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UniProtKB - P11609 (CD1D1_MOUSE)
Protein
Antigen-presenting glycoprotein CD1d1
Gene
Cd1d1
Organism
Mus musculus (Mouse)
Status
Functioni
Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.
3 PublicationsMiscellaneous
During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 98 | GalactosylceramideCombined sources3 Publications | 1 |
GO - Molecular functioni
- cell adhesion molecule binding Source: MGI
- endogenous lipid antigen binding Source: MGI
- exogenous lipid antigen binding Source: MGI
- histone binding Source: MGI
- lipid antigen binding Source: MGI
- lipopeptide binding Source: GO_Central
- T cell receptor binding Source: MGI
GO - Biological processi
- antigen processing and presentation Source: MGI
- antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: MGI
- antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: MGI
- innate immune response Source: UniProtKB-KW
- NK T cell differentiation Source: CACAO
- positive regulation of interferon-gamma production Source: MGI
- positive regulation of interleukin-2 production Source: MGI
- positive regulation of interleukin-4 production Source: MGI
- positive regulation of macrophage activation Source: MGI
- positive regulation of NK T cell activation Source: MGI
- positive regulation of NK T cell differentiation Source: MGI
- positive regulation of T cell mediated cytotoxicity Source: MGI
- positive regulation of T cell proliferation Source: MGI
- positive thymic T cell selection Source: MGI
- regulation of immature T cell proliferation in thymus Source: CACAO
- regulation of immune response Source: MGI
Keywordsi
Biological process | Immunity, Innate immunity |
Enzyme and pathway databases
Reactomei | R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Names & Taxonomyi
Protein namesi | Recommended name: Antigen-presenting glycoprotein CD1d1Alternative name(s): CD_antigen: CD1d.1 |
Gene namesi | Name:Cd1d1 Synonyms:Cd1.1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107674, Cd1d1 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Endosome
- Endosome membrane 1 Publication
Lysosome
- Lysosome membrane 1 Publication
Note: Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
Endosome
- early endosome Source: MGI
- endosome membrane Source: UniProtKB-SubCell
- late endosome Source: MGI
Extracellular region or secreted
- extracellular space Source: GO_Central
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
- lysosome Source: MGI
Plasma Membrane
- external side of plasma membrane Source: MGI
Other locations
- cell surface Source: MGI
- cytoplasm Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 305 | ExtracellularSequence analysisAdd BLAST | 284 | |
Transmembranei | 306 – 326 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 327 – 336 | CytoplasmicSequence analysis | 10 |
Keywords - Cellular componenti
Cell membrane, Endosome, Lysosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000014591 | 22 – 336 | Antigen-presenting glycoprotein CD1d1Add BLAST | 315 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 38 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Glycosylationi | 60 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Disulfide bondi | 122 ↔ 186 | Combined sources5 Publications | ||
Glycosylationi | 128 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 183 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Disulfide bondi | 226 ↔ 281 | Combined sources5 Publications |
Post-translational modificationi
N-glycosylated.5 Publications
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P11609 |
MaxQBi | P11609 |
PaxDbi | P11609 |
PeptideAtlasi | P11609 |
PRIDEi | P11609 |
ProteomicsDBi | 265621 |
PTM databases
GlyConnecti | 2130, 1 N-Linked glycan (1 site) |
GlyGeni | P11609, 5 sites, 1 N-linked glycan (1 site) |
iPTMneti | P11609 |
PhosphoSitePlusi | P11609 |
SwissPalmi | P11609 |
Expressioni
Tissue specificityi
Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
Interactioni
Subunit structurei
Heterodimer with B2M (beta-2-microglobulin).
Interacts with MHC II and CD74.
6 PublicationsGO - Molecular functioni
- cell adhesion molecule binding Source: MGI
- histone binding Source: MGI
- T cell receptor binding Source: MGI
Protein-protein interaction databases
DIPi | DIP-6127N |
IntActi | P11609, 1 interactor |
STRINGi | 10090.ENSMUSP00000029717 |
Miscellaneous databases
RNActi | P11609, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P11609 |
SMRi | P11609 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P11609 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 207 – 297 | Ig-likeAdd BLAST | 91 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 171 – 174 | Galactosylceramide bindingCombined sources4 Publications | 4 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 332 – 335 | Internalization signal | 4 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SJH6, Eukaryota |
InParanoidi | P11609 |
OrthoDBi | 827472at2759 |
PhylomeDBi | P11609 |
TreeFami | TF336723 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF16497, MHC_I_3, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P11609-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRYLPWLLLW AFLQVWGQSE AQQKNYTFRC LQMSSFANRS WSRTDSVVWL
60 70 80 90 100
GDLQTHRWSN DSATISFTKP WSQGKLSNQQ WEKLQHMFQV YRVSFTRDIQ
110 120 130 140 150
ELVKMMSPKE DYPIEIQLSA GCEMYPGNAS ESFLHVAFQG KYVVRFWGTS
160 170 180 190 200
WQTVPGAPSW LDLPIKVLNA DQGTSATVQM LLNDTCPLFV RGLLEAGKSD
210 220 230 240 250
LEKQEKPVAW LSSVPSSADG HRQLVCHVSG FYPKPVWVMW MRGDQEQQGT
260 270 280 290 300
HRGDFLPNAD ETWYLQATLD VEAGEEAGLA CRVKHSSLGG QDIILYWDAR
310 320 330
QAPVGLIVFI VLIMLVVVGA VVYYIWRRRS AYQDIR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J090 | A0A0R4J090_MOUSE | Antigen-presenting glycoprotein CD1... | Cd1d1 | 336 | Annotation score: | ||
E9Q395 | E9Q395_MOUSE | Antigen-presenting glycoprotein CD1... | Cd1d1 | 205 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 219 | D → H in BAB22206 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 219 | D → H in CAA31568 (PubMed:2460336).Curated | 1 | |
Sequence conflicti | 240 | W → C in AAA37391 (PubMed:1702817).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63695 mRNA Translation: AAA37391.1 AK002582 mRNA Translation: BAB22206.1 X13170 Genomic DNA Translation: CAA31568.1 |
CCDSi | CCDS17449.1 |
PIRi | I49581 S01297 |
RefSeqi | NP_031665.2, NM_007639.3 |
Genome annotation databases
GeneIDi | 12479 |
KEGGi | mmu:12479 |
UCSCi | uc012cre.1, mouse |
Similar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding CD1d1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63695 mRNA Translation: AAA37391.1 AK002582 mRNA Translation: BAB22206.1 X13170 Genomic DNA Translation: CAA31568.1 |
CCDSi | CCDS17449.1 |
PIRi | I49581 S01297 |
RefSeqi | NP_031665.2, NM_007639.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CD1 | X-ray | 2.67 | A/C | 22-336 | [»] | |
1Z5L | X-ray | 2.20 | A/C | 19-297 | [»] | |
1ZHN | X-ray | 2.80 | A | 25-297 | [»] | |
2AKR | X-ray | 1.90 | A/C | 19-297 | [»] | |
2FIK | X-ray | 1.80 | A | 19-297 | [»] | |
2GAZ | X-ray | 2.61 | A | 19-297 | [»] | |
2Q7Y | X-ray | 1.95 | A/C | 19-297 | [»] | |
3ARB | X-ray | 2.70 | A | 19-297 | [»] | |
3ARD | X-ray | 3.01 | A | 19-297 | [»] | |
3ARE | X-ray | 2.80 | A | 19-297 | [»] | |
3ARF | X-ray | 2.90 | A | 19-297 | [»] | |
3ARG | X-ray | 3.00 | A | 19-297 | [»] | |
3AU1 | X-ray | 2.50 | A | 19-297 | [»] | |
3G08 | X-ray | 1.60 | A | 19-297 | [»] | |
3GML | X-ray | 1.70 | A | 19-297 | [»] | |
3GMM | X-ray | 1.80 | A | 19-297 | [»] | |
3GMN | X-ray | 1.70 | A | 19-297 | [»] | |
3GMO | X-ray | 1.60 | A | 19-297 | [»] | |
3GMP | X-ray | 1.70 | A | 19-297 | [»] | |
3GMQ | X-ray | 1.80 | A | 19-297 | [»] | |
3GMR | X-ray | 1.90 | A | 19-297 | [»] | |
3HE6 | X-ray | 2.90 | A | 19-297 | [»] | |
3HE7 | X-ray | 2.80 | A | 19-297 | [»] | |
3ILP | X-ray | 1.85 | A | 19-297 | [»] | |
3ILQ | X-ray | 2.05 | C | 19-297 | [»] | |
3MA7 | X-ray | 2.29 | A/C | 19-297 | [»] | |
3O8X | X-ray | 2.74 | A | 19-297 | [»] | |
3O9W | X-ray | 2.80 | A | 19-297 | [»] | |
3QI9 | X-ray | 2.30 | A | 19-297 | [»] | |
3QUX | X-ray | 2.91 | A | 19-297 | [»] | |
3QUY | X-ray | 2.25 | A | 19-297 | [»] | |
3QUZ | X-ray | 2.30 | A | 19-297 | [»] | |
3RTQ | X-ray | 2.80 | A | 19-297 | [»] | |
3RUG | X-ray | 2.20 | A/C | 19-297 | [»] | |
3RZC | X-ray | 2.80 | A | 19-297 | [»] | |
3SCM | X-ray | 2.50 | A | 19-297 | [»] | |
3SDA | X-ray | 2.80 | A | 19-297 | [»] | |
3SDC | X-ray | 3.10 | A | 19-297 | [»] | |
3SDD | X-ray | 3.00 | A | 19-297 | [»] | |
3T1F | X-ray | 1.70 | A | 19-297 | [»] | |
3TA3 | X-ray | 2.70 | A | 19-297 | [»] | |
3TN0 | X-ray | 3.20 | A | 19-297 | [»] | |
3TO4 | X-ray | 3.10 | A | 19-297 | [»] | |
3TVM | X-ray | 2.80 | A/E | 19-297 | [»] | |
3UBX | X-ray | 3.10 | A/D | 19-297 | [»] | |
4APQ | X-ray | 3.00 | A | 19-297 | [»] | |
4EI5 | X-ray | 3.10 | A/E | 19-297 | [»] | |
4ELM | X-ray | 3.48 | A/C | 19-297 | [»] | |
4IRJ | X-ray | 3.00 | A | 19-297 | [»] | |
4IRS | X-ray | 2.80 | A | 19-297 | [»] | |
4MNG | X-ray | 3.01 | A/C | 204-297 | [»] | |
4MQ7 | X-ray | 2.60 | A | 205-297 | [»] | |
4MX7 | X-ray | 2.24 | A | 19-297 | [»] | |
4Y16 | X-ray | 2.60 | A | 19-297 | [»] | |
4Y2D | X-ray | 3.05 | A/E | 19-297 | [»] | |
4Y4F | X-ray | 3.19 | A/E | 19-297 | [»] | |
4Y4H | X-ray | 3.10 | A/E | 19-297 | [»] | |
4Y4K | X-ray | 2.90 | A | 19-297 | [»] | |
4ZAK | X-ray | 2.82 | A | 19-297 | [»] | |
5EFI | X-ray | 1.80 | A | 19-297 | [»] | |
5FKP | X-ray | 1.80 | A | 19-297 | [»] | |
5TW2 | X-ray | 1.75 | A | 19-297 | [»] | |
5TW5 | X-ray | 1.85 | A | 19-297 | [»] | |
5VCJ | X-ray | 3.16 | A | 19-297 | [»] | |
6BNK | X-ray | 3.20 | A/E | 19-297 | [»] | |
6BNL | X-ray | 2.60 | A/E | 19-297 | [»] | |
6C5M | X-ray | 2.45 | A | 19-297 | [»] | |
6C69 | X-ray | 1.94 | A | 19-297 | [»] | |
6C6A | X-ray | 2.45 | A | 19-297 | [»] | |
6C6C | X-ray | 2.08 | A | 19-297 | [»] | |
6C6E | X-ray | 2.18 | A | 19-297 | [»] | |
6C6F | X-ray | 1.67 | A | 19-297 | [»] | |
6C6H | X-ray | 2.00 | A | 19-297 | [»] | |
6C6J | X-ray | 1.79 | A | 19-297 | [»] | |
6CW6 | X-ray | 2.85 | A | 19-297 | [»] | |
6CW9 | X-ray | 2.00 | A | 24-297 | [»] | |
6CWB | X-ray | 2.85 | A | 19-297 | [»] | |
6CWE | X-ray | 2.20 | A | 19-297 | [»] | |
6CX5 | X-ray | 2.40 | A | 19-297 | [»] | |
6CX7 | X-ray | 2.60 | A | 19-297 | [»] | |
6CX9 | X-ray | 2.36 | A | 19-297 | [»] | |
6CXA | X-ray | 2.65 | A | 19-297 | [»] | |
6CXE | X-ray | 2.05 | A | 19-297 | [»] | |
6CXF | X-ray | 2.50 | A | 19-297 | [»] | |
6CYW | X-ray | 1.95 | A | 19-297 | [»] | |
6MIV | X-ray | 2.05 | A | 19-297 | [»] | |
6MIY | X-ray | 2.75 | A/E | 19-297 | [»] | |
6MJ4 | X-ray | 2.00 | A | 19-297 | [»] | |
6MJ6 | X-ray | 2.45 | A | 19-297 | [»] | |
6MJA | X-ray | 2.35 | A | 19-297 | [»] | |
6MJI | X-ray | 2.30 | A | 19-297 | [»] | |
6MJJ | X-ray | 1.93 | A | 19-297 | [»] | |
6MJQ | X-ray | 3.00 | A/E | 19-297 | [»] | |
6MSS | X-ray | 3.00 | C | 19-297 | [»] | |
6OJP | X-ray | 2.17 | A | 19-297 | [»] | |
6OMG | X-ray | 2.10 | A | 19-297 | [»] | |
6OOR | X-ray | 2.45 | A | 19-297 | [»] | |
6XNG | X-ray | 2.79 | A | 19-297 | [»] | |
7M72 | X-ray | 2.40 | A | 19-297 | [»] | |
AlphaFoldDBi | P11609 | |||||
SMRi | P11609 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-6127N |
IntActi | P11609, 1 interactor |
STRINGi | 10090.ENSMUSP00000029717 |
Chemistry databases
ChEMBLi | CHEMBL4523182 |
PTM databases
GlyConnecti | 2130, 1 N-Linked glycan (1 site) |
GlyGeni | P11609, 5 sites, 1 N-linked glycan (1 site) |
iPTMneti | P11609 |
PhosphoSitePlusi | P11609 |
SwissPalmi | P11609 |
Proteomic databases
jPOSTi | P11609 |
MaxQBi | P11609 |
PaxDbi | P11609 |
PeptideAtlasi | P11609 |
PRIDEi | P11609 |
ProteomicsDBi | 265621 |
Protocols and materials databases
ABCDi | P11609, 2 sequenced antibodies |
DNASUi | 12479 |
Genome annotation databases
GeneIDi | 12479 |
KEGGi | mmu:12479 |
UCSCi | uc012cre.1, mouse |
Organism-specific databases
CTDi | 12479 |
MGIi | MGI:107674, Cd1d1 |
Phylogenomic databases
eggNOGi | ENOG502SJH6, Eukaryota |
InParanoidi | P11609 |
OrthoDBi | 827472at2759 |
PhylomeDBi | P11609 |
TreeFami | TF336723 |
Enzyme and pathway databases
Reactomei | R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Miscellaneous databases
BioGRID-ORCSi | 12479, 1 hit in 75 CRISPR screens |
EvolutionaryTracei | P11609 |
PROi | PR:P11609 |
RNActi | P11609, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF16497, MHC_I_3, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CD1D1_MOUSE | |
Accessioni | P11609Primary (citable) accession number: P11609 Secondary accession number(s): Q91XK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | December 15, 1998 | |
Last modified: | May 25, 2022 | |
This is version 197 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references