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Entry version 194 (16 Oct 2019)
Sequence version 2 (19 Jul 2005)
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Protein

Cholesteryl ester transfer protein

Gene

CETP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).1 Publication1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8964041 LDL remodeling
R-HSA-8964058 HDL remodeling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P11597

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.40.1.8 the bactericidal permeability increasing protein (bpip) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000472

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cholesteryl ester transfer protein1 Publication
Alternative name(s):
Lipid transfer protein IImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CETPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1869 CETP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
118470 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11597

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hyperalphalipoproteinemia 1 (HALP1)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033099168L → P in HALP1; reduced secretion into plasma. 1 Publication1
Natural variantiVAR_033100299R → C in HALP1; reduced secretion into plasma. 1 PublicationCorresponds to variant dbSNP:rs142459781Ensembl.1
Natural variantiVAR_004172459D → G in HALP1. 1 PublicationCorresponds to variant dbSNP:rs2303790EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi155T → Y: Reduces triglyceride transfer and cholesteryl ester transfer 5-fold. 1 Publication1
Mutagenesisi215V → W: Reduces triglyceride transfer 10-fold. No effect on cholesteryl ester transfer. 1 Publication1
Mutagenesisi218R → S: Reduces triglyceride transfer 10-fold. Slight reduction of cholesteryl ester transfer. 1 Publication1
Mutagenesisi247S → A: Reduces triglyceride transfer 5-fold. Slight reduction of cholesteryl ester transfer. 1 Publication1
Mutagenesisi282F → R: Not secreted. 1 Publication1
Mutagenesisi287F → R: Not secreted. 1 Publication1
Mutagenesisi309F → D: Not secreted. 1 Publication1
Mutagenesisi313L → Q: Reduces cholesteryl ester transfer by 60%. 1 Publication1
Mutagenesisi392Y → S: Not secreted. 1 Publication1
Mutagenesisi399L → W: Not secreted. 1 Publication1
Mutagenesisi433V → R: Reduces activity by 60%. 1 Publication1

Keywords - Diseasei

Atherosclerosis, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1071

MalaCards human disease database

More...
MalaCardsi
CETP
MIMi143470 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000087237

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79506 Cholesterol-ester transfer protein deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA108

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P11597

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3572

Drug and drug target database

More...
DrugBanki
DB06281 Torcetrapib

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CETP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153497

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Add BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001715518 – 493Cholesteryl ester transfer proteinAdd BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi105N-linked (GlcNAc...) (complex) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi160 ↔ 2011 Publication
Glycosylationi257N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi358N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi413N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P11597

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11597

PeptideAtlas

More...
PeptideAtlasi
P11597

PRoteomics IDEntifications database

More...
PRIDEi
P11597

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52795 [P11597-1]
52796 [P11597-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1927

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11597

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P11597

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P11597

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000087237 Expressed in 94 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P11597 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P11597 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107498, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P11597, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000200676

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P11597

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1493
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11597

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P11597

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4160 Eukaryota
ENOG410Z88E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182632

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111553

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11597

KEGG Orthology (KO)

More...
KOi
K16835

Identification of Orthologs from Complete Genome Data

More...
OMAi
YGYAGAW

Database of Orthologous Groups

More...
OrthoDBi
484128at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11597

TreeFam database of animal gene trees

More...
TreeFami
TF333484

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR017130 Cholesteryl_ester_transfer
IPR001124 Lipid-bd_serum_glycop_C
IPR017954 Lipid-bd_serum_glycop_CS
IPR017942 Lipid-bd_serum_glycop_N

The PANTHER Classification System

More...
PANTHERi
PTHR47616 PTHR47616, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037185 Cholesteryl_ester_transf, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55394 SSF55394, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00400 LBP_BPI_CETP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P11597-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLAATVLTLA LLGNAHACSK GTSHEAGIVC RITKPALLVL NHETAKVIQT
60 70 80 90 100
AFQRASYPDI TGEKAMMLLG QVKYGLHNIQ ISHLSIASSQ VELVEAKSID
110 120 130 140 150
VSIQNVSVVF KGTLKYGYTT AWWLGIDQSI DFEIDSAIDL QINTQLTCDS
160 170 180 190 200
GRVRTDAPDC YLSFHKLLLH LQGEREPGWI KQLFTNFISF TLKLVLKGQI
210 220 230 240 250
CKEINVISNI MADFVQTRAA SILSDGDIGV DISLTGDPVI TASYLESHHK
260 270 280 290 300
GHFIYKNVSE DLPLPTFSPT LLGDSRMLYF WFSERVFHSL AKVAFQDGRL
310 320 330 340 350
MLSLMGDEFK AVLETWGFNT NQEIFQEVVG GFPSQAQVTV HCLKMPKISC
360 370 380 390 400
QNKGVVVNSS VMVKFLFPRP DQQHSVAYTF EEDIVTTVQA SYSKKKLFLS
410 420 430 440 450
LLDFQITPKT VSNLTESSSE SVQSFLQSMI TAVGIPEVMS RLEVVFTALM
460 470 480 490
NSKGVSLFDI INPEIITRDG FLLLQMDFGF PEHLLVDFLQ SLS
Length:493
Mass (Da):54,756
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD7762766A9B062E
GO
Isoform 2 (identifier: P11597-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-310: Missing.

Show »
Length:433
Mass (Da):47,787
Checksum:iED675FD1456F78F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRJ9H3BRJ9_HUMAN
Cholesteryl ester transfer protein
CETP
428Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in CETP define the high density lipoprotein cholesterol level quantitative trait locus 10 (HDLCQ10) [MIMi:143470].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01701815A → G1 PublicationCorresponds to variant dbSNP:rs34065661EnsemblClinVar.1
Natural variantiVAR_033098154R → W. Corresponds to variant dbSNP:rs34716057EnsemblClinVar.1
Natural variantiVAR_033099168L → P in HALP1; reduced secretion into plasma. 1 Publication1
Natural variantiVAR_033100299R → C in HALP1; reduced secretion into plasma. 1 PublicationCorresponds to variant dbSNP:rs142459781Ensembl.1
Natural variantiVAR_013919331G → S1 PublicationCorresponds to variant dbSNP:rs5881EnsemblClinVar.1
Natural variantiVAR_017019385V → M1 PublicationCorresponds to variant dbSNP:rs34855278EnsemblClinVar.1
Natural variantiVAR_013920390A → P2 PublicationsCorresponds to variant dbSNP:rs5880EnsemblClinVar.1
Natural variantiVAR_013921422V → I6 PublicationsCorresponds to variant dbSNP:rs5882EnsemblClinVar.1
Natural variantiVAR_031127455V → M. Corresponds to variant dbSNP:rs2228667Ensembl.1
Natural variantiVAR_004172459D → G in HALP1. 1 PublicationCorresponds to variant dbSNP:rs2303790EnsemblClinVar.1
Natural variantiVAR_013922468R → Q1 PublicationCorresponds to variant dbSNP:rs1800777EnsemblClinVar.1
Natural variantiVAR_013923486V → M1 PublicationCorresponds to variant dbSNP:rs5887Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023645251 – 310Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M30185 mRNA Translation: AAA51977.1
M32998
, M32992, M32993, M32994, M32995, M32996, M32997 Genomic DNA Translation: AAA51978.1
AY422211 Genomic DNA Translation: AAR03500.1
BC025739 mRNA Translation: AAH25739.1
U71187 Genomic DNA Translation: AAD14876.1
AF027656 Genomic DNA Translation: AAB86604.1
M83573 mRNA Translation: AAB59388.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10772.1 [P11597-1]
CCDS67032.1 [P11597-2]

Protein sequence database of the Protein Information Resource

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PIRi
A26941

NCBI Reference Sequences

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RefSeqi
NP_000069.2, NM_000078.2 [P11597-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000200676; ENSP00000200676; ENSG00000087237 [P11597-1]
ENST00000379780; ENSP00000369106; ENSG00000087237 [P11597-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1071

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1071

UCSC genome browser

More...
UCSCi
uc002eki.3 human [P11597-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Cholesterylester transfer protein entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30185 mRNA Translation: AAA51977.1
M32998
, M32992, M32993, M32994, M32995, M32996, M32997 Genomic DNA Translation: AAA51978.1
AY422211 Genomic DNA Translation: AAR03500.1
BC025739 mRNA Translation: AAH25739.1
U71187 Genomic DNA Translation: AAD14876.1
AF027656 Genomic DNA Translation: AAB86604.1
M83573 mRNA Translation: AAB59388.1
CCDSiCCDS10772.1 [P11597-1]
CCDS67032.1 [P11597-2]
PIRiA26941
RefSeqiNP_000069.2, NM_000078.2 [P11597-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OBDX-ray2.10A18-493[»]
4EWSX-ray2.59A18-493[»]
4F2AX-ray3.11A18-493[»]
SMRiP11597
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107498, 3 interactors
IntActiP11597, 3 interactors
STRINGi9606.ENSP00000200676

Chemistry databases

BindingDBiP11597
ChEMBLiCHEMBL3572
DrugBankiDB06281 Torcetrapib
SwissLipidsiSLP:000000472

Protein family/group databases

TCDBi1.C.40.1.8 the bactericidal permeability increasing protein (bpip) family

PTM databases

GlyConnecti1927
iPTMnetiP11597
PhosphoSitePlusiP11597
SwissPalmiP11597

Polymorphism and mutation databases

BioMutaiCETP
DMDMi71153497

Proteomic databases

MassIVEiP11597
PaxDbiP11597
PeptideAtlasiP11597
PRIDEiP11597
ProteomicsDBi52795 [P11597-1]
52796 [P11597-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1071

Genome annotation databases

EnsembliENST00000200676; ENSP00000200676; ENSG00000087237 [P11597-1]
ENST00000379780; ENSP00000369106; ENSG00000087237 [P11597-2]
GeneIDi1071
KEGGihsa:1071
UCSCiuc002eki.3 human [P11597-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1071
DisGeNETi1071

GeneCards: human genes, protein and diseases

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GeneCardsi
CETP
HGNCiHGNC:1869 CETP
MalaCardsiCETP
MIMi118470 gene
143470 phenotype
neXtProtiNX_P11597
OpenTargetsiENSG00000087237
Orphaneti79506 Cholesterol-ester transfer protein deficiency
PharmGKBiPA108

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00950000182632
HOGENOMiHOG000111553
InParanoidiP11597
KOiK16835
OMAiYGYAGAW
OrthoDBi484128at2759
PhylomeDBiP11597
TreeFamiTF333484

Enzyme and pathway databases

ReactomeiR-HSA-8964041 LDL remodeling
R-HSA-8964058 HDL remodeling
SIGNORiP11597

Miscellaneous databases

EvolutionaryTraceiP11597

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Cholesterylester_transfer_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1071
PharosiP11597

Protein Ontology

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PROi
PR:P11597

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000087237 Expressed in 94 organ(s), highest expression level in liver
ExpressionAtlasiP11597 baseline and differential
GenevisibleiP11597 HS

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR017130 Cholesteryl_ester_transfer
IPR001124 Lipid-bd_serum_glycop_C
IPR017954 Lipid-bd_serum_glycop_CS
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR47616 PTHR47616, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
PIRSFiPIRSF037185 Cholesteryl_ester_transf, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits
PROSITEiView protein in PROSITE
PS00400 LBP_BPI_CETP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCETP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11597
Secondary accession number(s): Q13987, Q13988, Q53YZ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 19, 2005
Last modified: October 16, 2019
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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