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Protein

Antigen-presenting glycoprotein CD1d1

Gene

Cd1d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.3 Publications

Miscellaneous

During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98GlycolipidCombined sources3 Publications1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Antigen-presenting glycoprotein CD1d1
Alternative name(s):
CD_antigen: CD1d.1
Gene namesi
Name:Cd1d1
Synonyms:Cd1.1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107674 Cd1d1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 305ExtracellularSequence analysisAdd BLAST284
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 336CytoplasmicSequence analysis10

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001459122 – 336Antigen-presenting glycoprotein CD1d1Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi38N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi60N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi122 ↔ 186Combined sources5 Publications
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi226 ↔ 281Combined sources5 Publications

Post-translational modificationi

N-glycosylated.5 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP11609
PaxDbiP11609
PeptideAtlasiP11609
PRIDEiP11609

PTM databases

iPTMnetiP11609
PhosphoSitePlusiP11609
SwissPalmiP11609

Expressioni

Tissue specificityi

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Gene expression databases

CleanExiMM_CD1D1

Interactioni

Subunit structurei

Heterodimer with B2M (beta-2-microglobulin). Interacts with MHC II and CD74.6 Publications

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-6127N
IntActiP11609, 1 interactor
STRINGi10090.ENSMUSP00000029717

Structurei

Secondary structure

1336
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP11609
SMRiP11609
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11609

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 297Ig-likeAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni171 – 174Glycolipid bindingCombined sources4 Publications4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi332 – 335Internalization signal4

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITUC Eukaryota
ENOG4111EG6 LUCA
HOGENOMiHOG000111666
HOVERGENiHBG004453
InParanoidiP11609
KOiK06448
PhylomeDBiP11609
TreeFamiTF336723

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF16497 MHC_I_3, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P11609-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRYLPWLLLW AFLQVWGQSE AQQKNYTFRC LQMSSFANRS WSRTDSVVWL
60 70 80 90 100
GDLQTHRWSN DSATISFTKP WSQGKLSNQQ WEKLQHMFQV YRVSFTRDIQ
110 120 130 140 150
ELVKMMSPKE DYPIEIQLSA GCEMYPGNAS ESFLHVAFQG KYVVRFWGTS
160 170 180 190 200
WQTVPGAPSW LDLPIKVLNA DQGTSATVQM LLNDTCPLFV RGLLEAGKSD
210 220 230 240 250
LEKQEKPVAW LSSVPSSADG HRQLVCHVSG FYPKPVWVMW MRGDQEQQGT
260 270 280 290 300
HRGDFLPNAD ETWYLQATLD VEAGEEAGLA CRVKHSSLGG QDIILYWDAR
310 320 330
QAPVGLIVFI VLIMLVVVGA VVYYIWRRRS AYQDIR
Length:336
Mass (Da):38,554
Last modified:December 15, 1998 - v3
Checksum:iE4A666E1942E0114
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q395E9Q395_MOUSE
Antigen-presenting glycoprotein CD1...
Cd1d1
205Annotation score:
A0A0R4J090A0A0R4J090_MOUSE
Antigen-presenting glycoprotein CD1...
Cd1d1 mCG_3074
336Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219D → H in BAB22206 (PubMed:16141072).Curated1
Sequence conflicti219D → H in CAA31568 (PubMed:2460336).Curated1
Sequence conflicti240W → C in AAA37391 (PubMed:1702817).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63695 mRNA Translation: AAA37391.1
AK002582 mRNA Translation: BAB22206.1
X13170 Genomic DNA Translation: CAA31568.1
CCDSiCCDS17449.1
PIRiI49581
S01297
RefSeqiNP_031665.2, NM_007639.3
UniGeneiMm.1894

Genome annotation databases

GeneIDi12479
KEGGimmu:12479
UCSCiuc012cre.1 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD1d1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63695 mRNA Translation: AAA37391.1
AK002582 mRNA Translation: BAB22206.1
X13170 Genomic DNA Translation: CAA31568.1
CCDSiCCDS17449.1
PIRiI49581
S01297
RefSeqiNP_031665.2, NM_007639.3
UniGeneiMm.1894

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CD1X-ray2.67A/C22-336[»]
1Z5LX-ray2.20A/C19-297[»]
1ZHNX-ray2.80A25-297[»]
2AKRX-ray1.90A/C19-297[»]
2FIKX-ray1.80A19-297[»]
2GAZX-ray2.61A19-297[»]
2Q7YX-ray1.95A/C19-297[»]
3ARBX-ray2.70A19-297[»]
3ARDX-ray3.01A19-297[»]
3AREX-ray2.80A19-297[»]
3ARFX-ray2.90A19-297[»]
3ARGX-ray3.00A19-297[»]
3AU1X-ray2.50A19-297[»]
3G08X-ray1.60A19-297[»]
3GMLX-ray1.70A19-297[»]
3GMMX-ray1.80A19-297[»]
3GMNX-ray1.70A19-297[»]
3GMOX-ray1.60A19-297[»]
3GMPX-ray1.70A19-297[»]
3GMQX-ray1.80A19-297[»]
3GMRX-ray1.90A19-297[»]
3HE6X-ray2.90A19-297[»]
3HE7X-ray2.80A19-297[»]
3ILPX-ray1.85A19-297[»]
3ILQX-ray2.05C19-297[»]
3MA7X-ray2.29A/C19-297[»]
3O8XX-ray2.74A19-297[»]
3O9WX-ray2.80A19-297[»]
3QI9X-ray2.30A19-297[»]
3QUXX-ray2.91A19-297[»]
3QUYX-ray2.25A19-297[»]
3QUZX-ray2.30A19-297[»]
3RTQX-ray2.80A19-297[»]
3RUGX-ray2.20A/C19-297[»]
3RZCX-ray2.80A19-297[»]
3SCMX-ray2.50A19-297[»]
3SDAX-ray2.80A19-297[»]
3SDCX-ray3.10A19-297[»]
3SDDX-ray3.00A19-297[»]
3T1FX-ray1.70A19-297[»]
3TA3X-ray2.70A19-297[»]
3TN0X-ray3.20A19-297[»]
3TO4X-ray3.10A19-297[»]
3TVMX-ray2.80A/E19-297[»]
3UBXX-ray3.10A/D19-297[»]
4APQX-ray3.00A19-297[»]
4EI5X-ray3.10A/E19-297[»]
4ELMX-ray3.48A/C19-297[»]
4IRJX-ray3.00A19-297[»]
4IRSX-ray2.80A19-297[»]
4MNGX-ray3.01A/C204-297[»]
4MQ7X-ray2.60A205-297[»]
4MX7X-ray2.24A19-297[»]
4Y16X-ray2.60A19-297[»]
4Y2DX-ray3.05A/E19-297[»]
4Y4FX-ray3.19A/E19-297[»]
4Y4HX-ray3.10A/E19-297[»]
4Y4KX-ray2.90A19-297[»]
4ZAKX-ray2.82A19-297[»]
5EFIX-ray1.80A19-297[»]
5FKPX-ray1.80A19-297[»]
5TW2X-ray1.75A19-297[»]
5TW5X-ray1.85A19-297[»]
5VCJX-ray3.16A19-297[»]
ProteinModelPortaliP11609
SMRiP11609
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6127N
IntActiP11609, 1 interactor
STRINGi10090.ENSMUSP00000029717

PTM databases

iPTMnetiP11609
PhosphoSitePlusiP11609
SwissPalmiP11609

Proteomic databases

MaxQBiP11609
PaxDbiP11609
PeptideAtlasiP11609
PRIDEiP11609

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12479
KEGGimmu:12479
UCSCiuc012cre.1 mouse

Organism-specific databases

CTDi12479
MGIiMGI:107674 Cd1d1

Phylogenomic databases

eggNOGiENOG410ITUC Eukaryota
ENOG4111EG6 LUCA
HOGENOMiHOG000111666
HOVERGENiHBG004453
InParanoidiP11609
KOiK06448
PhylomeDBiP11609
TreeFamiTF336723

Miscellaneous databases

EvolutionaryTraceiP11609
PROiPR:P11609
SOURCEiSearch...

Gene expression databases

CleanExiMM_CD1D1

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF16497 MHC_I_3, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD1D1_MOUSE
AccessioniPrimary (citable) accession number: P11609
Secondary accession number(s): Q91XK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: December 15, 1998
Last modified: November 7, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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