last modified:October 1, 1989 - v1
Checksum:i22BE57001CB2A538
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6PGJ3Q6PGJ3_MOUSE
L1 cell adhesion molecule
L1cam
1,259Annotation score:
A2AFG7A2AFG7_MOUSE
Neural cell adhesion molecule L1
L1cam
1,250Annotation score:
A2AFG8A2AFG8_MOUSE
Neural cell adhesion molecule L1
L1cam
1,255Annotation score:
B7ZCD3B7ZCD3_MOUSE
Neural cell adhesion molecule L1
L1cam
83Annotation score:
F7A5H7F7A5H7_MOUSE
Neural cell adhesion molecule L1
L1cam
190Annotation score:
F6UIL7F6UIL7_MOUSE
Neural cell adhesion molecule L1
L1cam
145Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12875 mRNA Translation: CAA31368.1
PIRiS05479
UniGeneiMm.260568

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

N-CAM 140

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12875 mRNA Translation: CAA31368.1
PIRiS05479
UniGeneiMm.260568

3D structure databases

ProteinModelPortaliP11627
SMRiP11627
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP11627
IntActiP11627, 10 interactors
MINTiP11627
STRINGi10090.ENSMUSP00000099935

PTM databases

iPTMnetiP11627
PhosphoSitePlusiP11627

Proteomic databases

MaxQBiP11627
PaxDbiP11627
PeptideAtlasiP11627
PRIDEiP11627

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96721 L1cam

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
HOGENOMiHOG000231380
HOVERGENiHBG000144
InParanoidiP11627
PhylomeDBiP11627

Miscellaneous databases

ChiTaRSiL1cam mouse
PMAP-CutDBiP11627
PROiPR:P11627
SOURCEiSearch...

Gene expression databases

CleanExiMM_L1CAM

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR026966 Neurofascin/L1/NrCAM_C
PfamiView protein in Pfam
PF13882 Bravo_FIGEY, 1 hit
PF00041 fn3, 4 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiL1CAM_MOUSE
AccessioniPrimary (citable) accession number: P11627
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 12, 2018
This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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