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Protein

Female-specific protein transformer

Gene

tra

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Member of the regulatory pathway controlling female somatic sexual differentiation, regulated by Sxl. Activates dsx female-specific splicing by promoting the formation of a splicing enhancer complex which consists of tra, tra2 and sr proteins. Together with tra-2, plays a role in switching fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. No known function in males.2 Publications

Miscellaneous

The sexual regulation of tra occurs through a mechanism of sex-specific alternative RNA splicing. The non-sex-specific RNA expressed in males is not translated.

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.Curated

GO - Molecular functioni

  • pre-mRNA binding Source: FlyBase

GO - Biological processi

Keywordsi

Biological processDifferentiation, Sexual differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Female-specific protein transformer
Gene namesi
Name:tra
ORF Names:CG16724
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0003741 tra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000656451 – 197Female-specific protein transformerAdd BLAST197

Proteomic databases

PaxDbiP11596
PRIDEiP11596

Expressioni

Gene expression databases

BgeeiFBgn0003741 Expressed in 30 organ(s), highest expression level in head
ExpressionAtlasiP11596 baseline and differential
GenevisibleiP11596 DM

Interactioni

Protein-protein interaction databases

BioGridi65151, 13 interactors
STRINGi7227.FBpp0075123

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 125Arg/Ser-rich (RS domain)Add BLAST111

Domaini

RS domain directs localization of proteins to the speckled subnuclear compartment and the purpose of this localization is to allow colocalization and co-concentration of components of the splicing and splicing regulatory machinery to permit relatively high rates and/or efficiencies of reaction and interaction.

Phylogenomic databases

InParanoidiP11596
OrthoDBiEOG091G194U

Family and domain databases

InterProiView protein in InterPro
IPR010519 Tra
PfamiView protein in Pfam
PF06495 Transformer, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P11596-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMDADSSGT QHRDSRGSRS RSRREREYHG RSSERDSRKK EHKIPYFADE
60 70 80 90 100
VREQDRLRRL RQRAHQSTRR TRSRSRSQSS IRESRHRRHR QRSRSRNRSR
110 120 130 140 150
SRSSERKRRQ RSRSRSSERR RRQRSPHRYN PPPKIINYYV QVPPQDFYGM
160 170 180 190
SGMQQSFGYQ RLPRPPPFPP APYRYRQRPP FIGVPRFGYR NAGRPPY
Length:197
Mass (Da):24,134
Last modified:January 1, 1990 - v1
Checksum:i10C0B7A6F0C1AF81
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q59E32Q59E32_DROME
Transformer, isoform B
tra Dmel\CG16724, Dmtra, TRA, Tra, CG16724
36Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99S → N in AAF49441 (PubMed:10731132).Curated1
Sequence conflicti111R → H in AAF49441 (PubMed:10731132).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti94R → M in strain: 14021-0231.6. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17478 Genomic DNA Translation: AAB59226.1
L19464 Genomic DNA Translation: AAA75340.1
L19465 Genomic DNA Translation: AAA75341.1
L19466 Genomic DNA Translation: AAA75342.1
L19467 Genomic DNA Translation: AAA28958.1
L19468 Genomic DNA Translation: AAA28959.1
L19469 Genomic DNA Translation: AAA28960.1
L19470 Genomic DNA Translation: AAA28961.1
L19618 Genomic DNA Translation: AAA28962.1
L19619 Genomic DNA Translation: AAA28963.1
L19620 Genomic DNA Translation: AAA28964.1
AY183383 Genomic DNA Translation: AAO38891.1
AY183385 Genomic DNA Translation: AAO38893.1
AY183386 Genomic DNA Translation: AAO38894.1
AY183387 Genomic DNA Translation: AAO38895.1
AY183388 Genomic DNA Translation: AAO38896.1
AY183389 Genomic DNA Translation: AAO38897.1
AY183390 Genomic DNA Translation: AAO38898.1
AY183382 Genomic DNA Translation: AAO38890.1
AY183384 Genomic DNA Translation: AAO38892.1
AE014296 Genomic DNA Translation: AAF49441.1
PIRiA29648
RefSeqiNP_524114.1, NM_079390.3
UniGeneiDm.29698

Genome annotation databases

GeneIDi39849
KEGGidme:Dmel_CG16724
UCSCiCG16724-RA d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17478 Genomic DNA Translation: AAB59226.1
L19464 Genomic DNA Translation: AAA75340.1
L19465 Genomic DNA Translation: AAA75341.1
L19466 Genomic DNA Translation: AAA75342.1
L19467 Genomic DNA Translation: AAA28958.1
L19468 Genomic DNA Translation: AAA28959.1
L19469 Genomic DNA Translation: AAA28960.1
L19470 Genomic DNA Translation: AAA28961.1
L19618 Genomic DNA Translation: AAA28962.1
L19619 Genomic DNA Translation: AAA28963.1
L19620 Genomic DNA Translation: AAA28964.1
AY183383 Genomic DNA Translation: AAO38891.1
AY183385 Genomic DNA Translation: AAO38893.1
AY183386 Genomic DNA Translation: AAO38894.1
AY183387 Genomic DNA Translation: AAO38895.1
AY183388 Genomic DNA Translation: AAO38896.1
AY183389 Genomic DNA Translation: AAO38897.1
AY183390 Genomic DNA Translation: AAO38898.1
AY183382 Genomic DNA Translation: AAO38890.1
AY183384 Genomic DNA Translation: AAO38892.1
AE014296 Genomic DNA Translation: AAF49441.1
PIRiA29648
RefSeqiNP_524114.1, NM_079390.3
UniGeneiDm.29698

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65151, 13 interactors
STRINGi7227.FBpp0075123

Proteomic databases

PaxDbiP11596
PRIDEiP11596

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi39849
KEGGidme:Dmel_CG16724
UCSCiCG16724-RA d. melanogaster

Organism-specific databases

CTDi6955
FlyBaseiFBgn0003741 tra

Phylogenomic databases

InParanoidiP11596
OrthoDBiEOG091G194U

Miscellaneous databases

GenomeRNAii39849
PROiPR:P11596

Gene expression databases

BgeeiFBgn0003741 Expressed in 30 organ(s), highest expression level in head
ExpressionAtlasiP11596 baseline and differential
GenevisibleiP11596 DM

Family and domain databases

InterProiView protein in InterPro
IPR010519 Tra
PfamiView protein in Pfam
PF06495 Transformer, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRSF_DROME
AccessioniPrimary (citable) accession number: P11596
Secondary accession number(s): Q540G8, Q86LR9, Q9VV78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 10, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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