Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Atypical chemokine receptor 3

Gene

ACKR3

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-CFA-380108 Chemokine receptors bind chemokines
R-CFA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Atypical chemokine receptor 3
Alternative name(s):
C-X-C chemokine receptor type 7
Short name:
CXC-R7
Short name:
CXCR-7
Chemokine orphan receptor 1
G-protein coupled receptor RDC1
Short name:
RDC-1
Gene namesi
Name:ACKR3
Synonyms:CMKOR1, CXCR7, RDC1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:37509 ACKR3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularSequence analysisAdd BLAST40
Transmembranei41 – 61Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini62 – 81CytoplasmicSequence analysisAdd BLAST20
Transmembranei82 – 102Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini103 – 118ExtracellularSequence analysisAdd BLAST16
Transmembranei119 – 139Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini140 – 162CytoplasmicSequence analysisAdd BLAST23
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 213ExtracellularSequence analysisAdd BLAST30
Transmembranei214 – 234Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini235 – 252CytoplasmicSequence analysisAdd BLAST18
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 296ExtracellularSequence analysisAdd BLAST23
Transmembranei297 – 319Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini320 – 362CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701001 – 362Atypical chemokine receptor 3Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 196PROSITE-ProRule annotation
Modified residuei347PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1
Modified residuei355PhosphoserineBy similarity1

Post-translational modificationi

The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.By similarity
Ubiquitinated at the Lys residues in its C-terminal cytoplasmic tail and is essential for correct trafficking from and to the cell membrane. Deubiquitinated by CXCL12-stimulation in a reversible manner (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP11613

Expressioni

Gene expression databases

BgeeiENSCAFG00000012206 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactioni

Subunit structurei

Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity (By similarity). Interacts with ARRB1 and ARRB2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000017975

Structurei

3D structure databases

ProteinModelPortaliP11613
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni324 – 362C-terminal cytoplasmic tailBy similarityAdd BLAST39

Domaini

The C-terminal cytoplasmic tail, plays a key role in: correct trafficking to the cell membrane, recruitment of beta-arrestin, ubiquitination, and in chemokine scavenging and signaling functions. The Ser/Thr residues and the Lys residues in the C-terminal cytoplasmic tail are essential for beta-arrestin recruitment and ubiquitination respectively (By similarity).By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000261660
HOVERGENiHBG106832
InParanoidiP11613
KOiK04304
OMAiYIPFTCQ
OrthoDBiEOG091G091W
TreeFamiTF333489

Family and domain databases

CDDicd14987 7tmA_ACKR3_CXCR7, 1 hit
InterProiView protein in InterPro
IPR001416 ACKR3
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR44720 PTHR44720, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00646 RDC1ORPHANR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P11613-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLHLFDYAE PGNFSDISWP CNSSDCIVVD TVLCPNMPNK SVLLYTLSFI
60 70 80 90 100
YIFIFVIGMI ANSVVVWVNI QAKTTGYDTH CYILNLAIAD LWVVVTIPVW
110 120 130 140 150
VVSLVQHNQW PMGELTCKIT HLIFSINLFG SIFFLTCMSV DRYLSITYFA
160 170 180 190 200
STSSRRKKVV RRAVCVLVWL LAFCVSLPDT YYLKTVTSAS NNETYCRSFY
210 220 230 240 250
PEHSVKEWLI SMELVSVVLG FAIPFCVIAV FYCLLARAIS ASSDQEKQSS
260 270 280 290 300
RKIIFSYVVV FLVCWLPYHV VVLLDIFSIL HYIPFTCQLE NFLFTALHVT
310 320 330 340 350
QCLSLVHCCV NPVLYSFINR NYRYELMKAF IFKYSAKTGL TKLIDASRVS
360
ETEYSALEQN AK
Length:362
Mass (Da):41,416
Last modified:October 1, 1989 - v1
Checksum:iAA1B288DB9674343
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14048 mRNA Translation: CAA32206.1
PIRiA30341
RefSeqiNP_001003281.1, NM_001003281.2
XP_005635961.1, XM_005635904.2
XP_005635962.1, XM_005635905.2
XP_005635963.1, XM_005635906.2
UniGeneiCfa.3822

Genome annotation databases

EnsembliENSCAFT00000019378; ENSCAFP00000017975; ENSCAFG00000012206
GeneIDi403964
KEGGicfa:403964

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14048 mRNA Translation: CAA32206.1
PIRiA30341
RefSeqiNP_001003281.1, NM_001003281.2
XP_005635961.1, XM_005635904.2
XP_005635962.1, XM_005635905.2
XP_005635963.1, XM_005635906.2
UniGeneiCfa.3822

3D structure databases

ProteinModelPortaliP11613
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000017975

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP11613

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000019378; ENSCAFP00000017975; ENSCAFG00000012206
GeneIDi403964
KEGGicfa:403964

Organism-specific databases

CTDi57007
VGNCiVGNC:37509 ACKR3

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000261660
HOVERGENiHBG106832
InParanoidiP11613
KOiK04304
OMAiYIPFTCQ
OrthoDBiEOG091G091W
TreeFamiTF333489

Enzyme and pathway databases

ReactomeiR-CFA-380108 Chemokine receptors bind chemokines
R-CFA-418594 G alpha (i) signalling events

Gene expression databases

BgeeiENSCAFG00000012206 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDicd14987 7tmA_ACKR3_CXCR7, 1 hit
InterProiView protein in InterPro
IPR001416 ACKR3
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR44720 PTHR44720, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00646 RDC1ORPHANR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACKR3_CANLF
AccessioniPrimary (citable) accession number: P11613
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again